TDR Targets

Basic information

Technical information

TDR Targets ID: 1789829
Name: 2-fluoro-N-(5-pyridin-2-yl-1,3,4-oxadiazol-2- yl)benzamide
MW: 284.245 | Formula: C14H9FN4O2
H donors: 1 H acceptors: 4 LogP: 1.65 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1F)Nc1nnc(o1)c1ccccn1
InChi: 1S/C14H9FN4O2/c15-10-6-2-1-5-9(10)12(20)17-14-19-18-13(21-14)11-7-3-4-8-16-11/h1-8H,(H,17,19,20)
InChiKey: WAJOUOUBWHAXPK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-fluoro-N-[5-(2-pyridyl)-1,3,4-oxadiazol-2-yl]benzamide
ZINC04264958

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0114	0.1147	0.1147
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0117	0.1184	0.3809
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0051	0.0214	0.0287
Echinococcus granulosus	lysine specific demethylase 5A	0.0091	0.0805	0.1081
Brugia malayi	Bromodomain containing protein	0.0075	0.057	0.1834
Brugia malayi	intermediate filament protein	0.0042	0.0073	0.0235
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0098	0.0904	0.0904
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0091	0.0805	0.0877
Echinococcus granulosus	survival motor neuron protein 1	0.0199	0.2412	0.324
Schistosoma mansoni	hypothetical protein	0.0097	0.0897	0.0977
Plasmodium vivax	importin-beta 2, putative	0.005	0.0196	0.0696
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0097	0.0897	0.1205
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0226	0.2812	1
Schistosoma mansoni	egf-like domain protein	0.0113	0.1135	0.1236
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0181	0.2145	0.7433
Echinococcus granulosus	tar DNA binding protein	0.0098	0.0907	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0126	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0073	0.0099
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0117	0.1184	0.159
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0125	0.1309	0.4655
Loa Loa (eye worm)	thymidylate synthase	0.0226	0.2812	0.3817
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1867	0.2535
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0117	0.1184	0.1184
Schistosoma mansoni	hypothetical protein	0.0051	0.0218	0.0237
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0226	0.2812	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0163	0.1867	0.2535
Plasmodium falciparum	importin beta, putative	0.005	0.0196	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1309	0.1777
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.0656	0.918	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0218	0.0296
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0117	0.1184	0.1607
Onchocerca volvulus		0.0188	0.2246	0.7946
Loa Loa (eye worm)	hypothetical protein	0.0188	0.2246	0.3049
Echinococcus multilocularis	thymidylate synthase	0.0226	0.2812	0.2812
Onchocerca volvulus	Alhambra homolog	0.0075	0.057	0.1861
Echinococcus granulosus	thymidylate synthase	0.0226	0.2812	0.3777
Onchocerca volvulus		0.0079	0.0624	0.2056
Brugia malayi	PHD-finger family protein	0.0075	0.057	0.1834
Echinococcus multilocularis	snurportin 1	0.0534	0.7366	0.7366
Schistosoma mansoni	hypothetical protein	0.0051	0.0218	0.0237
Echinococcus granulosus	peregrin	0.0075	0.057	0.0766
Brugia malayi	Nematode astacin protease protein 30	0.0045	0.0126	0.0407
Brugia malayi	jmjC domain containing protein	0.0091	0.0805	0.259
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0119	0.1223	0.1332
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0041	0.0055	0.0528
Echinococcus granulosus	laminin	0.0125	0.1309	0.1758
Brugia malayi	Fibulin-1 precursor	0.0125	0.1309	0.421
Brugia malayi	Calcium binding EGF domain containing protein	0.0125	0.1309	0.421
Brugia malayi	Latrophilin receptor protein 2	0.0051	0.0218	0.0701
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0051	0.0214	0.0214
Brugia malayi	RNA, U transporter 1	0.0142	0.1562	0.5025
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0042	0.0073	0.0099
Loa Loa (eye worm)	AStacin protease	0.0226	0.2803	0.3805
Brugia malayi	RNA recognition motif domain containing protein	0.0098	0.0907	0.2918
Onchocerca volvulus		0.0042	0.0073	0.0055
Echinococcus granulosus	intermediate filament protein	0.0042	0.0073	0.0098
Schistosoma mansoni	survival motor neuron protein	0.0041	0.0058	0.0063
Echinococcus granulosus	lamin	0.0042	0.0073	0.0098
Onchocerca volvulus		0.0082	0.0669	0.2218
Toxoplasma gondii	HEAT repeat-containing protein	0.005	0.0196	0.0696
Schistosoma mansoni	transcription factor LCR-F1	0.0097	0.0897	0.0977
Onchocerca volvulus		0.0045	0.0126	0.0249
Brugia malayi	thymidylate synthase	0.0226	0.2812	0.9045
Toxoplasma gondii	aldehyde dehydrogenase	0.0051	0.0214	0.0761
Brugia malayi	hypothetical protein	0.0108	0.1052	0.3383
Plasmodium falciparum	phd finger protein, putative	0.0075	0.057	0.2028
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1135	0.1541
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1763	0.2393
Schistosoma mansoni	lamin	0.0042	0.0073	0.0079
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0075	0.057	0.0621
