TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 480.967 | Formula: C24H21ClN4O3S
H donors: 2 H acceptors: 3 LogP: 4.59 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cn1cc(c2c1cccc2)/C=N/NS(=O)(=O)c1ccc(cc1)C)Nc1ccccc1Cl
InChi: 1S/C24H21ClN4O3S/c1-17-10-12-19(13-11-17)33(31,32)28-26-14-18-15-29(23-9-5-2-6-20(18)23)16-24(30)27-22-8-4-3-7-21(22)25/h2-15,28H,16H2,1H3,(H,27,30)/b26-14+
InChiKey: VEWUIZXHYJNEPF-VULFUBBASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, shaker-related subfamily, member 5	Starlite/ChEMBL	References
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	potassium voltage gated channel subfamily A	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus multilocularis	potassium voltage gated channel protein	Get druggable targets OG5_127659	All targets in OG5_127659
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma japonicum	ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus granulosus	potassium voltage gated channel subfamily A	Get druggable targets OG5_127659	All targets in OG5_127659
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily A member 5, putative	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma japonicum	Potassium voltage-gated channel protein Shaker, putative	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus granulosus	potassium voltage gated channel protein	Get druggable targets OG5_127659	All targets in OG5_127659
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	voltage gated potassium channel	potassium voltage-gated channel, shaker-related subfamily, member 5	613 aa	521 aa	34.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0963	0.0963
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0128	0.1328
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.2264	0.8999	0.8999
Schistosoma mansoni	serine/threonine protein kinase	0.0257	0.0987	0.0987
Schistosoma mansoni	regulator of G protein signaling	0.0251	0.0963	0.0963
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0011	0.0007	0.0008
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.0029	0.0029
Loa Loa (eye worm)	voltage-gated potassium channel	0.0011	0.0007	0.0007
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0251	0.0963	1
Brugia malayi	Egg laying defective protein 4	0.0012	0.0009	0.0009
Entamoeba histolytica	hypothetical protein	0.0251	0.0963	1
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0107	0.0107
Schistosoma mansoni	axis inhibition protein axin	0.0251	0.0963	0.0963
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0092	0.5
Echinococcus multilocularis	regulator of G protein signaling	0.0251	0.0963	0.107
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0172	0.0647	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0387	0.0387
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0013	0.0013	0.0013
Schistosoma mansoni	voltage-gated potassium channel	0.0053	0.0172	0.0172
Loa Loa (eye worm)	inositol-1	0.0036	0.0107	0.0107
Schistosoma mansoni	axis inhibition protein axin	0.0251	0.0963	0.0963
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0142	0.0142
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.2264	0.8999	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0048	0.0155	0.0155
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0107	0.0387	0.0387
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0142	0.0142
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0013	0.0013	0.0014
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.0007	0.0008
Echinococcus multilocularis	regulator of G protein signaling 7	0.0251	0.0963	0.107
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0013	0.0013	0.0014
Trichomonas vaginalis	conserved hypothetical protein	0.0251	0.0963	1
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0107	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0011	0.0007	0.0008
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0007	0.0007
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0013	0.0013	0.0013
Brugia malayi	MH2 domain containing protein	0.0116	0.0425	0.0425
Brugia malayi	PXA domain containing protein	0.0251	0.0963	0.0963
Schistosoma mansoni	regulator of G protein signaling	0.0251	0.0963	0.0963
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0132	0.0132
Echinococcus granulosus	potassium voltage gated channel protein	0.0107	0.0387	0.0431
Schistosoma mansoni	vesicular amine transporter	0.0011	0.0007	0.0007
Echinococcus granulosus	voltage gated potassium channel	0.0017	0.0029	0.0032
Echinococcus multilocularis	regulator of G protein signaling 3	0.0251	0.0963	0.107
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0048	0.0155	0.0173
Echinococcus multilocularis	expressed conserved protein	0.0012	0.0009	0.001
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0007	0.0007
Echinococcus granulosus	axis inhibition protein axin	0.0251	0.0963	0.107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0029	0.0029
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0107	0.1111
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0013	0.0013	0.0013
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0012	0.0009	0.0879
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0013	0.0013	0.0013
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0142	0.0157
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0012	0.0009	0.0009
Echinococcus granulosus	Regulator of G protein signaling 20	0.0251	0.0963	0.107
Trichomonas vaginalis	conserved hypothetical protein	0.0251	0.0963	1
