TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 245.276 | Formula: C10H19N3O4
H donors: 3 H acceptors: 4 LogP: -0.37 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=CN(C[C@H](C(=O)NC(=O)CN)CC(C)C)O
InChi: 1S/C10H19N3O4/c1-7(2)3-8(5-13(17)6-14)10(16)12-9(15)4-11/h6-8,17H,3-5,11H2,1-2H3,(H,12,15,16)/t8-/m1/s1
InChiKey: UPXVLGSXKVASHE-MRVPVSSYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bacillus thermoproteolyticus	Thermolysin	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0082	0.0423	0.042
Echinococcus granulosus	defective proboscis extension response	0.0035	0.0016	0.0012
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.004	0.0055	0.0062
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0158	0.1096	0.1093
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0149	0.1017	0.1148
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0097	0.0109
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0289	0.2251	0.2248
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0021	0.0023
Echinococcus multilocularis		0.0045	0.0102	0.0098
Echinococcus multilocularis	Zinc finger, PHD finger	0.0158	0.1096	0.1093
Schistosoma mansoni	tyrosine kinase	0.0078	0.0387	0.0384
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0255	0.1945	0.2492
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0036	0.0021	0.0017
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0038	0.0042	0.0039
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0166	0.1164	0.2362
Loa Loa (eye worm)	hypothetical protein	0.0428	0.347	0.3918
Echinococcus multilocularis	insulin receptor	0.005	0.0143	0.014
Schistosoma mansoni	cell adhesion molecule	0.0038	0.0042	0.0039
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0879	0.7442	0.9591
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0021	0.0023
Trypanosoma brucei	cdc2-related kinase 3	0.0042	0.0077	0.0256
Echinococcus granulosus	twitchin	0.0042	0.0076	0.0073
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0036	0.0021	0.0017
Onchocerca volvulus		0.0036	0.0021	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0036	0.0021	0.0006
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0158	0.1096	0.139
Giardia lamblia	Kinase, CMGC CDK	0.0042	0.0077	0.0117
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0036	0.0021	0.0017
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0042	0.0077	0.0527
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0042	0.0077	0.0087
Brugia malayi	cell division control protein 2 homolog	0.0042	0.0077	0.008
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0288	0.224	0.2868
Echinococcus granulosus	cyclin dependent kinase 1	0.0042	0.0077	0.0074
Echinococcus granulosus	protein tyrosine kinase	0.025	0.1907	0.1905
Trichomonas vaginalis	CMGC family protein kinase	0.0042	0.0077	0.0073
Echinococcus granulosus	insulin receptor	0.005	0.0143	0.014
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0158	0.1096	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0046	0.0052
Schistosoma mansoni	tyrosine kinase	0.025	0.1907	0.1905
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0016	0.0018
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0915	0.7759	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0021	0.0023
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0288	0.224	0.2868
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0036	0.0021	0.0006
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0036	0.0021	0.0017
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0036	0.0021	0.0017
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0158	0.1096	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0036	0.0021	0.0017
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.005	0.0143	0.014
Brugia malayi	hypothetical protein	0.0058	0.0218	0.0261
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.005	0.0143	0.014
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0036	0.0021	0.0017
Echinococcus multilocularis	epidermal growth factor receptor	0.0149	0.1017	0.1014
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0036	0.0021	0.0023
Echinococcus multilocularis	serine protein kinase ATM	0.0036	0.0021	0.0017
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0077	0.008
Schistosoma mansoni	tyrosine kinase	0.005	0.0143	0.014
Schistosoma mansoni	nephrin	0.0042	0.0071	0.0067
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0158	0.1096	0.4848
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0077	0.0074
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0036	0.0021	0.0017
Echinococcus multilocularis	epidermal growth factor receptor	0.0082	0.0423	0.042
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0016	0.0018
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0288	0.224	0.2868
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0158	0.1096	0.139
Schistosoma mansoni	tyrosine kinase	0.0078	0.0387	0.0384
Echinococcus granulosus	epidermal growth factor receptor	0.0082	0.0423	0.042
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0158	0.1096	0.139
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0021	0.5
