Detailed information for compound 178845

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 450.576 | Formula: C24H28N5O2S+
  • H donors: 4 H acceptors: 2 LogP: 2.94 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCCS(=O)(=O)Nc1ccc(cc1)Nc1c2ccccc2[n+](c2c1ccc(c2)N)C
  • InChi: 1S/C24H27N5O2S/c1-29-22-7-3-2-6-20(22)24(21-13-8-17(26)16-23(21)29)27-18-9-11-19(12-10-18)28-32(30,31)15-5-4-14-25/h2-3,6-13,16,28H,4-5,14-15,25H2,1H3,(H2,26,27)/p+1
  • InChiKey: DGWVHDYGZOFXJK-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glucose transport protein 0.0101 0.2184 0.3592
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0258 0.0425
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2184 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0258 0.1182
Onchocerca volvulus Putative nachr subunit 0.002 0.0258 0.4242
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0229 0.0114
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0041 0.0743 0.5813
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.1019 0.1513
Entamoeba histolytica hypothetical protein 0.0023 0.0316 0.5685
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0609 0.1001
Brugia malayi jmjC domain containing protein 0.0016 0.015 0.0246
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0026 0.0403 0.0663
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.1131 1
Toxoplasma gondii hypothetical protein 0.0052 0.1019 0.1395
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.1131 0.5179
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1169 0.1922
Leishmania major glucose transporter, lmgt2 0.0031 0.0525 0.3789
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Schistosoma mansoni protein kinase 0.0031 0.0527 0.0867
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0258 0.1182
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0258 0.0425
Loa Loa (eye worm) hypothetical protein 0.0016 0.015 0.0246
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.1131 0.9424
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0229 0.0324
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.015 0.0246
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0258 0.0425
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.3678 0.3603
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0258 0.1182
Loa Loa (eye worm) hypothetical protein 0.003 0.05 0.0823
Plasmodium vivax JmjC domain containing protein 0.0016 0.015 0.0033
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0316 0.1846
Schistosoma mansoni protein kinase 0.0031 0.0527 0.0867
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0258 0.0425
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.2184 0.3195
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0117 0.0536
Onchocerca volvulus 0.0014 0.0117 0.1922
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0525 0.3789
Loa Loa (eye worm) hypothetical protein 0.0025 0.0365 0.06
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Schistosoma mansoni glutaminase 0.0265 0.6081 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2184 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.1193 0.1804
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0258 0.1182
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0258 0.0425
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.015 0.0685
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Entamoeba histolytica protein kinase, putative 0.0031 0.0527 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.3678 0.3603
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.1193 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0833 0.137
Trypanosoma cruzi hexose transporter 0.0031 0.0525 0.3789
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.015 0.0685
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.062 0.4674
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0258 0.0425
Toxoplasma gondii hypothetical protein 0.0019 0.0229 0.0174
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0609 0.457
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.3678 0.5503
Leishmania major hypothetical protein, conserved 0.0016 0.015 0.0302
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.047 0.2151
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0019 0.0229 0.0226
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.1131 0.5179
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0059 0.1193 1
Toxoplasma gondii hypothetical protein 0.0019 0.0229 0.0174
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0037 0.0061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0833 0.137
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0609 0.1001
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0235 0.0237
Loa Loa (eye worm) hypothetical protein 0.0016 0.015 0.0246
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.1131 0.9424
Loa Loa (eye worm) hypothetical protein 0.0016 0.015 0.0246
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0609 0.1001
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0609 0.2788
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.015 0.005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0229 0.0377
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.1131 0.5179
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0609 0.457
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.015 0.0246
Onchocerca volvulus 0.0014 0.0117 0.1922
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0117 0.0192
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.015 0.0246
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0061
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0235 0.0237
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0527 0.2414
Mycobacterium ulcerans hypothetical protein 0.0035 0.0609 0.0951
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0609 0.2788
Echinococcus granulosus solute carrier family 22 0.0014 0.0117 0.0536
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0527 0.2414
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.015 0.0685
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0258 0.1182
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1131 0.17