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0251	0.0963	1
Onchocerca volvulus		0.001	0	0.5
Echinococcus multilocularis	alkaline phosphatase	0.0172	0.0647	0.0719
Chlamydia trachomatis	DNA ligase	0.001	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0013	0.0013
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0013	0.0013	0.0013
Brugia malayi	regulator of G-protein signaling rgs-7	0.0251	0.0963	0.0963
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0107	1
Plasmodium falciparum	cGMP-dependent protein kinase	0.0012	0.0009	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0107	1
Loa Loa (eye worm)	PXA domain-containing protein	0.0251	0.0963	0.0963
Brugia malayi	hypothetical protein	0.0251	0.0963	0.0963
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0251	0.0963	0.107
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0963	0.0963
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0013	0.0013	0.0014
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0107	0.1111
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0107	0.0107
Echinococcus multilocularis	transfer RNA-Gly	0.0011	0.0007	0.0008
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0425	0.0425
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0425	0.0425
Schistosoma mansoni	voltage-gated potassium channel	0.0107	0.0387	0.0387
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0005	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0009	0.0009
Echinococcus granulosus	expressed protein	0.0251	0.0963	0.107
Treponema pallidum	DNA ligase (lig)	0.001	0	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0142	0.0142
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0007	0.0007
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0251	0.0963	0.0963
Trichomonas vaginalis	conserved hypothetical protein	0.0251	0.0963	1
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0172	0.0647	0.0719
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0007	0.0007
Echinococcus multilocularis	expressed protein	0.0251	0.0963	0.107
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0013	0.0013	0.0013
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0251	0.0963	0.0963
Echinococcus multilocularis	voltage gated potassium channel	0.0017	0.0029	0.0032
Entamoeba histolytica	hypothetical protein	0.0251	0.0963	1
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0251	0.0963	0.0963
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0963	0.0963
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0007	0.0007
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0017	0.0029	0.0029
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0128	0.1328
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0107	0.1111
Schistosoma mansoni	regulator of G protein signaling	0.0251	0.0963	0.0963
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0172	0.0647	0.0719
Brugia malayi	regulator of G-protein signaling egl-10	0.0251	0.0963	0.0963
Echinococcus multilocularis	calcium activated potassium channel	0.0013	0.0013	0.0015
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.2515	1	1
Schistosoma mansoni	z-protein (S1r protein)	0.0251	0.0963	0.0963
Trichomonas vaginalis	conserved hypothetical protein	0.0251	0.0963	1
Echinococcus granulosus	shaker cognate	0.0011	0.0007	0.0008
Giardia lamblia	Replication factor C, subunit 1	0.001	0	0.5
Schistosoma mansoni	hypothetical protein	0.0089	0.0318	0.0318
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0011	0.0007	0.0007
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0011	0.0007	0.0008
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0007	0.0007
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0142	0.0142
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0012	0.0009	0.001
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0011	0.0007	0.0008
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.0007	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0963	0.0963
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0102	0.0369	0.041
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0011	0.0007	0.0007
Brugia malayi	PXA domain containing protein	0.0251	0.0963	0.0963
Echinococcus granulosus	cGMP dependent protein kinase	0.0012	0.0009	0.001
Schistosoma mansoni	alkaline phosphatase	0.0172	0.0647	0.0647
Brugia malayi	hypothetical protein	0.0251	0.0963	0.0963
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0013	0.0013	0.0014
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0013	0.0013	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0963	0.0963
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.2264	0.8999	0.8999
Echinococcus granulosus	hyperpolarization activated cyclic	0.0013	0.0013	0.0014
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0011	0.0007	0.0008
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0142	0.0157
Schistosoma mansoni	voltage-gated potassium channel	0.0107	0.0387	0.0387
Loa Loa (eye worm)	RGS-3 protein	0.0251	0.0963	0.0963
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0092	1
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.001	0.0002	0.0211
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0107	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0013	0.0013	0.0013
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0009	0.0009
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0107	0.0387	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0963	0.0963
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0011	0.0007	0.0008