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0915	0.7759	1
Schistosoma mansoni	vesicular amine transporter	0.0035	0.0016	0.0012
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0036	0.0021	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0021	0.0023
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0041	0.0063	0.0071
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0915	0.7759	1
Echinococcus multilocularis	cyclin dependent kinase 5	0.0042	0.0077	0.0074
Echinococcus granulosus	Immunoglobulin	0.0035	0.0016	0.0012
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0042	0.0078	0.008
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0288	0.224	0.2868
Loa Loa (eye worm)	phosphatidylinositol 3	0.0252	0.1923	0.2172
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0021	0.0023
Echinococcus granulosus	epidermal growth factor receptor	0.0149	0.1017	0.1014
Trichomonas vaginalis	CMGC family protein kinase	0.0042	0.0077	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0016	0.0018
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.1169	1	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0072	0.0081
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0021	0.0023
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0036	0.0021	0.0006
Echinococcus granulosus	roundabout 2	0.0045	0.0097	0.0094
Echinococcus multilocularis	Immunoglobulin	0.0035	0.0016	0.0012
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0288	0.224	0.2868
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0036	0.0021	0.0017
Echinococcus multilocularis	cyclin dependent kinase 1	0.0042	0.0077	0.0074
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0716	0.6005	0.7734
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0288	0.224	0.2873
Loa Loa (eye worm)	TK/INSR protein kinase	0.005	0.0143	0.0162
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0036	0.0021	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0042	0.0047
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0252	0.1923	0.2459
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0042	0.0077	0.0527
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0158	0.1096	0.139
Entamoeba histolytica	cell division protein kinase 2, putative	0.0042	0.0077	0.0073
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0042	0.0077	0.0527
Echinococcus granulosus	nephrin	0.0037	0.0029	0.0025
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0036	0.0021	0.0006
Echinococcus multilocularis	cyclin dependent kinase	0.0042	0.0077	0.0074
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0158	0.1096	0.1238
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0158	0.1096	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0158	0.1096	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0042	0.0077	0.0073
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0021	0.0023
Echinococcus multilocularis	protein tyrosine kinase	0.025	0.1907	0.1905
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0016	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0016	0.0018
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0036	0.0021	0.0017
Onchocerca volvulus		0.0036	0.0021	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0915	0.7759	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0488	0.4004	0.5151
Trypanosoma brucei	cdc2-related kinase 1	0.0042	0.0077	0.0256
Plasmodium falciparum	protein kinase 5	0.0042	0.0077	0.0527
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0035	0.0016	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0021	0.0023
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0036	0.0021	0.0006
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0288	0.224	0.2868
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0035	0.0016	0.0012
Echinococcus granulosus	cyclin dependent kinase 5	0.0042	0.0077	0.0074
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0036	0.0021	0.0017
Echinococcus multilocularis	cyclin dependent kinase 1	0.0042	0.0077	0.0074
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0158	0.1096	1
Trypanosoma cruzi	cdc2-related kinase 1	0.0042	0.0077	0.0073
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0158	0.1096	0.139
Schistosoma mansoni	tyrosine kinase	0.0078	0.0387	0.0384
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0188	0.0184
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0716	0.6005	0.7734
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0036	0.0021	0.0017
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0487	0.3993	0.3991
Loa Loa (eye worm)	phosphatidylinositol 3	0.1039	0.8857	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0915	0.7759	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.004	0.0055	0.0051
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0035	0.0016	0.0012
Schistosoma mansoni	hypothetical protein	0.0036	0.0021	0.0017
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0915	0.7759	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0357	0.285	0.3656
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0158	0.1096	0.1396
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0915	0.7759	1
