Detailed information for compound 178427

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.377 | Formula: C17H20N6O6
  • H donors: 2 H acceptors: 6 LogP: -0.76 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)O[C@H]1C(OC(=O)C)[C@H](O[C@H]1n1cnc2c1ncnc2N)C(=O)NC1CC1
  • InChi: 1S/C17H20N6O6/c1-7(24)27-11-12(16(26)22-9-3-4-9)29-17(13(11)28-8(2)25)23-6-21-10-14(18)19-5-20-15(10)23/h5-6,9,11-13,17H,3-4H2,1-2H3,(H,22,26)(H2,18,19,20)/t11?,12-,13-,17+/m0/s1
  • InChiKey: LMYUSWXPSNCBOL-WLRYYPKHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tubulin subunit beta 0.0178 0.2599 0.2584
Schistosoma mansoni tubulin subunit beta 0.0178 0.2599 0.2584
Brugia malayi G-protein coupled receptor 0.0225 0.3351 0.368
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0225 0.3351 0.3337
Schistosoma mansoni amine GPCR 0.0225 0.3351 0.3337
Plasmodium vivax subtilisin-like serine protease, putative 0.0025 0.0145 0.0484
Onchocerca volvulus 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0183
Schistosoma mansoni ephrin receptor 0.0126 0.1764 0.1747
Leishmania major beta tubulin 0.0178 0.2599 1
Toxoplasma gondii subtilisin SUB11 0.0025 0.0145 0.0484
Echinococcus multilocularis beta tubulin 0.0178 0.2599 0.2584
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0225 0.3351 0.3337
Echinococcus multilocularis serotonin receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) G-protein coupled receptor 0.0225 0.3351 0.3351
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1555 0.2836
Schistosoma mansoni hypothetical protein 0.0225 0.3351 0.3337
Loa Loa (eye worm) BEN-1 protein 0.0178 0.2599 0.2599
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0025 0.0145 0.5
Echinococcus granulosus serotonin receptor 0.0225 0.3351 0.3337
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0225 0.3351 0.3337
Brugia malayi Dopamine receptor protein 1 0.0225 0.3351 0.368
Toxoplasma gondii subtilisin SUB9 0.0025 0.0145 0.0484
Brugia malayi sulfakinin receptor protein 0.0225 0.3351 0.368
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0528 0.0528
Trichomonas vaginalis tubulin epsilon chain, putative 0.0178 0.2599 0.4763
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Echinococcus granulosus neuropeptide Y receptor 0.0225 0.3351 0.3337
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0225 0.3351 0.3337
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0225 0.3351 0.3337
Echinococcus granulosus neuropeptide receptor A26 0.0225 0.3351 0.3337
Echinococcus multilocularis tubulin subunit beta 0.0178 0.2599 0.2584
Echinococcus multilocularis g protein coupled receptor 0.0225 0.3351 0.3337
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0025 0.0145 1
Echinococcus granulosus orexin receptor type 2 0.0225 0.3351 0.3337
Brugia malayi hypothetical protein 0.0225 0.3351 0.368
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0021 0.0076 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Toxoplasma gondii subtilisin SUB10 0.0025 0.0145 0.0484
Loa Loa (eye worm) hypothetical protein 0.0229 0.3416 0.3416
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Onchocerca volvulus 0.0225 0.3351 0.3337
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0025 0.0145 0.0125
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Echinococcus multilocularis fmrfamide receptor 0.0225 0.3351 0.3337
Brugia malayi putative neuropeptide receptor NPR1 0.0225 0.3351 0.368
Schistosoma mansoni opsin-like receptor 0.0225 0.3351 0.3337
Toxoplasma gondii beta tubulin 0.0178 0.2599 1
Schistosoma mansoni furin-1 (S08 family) 0.0254 0.3816 0.3804
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0225 0.3351 0.368
Schistosoma mansoni alpha-1 adrenergic receptor 0.0225 0.3351 0.3337
Echinococcus granulosus neuropeptides capa receptor 0.0225 0.3351 0.3337
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0138 0.1955 0.3575
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0138 0.1955 0.3575
Toxoplasma gondii subtilisin SUB7 0.0025 0.0145 0.0484
Loa Loa (eye worm) endoprotease bli-4 0.0584 0.9105 0.9105
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0225 0.3351 0.368
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0025 0.0145 1
Onchocerca volvulus 0.0225 0.3351 0.3337
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0025 0.0145 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0225 0.3351 0.368
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0138 0.1955 0.3575
