TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 508.138 | Formula: C31H42ClN3O
H donors: 2 H acceptors: 1 LogP: 9.8 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCCCc1c([nH]c2c1cc(Cl)cc2)C(=O)NCCc1ccc(cc1)N1CCCCC1
InChi: 1S/C31H42ClN3O/c1-2-3-4-5-6-7-9-12-27-28-23-25(32)15-18-29(28)34-30(27)31(36)33-20-19-24-13-16-26(17-14-24)35-21-10-8-11-22-35/h13-18,23,34H,2-12,19-22H2,1H3,(H,33,36)
InChiKey: VXYIJMBVCMJECP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.0445	0.0445
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Echinococcus granulosus	metabotropic glutamate receptor 5	0.005	0.1029	0.1029
Onchocerca volvulus		0.0026	0.0445	0.0952
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0064	0.0058
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0014	0.0159	0.098
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0014	0.0159	0.0303
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0034	0.0643	0.0643
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0051
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.1246	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0445	0.0445
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0445	0.0952
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0064	0.0064
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0159	0.0303
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0445	0.1219
Schistosoma mansoni	cathepsin B (C01 family)	0.001	0.0064	0.0064
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0014	0.0159	0.2488
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0059	0.1249	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0139	0.3188	0.3188
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0014	0.0159	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0159	0.0286
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0059	0.1249	0.1249
Loa Loa (eye worm)	cathepsin B	0.005	0.103	0.2453
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0445	0.0445
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0059	0.1249	0.1249
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.001	0.0064	0.0064
Loa Loa (eye worm)	cysteine protease	0.0026	0.0445	0.0998
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1338	0.1338
Brugia malayi	cathepsin L precursor	0.001	0.0064	0.0058
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0445	0.1219
Brugia malayi	prolyl oligopeptidase family protein	0.0175	0.4065	1
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0175	0.4065	0.4065
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.001	0.0064	0.0058
Brugia malayi	prolyl oligopeptidase family protein	0.0014	0.0159	0.0293
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0159	0.0303
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0139	0.3188	0.3188
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0014	0.0159	0.0303
Giardia lamblia	Cathepsin B precursor	0.005	0.103	1
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0014	0.0159	0.0159
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0913	0.2161
Plasmodium vivax	vivapain-2	0.0026	0.0445	1
Brugia malayi	Receptor family ligand binding region containing protein	0.001	0.0074	0.0082
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.001	0.0064	0.0064
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.0445	0.0445
Onchocerca volvulus		0.0029	0.0537	0.1182
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0059	0.1249	1
Schistosoma mansoni	cathepsin C	0.001	0.0064	0.0064
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0059	0.1249	0.1249
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0064	0.0064
Echinococcus granulosus	prolyl endopeptidase	0.0014	0.0159	0.0159
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0059	0.1249	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0445	0.0998
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma cruzi	oligopeptidase b	0.0014	0.0159	0.0303
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Loa Loa (eye worm)	hypothetical protein	0.005	0.1029	0.245
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0064	0.0058
Loa Loa (eye worm)	prolyl oligopeptidase	0.0014	0.0159	0.0286
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.0445	0.0998
Loa Loa (eye worm)	ctsf protein	0.0026	0.0445	0.0998
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0537	0.1227
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0014	0.0159	0.0159
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0445	0.1219
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.005	0.1029	0.1029
Echinococcus multilocularis	prolyl endopeptidase	0.0014	0.0159	0.0159
Brugia malayi	cathepsin L-like cysteine proteinase	0.001	0.0064	0.0058
Trypanosoma cruzi	prolyl endopeptidase	0.0014	0.0159	0.0303
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.001	0.0064	0.0051
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.001	0.0074	0.0075
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1246	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.001	0.0064	0.0058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0175	0.4065	0.4065
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1246	1
Toxoplasma gondii	prolyl endopeptidase	0.0014	0.0159	0.0799
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.001	0.0064	0.0064
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1246	0.1246
Brugia malayi	fibroinase precursor	0.001	0.0064	0.0058
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.001	0.0074	0.0075
