Detailed information for compound 1791961

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.967 | Formula: C24H21ClN4O3S
  • H donors: 2 H acceptors: 3 LogP: 4.59 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1cc(c2c1cccc2)/C=N/NS(=O)(=O)c1ccc(cc1)C)Nc1ccccc1Cl
  • InChi: 1S/C24H21ClN4O3S/c1-17-10-12-19(13-11-17)33(31,32)28-26-14-18-15-29(23-9-5-2-6-20(18)23)16-24(30)27-22-8-4-3-7-21(22)25/h2-15,28H,16H2,1H3,(H,27,30)/b26-14+
  • InChiKey: VEWUIZXHYJNEPF-VULFUBBASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 5 Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus potassium voltage gated channel subfamily A Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative Get druggable targets OG5_127659 All targets in OG5_127659
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum Potassium voltage-gated channel subfamily A member 5, putative Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_127659 All targets in OG5_127659
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus granulosus potassium voltage gated channel protein Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Potassium voltage-gated channel protein Shaker, putative Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis potassium voltage gated channel subfamily A Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus multilocularis potassium voltage gated channel protein Get druggable targets OG5_127659 All targets in OG5_127659
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis voltage gated potassium channel potassium voltage-gated channel, shaker-related subfamily, member 5 613 aa 521 aa 34.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0251 0.0963 0.0963
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.0013 0.0131
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0107 1
Treponema pallidum DNA ligase (lig) 0.001 0 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0011 0.0007 0.0008
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0172 0.0647 0.0719
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0009 0.001
Echinococcus multilocularis expressed conserved protein 0.0012 0.0009 0.001
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0013 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0251 0.0963 0.0963
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0009 0.0009
Echinococcus multilocularis calcium activated potassium channel 0.0013 0.0013 0.0015
Schistosoma mansoni axis inhibition protein axin 0.0251 0.0963 0.0963
Onchocerca volvulus 0.001 0 0.5
Echinococcus multilocularis potassium voltage gated channel protein 0.0011 0.0007 0.0008
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0251 0.0963 0.107
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0013 0.0013 0.0014
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.0172 0.0172
Schistosoma mansoni regulator of G protein signaling 0.0251 0.0963 0.0963
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0172 0.0647 0.0719
Echinococcus granulosus intestinal type alkaline phosphatase 0.0172 0.0647 0.0719
Brugia malayi Regulator of G protein signaling domain containing protein 0.0251 0.0963 0.0963
Echinococcus granulosus regulator of G protein signaling 7 0.0251 0.0963 0.107
Loa Loa (eye worm) RGS-3 protein 0.0251 0.0963 0.0963
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0013 0.0013
Echinococcus granulosus cGMP dependent protein kinase 0.0012 0.0009 0.001
Echinococcus granulosus alkaline phosphatase 0.0172 0.0647 0.0719
Brugia malayi hypothetical protein 0.0251 0.0963 0.0963
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0013 0.0013 0.0014
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.0172 0.0172
Echinococcus multilocularis Regulator of G protein signaling 20 0.0251 0.0963 0.107
Echinococcus multilocularis potassium voltage gated channel protein 0.0107 0.0387 0.0431
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.0987 0.0987
Echinococcus granulosus regulator of G protein signaling 3 0.0251 0.0963 0.107
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0048 0.0155 0.0173
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0011 0.0007 0.0008
Echinococcus granulosus shaker cognate 0.0011 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0251 0.0963 0.0963
Entamoeba histolytica hypothetical protein 0.0251 0.0963 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0013 0.0013 0.0013
Echinococcus granulosus hyperpolarization activated cyclic 0.0013 0.0013 0.0014
Chlamydia trachomatis DNA ligase 0.001 0 0.5
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0251 0.0963 0.107
Echinococcus granulosus Regulator of G protein signaling 20 0.0251 0.0963 0.107
Echinococcus multilocularis hyperpolarization activated cyclic 0.0013 0.0013 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0142 0.0157
Echinococcus granulosus potassium voltage gated channel protein 0.0107 0.0387 0.0431
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0029 0.0032
Loa Loa (eye worm) hypothetical protein 0.0251 0.0963 0.0963
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0007 0.0007
Schistosoma mansoni inositol monophosphatase 0.0036 0.0107 0.0107
Schistosoma mansoni axis inhibition protein axin 0.0251 0.0963 0.0963
Loa Loa (eye worm) voltage-gated potassium channel 0.0011 0.0007 0.0007
Echinococcus multilocularis potassium voltage gated channel protein 0.0011 0.0007 0.0008