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0036	0.0021	0.0017
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0188	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0315	0.0355
Brugia malayi	Protein kinase c protein 2	0.0047	0.0115	0.0129
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0036	0.0021	0.0017
Onchocerca volvulus	Tyrosine kinase homolog	0.0035	0.0013	0.5589
Entamoeba histolytica	cell division protein kinase 2, putative	0.0042	0.0077	0.0073
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0158	0.1096	1
Schistosoma mansoni	tyrosine kinase	0.0082	0.0423	0.042
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0158	0.1096	0.1093
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0158	0.1096	0.1093
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0036	0.0021	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0487	0.3993	0.4509
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0042	0.0077	0.0087
Schistosoma mansoni	tyrosine kinase	0.005	0.0143	0.014
Trypanosoma cruzi	cdc2-related kinase 1	0.0042	0.0077	0.0073
Brugia malayi	Immunoglobulin I-set domain containing protein	0.004	0.0055	0.0051
Echinococcus granulosus	RNA directed DNA polymerase	0.0039	0.0046	0.0043
Brugia malayi	Protein kinase domain containing protein	0.005	0.0143	0.0165
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0042	0.0077	0.0087
Echinococcus granulosus	Protein kinase C brain isozyme	0.0055	0.0188	0.0184
Brugia malayi	Protein kinase domain containing protein	0.0253	0.1933	0.2477
Plasmodium vivax	protein kinase Crk2	0.0042	0.0077	0.0527
Echinococcus multilocularis	Immunoglobulin	0.0066	0.0285	0.0282
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0042	0.0078	0.0088
Schistosoma mansoni	tyrosine kinase	0.0149	0.1017	0.1014
Echinococcus multilocularis	serine threonine protein kinase	0.0049	0.0135	0.0132
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0036	0.0021	0.0006
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0036	0.0021	0.0017
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0158	0.1096	0.1093
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0082	0.0423	0.042
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0055	0.0188	0.0184
Echinococcus granulosus	serine protein kinase ATM	0.0036	0.0021	0.0017
Echinococcus multilocularis		0.0036	0.0021	0.0017
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0288	0.224	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0042	0.0077	0.0073
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0487	0.3993	0.3991
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0158	0.1096	0.139
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0077	0.0074
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0039	0.0046	0.0043
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0036	0.0021	0.0017
Giardia lamblia	Kinase, CMGC CDK	0.0042	0.0077	0.0117
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0586	0.4862	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.1169	1	1
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0042	0.0077	0.0074
Loa Loa (eye worm)	TK/FAK protein kinase	0.0253	0.1933	0.2183
Echinococcus granulosus	protein kinase C gamma type	0.0049	0.0135	0.0132
Mycobacterium tuberculosis	Possible exported protein	0.0612	0.5089	1
Echinococcus multilocularis	roundabout 2	0.0045	0.0097	0.0094
Echinococcus granulosus	neuroglian	0.0042	0.0071	0.0067
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0021	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0099	0.0111
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0785	0.6615	0.8522
Echinococcus multilocularis	RNA directed DNA polymerase	0.0039	0.0046	0.0043
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0158	0.1096	0.139
Echinococcus granulosus	cyclin dependent kinase	0.0042	0.0077	0.0074
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0036	0.0021	0.0017
Trichomonas vaginalis	CMGC family protein kinase	0.0042	0.0077	0.0073
Echinococcus multilocularis	neuroglian	0.0042	0.0071	0.0067
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0036	0.0021	0.0017
Entamoeba histolytica	hypothetical protein	0.0785	0.6615	0.8522
Brugia malayi	Furin-like cysteine rich region family protein	0.0149	0.1017	0.1293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0016	0.0018
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0158	0.1096	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 10.87 uM	Inhibitory activity against thermolysin	ChEMBL.	12951085
Ki (binding)	= 10.87 uM	Inhibitory activity against thermolysin	ChEMBL.	12951085
Ki (binding)	= 14.7 uM	Inhibitory activity against thermolysin using N-[3-(2-furyl)acryloyl]-Gly-l-leucineamide (FA-Gly-l-Leu-NH2) as substrate	ChEMBL.	12951085
Ki (binding)	= 14.7 uM	Inhibitory activity against thermolysin using N-[3-(2-furyl)acryloyl]-Gly-l-leucineamide (FA-Gly-l-Leu-NH2) as substrate	ChEMBL.	12951085
Km/Kcat (binding)	= 165 uM s-1	Ratio of Km to that of Kcat against thermolysin	ChEMBL.	12951085

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL324446

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 178637