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0226	0.2812	1
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.037	0.4937	0.6702
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0051	0.0218	0.0218
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0226	0.2812	1
Loa Loa (eye worm)	hypothetical protein	0.0199	0.2412	0.3275
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0534	0.7366	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0163	0.1867	0.6007
Schistosoma mansoni	hypothetical protein	0.0111	0.1104	0.1202
Loa Loa (eye worm)	DPY-31 protein	0.0045	0.0126	0.0172
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0125	0.1309	0.1777
Loa Loa (eye worm)	TAR-binding protein	0.0098	0.0907	0.1231
Echinococcus multilocularis	fibrillin 1	0.0125	0.1309	0.1309
Echinococcus granulosus	GPCR family 2	0.0051	0.0218	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1104	0.1499
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0226	0.2812	1
Brugia malayi	Importin beta-1 subunit	0.005	0.0196	0.0629
Mycobacterium tuberculosis	Hypothetical protein	0.0108	0.1052	0.3225
Brugia malayi	hypothetical protein	0.0199	0.2412	0.7759
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0226	0.2812	1
Echinococcus granulosus	tumor protein p63	0.0539	0.7444	1
Onchocerca volvulus		0.017	0.1971	0.6948
Echinococcus multilocularis	tumor protein p63	0.0539	0.7444	0.7444
Echinococcus multilocularis	Tolloid protein 1	0.037	0.4937	0.4937
Schistosoma mansoni	hypothetical protein	0.0534	0.7366	0.8024
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0062	0.0084
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0125	0.1309	0.4655
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0051	0.0218	0.0701
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0041	0.0058	0.0186
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0097	0.0897	0.0897
Schistosoma mansoni	hypothetical protein	0.0051	0.0218	0.0237
Loa Loa (eye worm)	PHD-finger family protein	0.0075	0.057	0.0774
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0091	0.0805	0.0877
Echinococcus granulosus	Tolloid protein 1	0.037	0.4937	0.6632
Brugia malayi	TAR-binding protein	0.0098	0.0907	0.2918
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0051	0.0218	0.0296
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0226	0.2812	0.5
Entamoeba histolytica	hypothetical protein	0.0097	0.0897	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0219	0.27	0.2941
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0041	0.0055	0.0528
Onchocerca volvulus		0.0226	0.2812	1
Schistosoma mansoni	tar DNA-binding protein	0.0098	0.0907	0.0988
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0246	0.3109	0.4176
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0624	0.0847
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0098	0.0907	0.1231
Schistosoma mansoni	lamin	0.0042	0.0073	0.0079
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0113	0.1135	0.1541
Trypanosoma brucei	importin beta-1 subunit, putative	0.005	0.0196	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0355	0.4719	0.6407
Echinococcus granulosus	jumonji domain containing protein	0.0105	0.1007	0.1353
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0108	0.1052	0.374
Echinococcus multilocularis	laminin	0.0125	0.1309	0.1309
Giardia lamblia	PHD finger protein 15	0.0075	0.057	1
Entamoeba histolytica	hypothetical protein	0.0097	0.0897	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0041	0.0055	0.0197
Brugia malayi	Intermediate filament tail domain containing protein	0.0042	0.0073	0.0235
Brugia malayi	Nematode astacin protease protein 30	0.0045	0.0126	0.0407
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0117	0.1184	0.159
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0051	0.0214	0.0761
Brugia malayi	Zinc metalloproteinase toh-2 precursor	0.0045	0.0126	0.0407
Trichomonas vaginalis	importin beta-1, putative	0.0041	0.0055	0.0528
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0049	0.0184	0.02
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1367	0.1856
Brugia malayi	hypothetical protein	0.0097	0.0897	0.2885
Schistosoma mansoni	intermediate filament proteins	0.0042	0.0073	0.0079
Brugia malayi	astacin protease protein 30	0.0045	0.0126	0.0407
Loa Loa (eye worm)	RNA binding protein	0.0098	0.0907	0.1231
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.037	0.4937	0.5378
Echinococcus multilocularis	peregrin	0.0075	0.057	0.057
Schistosoma mansoni	hypothetical protein	0.0051	0.0218	0.0237
Loa Loa (eye worm)	jmjC domain-containing protein	0.0091	0.0805	0.1093
Schistosoma mansoni	aldehyde dehydrogenase	0.0051	0.0214	0.0233
Brugia malayi	Trypsin family protein	0.0188	0.2246	0.7226
Schistosoma mansoni	hypothetical protein	0.0075	0.057	0.0621
Echinococcus multilocularis	tar DNA binding protein	0.0098	0.0907	0.0907
Echinococcus multilocularis	lysine specific demethylase 5A	0.0091	0.0805	0.0805
Brugia malayi	latrophilin 2 splice variant baaae	0.0111	0.1104	0.3551
