TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 420.852 | Formula: C21H17ClN6O2
H donors: 2 H acceptors: 4 LogP: 3.25 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: C=CC(=O)Nc1ccc(c(c1)Nc1ncc(c(n1)c1cnn2c1cccc2)Cl)OC
InChi: 1S/C21H17ClN6O2/c1-3-19(29)25-13-7-8-18(30-2)16(10-13)26-21-23-12-15(22)20(27-21)14-11-24-28-9-5-4-6-17(14)28/h3-12H,1H2,2H3,(H,25,29)(H,23,26,27)
InChiKey: ZHNZZAFDNOFVRY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References
Homo sapiens	erb-b2 receptor tyrosine kinase 4		References
Homo sapiens	erb-b2 receptor tyrosine kinase 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0014	0.0014
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0016	0.0046	0.0046
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0731	0.4784	0.4784
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0014	0.0027
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0014	0.0027
Schistosoma mansoni	hypothetical protein	0.0018	0.0059	0.0059
Loa Loa (eye worm)	PXA domain-containing protein	0.0081	0.0478	0.0899
Loa Loa (eye worm)	histone methyltransferase	0.002	0.0071	0.0134
Schistosoma mansoni	regulator of G protein signaling	0.0081	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0027
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0059	0.0111
Echinococcus granulosus	dnaJ subfamily B	0.09	0.5904	0.5904
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0081	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0195	0.0366
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0812	0.532	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0014	0.0014
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0016	0.0046	0.0046
Schistosoma mansoni	serine/threonine protein kinase	0.0812	0.532	0.532
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0041	0.0216	0.0216
Schistosoma mansoni	regulator of G protein signaling	0.0081	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0135	0.0253
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0478	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0027
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0014	0.0027
Echinococcus multilocularis	lamin	0.0029	0.0135	0.0135
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0333	0.2146	0.2146
Echinococcus multilocularis	insulin receptor	0.0156	0.0978	0.0978
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0014	0.0027
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0041	0.0216	0.4069
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0812	0.532	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0014	0.0027
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0081	0.0478	0.0899
Schistosoma mansoni	cpg binding protein	0.0067	0.0384	0.0384
Echinococcus granulosus	regulator of G protein signaling 7	0.0081	0.0478	0.0478
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0014	0.0014
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0478	0.0899
Loa Loa (eye worm)	TK/INSR protein kinase	0.0156	0.0978	0.1838
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0135	0.0253
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0014	0.0027
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0081	0.0478	0.0478
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0014	0.0027
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0059	0.0059
Echinococcus multilocularis	axis inhibition protein axin	0.0081	0.0478	0.0478
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0081	0.0478	0.0899
Echinococcus granulosus	regulator of G protein signaling 7	0.0081	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0027
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0014	0.0014
Echinococcus granulosus	epidermal growth factor receptor	0.05	0.325	0.325
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0083	0.0491	0.0491
Schistosoma mansoni	lamin	0.0029	0.0135	0.0135
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0027
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0014	0.0027
Onchocerca volvulus		0.0063	0.036	1
Brugia malayi	steroid hormone receptor	0.0011	0.0014	0.0027
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0135	0.0135
Schistosoma mansoni	axis inhibition protein axin	0.0081	0.0478	0.0478
Echinococcus granulosus	cpg binding protein	0.0067	0.0384	0.0384
Entamoeba histolytica	hypothetical protein	0.0081	0.0478	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0312	0.0586
Brugia malayi	hypothetical protein	0.0081	0.0478	0.0899
Brugia malayi	regulator of G-protein signaling egl-10	0.0081	0.0478	0.0899
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0041	0.0216	0.0216
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0014	0.0014
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0014	0.0014
Echinococcus multilocularis	musashi	0.0029	0.0135	0.0135
Schistosoma mansoni	cpg binding protein	0.0063	0.036	0.036
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0731	0.4784	0.4784
Schistosoma mansoni	hypothetical protein	0.0038	0.0195	0.0195
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0016	0.0046	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0014	0.0027
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0014	0.0014
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0014	0.0027
Echinococcus granulosus	regulator of G protein signaling 3	0.0081	0.0478	0.0478
Brugia malayi	CXXC zinc finger family protein	0.0063	0.036	0.0677
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0016	0.0046	0.0046
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0014	0.0014
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0081	0.0478	0.0478
Echinococcus multilocularis	epidermal growth factor receptor	0.0333	0.2146	0.2146