Schistosoma mansoni vesicular amine transporter 0.0011 0.0007 0.0007
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.2264 0.8999 0.8999
Echinococcus multilocularis axis inhibition protein axin 0.0251 0.0963 0.107
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2264 0.8999 0.8999
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0092 0.5
Schistosoma mansoni alkaline phosphatase 0.0172 0.0647 0.0647
Loa Loa (eye worm) hypothetical protein 0.0017 0.0029 0.0029
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0029 0.0029
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0257 0.0987 0.0987
Schistosoma mansoni 60S ribosomal protein L21 0.0011 0.0005 0.0005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0107 1
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0007 0.0008
Brugia malayi PXA domain containing protein 0.0251 0.0963 0.0963
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2515 1 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0013 0.0013 0.0014
Echinococcus multilocularis hyperpolarization activated cyclic 0.0013 0.0013 0.0014
Echinococcus granulosus potassium voltage gated channel protein 0.0011 0.0007 0.0008
Brugia malayi PXA domain containing protein 0.0251 0.0963 0.0963
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0013 0.0013
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0107 0.1111
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0029 0.0029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0142 0.0142
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0029 0.0032
Loa Loa (eye worm) hypothetical protein 0.0251 0.0963 0.0963
Trichomonas vaginalis conserved hypothetical protein 0.0251 0.0963 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0107 1
Plasmodium vivax replication factor C subunit 1, putative 0.001 0 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0142 0.0157
Schistosoma mansoni z-protein (S1r protein) 0.0251 0.0963 0.0963
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0013 0.0013 0.0014
Echinococcus granulosus potassium voltage gated channel protein 0.0011 0.0007 0.0008
Brugia malayi Egg laying defective protein 4 0.0012 0.0009 0.0009
Schistosoma mansoni regulator of G protein signaling 0.0251 0.0963 0.0963
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.001 0.0002 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0251 0.0963 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0011 0.0007 0.0008
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0128 0.1328
Loa Loa (eye worm) hypothetical protein 0.0043 0.0132 0.0132
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0251 0.0963 0.0963
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0142 0.0157
Brugia malayi hypothetical protein 0.0251 0.0963 0.0963
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0029 0.0032
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0251 0.0963 1
Loa Loa (eye worm) PXA domain-containing protein 0.0251 0.0963 0.0963
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0029 0.0032
Echinococcus multilocularis transfer RNA-Gly 0.0011 0.0007 0.0008
Echinococcus multilocularis beta adrenergic receptor kinase 0.0257 0.0987 0.1097
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0251 0.0963 0.0963
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0013 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0107 0.0387 0.0387
Echinococcus multilocularis G protein coupled receptor kinase 6 0.2264 0.8999 1
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0172 0.0647 0.0719
Echinococcus multilocularis shaker cognate 0.0011 0.0007 0.0008
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0107 1
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0011 0.0007 0.0008
Schistosoma mansoni voltage-gated potassium channel 0.0107 0.0387 0.0387
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0048 0.0155 0.0173
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0013 0.0013 0.0013
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0012 0.0009 0.0879
Entamoeba histolytica hypothetical protein 0.0251 0.0963 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0011 0.0007 0.0008
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.2264 0.8999 0.8999
Trichomonas vaginalis conserved hypothetical protein 0.0251 0.0963 1
Schistosoma mansoni regulator of G protein signaling 0.0251 0.0963 0.0963
Brugia malayi Cyclic-nucleotide gated cation channel 0.0013 0.0013 0.0013
Schistosoma mansoni regulator of G protein signaling 0.0251 0.0963 0.0963
Loa Loa (eye worm) hypothetical protein 0.0251 0.0963 0.0963
Echinococcus multilocularis regulator of G protein signaling 0.0251 0.0963 0.107
Giardia lamblia Replication factor C, subunit 1 0.001 0 0.5
Echinococcus multilocularis regulator of G protein signaling 7 0.0251 0.0963 0.107
Echinococcus multilocularis regulator of G protein signaling 7 0.0251 0.0963 0.107
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0142 0.0157
Echinococcus granulosus beta-adrenergic receptor kinase 0.0257 0.0987 0.1097
Trichomonas vaginalis conserved hypothetical protein 0.0251 0.0963 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0963 0.0963
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0013 0.0013
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0251 0.0963 0.0963
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0107 0.0387 0.0387