Trichomonas vaginalis tubulin epsilon chain, putative 0.0178 0.2599 0.4763
Brugia malayi hypothetical protein 0.0225 0.3351 0.368
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0138 0.1955 0.1939
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Echinococcus granulosus Tubulin beta 2C chain 0.0178 0.2599 0.2584
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Schistosoma mansoni myosin xvIII 0.0225 0.3351 0.3337
Echinococcus multilocularis fmrfamide receptor 0.0225 0.3351 0.3337
Echinococcus granulosus beta tubulin 0.0178 0.2599 0.2584
Trypanosoma brucei beta tubulin 0.0178 0.2599 1
Schistosoma mansoni hypothetical protein 0.0406 0.6256 0.6248
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0076 0.0218
Brugia malayi Melatonin receptor type 1A 0.0225 0.3351 0.368
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Leishmania major beta tubulin 0.0178 0.2599 1
Echinococcus granulosus Tubulin beta 2C chain 0.0178 0.2599 0.2584
Echinococcus granulosus 7tm_1 domain containing protein 0.0225 0.3351 0.3337
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0225 0.3351 0.3337
Giardia lamblia Beta tubulin 0.0178 0.2599 0.6256
Loa Loa (eye worm) tubulin beta-2A chain 0.0178 0.2599 0.2599
Echinococcus granulosus tm gpcr rhodopsin 0.0225 0.3351 0.3337
Trichomonas vaginalis hypothetical protein 0.0113 0.1555 0.2836
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Loa Loa (eye worm) TK/ALK protein kinase 0.0023 0.012 0.012
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0355 0.5433 0.5424
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.3351 0.3337
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0528 0.058
Schistosoma mansoni tubulin subunit beta 0.0178 0.2599 0.2584
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0021 0.0076 0.0218
Loa Loa (eye worm) hypothetical protein 0.0444 0.6872 0.6872
Schistosoma mansoni neuropeptide F-like receptor 0.0225 0.3351 0.3337
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0025 0.0145 0.0159
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0225 0.3351 0.368
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0225 0.3351 0.368
Echinococcus granulosus alpha 1A adrenergic receptor 0.0225 0.3351 0.3337
Brugia malayi AKH receptor 0.0225 0.3351 0.368
Schistosoma mansoni hypothetical protein 0.0033 0.028 0.0261
Schistosoma mansoni peptide (allatostatin)-like receptor 0.064 1 1
Echinococcus multilocularis MAM 0.0022 0.0098 0.0078
Echinococcus multilocularis neuropeptide Y receptor 0.0225 0.3351 0.3337
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Loa Loa (eye worm) hypothetical protein 0.0063 0.0761 0.0761
Echinococcus granulosus MAM 0.0022 0.0098 0.0078
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0225 0.3351 0.3337
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Onchocerca volvulus 0.0225 0.3351 0.3337
Leishmania major beta tubulin 0.0178 0.2599 1
Schistosoma mansoni hypothetical protein 0.0113 0.1555 0.1538
Echinococcus multilocularis 0.0471 0.7294 0.7289
Brugia malayi Subtilase family protein 0.0025 0.0145 0.0159
Schistosoma mansoni opsin-like receptor 0.0225 0.3351 0.3337
Schistosoma mansoni neuropeptide receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) TK/EPH protein kinase 0.016 0.2311 0.2311
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0225 0.3351 0.3337
Schistosoma mansoni neuropeptide receptor 0.0225 0.3351 0.3337
Brugia malayi hypothetical protein 0.0225 0.3351 0.368
Loa Loa (eye worm) tubulin beta-4 chain 0.0178 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Onchocerca volvulus 0.0225 0.3351 0.3337
Schistosoma mansoni histamine h1 receptor 0.0225 0.3351 0.3337
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0022 0.0098 0.0098
Chlamydia trachomatis DNA topoisomerase I 0.0021 0.0076 0.5
Trypanosoma cruzi beta tubulin, putative 0.0178 0.2599 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0145 0.023
Echinococcus granulosus ephrin type A receptor 4 A 0.0126 0.1764 0.1747
Echinococcus multilocularis G-protein coupled receptor, putative 0.0225 0.3351 0.3337
Onchocerca volvulus 0.0225 0.3351 0.3337
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) tubulin beta chain 0.0178 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Echinococcus granulosus neuropeptide receptor 0.0225 0.3351 0.3337
Echinococcus multilocularis Furin 1 0.0138 0.1955 0.1939
Brugia malayi ephrin receptor 1 precursor 0.006 0.0708 0.0778