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.1131 0.1568
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0061
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0527 0.2414
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0229 0.0114
Onchocerca volvulus 0.0014 0.0117 0.1922
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0316 0.0307
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Entamoeba histolytica protein kinase, putative 0.0031 0.0527 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0041 0.0743 0.1049
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0527 0.3811
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.1193 0.1804
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0258 0.0425
Loa Loa (eye worm) hypothetical protein 0.0023 0.0316 0.0519
Schistosoma mansoni nAChR subunit 0.002 0.0258 0.0425
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0528 0.0415
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0316 0.0466
Echinococcus multilocularis solute carrier family 22 0.0014 0.0117 0.0536
Brugia malayi Cation transporter family protein 0.002 0.0258 0.0425
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0527 0.0867
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0258 0.0425
Echinococcus multilocularis phd:f box containing protein 0.0016 0.015 0.0685
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0061
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0026 0.0403 0.1846
Loa Loa (eye worm) sugar transporter 0.0014 0.0117 0.0192
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0609 0.0825
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.05 0.2291
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0609 0.0991
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0609 0.0991
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0117 0.0138
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0525 0.0684
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.1193 0.1804
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0258 0.0425
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0833 0.3816
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0527 0.0688
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0527 0.2414
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Brugia malayi glutaminase DH11.1 0.0265 0.6081 1
Onchocerca volvulus 0.0011 0.0037 0.061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0609 0.1001
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0258 0.0425
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0403 0.048
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0609 0.0951
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.1169 0.5352
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0117 0.0192
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0316 0.1446
Brugia malayi hypothetical protein 0.0014 0.0117 0.0192
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0316 0.0201
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0258 0.1182
Schistosoma mansoni nAChR subunit 0.002 0.0258 0.0425
Echinococcus granulosus General substrate transporter 0.0087 0.1846 0.8452
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0012 0.0075 0.0123
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0041 0.0743 0.1049
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.015 0.0246
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.2184 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0316 0.1446
Onchocerca volvulus 0.002 0.0258 0.4242
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0609 0.0991
Brugia malayi major facilitator superfamily protein 0.0014 0.0117 0.0192
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0258 0.1182
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.062 0.4674
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.015 0.0302
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0258 0.0425
Trypanosoma brucei glucose transporter, putative 0.0031 0.0525 0.3789
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0258 0.1182
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0061
Schistosoma mansoni nAChR subunit 0.002 0.0258 0.0425
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0229 0.0188
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0525 0.3789
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0609 0.0825
Brugia malayi follicle stimulating hormone receptor 0.025 0.5717 0.9401
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0609 0.0991
Trypanosoma brucei glucose transporter 2A 0.0031 0.0525 0.3789
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.1131 0.9424
Loa Loa (eye worm) glutaminase 0.0265 0.6081 1
Loa Loa (eye worm) LGC-31 protein 0.002 0.0258 0.0425
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0117 0.0138
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0258 0.1182
Schistosoma mansoni jumonji domain containing protein 0.0058 0.1169 0.1922
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0258 0.0425
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0061
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0609 0.0991
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0117 0.0192
Onchocerca volvulus 0.0014 0.0117 0.1922
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0258 0.1182
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0059 0.1193 0.1804
Echinococcus granulosus solute carrier family 22 0.0014 0.0117 0.0536
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0229 0.0324
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.1131 0.9424
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0258 0.1182
Loa Loa (eye worm) hypothetical protein 0.0035 0.0609 0.1001
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.1131 0.9424
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0525 0.0684
Onchocerca volvulus 0.0014 0.0117 0.1922
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.015 0.0685
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.015 0.0246
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0316 0.0201
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0528 0.0415
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0609 1
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0258 0.1182
