Detailed information for compound 1787490

Basic information

Technical information
  • TDR Targets ID: 1787490
  • Name: 2-(trifluoromethyl)-1H-pyrimido[3,2-a]benzimi dazol-4-one
  • MW: 253.18 | Formula: C11H6F3N3O
  • H donors: 1 H acceptors: 1 LogP: 1.37 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(nc2n1c1ccccc1[nH]2)C(F)(F)F
  • InChi: 1S/C11H6F3N3O/c12-11(13,14)8-5-9(18)17-7-4-2-1-3-6(7)15-10(17)16-8/h1-5H,(H,15,16)
  • InChiKey: ARCFHAKHLISNGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • STK263014
  • 2-[Trifluoromethyl]pyrimido[1,2-a]benzimidazol-4-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0118 0.0088
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0135 0.0152
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0301 0.0272
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0615 0.1444
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.006 0.006
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0215 0.1834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0615 0.1444
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0113 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.003 0.003
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0855 0.0855
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1063 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0113 0.0719
Brugia malayi hypothetical protein 0.0019 0.006 0.0346
Brugia malayi jmjC domain containing protein 0.0038 0.0301 0.2666
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0995 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0258 0.2362
Brugia malayi Bromodomain containing protein 0.0029 0.0184 0.154
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0352 0.0904
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0292
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0403 0.3862
Schistosoma mansoni regulator of G protein signaling 0.0019 0.006 0.003
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.006 0.0346
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0995 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0615 0.1444
Entamoeba histolytica hypothetical protein 0.0019 0.006 0.0312
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0184 0.1492
Schistosoma mansoni hypothetical protein 0.0031 0.0215 0.0185
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.006 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0615 0.1444
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0135 0.0917
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0184 0.0155
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0044 0.0044
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.056 0.6923 1
Echinococcus granulosus GPCR family 2 0.0031 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0292
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0258 0.0419
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0184 0.0184
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0135 0.0295
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0301 0.2625
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0995 0.0968
Schistosoma mansoni transcription factor btf3 0.0034 0.0258 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0258 0.2362
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0995 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0135 0.0295
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0113 0.012
Echinococcus granulosus neuropeptide s receptor 0.0462 0.5676 0.5676
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0258 0.2208
Brugia malayi PXA domain containing protein 0.0019 0.006 0.0346
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0403 0.3862
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1604 0.4425
Toxoplasma gondii hypothetical protein 0.0048 0.043 0.3485
Echinococcus granulosus neuropeptide receptor A26 0.0462 0.5676 0.5676
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0261 0.0261
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1063 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0056
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0855 0.0827
Echinococcus multilocularis neuropeptide receptor A26 0.0462 0.5676 0.5676
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.006 0.006
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0113 0.0232
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.006 0.0346
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0301 0.0301
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0855 0.0855
Loa Loa (eye worm) RGS-3 protein 0.0019 0.006 0.0292
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.006 0.006
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0064 0.0329
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0067 0.067 0.0642
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0352 0.0904
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.006 0.0346
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.003 0.0056
Onchocerca volvulus 0.0056 0.0537 0.5251
Echinococcus granulosus cpg binding protein 0.006 0.0578 0.0578
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0113 0.0719
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0855 0.7996
Echinococcus multilocularis transcription factor btf3 0.0034 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0029 0.0184 0.1492
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0135 0.0152
Echinococcus granulosus axis inhibition protein axin 0.0019 0.006 0.006
Entamoeba histolytica hypothetical protein 0.0019 0.006 0.0312
Echinococcus granulosus transcription factor btf3 0.0034 0.0258 0.0258
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0445 0.1166
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1604 0.4293
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.006 0.006
Brugia malayi hypothetical protein 0.0025 0.0135 0.1068
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0135 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0312
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0995 0.2713
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0064 0.0064
Brugia malayi PXA domain containing protein 0.0019 0.006 0.0346
Schistosoma mansoni regulator of G protein signaling 0.0019 0.006 0.003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0215 0.0215
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0995 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.3587 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.3587 1
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.056 0.6923 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0292
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.006 0.006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0215 0.0215
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0995 0.2713
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0615 0.1444
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1806 0.2486
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0292
Mycobacterium ulcerans hypothetical protein 0.0156 0.1806 0.2486
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0312
Echinococcus multilocularis dnaJ subfamily B 0.0803 1 1
Brugia malayi PHD-finger family protein 0.0029 0.0184 0.154
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0056
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.006 0.0346
Echinococcus granulosus peregrin 0.0029 0.0184 0.0184
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0258 0.0331
Loa Loa (eye worm) hypothetical protein 0.0031 0.0215 0.1788
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0064 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0615 0.1444
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0215 0.0215
Brugia malayi hypothetical protein 0.0019 0.006 0.0346
Schistosoma mansoni axis inhibition protein axin 0.0019 0.006 0.003
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0159 0.1296
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0258 0.0331
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.006 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0615 0.1444
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0615 0.1444
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0064 0.0034
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0258 0.0641
Echinococcus multilocularis cpg binding protein 0.006 0.0578 0.0578
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0258 0.2362
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.006 0.0292
Entamoeba histolytica hypothetical protein 0.0034 0.0258 0.2362