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0025 0.0145 0.0125
Brugia malayi Dopamine receptor protein 2 0.0225 0.3351 0.368
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1555 0.2836
Brugia malayi hypothetical protein 0.0225 0.3351 0.368
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0225 0.3351 0.3351
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Trichomonas vaginalis tubulin, putative 0.0178 0.2599 0.4763
Loa Loa (eye worm) hypothetical protein 0.064 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0225 0.3351 0.3337
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1555 0.2836
Brugia malayi SWIB/MDM2 domain containing protein 0.0021 0.0076 0.0084
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0225 0.3351 0.3337
Echinococcus multilocularis neuropeptide receptor A26 0.0225 0.3351 0.3337
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.3351 0.3337
Brugia malayi putative neuropeptide receptor 0.0225 0.3351 0.368
Echinococcus granulosus sex peptide receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0022 0.0098 0.0098
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Echinococcus granulosus Tubulin beta 2C chain 0.0178 0.2599 0.2584
Toxoplasma gondii subtilisin SUB2 0.0025 0.0145 0.0484
Brugia malayi map kinase activated protein kinase protein 2 0.0179 0.2613 0.287
Plasmodium vivax tubulin beta chain, putative 0.0178 0.2599 1
Schistosoma mansoni hypothetical protein 0.0022 0.0098 0.0078
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Entamoeba histolytica tubulin family protein 0.0178 0.2599 0.5
Echinococcus granulosus dnaJ subfamily B 0.0406 0.6256 0.6248
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0138 0.1955 0.3575
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.2613 0.2598
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0145 0.023
Leishmania major beta tubulin 0.0178 0.2599 1
Onchocerca volvulus 0.064 1 1
Echinococcus granulosus g protein coupled receptor 0.0225 0.3351 0.3337
Echinococcus multilocularis Tubulin beta 2C chain 0.0178 0.2599 0.2584
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0225 0.3351 0.3337
Onchocerca volvulus 0.0225 0.3351 0.3337
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0102 0.0083
Brugia malayi Protein kinase domain containing protein 0.0019 0.0042 0.0046
Schistosoma mansoni hypothetical protein 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0025 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Loa Loa (eye worm) subtilase 0.0025 0.0145 0.0145
Trichomonas vaginalis tubulin beta chain, putative 0.0178 0.2599 0.4763
Echinococcus granulosus g-protein coupled receptor 0.0225 0.3351 0.3337
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0025 0.0145 0.0159
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0021 0.0076 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1555 0.2836
Echinococcus multilocularis somatostatin receptor 0.0225 0.3351 0.3337
Schistosoma mansoni amine GPCR 0.0225 0.3351 0.3337
Entamoeba histolytica tubulin family protein 0.0178 0.2599 0.5
Schistosoma mansoni tubulin subunit beta 0.0178 0.2599 0.2584
Chlamydia trachomatis SWIB complex protein 0.0021 0.0076 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1555 0.2836
Plasmodium falciparum tubulin beta chain 0.0178 0.2599 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0145 0.023
Brugia malayi hypothetical protein 0.0225 0.3351 0.368
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1555 0.2836
Echinococcus multilocularis ephrin type A receptor 4 A 0.0126 0.1764 0.1747
Onchocerca volvulus Neuropeptide F receptor homolog 0.0225 0.3351 0.3337
Schistosoma mansoni neuropeptide F-like receptor 0.0225 0.3351 0.3337
Brugia malayi neuroendocrine convertase 1 precursor 0.0367 0.5627 0.618
Onchocerca volvulus 0.0125 0.1742 0.1725
Echinococcus granulosus tubulin beta 1 chain 0.0178 0.2599 0.2584
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0035 0.0308 0.0664
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Echinococcus multilocularis orexin receptor type 2 0.0225 0.3351 0.3337
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0225 0.3351 0.3337
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Onchocerca volvulus 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Brugia malayi celfurPC protein 0.0471 0.7294 0.8011
Loa Loa (eye worm) G-protein coupled receptor 0.0225 0.3351 0.3351