Brugia malayi Cam kinase protein 1 0.0031 0.0527 0.0867
Trypanosoma brucei glucose transporter, putative 0.0031 0.0525 0.3789
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0258 0.0425
Brugia malayi hypothetical protein 0.0014 0.0117 0.0192
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0609 0.0951
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.015 0.0302
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.062 0.0777
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0525 0.0684
Leishmania major glucose transporter, lmgt1 0.0031 0.0525 0.3789
Mycobacterium tuberculosis Conserved protein 0.0035 0.0609 0.0991
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0258 0.0425
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Onchocerca volvulus 0.0035 0.0609 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0528 0.0415
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Schistosoma mansoni hypothetical protein 0.0101 0.2184 0.3592
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0527 0.2414
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.5082 1
Schistosoma mansoni protein phosphatase 2C 0.0016 0.015 0.0246
Trypanosoma brucei glucose transporter, putative 0.0031 0.0525 0.3789
Brugia malayi Cation transporter family protein 0.002 0.0258 0.0425
Plasmodium vivax CDK-related protein kinase 6, putative 0.043 1 1
Brugia malayi hypothetical protein 0.0014 0.0117 0.0192
Loa Loa (eye worm) hypothetical protein 0.0035 0.0609 0.1001
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0187 0.0646
Trichomonas vaginalis esterase, putative 0.0035 0.0609 0.0825
Echinococcus granulosus solute carrier family 22 0.0014 0.0117 0.0536
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0258 0.1182
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.05 0.0643
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0403 0.048
Onchocerca volvulus Putative transporter 0.0014 0.0117 0.1922
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.05 0.7143
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0258 0.1182
Schistosoma mansoni sugar transporter 0.0014 0.0117 0.0192
Mycobacterium tuberculosis Conserved protein 0.0035 0.0609 0.0991
Brugia malayi Sugar transporter family protein 0.0014 0.0117 0.0192
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0258 0.1182
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0527 0.0867
Trypanosoma brucei glucose transporter 1E 0.0031 0.0525 0.3789
Onchocerca volvulus 0.0014 0.0117 0.1922
Brugia malayi beta-lactamase 0.0035 0.0609 0.1001
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0258 0.0425
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2531 0.4162
Leishmania major glucose transporter, lmgt3 0.0031 0.0525 0.3789
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0011 0.0037 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0525 0.0684
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.1169 0.5352
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0258 0.1182
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0316 0.1846
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0833 0.137
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.062 0.4674
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0059 0.1193 0.5463
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0258 0.0425
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0258 0.1182
Loa Loa (eye worm) ACC-1 protein 0.002 0.0258 0.0425
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0258 0.0425
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.05 0.9455
Brugia malayi jmjC domain containing protein 0.0016 0.015 0.0246
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0528 0.0415
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0316 0.0333
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.05 0.0823
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0061
Onchocerca volvulus 0.002 0.0258 0.4242
Schistosoma mansoni sugar transporter 0.0014 0.0117 0.0192
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0258 0.1182
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.1193 1
Loa Loa (eye worm) glutaminase 2 0.0265 0.6081 1
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1131 0.17
Schistosoma mansoni nAChR subunit 0.002 0.0258 0.0425
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.1131 0.5179
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Onchocerca volvulus 0.0014 0.0117 0.1922
Loa Loa (eye worm) sugar transporter 0.0101 0.2184 0.3592
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0833 0.137
Onchocerca volvulus 0.0014 0.0117 0.1922
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0527 0.2414
Echinococcus granulosus nAChR subunit 0.002 0.0258 0.1182
Loa Loa (eye worm) beta-lactamase 0.0035 0.0609 0.1001
Onchocerca volvulus 0.0014 0.0117 0.1922
Schistosoma mansoni glucose transport protein 0.0101 0.2184 0.3592
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0258 0.1182
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.1131 0.186
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2184 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.1019 0.1513
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0059 0.1193 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0609 0.0951
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Schistosoma mansoni sugar transporter 0.0014 0.0117 0.0192
Leishmania major protein kinase, putative 0.0031 0.0527 0.3811
Echinococcus multilocularis General substrate transporter 0.0087 0.1846 0.8452
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.0403 0.048
Onchocerca volvulus 0.002 0.0258 0.4242
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0026 0.0403 0.0663
Schistosoma mansoni sugar transporter 0.0014 0.0117 0.0192
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.1193 0.1804
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.1193 0.1804
Mycobacterium ulcerans glutaminase 0.0265 0.6081 1
Toxoplasma gondii protein kinase, putative 0.0286 0.6587 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0525 0.3789
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0258 0.0425
Schistosoma mansoni phd/f-box containing protein 0.0016 0.015 0.0246