Schistosoma mansoni	hypothetical protein	0.0041	0.0058	0.0063
Schistosoma mansoni	hypothetical protein	0.0139	0.1515	0.165
Schistosoma mansoni	thyroid hormone receptor	0.0114	0.1147	0.1249
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0051	0.0218	0.0218
Onchocerca volvulus	Putative cubilin	0.0053	0.024	0.0663
Mycobacterium ulcerans	thymidylate synthase	0.0226	0.2812	1
Entamoeba histolytica	hypothetical protein	0.0097	0.0897	1
Onchocerca volvulus	Arrow homolog	0.0113	0.1135	0.3911
Echinococcus granulosus	lamin dm0	0.0042	0.0073	0.0098
Loa Loa (eye worm)	hypothetical protein	0.005	0.0196	0.0266
Brugia malayi	jmjC domain containing protein	0.0246	0.3109	1
Schistosoma mansoni	cellular tumor antigen P53	0.0079	0.0624	0.068
Echinococcus multilocularis	importin subunit beta 1	0.005	0.0196	0.0196
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0188	0.2246	0.2447
Brugia malayi	RNA binding protein	0.0098	0.0907	0.2918
Schistosoma mansoni	hypothetical protein	0.0098	0.0904	0.0985
Echinococcus multilocularis	lamin dm0	0.0042	0.0073	0.0073
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0226	0.2812	1
Echinococcus granulosus	snurportin 1	0.0534	0.7366	0.9895
Entamoeba histolytica	hypothetical protein	0.0041	0.0055	0.0619
Schistosoma mansoni	tar DNA-binding protein	0.0098	0.0907	0.0988
Brugia malayi	Calcium binding EGF domain containing protein	0.0053	0.024	0.0773
Brugia malayi	zinc metalloproteinase toh-2 precursor	0.0045	0.0126	0.0407
Echinococcus granulosus	geminin	0.0139	0.1515	0.2035
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0113	0.1135	0.3651
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0051	0.0218	0.0293
Echinococcus multilocularis	survival motor neuron protein 1	0.0199	0.2412	0.2412
Schistosoma mansoni	tar DNA-binding protein	0.0098	0.0907	0.0988
Toxoplasma gondii	PHD-finger domain-containing protein	0.0075	0.057	0.2028
Echinococcus multilocularis	musashi	0.0042	0.0073	0.0073
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0163	0.1867	0.6007
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0117	0.1184	0.129
Schistosoma mansoni	hypothetical protein	0.0139	0.1515	0.165
Leishmania major	importin beta-1 subunit, putative	0.0041	0.0055	0.0197
Onchocerca volvulus		0.0042	0.0073	0.0055
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0117	0.1184	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0188	0.2246	0.3049
Toxoplasma gondii	PHD-finger domain-containing protein	0.0075	0.057	0.2028
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1135	0.1541
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0098	0.0904	0.1215
Echinococcus multilocularis	GPCR, family 2	0.0051	0.0218	0.0218
Echinococcus multilocularis	jumonji domain containing protein	0.0105	0.1007	0.1007
Schistosoma mansoni	aldehyde dehydrogenase	0.0051	0.0214	0.0233
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.1052	1
Echinococcus granulosus	importin subunit beta 1	0.005	0.0196	0.0263
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0051	0.0218	0.0293
Schistosoma mansoni	jumonji domain containing protein	0.0196	0.2358	0.2568
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0117	0.1184	0.129
Loa Loa (eye worm)	hypothetical protein	0.0075	0.057	0.0774
Plasmodium vivax	hypothetical protein, conserved	0.0075	0.057	0.2028
Loa Loa (eye worm)	zinc metalloproteinase toh-2	0.0045	0.0126	0.0172
Echinococcus granulosus	PHD finger protein rhinoceros	0.0075	0.057	0.0766
Schistosoma mansoni	tar DNA-binding protein	0.0098	0.0907	0.0988
Schistosoma mansoni	thyroid hormone receptor	0.0114	0.1147	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0053	0.024	0.0326
Echinococcus multilocularis	geminin	0.0139	0.1515	0.1515
Trypanosoma brucei	importin beta-1 subunit, putative	0.005	0.0196	0.0696
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0117	0.1184	0.129
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0075	0.057	0.057
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0246	0.3109	0.3109
Entamoeba histolytica	hypothetical protein	0.0097	0.0897	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0155	0.1758	0.2387
Schistosoma mansoni	tar DNA-binding protein	0.0098	0.0907	0.0988
Loa Loa (eye worm)	intermediate filament protein	0.0042	0.0073	0.0099
Schistosoma mansoni	importin beta-1	0.005	0.0196	0.0213
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0226	0.2812	0.3063
Echinococcus multilocularis	lamin	0.0042	0.0073	0.0073

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC99 (functional)	= 6.25 uM	Antitubercular activity against Mycobacterium tuberculosis H37Rv in GAST media with glycerol and alanine after 7 to 14 days by broth microdilution method	ChEMBL.	24075144
MIC99 (functional)	= 12.5 uM	Antitubercular activity against Mycobacterium tuberculosis H37Rv in Middlebrook 7H9 broth with glucose after 7 to 14 days by broth microdilution method	ChEMBL.	24075144

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2441177

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1789829