Schistosoma mansoni brg-1 associated factor 0.0021 0.0076 0.0056
Loa Loa (eye worm) neuropeptide F receptor 0.0225 0.3351 0.3351
Echinococcus granulosus tubulin beta 4A class IVa 0.0178 0.2599 0.2584
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0355 0.5433 0.5424
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0225 0.3351 0.3337
Schistosoma mansoni amine GPCR 0.0225 0.3351 0.3337
Echinococcus granulosus furin 0.0584 0.9105 0.9103
Schistosoma mansoni hypothetical protein 0.0225 0.3351 0.3337
Toxoplasma gondii beta-1 tubulin, putative 0.0178 0.2599 1
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Echinococcus granulosus biogenic amine 5HT receptor 0.0225 0.3351 0.3337
Schistosoma mansoni amine GPCR 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0225 0.3351 0.3337
Brugia malayi Serotonin receptor 0.0225 0.3351 0.368
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0178 0.2599 0.2584
Trypanosoma brucei beta tubulin 0.0178 0.2599 1
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Onchocerca volvulus 0.0021 0.0076 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0225 0.3351 0.3337
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0021 0.0076 0.0076
Brugia malayi GnHR receptor homolog 0.0225 0.3351 0.368
Brugia malayi brahma associated protein 60 kDa 0.0021 0.0076 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1555 0.2836
Onchocerca volvulus 0.0025 0.0145 0.0125
Toxoplasma gondii subtilisin SUB8 0.0025 0.0145 0.0484
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0225 0.3351 0.3337
Brugia malayi hypothetical protein 0.0225 0.3351 0.368
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Brugia malayi hypothetical protein 0.0022 0.0098 0.0107
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0225 0.3351 0.368
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Echinococcus multilocularis SWI:SNF matrix associated 0.0021 0.0076 0.0056
Trypanosoma brucei beta tubulin 0.0178 0.2599 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.028 0.0308
Leishmania major beta tubulin 0.0178 0.2599 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0021 0.0076 0.0056
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Brugia malayi ORL1-like opioid receptor 0.0225 0.3351 0.368
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Echinococcus granulosus neuropeptide receptor 0.0225 0.3351 0.3337
Schistosoma mansoni hypothetical protein 0.0022 0.0098 0.0078
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.6256 0.6248
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0021 0.0076 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0076 0.0104
Onchocerca volvulus 0.0225 0.3351 0.3337
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0225 0.3351 0.3337
Toxoplasma gondii subtilisin SUB12 0.0025 0.0145 0.0484
Echinococcus multilocularis g-protein coupled receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) beta-tubulin 0.0178 0.2599 0.2599
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1555 0.2836
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0225 0.3351 0.3337
Echinococcus granulosus dro:myosuppressin receptor 0.0225 0.3351 0.3337
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0025 0.0145 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.1742 0.1742
Schistosoma mansoni site-1 peptidase (S08 family) 0.0025 0.0145 0.0125
Echinococcus multilocularis g protein coupled receptor 0.0225 0.3351 0.3337
Onchocerca volvulus 0.0225 0.3351 0.3337
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0035 0.0308 0.0664
Schistosoma mansoni tubulin subunit beta 0.0178 0.2599 0.2584
Mycobacterium leprae Possible secreted protease 0.0025 0.0145 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0225 0.3351 0.3337
Brugia malayi hypothetical protein 0.0225 0.3351 0.368
Echinococcus multilocularis neuropeptides capa receptor 0.0225 0.3351 0.3337
Leishmania major beta tubulin 0.0178 0.2599 1
Onchocerca volvulus 0.0225 0.3351 0.3337
Leishmania major beta tubulin 0.0178 0.2599 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Plasmodium falciparum subtilisin-like protease 1 0.0025 0.0145 0.0484
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0179 0.2613 0.2598
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Echinococcus multilocularis Tubulin beta 2C chain 0.0178 0.2599 0.2584
Schistosoma mansoni biogenic amine receptor 0.0225 0.3351 0.3337
Echinococcus multilocularis SWI:SNF matrix associated 0.0021 0.0076 0.0056