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0014	0.0027
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0014	0.0014
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0059	0.0111
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0035	0.0035
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0731	0.4784	0.8991
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0478	0.0899
Echinococcus multilocularis	ubiquitin specific protease 41	0.0041	0.0216	0.0216
Schistosoma mansoni	hypothetical protein	0.0018	0.0059	0.0059
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0131	0.0246
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0045	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0478	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0014	0.0014
Echinococcus granulosus	Regulator of G protein signaling 20	0.0081	0.0478	0.0478
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0014	0.0014
Schistosoma mansoni	regulator of G protein signaling	0.0081	0.0478	0.0478
Echinococcus multilocularis	expressed protein	0.0081	0.0478	0.0478
Echinococcus multilocularis	regulator of G protein signaling 3	0.0081	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0478	0.0899
Entamoeba histolytica	hypothetical protein	0.0081	0.0478	1
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0478	0.0899
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0014	0.0027
Schistosoma mansoni	lamin	0.0029	0.0135	0.0135
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0731	0.4784	0.8991
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0135	0.0253
Brugia malayi	Protein kinase domain containing protein	0.0156	0.0978	0.1838
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0134	0.083	0.083
Echinococcus granulosus	lamin dm0	0.0029	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0027
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0014	0.0014
Brugia malayi	intermediate filament protein	0.0029	0.0135	0.0253
Schistosoma mansoni	tyrosine kinase	0.0333	0.2146	0.2146
Loa Loa (eye worm)	TK/EGFR protein kinase	0.05	0.325	0.6109
Echinococcus granulosus	axis inhibition protein axin	0.0081	0.0478	0.0478
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0041	0.0216	0.5
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0083	0.0491	0.0923
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0002	0.0002
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.002	0.0071	0.0071
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0312	0.0586
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0081	0.0478	0.0899
Echinococcus multilocularis	regulator of G protein signaling 7	0.0081	0.0478	0.0478
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0731	0.4784	0.8991
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0041	0.0216	0.0216
Schistosoma mansoni	tyrosine kinase	0.0331	0.2133	0.2133
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0312	0.0586
Schistosoma mansoni	tyrosine kinase	0.0333	0.2146	0.2146
Schistosoma mansoni	cpg binding protein	0.0067	0.0384	0.0384
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0014	0.0014
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0059	0.0111
Echinococcus multilocularis	lamin dm0	0.0029	0.0135	0.0135
Schistosoma mansoni	regulator of G protein signaling	0.0081	0.0478	0.0478
Schistosoma mansoni	tyrosine kinase	0.0331	0.2133	0.2133
Onchocerca volvulus		0.0029	0.0135	0.3481
Schistosoma mansoni	serine/threonine protein kinase	0.0083	0.0491	0.0491
Echinococcus granulosus	ubiquitin specific protease 41	0.0041	0.0216	0.0216
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.0795	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0216	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0031	0.0059
Echinococcus granulosus	intermediate filament protein	0.0029	0.0135	0.0135
Schistosoma mansoni	hypothetical protein	0.09	0.5904	0.5904
Echinococcus multilocularis	dnaJ subfamily B	0.09	0.5904	0.5904
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0195	0.0366
Schistosoma mansoni	tyrosine kinase	0.0331	0.2133	0.2133
Schistosoma mansoni	microtubule-associated protein tau	0.1519	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0014	0.0027
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0014	0.0014
Schistosoma mansoni	coup transcription factor	0.0011	0.0014	0.0014
Brugia malayi	hypothetical protein	0.0081	0.0478	0.0899
Echinococcus granulosus	lamin	0.0029	0.0135	0.0135
Echinococcus multilocularis	microtubule associated protein 2	0.1519	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0014	0.0027
Brugia malayi	A-kinase anchor protein 10, precursor	0.0081	0.0478	0.0899
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0045	0.0085
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0041	0.0216	0.0216
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0014	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0031	0.0059
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0014	0.0027
Echinococcus multilocularis	epidermal growth factor receptor	0.05	0.325	0.325
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.0795	0.1495
Brugia malayi	ecdysteroid receptor	0.0011	0.0014	0.0027
Schistosoma mansoni	hypothetical protein	0.0018	0.0059	0.0059
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.007	0.0131
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0156	0.0978	0.0978
Schistosoma mansoni	hypothetical protein	0.0018	0.0059	0.0059
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0014	0.0014
Brugia malayi	PXA domain containing protein	0.0081	0.0478	0.0899
Echinococcus multilocularis	regulator of G protein signaling 7	0.0081	0.0478	0.0478
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0478	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0063	0.036	0.0677