Echinococcus multilocularis solute carrier family 22 0.0014 0.0117 0.0536
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0059 0.1193 0.5463
Trypanosoma brucei glucose transporter, putative 0.0031 0.0525 0.3789
Leishmania major hypothetical protein, conserved 0.0035 0.0609 0.457
Echinococcus multilocularis nAChR subunit 0.0011 0.0037 0.017
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0527 0.0867
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0034 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.1169 0.1922
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0525 0.3789
Trypanosoma brucei glucose transporter, putative 0.0031 0.0525 0.3789
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.1193 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0609 0.1001
Mycobacterium ulcerans sugar transporter 0.0014 0.0117 0.0138
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.015 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0061
Mycobacterium tuberculosis Conserved protein 0.0035 0.0609 0.0991
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.015 0.0685
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Brugia malayi jmjC domain containing protein 0.0016 0.015 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.1019 0.1513
Onchocerca volvulus 0.0014 0.0117 0.1922
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0258 0.1182
Onchocerca volvulus 0.0011 0.0037 0.061
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0525 0.0684
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0258 0.0425
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0528 0.0635
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.05 0.2291
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.015 0.0685
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Mycobacterium leprae Probable lipase LipE 0.0035 0.0609 1
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.047 0.2151
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0609 0.457
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.1193 0.1804
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0026 0.0403 0.1846
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0316 0.0466
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1131 0.17
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0527 0.2414
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0527 0.0867
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0011 0.0037 0.0061
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0525 0.3789
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0117 0.0536
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0258 0.0425
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.015 0.0685
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0117 0.0192
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.1169 0.5352
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2531 0.4162
Loa Loa (eye worm) hypothetical protein 0.0035 0.0609 0.1001
Trypanosoma brucei glucose transporter, putative 0.0031 0.0525 0.3789
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0525 0.3789
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.05 0.0823
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0258 0.0425
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.1193 0.1804
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0833 0.137
Toxoplasma gondii ABC1 family protein 0.0035 0.0609 0.076
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0258 0.0425
Echinococcus granulosus nAChR subunit 0.0011 0.0037 0.017
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.062 0.0509
Onchocerca volvulus 0.0014 0.0117 0.1922
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Plasmodium vivax hexose transporter 0.0101 0.2184 0.2092
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0316 0.1846
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0525 0.3789
Plasmodium falciparum proline--tRNA ligase 0.0035 0.062 0.0509
Onchocerca volvulus 0.0014 0.0117 0.1922
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0663
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.1193 0.1804
Onchocerca volvulus 0.0035 0.0609 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0316 0.2275
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0011 0.0037 0.0061
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1169 0.1922
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0528 0.0635
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.0403 0.0663
Brugia malayi beta-lactamase family protein 0.0035 0.0609 0.1001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0609 0.1001
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0258 0.1182
Onchocerca volvulus 0.0014 0.0117 0.1922
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.1193 0.1804
Plasmodium falciparum hexose transporter 0.0101 0.2184 0.2092
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.025 0.0222
Brugia malayi jmjC domain containing protein 0.0058 0.1169 0.1922
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0258 0.1182
Onchocerca volvulus 0.0014 0.0117 0.1922
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0117 0.0192
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0528 0.0415
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0258 0.1182
Brugia malayi beta-lactamase family protein 0.0035 0.0609 0.1001
Brugia malayi MH2 domain containing protein 0.0116 0.2531 0.4162
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0316 0.0519
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0609 0.0825
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0258 0.0425
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0061
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2184 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0258 0.0425
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0609 0.0498
Brugia malayi Cation transporter family protein 0.002 0.0258 0.0425
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0316 0.0519
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0229 0.0324
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1131 0.17
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0061
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0525 0.3789