Leishmania major beta tubulin 0.0178 0.2599 1
Toxoplasma gondii subtilisin SUB1 0.0025 0.0145 0.0484
Brugia malayi G-protein coupled receptor 0.0225 0.3351 0.368
Echinococcus multilocularis neuropeptide receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Schistosoma mansoni growth hormone secretagogue receptor 0.0225 0.3351 0.3337
Schistosoma mansoni adenoreceptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Onchocerca volvulus 0.0225 0.3351 0.3337
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0022 0.0098 0.0098
Giardia lamblia High cysteine membrane protein Group 2 0.0217 0.3223 1
Brugia malayi Protein kinase domain containing protein 0.0023 0.012 0.0131
Echinococcus multilocularis neuropeptides capa receptor 0.0225 0.3351 0.3337
Schistosoma mansoni biogenic amine (5HT) receptor 0.0225 0.3351 0.3337
Trichomonas vaginalis tubulin gamma chain, putative 0.0178 0.2599 0.4763
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Brugia malayi larval opioid receptor 0.0225 0.3351 0.368
Echinococcus granulosus peptide allatostatin:somatostatin 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0225 0.3351 0.3337
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0225 0.3351 0.3337
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0025 0.0145 0.0125
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Leishmania major beta tubulin 0.0178 0.2599 1
Echinococcus multilocularis serotonin receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0355 0.5433 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0138 0.1955 0.3575
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.3351 0.3337
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0179 0.2613 0.2613
Onchocerca volvulus 0.0022 0.0098 0.0078
Loa Loa (eye worm) hypothetical protein 0.0049 0.0528 0.0528
Plasmodium vivax subtilisin-like protease 2, putative 0.0025 0.0145 0.0484
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0225 0.3351 0.3337
Schistosoma mansoni tubulin subunit beta 0.0178 0.2599 0.2584
Schistosoma mansoni neuropeptide f receptor 76f 0.0225 0.3351 0.3337
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0225 0.3351 0.3337
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0225 0.3351 0.3337
Brugia malayi Dopamine receptor 0.0225 0.3351 0.368
Echinococcus granulosus neuropeptide s receptor 0.0225 0.3351 0.3337
Echinococcus multilocularis G protein coupled receptor 139 0.0225 0.3351 0.3337
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.3351 0.3337
Echinococcus granulosus beta tubulin 0.0178 0.2599 0.2584
Echinococcus multilocularis neuropeptide Y receptor 0.0225 0.3351 0.3337
Brugia malayi beta-tubulin, identical 0.0178 0.2599 0.2854
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1555 0.2836
Echinococcus multilocularis tubulin beta 1 chain 0.0178 0.2599 0.2584
Brugia malayi brahma associated protein 60 kDa 0.0021 0.0076 0.0084
Onchocerca volvulus 0.0225 0.3351 0.3337
Schistosoma mansoni neuropeptide receptor 0.0225 0.3351 0.3337
Brugia malayi RE15519p 0.0225 0.3351 0.368
Echinococcus granulosus G protein coupled receptor 139 0.0225 0.3351 0.3337
Schistosoma mansoni hypothetical protein 0.0021 0.0076 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Echinococcus granulosus neuropeptide Y receptor 0.0225 0.3351 0.3337
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0113 0.1555 0.2836
Leishmania major beta tubulin 0.0178 0.2599 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0025 0.0145 0.0125
Echinococcus granulosus somatostatin receptor 0.0225 0.3351 0.3337
Echinococcus granulosus g protein coupled receptor 0.0225 0.3351 0.3337
Toxoplasma gondii subtilisin SUB5 0.0025 0.0145 0.0484
Echinococcus multilocularis g protein coupled receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0225 0.3351 0.3351
Echinococcus granulosus g protein coupled receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) proprotein convertase 2 0.0138 0.1955 0.1955
Plasmodium vivax subtilisin-like protease 1 0.0025 0.0145 0.0484
Onchocerca volvulus 0.0225 0.3351 0.3337
Schistosoma mansoni hypothetical protein 0.0021 0.0076 0.0056
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0225 0.3351 0.3351
Brugia malayi follicle stimulating hormone receptor 0.0225 0.3351 0.368
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0225 0.3351 0.3337
Leishmania major beta tubulin 0.0178 0.2599 1
Loa Loa (eye worm) BEN-1 protein 0.0178 0.2599 0.2599