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0107 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0102 0.0369 0.041
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0009 0.001
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0107 1
Entamoeba histolytica hypothetical protein 0.0251 0.0963 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0251 0.0963 0.0963
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0009 0.0009
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0013
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0107 0.0119
Echinococcus granulosus calcium activated potassium channel 0.0013 0.0013 0.0015
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0048 0.0155 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0007 0.0007
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0048 0.0155 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0007 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0142 0.0142
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0172 0.0647 0.0719
Schistosoma mansoni alkaline phosphatase 0.0172 0.0647 0.0647
Echinococcus granulosus axis inhibition protein axin 0.0251 0.0963 0.107
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0107 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0011 0.0007 0.0008
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0007 0.0007
Brugia malayi regulator of G-protein signaling rgs-7 0.0251 0.0963 0.0963
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0107 0.1111
Echinococcus granulosus axis inhibition protein axin 0.0251 0.0963 0.107
Schistosoma mansoni serine/threonine protein kinase 0.2515 1 1
Brugia malayi MH2 domain containing protein 0.0116 0.0425 0.0425
Loa Loa (eye worm) inositol-1 0.0036 0.0107 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.0987 0.0987
Echinococcus multilocularis regulator of G protein signaling 3 0.0251 0.0963 0.107
Trichomonas vaginalis conserved hypothetical protein 0.0251 0.0963 1
Echinococcus multilocularis alkaline phosphatase 0.0172 0.0647 0.0719
Brugia malayi regulator of G-protein signaling egl-10 0.0251 0.0963 0.0963
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0172 0.0647 0.0719
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0107 0.0119
Brugia malayi Regulator of G protein signaling domain containing protein 0.0251 0.0963 0.0963
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0107 0.0387 0.0431
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0011 0.0007 0.0007
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0013 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0009 0.0009
Loa Loa (eye worm) AGC/PKG protein kinase 0.0012 0.0009 0.0009
Echinococcus granulosus expressed protein 0.0251 0.0963 0.107
Echinococcus granulosus regulator of G protein signaling 3 0.0251 0.0963 0.107
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0425 0.0425
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0107 0.0387 0.0387
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.2264 0.8999 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.0089 0.0318 0.0318
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0005 0.0005
Echinococcus multilocularis regulator of G protein signaling 3 0.0251 0.0963 0.107
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0013 0.0013 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0251 0.0963 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0142 0.0142
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.0013 0.0131
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0107 0.1111
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0011 0.0007 0.0007
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0007 0.0007
Echinococcus granulosus regulator of G protein signaling 7 0.0251 0.0963 0.107
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0128 0.1328
Echinococcus multilocularis axis inhibition protein axin 0.0251 0.0963 0.107
Echinococcus multilocularis expressed protein 0.0251 0.0963 0.107
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0011 0.0007 0.0008
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0009 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0425 0.0425
Plasmodium falciparum cGMP-dependent protein kinase 0.0012 0.0009 1
Schistosoma mansoni regulator of G protein signaling 0.0251 0.0963 0.0963
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0007 0.0008
Echinococcus granulosus hyperpolarization activated cyclic 0.0013 0.0013 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0017 0.0029 0.0029
Brugia malayi Inositol-1 0.0036 0.0107 0.0107
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0107 0.1111
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0142 0.0142
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0092 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.74 uM Inhibition of human Kv1.5 channel expressed in HEK293 cells by whole cell patch clamp technique ChEMBL. 24071446
IC50 (binding) = 18.66 uM Inhibition of human ERG channel expressed in CHO cells by whole cell patch clamp technique ChEMBL. 24071446
Inhibition (binding) Inhibition of human Kv1.5 channel expressed in HEK293 cells by whole cell patch clamp technique ChEMBL. 24071446

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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