Loa Loa (eye worm) hypothetical protein 0.0031 0.0527 0.0867
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0258 0.0425
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.2184 0.3466
Loa Loa (eye worm) hypothetical protein 0.0035 0.0609 0.1001
Echinococcus granulosus phd:f box containing protein 0.0016 0.015 0.0685
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0609 0.0825
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.062 0.4674
Echinococcus multilocularis solute carrier family 22 0.0014 0.0117 0.0536
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0528 0.0415
Schistosoma mansoni glucose transport protein 0.0101 0.2184 0.3592
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0258 0.0425
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0037 0.0061
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.062 0.4674
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0316 0.1959
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2184 1
Plasmodium falciparum protein kinase 7 0.0286 0.6587 0.6546
Trypanosoma brucei glucose transporter, putative 0.0031 0.0525 0.3789
Schistosoma mansoni glucose transporter 0.0014 0.0117 0.0192
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.05 0.0823
Schistosoma mansoni neurotransmitter gated ion channel 0.0011 0.0037 0.0061
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0059 0.1193 0.1962
Onchocerca volvulus 0.0014 0.0117 0.1922
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0117 0.0536
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0316 0.0519
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0609 0.0991
Onchocerca volvulus 0.002 0.0258 0.4242
Brugia malayi Sugar transporter family protein 0.0014 0.0117 0.0192
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.1131 0.186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0833 0.3816
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.015 0.0302
Brugia malayi major facilitator superfamily protein 0.0014 0.0117 0.0192
Mycobacterium ulcerans beta-lactamase 0.0035 0.0609 0.0951
Brugia malayi Sugar transporter family protein 0.0101 0.2184 0.3592
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.05 0.3781
Echinococcus granulosus solute carrier family 22 0.0014 0.0117 0.0536
Brugia malayi jmjC domain containing protein 0.0058 0.1169 0.1922
Trypanosoma brucei protein kinase, putative 0.0057 0.1131 0.9424
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0525 0.0684
Loa Loa (eye worm) ACC-1 protein 0.002 0.0258 0.0425
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2184 1
Onchocerca volvulus 0.002 0.0258 0.4242
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0528 0.0415
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0833 0.3816
Onchocerca volvulus 0.002 0.0258 0.4242
Schistosoma mansoni nAChR subunit 0.002 0.0258 0.0425
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0117 0.0536
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0258 0.0425
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.1193 0.1804
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0011 0.0037 0.0061
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0117 0.5
Brugia malayi jmjC domain containing protein 0.0016 0.015 0.0246
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0609 0.0825
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0528 0.0415
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.015 0.0685
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0258 0.1182
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0229 0.0174
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0833 0.3816
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.1131 0.9424
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0117 0.0192
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.1193 0.1804
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0235 0.0142
Loa Loa (eye worm) hypothetical protein 0.003 0.05 0.0823
Echinococcus multilocularis solute carrier family 22 0.0014 0.0117 0.0536
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0528 0.0635
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2184 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0525 0.0684
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0019 0.0229 0.0226
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0117 0.0138
Loa Loa (eye worm) hypothetical protein 0.0014 0.0117 0.0192
Brugia malayi MAP kinase sur-1 0.0057 0.1131 0.186
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.5717 0.9401
Schistosoma mansoni nAChR subunit 0.002 0.0258 0.0425
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0527 0.2414
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0316 1
Trichomonas vaginalis glutaminase, putative 0.0265 0.6081 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0528 0.0415
Loa Loa (eye worm) GABA receptor subunit 0.0011 0.0037 0.0061
Schistosoma mansoni nAChR subunit 0.002 0.0258 0.0425
Onchocerca volvulus 0.0014 0.0117 0.1922
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0258 0.1182
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0258 0.0425
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.015 0.005
Schistosoma mansoni protein kinase 0.0031 0.0527 0.0867
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0609 0.0991
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0425
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0258 0.0425
Onchocerca volvulus 0.0035 0.0609 1
Schistosoma mansoni jumonji domain containing protein 0.0016 0.015 0.0246
Echinococcus multilocularis nAChR subunit 0.002 0.0258 0.1182
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.1193 0.1804
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.05 0.0823
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.1169 0.5352
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.1131 0.9424

Activities

Activity type Activity value Assay description Source Reference
Log 1/D50 (functional) = 5.64 Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. ChEMBL. 7069706
Log 1/LD10 (ADMET) = 4.45 Compound concentration in mole/kg/day lethal to 10% of mice ChEMBL. 7069706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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