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0113 0.1555 0.2836
Echinococcus granulosus hypothetical protein 0.0225 0.3351 0.3337
Leishmania major beta tubulin 0.0178 0.2599 1
Plasmodium falciparum subtilisin-like protease 3 0.0025 0.0145 0.0484
Echinococcus granulosus tm gpcr rhodopsin 0.0225 0.3351 0.3337
Echinococcus granulosus Furin 1 0.0138 0.1955 0.1939
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0355 0.5433 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0225 0.3351 0.3337
Echinococcus granulosus Tubulin beta 2C chain 0.0178 0.2599 0.2584
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Trypanosoma brucei beta tubulin 0.0178 0.2599 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Echinococcus granulosus neuroendocrine convertase 2 0.0367 0.5627 0.5618
Leishmania major beta tubulin 0.0178 0.2599 1
Brugia malayi proprotein convertase 2 0.0367 0.5627 0.618
Brugia malayi Tubulin beta-1 chain 0.0178 0.2599 0.2854
Toxoplasma gondii beta-tubulin, putative 0.0178 0.2599 1
Schistosoma mansoni tubulin subunit beta 0.0178 0.2599 0.2584
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1555 0.2836
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0225 0.3351 0.3337
Echinococcus multilocularis beta tubulin 0.0178 0.2599 0.2584
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1555 0.2836
Brugia malayi Serotonin receptor 0.0225 0.3351 0.368
Schistosoma mansoni hypothetical protein 0.0225 0.3351 0.3337
Echinococcus multilocularis membrane bound transcription factor site 1 0.0025 0.0145 0.0125
Echinococcus multilocularis sex peptide receptor 0.0225 0.3351 0.3337
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0225 0.3351 0.3337
Echinococcus multilocularis Tubulin beta 2C chain 0.0178 0.2599 0.2584
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.3351 0.3337
Echinococcus multilocularis dro:myosuppressin receptor 0.0225 0.3351 0.3337
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0021 0.0076 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Brugia malayi endoprotease bli-4 precursor 0.0584 0.9105 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Trichomonas vaginalis tubulin alpha chain, putative 0.0178 0.2599 0.4763
Leishmania major beta tubulin 0.0178 0.2599 1
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0021 0.0076 0.0056
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0025 0.0145 1
Plasmodium falciparum subtilisin-like protease 2 0.0025 0.0145 0.0484
Leishmania major beta tubulin 0.0178 0.2599 1
Echinococcus granulosus tm gpcr rhodopsin 0.0225 0.3351 0.3337
Brugia malayi Tachykinin-like peptides receptor 99D 0.0444 0.6872 0.7548
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0225 0.3351 0.3337
Brugia malayi hypothetical protein 0.0225 0.3351 0.368
Schistosoma mansoni opsin-like receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.3351 0.3351
Echinococcus multilocularis neuropeptide s receptor 0.0225 0.3351 0.3337
Schistosoma mansoni hypothetical protein 0.0021 0.0076 0.0056
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0225 0.3351 0.3337
Loa Loa (eye worm) tubulin beta-1 chain 0.0178 0.2599 0.2599
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0025 0.0145 1
Brugia malayi hypothetical protein 0.0225 0.3351 0.368
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0035 0.0308 0.0664
Brugia malayi hypothetical protein 0.0225 0.3351 0.368
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Brugia malayi neuropeptide F receptor 0.0225 0.3351 0.368
Echinococcus granulosus SWI:SNF matrix associated 0.0021 0.0076 0.0056
Onchocerca volvulus 0.0225 0.3351 0.3337
Echinococcus granulosus neuropeptide FF receptor 2 0.0444 0.6872 0.6866
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0025 0.0145 0.5
Onchocerca volvulus 0.0225 0.3351 0.3337
Onchocerca volvulus 0.0019 0.0042 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0145 0.023
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0528 0.058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) TYRA-2 protein 0.0225 0.3351 0.3351
Onchocerca volvulus 0.0027 0.0173 0.0153
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0113 0.1555 0.2836
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Echinococcus granulosus membrane bound transcription factor site 1 0.0025 0.0145 0.0125
Echinococcus granulosus biogenic amine 5HT receptor 0.0225 0.3351 0.3337
Giardia lamblia Beta tubulin 0.0178 0.2599 0.6256