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Onchocerca volvulus		0.0026	0.0445	0.0952
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0139	0.3188	0.3188
Giardia lamblia	Cathepsin B precursor	0.005	0.103	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0445	0.0998
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.005	0.103	0.3093
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0445	0.0952
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0014	0.0159	0.2488
Schistosoma mansoni	cpg binding protein	0.0031	0.0578	0.0578
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0014	0.0159	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0159	0.0286
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0014	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0051
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0026	0.0445	1
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0445	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3188	0.7819
Trypanosoma cruzi	cruzipain precursor, putative	0.0026	0.0445	0.1219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0014	0.0159	0.0799
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Trypanosoma cruzi	oligopeptidase b	0.0014	0.0159	0.0303
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Echinococcus granulosus	cathepsin b	0.0139	0.3188	0.3188
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Brugia malayi	prolyl oligopeptidase family protein	0.0059	0.1249	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0159	0.0286
Brugia malayi	hypothetical protein	0.0045	0.0913	0.2167
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0445	1
Brugia malayi	prolyl oligopeptidase family protein	0.0014	0.0159	0.0293
Echinococcus multilocularis	dnaJ subfamily B	0.0419	1	1
Echinococcus granulosus	cathepsin l1	0.0026	0.0445	0.0445
Onchocerca volvulus		0.0026	0.0445	0.0952
Trypanosoma brucei	oligopeptidase b	0.0014	0.0159	0.0799
Schistosoma mansoni	hypothetical protein	0.0419	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.001	0.0064	0.0064
Brugia malayi	metabotropic glutamate receptor type 2	0.002	0.03	0.0645
Toxoplasma gondii	cathepsin CPL	0.0026	0.0445	0.3214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Brugia malayi	cathepsin L-like precursor	0.0026	0.0445	0.1004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0064	0.0058
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.001	0.0064	0.0051
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0445	0.1219
Leishmania major	cysteine peptidase A (CPA)	0.0026	0.0445	0.2624
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Onchocerca volvulus		0.0026	0.0445	0.0952
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0014	0.0159	0.0237
Trypanosoma brucei	prolyl endopeptidase	0.0014	0.0159	0.0799
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0051
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1176	0.9388
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Loa Loa (eye worm)	hypothetical protein	0.001	0.0074	0.0075
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0014	0.0159	0.0159
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0014	0.0159	0.098
Loa Loa (eye worm)	glutamate receptor	0.0016	0.0208	0.0409
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0139	0.3188	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1246	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.005	0.103	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0445	0.0998
Echinococcus multilocularis	cpg binding protein	0.0031	0.0578	0.0578
Echinococcus granulosus	cysteine protease	0.001	0.0064	0.0064
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0026	0.0445	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0064	0.0064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Brugia malayi	prolyl oligopeptidase family protein	0.0014	0.0159	0.0293
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Schistosoma mansoni	metabotropic glutamate receptor	0.002	0.03	0.03
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.1246	0.9979
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0051
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0014	0.0159	0.0799
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0064	0.0058
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0537	0.1233
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0014	0.0159	0.2488
Echinococcus granulosus	cathepsin L cysteine protease	0.001	0.0064	0.0064
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0059	0.1249	1
Toxoplasma gondii	cathepsin B	0.005	0.103	0.8154
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.1246	0.9978
Echinococcus granulosus	acylamino acid releasing enzyme	0.0014	0.0159	0.0159
Onchocerca volvulus		0.0026	0.0445	0.0952
Onchocerca volvulus		0.0026	0.0445	0.0952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Toxoplasma gondii	hypothetical protein	0.0014	0.0159	0.0799
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0044	0.0044
Echinococcus granulosus	cpg binding protein	0.0031	0.0578	0.0578
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma brucei	cysteine peptidase C (CPC)	0.005	0.103	0.8154
Onchocerca volvulus	Cathepsin F homolog	0.0026	0.0445	0.0952
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0051
Onchocerca volvulus		0.0026	0.0445	0.0952
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0445	1
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.103	0.103