Echinococcus granulosus	epidermal growth factor receptor	0.0333	0.2146	0.2146
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0041	0.0216	0.0216
Onchocerca volvulus		0.0029	0.0135	0.3481
Echinococcus multilocularis	regulator of G protein signaling	0.0081	0.0478	0.0478
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0135	0.0253
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0014	0.0027
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.002	0.0071	0.0071
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0014	0.0027
Schistosoma mansoni	z-protein (S1r protein)	0.0081	0.0478	0.0478
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0014	0.0014
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0041	0.0216	0.5
Loa Loa (eye worm)	RGS-3 protein	0.0081	0.0478	0.0899
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0081	0.0478	1
Brugia malayi	regulator of G-protein signaling rgs-7	0.0081	0.0478	0.0899
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0014	0.0014
Toxoplasma gondii	histone lysine methyltransferase SET1	0.012	0.0735	0.5
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0081	0.0478	0.0478
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0014	0.0014
Brugia malayi	MH2 domain containing protein	0.0129	0.0795	0.1495
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0059	0.0059
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0083	0.0491	0.0491
Echinococcus multilocularis	axis inhibition protein axin	0.0081	0.0478	0.0478
Echinococcus granulosus	axis inhibition protein axin	0.0081	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0478	0.0899
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0081	0.0478	0.0478
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0014	0.0027
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0014	0.0014
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0041	0.0216	0.0407
Brugia malayi	PXA domain containing protein	0.0081	0.0478	0.0899
Schistosoma mansoni	axis inhibition protein axin	0.0081	0.0478	0.0478
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0041	0.0216	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0216	0.4069
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0014	0.0014
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0014	0.0027
Echinococcus granulosus	insulin receptor	0.0156	0.0978	0.0978
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0014	0.0027
Schistosoma mansoni	regulator of G protein signaling	0.0081	0.0478	0.0478
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0014	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0027
Echinococcus multilocularis	regulator of G protein signaling 3	0.0081	0.0478	0.0478
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0478	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0041	0.0216	0.0216
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0014	0.0014
Echinococcus multilocularis		0.0251	0.1603	0.1603
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0014	0.0027
Brugia malayi	nuclear hormone receptor	0.0011	0.0014	0.0027
Schistosoma mansoni	tyrosine kinase	0.0156	0.0978	0.0978
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0035	0.0035
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0035	0.0066
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0041	0.0216	0.5
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0041	0.0216	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0027
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0016	0.0046	0.0046
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0014	0.0014
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0478	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0312	0.0586
Schistosoma mansoni	serine/threonine protein kinase	0.0083	0.0491	0.0491
Schistosoma mansoni	tyrosine kinase	0.0156	0.0978	0.0978
Entamoeba histolytica	hypothetical protein	0.0081	0.0478	1
Echinococcus multilocularis	cpg binding protein	0.0067	0.0384	0.0384
Echinococcus granulosus	regulator of G protein signaling 3	0.0081	0.0478	0.0478
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0478	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0156	0.0978	0.0978
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0081	0.0478	0.0478
Brugia malayi	Furin-like cysteine rich region family protein	0.05	0.325	0.6109
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0478	0.0899
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0014	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0027
Echinococcus granulosus	GPCR family 2	0.0018	0.0059	0.0059
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0059	0.0059
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0014	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0059	0.0111
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0041	0.0216	0.4069
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0014	0.0014
Echinococcus granulosus	expressed protein	0.0081	0.0478	0.0478
Schistosoma mansoni	tyrosine kinase	0.05	0.325	0.325
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0014	0.0014
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0014	0.0014
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0014	0.0014

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.033 uM	Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assay	ChEMBL.	23930994
IC50 (binding)	= 0.15 uM	Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assay	ChEMBL.	23930994
IC50 (binding)	= 12.8 uM	Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assay	ChEMBL.	23930994

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2426286

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1789000