Echinococcus granulosus fmrfamide receptor 0.0225 0.3351 0.3337
Echinococcus multilocularis neuropeptide FF receptor 2 0.0444 0.6872 0.6866
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0102 0.0083
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0033 0.028 0.028
Schistosoma mansoni amine GPCR 0.0225 0.3351 0.3337
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.3351 0.3337
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0138 0.1955 0.3575
Echinococcus multilocularis neuropeptide receptor 0.0225 0.3351 0.3337
Toxoplasma gondii subtilisin SUB6 0.0025 0.0145 0.0484
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0179 0.2613 0.2598
Brugia malayi neuropeptide F receptor 0.0225 0.3351 0.368
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0021 0.0076 0.0218
Loa Loa (eye worm) brahma associated protein 0.0021 0.0076 0.0076
Toxoplasma gondii subtilisin SUB4 0.0025 0.0145 0.0484
Loa Loa (eye worm) neuropeptide F receptor 0.0225 0.3351 0.3351
Leishmania major beta tubulin 0.0178 0.2599 1
Schistosoma mansoni neuropeptide receptor 0.0225 0.3351 0.3337
Echinococcus multilocularis neuroendocrine convertase 2 0.0367 0.5627 0.5618
Loa Loa (eye worm) hypothetical protein 0.0584 0.9105 0.9105
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Echinococcus granulosus tachykinin peptides receptor 99D 0.0225 0.3351 0.3337
Leishmania major beta tubulin 0.0178 0.2599 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0225 0.3351 0.3337
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Brugia malayi G protein-coupled receptor 0.0225 0.3351 0.368
Echinococcus granulosus Tubulin beta 2C chain 0.0178 0.2599 0.2584
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0025 0.0145 0.5
Giardia lamblia Beta tubulin 0.0178 0.2599 0.6256
Schistosoma mansoni biogenic amine receptor 0.0225 0.3351 0.3337
Leishmania major beta tubulin 0.0178 0.2599 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0225 0.3351 0.3351
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0145 0.023
Echinococcus multilocularis allatostatin A receptor 0.064 1 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0584 0.9105 0.9103
Echinococcus multilocularis Tubulin beta 2C chain 0.0178 0.2599 0.2584
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0145 0.023
Loa Loa (eye worm) hypothetical protein 0.0225 0.3351 0.3351
Loa Loa (eye worm) melatonin receptor type 1A 0.0225 0.3351 0.3351
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0025 0.0145 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.3351 0.3337
Echinococcus multilocularis Tubulin beta 2C chain 0.0178 0.2599 0.2584
Schistosoma mansoni biogenic amine receptor 0.0225 0.3351 0.3337

Activities

Activity type Activity value Assay description Source Reference
BP (functional) = 31 mmHg Tested for the percent increase in aortic blood pressure (BP) in open chest anesthetized dog at intravenous dosage of 0.01 mg/kg ChEMBL. 7365748
Duration (functional) = 270 min Total time in minutes elapsed from the initiation of the change until return to the pretest value of oxygen partial pressure in coronary sinus of anesthetized dog at intravenous dosage of 0.01 mg/kg ChEMBL. 7365748
Duration (functional) = 270 min Total time in minutes elapsed from the initiation of the change until return to the pretest value of blood pressure in coronary sinus of anesthetized dog at intravenous dosage of 0.01 mg/kg ChEMBL. 7365748
Duration (functional) = 270 min Total time in minutes elapsed from the initiation of the change until return to the pretest value of heart rate in coronary sinus of anesthetized dog at intravenous dosage of 0.01 mg/kg ChEMBL. 7365748
HR (functional) = 13 % Tested for the percent increase in heart rate (HR) in open chest anesthetized dog at intravenous dosage of 0.01 mg/kg ChEMBL. 7365748
LD50 (ADMET) = 5 mg kg-1 Lethal dose in mice after intraperitoneal administration ChEMBL. 7365748
LD50 (ADMET) = 5 mg kg-1 Lethal dose in mice after intraperitoneal administration ChEMBL. 7365748
LD50 (ADMET) = 20 mg kg-1 Lethal dose in mice after peroral administration ChEMBL. 7365748
LD50 (ADMET) = 20 mg kg-1 Lethal dose in mice after peroral administration ChEMBL. 7365748
PO2 (functional) = 67 % Tested for percent increase in coronary sinus partial pressure of oxygen (PO2) in open chest anesthetized dog at intravenous dosage of 0.01 mg/kg ChEMBL. 7365748

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.