Brugia malayi	A-kinase anchor protein 10, precursor	0.0251	0.0963	0.0963
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0251	0.0963	0.107
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0012	0.0009	0.001
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0012	0.0009	0.001
Echinococcus granulosus	axis inhibition protein axin	0.0251	0.0963	0.107
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0013	0.0013
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0172	0.0647	0.0719
Schistosoma mansoni	regulator of G protein signaling	0.0251	0.0963	0.0963
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0013	0.0013	0.0013
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0013	0.0013	0.0131
Trichomonas vaginalis	conserved hypothetical protein	0.0251	0.0963	1
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.2264	0.8999	0.8999
Schistosoma mansoni	regulator of G protein signaling	0.0251	0.0963	0.0963
Echinococcus granulosus	calcium activated potassium channel	0.0013	0.0013	0.0015
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0017	0.0029	0.0032
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0017	0.0029	0.0032
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0048	0.0155	0.0173
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0107	1
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0107	0.0119
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0007	0.0007
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0257	0.0987	0.0987
Echinococcus multilocularis	shaker cognate	0.0011	0.0007	0.0008
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0107	0.0119
Schistosoma mansoni	serine/threonine protein kinase	0.2515	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0009	0.0009
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0013	0.0013	0.0014
Entamoeba histolytica	hypothetical protein	0.0251	0.0963	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0011	0.0007	0.0008
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0257	0.0987	0.1097
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.2264	0.8999	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0013	0.0013	0.0131
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0048	0.0155	0.0155
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0251	0.0963	0.0963
Schistosoma mansoni	voltage-gated potassium channel	0.0053	0.0172	0.0172
Echinococcus granulosus	regulator of G protein signaling 7	0.0251	0.0963	0.107
Echinococcus multilocularis	regulator of G protein signaling 3	0.0251	0.0963	0.107
Echinococcus multilocularis	axis inhibition protein axin	0.0251	0.0963	0.107
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0011	0.0007	0.0008
Echinococcus multilocularis	potassium voltage gated channel protein	0.0011	0.0007	0.0008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0142	0.0142
Echinococcus multilocularis	axis inhibition protein axin	0.0251	0.0963	0.107
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0107	1
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0251	0.0963	0.0963
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0107	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0107	0.0387	0.0431
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.0029	0.0029
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0142	0.0157
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0172	0.0647	0.0719
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0251	0.0963	0.107
Schistosoma mansoni	60S ribosomal protein L21	0.0011	0.0005	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0257	0.0987	0.0987
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0013	0.0013	0.0014
Brugia malayi	Inositol-1	0.0036	0.0107	0.0107
Echinococcus multilocularis	regulator of G protein signaling 7	0.0251	0.0963	0.107
Echinococcus granulosus	potassium voltage gated channel protein	0.0011	0.0007	0.0008
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0013	0.0013	0.0014
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0012	0.0009	0.001
Echinococcus granulosus	hyperpolarization activated cyclic	0.0013	0.0013	0.0014
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0107	0.1111
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0251	0.0963	0.0963
Schistosoma mansoni	alkaline phosphatase	0.0172	0.0647	0.0647
Echinococcus granulosus	regulator of G protein signaling 3	0.0251	0.0963	0.107
Echinococcus granulosus	regulator of G protein signaling 7	0.0251	0.0963	0.107
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0142	0.0157
Echinococcus granulosus	alkaline phosphatase	0.0172	0.0647	0.0719
Echinococcus granulosus	regulator of G protein signaling 3	0.0251	0.0963	0.107
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0257	0.0987	0.1097
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0013	0.0013	0.0014
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0011	0.0007	0.0008
Echinococcus granulosus	intestinal type alkaline phosphatase	0.0172	0.0647	0.0719

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.74 uM	Inhibition of human Kv1.5 channel expressed in HEK293 cells by whole cell patch clamp technique	ChEMBL.	24071446
IC50 (binding)	= 18.66 uM	Inhibition of human ERG channel expressed in CHO cells by whole cell patch clamp technique	ChEMBL.	24071446
Inhibition (binding)		Inhibition of human Kv1.5 channel expressed in HEK293 cells by whole cell patch clamp technique	ChEMBL.	24071446

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2440383

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1791961