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.006 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0615 0.1444
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0995 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0995 1
Schistosoma mansoni cpg binding protein 0.0056 0.0537 0.0508
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0064 0.0329
Echinococcus multilocularis GPCR, family 2 0.0031 0.0215 0.0215
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0056
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0215 0.1788
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0615 0.1642
Onchocerca volvulus Alhambra homolog 0.0029 0.0184 0.1597
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0292
Schistosoma mansoni hypothetical protein 0.0031 0.0215 0.0185
Echinococcus multilocularis neuropeptide s receptor 0.0462 0.5676 0.5676
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.006 0.006
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.006 0.0346
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0995 0.0995
Schistosoma mansoni regulator of G protein signaling 0.0019 0.006 0.003
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.056 0.6923 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.006 0.003
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.006 0.003
Echinococcus multilocularis expressed protein 0.0366 0.4457 0.4457
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0064 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0995 1
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0615 0.1642
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0301 0.0272
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0215 0.1834
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1008 0.1008
Schistosoma mansoni regulator of G protein signaling 0.0019 0.006 0.003
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0995 0.0995
Schistosoma mansoni hypothetical protein 0.0029 0.0184 0.0155
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0537 0.4907
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0615 0.1642
Echinococcus granulosus jumonji domain containing protein 0.004 0.0326 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0258 0.2362
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0326 0.0326
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.006 0.006
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0615 0.1642
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.1338 0.1312
Trypanosoma brucei polo-like protein kinase 0.0093 0.0995 0.254
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0312
Schistosoma mansoni cpg binding protein 0.006 0.0578 0.0549
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0184 0.0184
Echinococcus multilocularis peregrin 0.0029 0.0184 0.0184
Schistosoma mansoni cpg binding protein 0.006 0.0578 0.0549
Loa Loa (eye worm) hypothetical protein 0.0049 0.0443 0.3997
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.006 0.003
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0258 0.1989
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.006 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0468 0.1229
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0546 0.1449
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.003 0.003
Leishmania major cathepsin L-like protease 0.0062 0.0615 0.1642
Schistosoma mansoni axis inhibition protein axin 0.0019 0.006 0.003
Echinococcus granulosus cathepsin l1 0.0016 0.003 0.003
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.006 0.0312
Echinococcus granulosus axis inhibition protein axin 0.0019 0.006 0.006
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0184 0.1345
Plasmodium falciparum phd finger protein, putative 0.0029 0.0184 0.0224
Leishmania major cathepsin L-like protease 0.0062 0.0615 0.1642
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.006 0.003
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.057 0.5225
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.8391 0.8391
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0995 0.9346
Giardia lamblia Kinase, PLK 0.0093 0.0995 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0995 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1604 0.4425
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1008 0.1008
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.8391 0.8386
Loa Loa (eye worm) hypothetical protein 0.0098 0.1063 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.1018
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0067 0.067 0.6199
Echinococcus granulosus microtubule associated protein 2 0.0676 0.8391 0.8391
Schistosoma mansoni hypothetical protein 0.0803 1 1
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.056 0.6923 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.003 0.003
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0135 0.0065
Echinococcus granulosus expressed protein 0.0366 0.4457 0.4457
Treponema pallidum hypothetical protein 0.056 0.6923 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0352 0.0688
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.003 0.003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0031 0.0215 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0064 0.0034
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.006 0.006
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0064 0.0383
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.003 0.003
Echinococcus multilocularis cysteine protease 0.0016 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0019 0.006 0.0312
Leishmania major basic transcription factor 3a, putative 0.0034 0.0258 0.0641
Entamoeba histolytica hypothetical protein 0.0023 0.0113 0.0854
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0258 0.0641
Leishmania major cathepsin L-like protease 0.0062 0.0615 0.1642
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0056
Brugia malayi CXXC zinc finger family protein 0.0056 0.0537 0.4936
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0184 0.0224
Leishmania major hypothetical protein, conserved 0.0025 0.0135 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0312
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.1176 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0184 0.1345
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.3587 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.006 0.006
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0113 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0995 0.2713
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0615 0.1444
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.3587 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.006 0.0312
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0995 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0215 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0615 0.1444
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0995 0.9349
Onchocerca volvulus 0.0081 0.0855 0.8544
Schistosoma mansoni hypothetical protein 0.0031 0.0215 0.0185
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0044 0.0128
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.056 0.6923 1
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.006 0.0292
Loa Loa (eye worm) hypothetical protein 0.0081 0.0855 0.7985
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0764 0.0736
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.067 0.622
Brugia malayi beta-NAC-like protein 0.0034 0.0258 0.2252
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0056
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.006 0.006
Echinococcus multilocularis cysteine protease 0.0016 0.003 0.003
Brugia malayi jmjC domain containing protein 0.0094 0.1008 0.9472
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0352 0.0904
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1063 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0113 0.012
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0292
Schistosoma mansoni kinase 0.0047 0.0419 0.0389

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 1.6 ug ml-1 Antifungal activity against Candida albicans assessed as growth inhibition after 48 to 72 hrs by broth microdilution method ChEMBL. 24056147
MIC (functional) = 100 ug ml-1 Antibacterial activity against Escherichia coli assessed as growth inhibition after 18 hrs by broth microdilution method ChEMBL. 24056147

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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