Schistosoma mansoni	cpg binding protein	0.0031	0.0578	0.0578
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.001	0.0064	0.0064
Brugia malayi	Papain family cysteine protease containing protein	0.001	0.0064	0.0058
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0064	0.0064
Entamoeba histolytica	hypothetical protein, conserved	0.0014	0.0159	0.2488
Echinococcus granulosus	cathepsin b	0.0139	0.3188	0.3188
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0014	0.0159	0.0799
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0046	0.0937	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0445	0.0998
Echinococcus multilocularis	cysteine protease	0.0026	0.0445	0.0445
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0175	0.4065	0.4065
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0026	0.0445	0.1004
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.1246	0.1246
Echinococcus multilocularis	cysteine protease	0.0026	0.0445	0.0445
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0014	0.0159	0.098
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0445	0.1004
Brugia malayi	Metabotropic glutamate receptor precursor.	0.004	0.0802	0.1893
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0445	0.0445
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0445	0.0445
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0064	0.0064
Loa Loa (eye worm)	prolyl oligopeptidase	0.0175	0.4065	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Echinococcus multilocularis	cathepsin L	0.001	0.0064	0.0064
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0059	0.1249	0.3793
Brugia malayi	cathepsin F-like cysteine proteinase	0.001	0.0064	0.0058
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0445	0.1004
Schistosoma mansoni	metabotropic glutamate receptor	0.0034	0.0643	0.0643
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0064	0.0064
Loa Loa (eye worm)	glutamate receptor	0.004	0.0802	0.1887
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0014	0.0159	0.0159
Echinococcus granulosus	cathepsin L	0.001	0.0064	0.0064
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0445	0.0445
Brugia malayi	cathepsin B-like cysteine proteinase	0.0139	0.3188	0.782
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0014	0.0159	0.2488
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0175	0.4065	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0026	0.0445	0.1219
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0034	0.0643	0.0643
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0445	0.3941
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0139	0.3188	0.3188
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0014	0.0159	0.098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0445	0.3941
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0445	0.3214
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.001	0.0064	0.0064
Echinococcus multilocularis	cathepsin L	0.001	0.0064	0.0064
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.001	0.0064	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0037	0.071	0.1664
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.005	0.103	0.7994
Echinococcus granulosus	cathepsin l1	0.0026	0.0445	0.0445
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0445	0.3941
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0159	0.098
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.1246	0.1246
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1246	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0051
Echinococcus multilocularis	cathepsin b	0.0139	0.3188	0.3188
Echinococcus multilocularis	cathepsin b	0.0139	0.3188	0.3188
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0445	1
Leishmania major	cathepsin L-like protease	0.0026	0.0445	0.2624
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0059	0.1249	0.3793
Onchocerca volvulus		0.0026	0.0445	0.0952
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0159	0.2488
Brugia malayi	cathepsin Z-like cysteine proteinase	0.001	0.0064	0.0058
Giardia lamblia	Cathepsin B precursor	0.005	0.103	1
Plasmodium vivax	vivapain-2	0.0026	0.0445	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0026	0.0445	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0445	0.0998
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0445	1
Plasmodium falciparum	peptidase, putative	0.0014	0.0159	0.2488
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0445	0.0445
Loa Loa (eye worm)	fibroinase	0.0026	0.0445	0.0998
Schistosoma mansoni	cpg binding protein	0.0029	0.0537	0.0537
Echinococcus granulosus	cathepsin L	0.001	0.0064	0.0064
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0014	0.0159	0.2488
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.001	0.0064	0.0064

Activities

Activity type	Activity value	Assay description	Source	Reference
Emax (functional)	= 61.4 fmol/mg	Antagonist activity CB1 receptor (unknown origin) expressed in HEK293 cell membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding at 3.2 uM after 60 mins by liquid scintillation counting analysis relative to control	ChEMBL.	24053617
Kb (binding)	= 259.7 nM	Positive allosteric modulation of CB1 receptor (unknown origin) expressed in HEK293 cell membranes assessed as stimulation of [3H]CP55,940 binding after 60 mins by liquid scintillation counting analysis	ChEMBL.	24053617

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2431221

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1786872