Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.0131 | 0.0131 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Mycobacterium leprae | conserved hypothetical protein | 0.002 | 0.0049 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.002 | 0.0049 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0495 | 0.306 | 0.4169 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1161 | 0.7272 | 0.7272 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0834 | 0.1147 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0139 | 0.0139 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.1161 | 0.7272 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0049 | 0.0049 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.002 | 0.0049 | 0.5 |
Echinococcus granulosus | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0139 | 0.0139 |
Trichomonas vaginalis | set domain proteins, putative | 0.0269 | 0.1626 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0685 | 0.4261 | 1 |
Plasmodium falciparum | phosphoglycerate mutase, putative | 0.002 | 0.0049 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0049 | 0.0067 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0495 | 0.306 | 0.4169 |
Schistosoma mansoni | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Mycobacterium tuberculosis | Conserved protein | 0.002 | 0.0049 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1161 | 0.7272 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.1142 | 0.1142 |
Echinococcus granulosus | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.002 | 0.0049 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0049 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0542 | 0.3356 | 0.3356 |
Schistosoma mansoni | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0253 | 0.0253 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0139 | 0.0139 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0253 | 0.0253 |
Mycobacterium ulcerans | hypothetical protein | 0.0685 | 0.4261 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0253 | 0.0349 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.1142 | 0.1142 |
Loa Loa (eye worm) | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0067 |
Brugia malayi | phosphoglycerate mutase family protein | 0.002 | 0.0049 | 0.0345 |
Echinococcus granulosus | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Mycobacterium leprae | conserved hypothetical protein | 0.002 | 0.0049 | 0.5 |
Onchocerca volvulus | 0.002 | 0.0049 | 0.0067 | |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.002 | 0.0049 | 0.5 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.002 | 0.0049 | 0.0067 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.002 | 0.0049 | 0.0067 |
Onchocerca volvulus | 0.0269 | 0.1626 | 0.2236 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1161 | 0.7272 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0139 | 0.0982 |
Onchocerca volvulus | Huntingtin homolog | 0.0144 | 0.0834 | 0.1147 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1592 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1141 | 0.7147 | 0.9829 |
Brugia malayi | phosphoglycerate mutase family protein | 0.002 | 0.0049 | 0.0345 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0495 | 0.306 | 0.4169 |
Echinococcus granulosus | geminin | 0.0192 | 0.1142 | 0.1142 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.002 | 0.0049 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0236 | 0.1419 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0253 | 0.1786 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0049 | 0.0049 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0834 | 0.1147 |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.002 | 0.0049 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0049 | 0.0067 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0495 | 0.306 | 0.4169 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1141 | 0.7147 | 0.9828 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.002 | 0.0049 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0139 | 0.0192 | |
Treponema pallidum | phosphoglyceromutase | 0.002 | 0.0049 | 0.5 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Onchocerca volvulus | 0.002 | 0.0049 | 0.0067 | |
Mycobacterium tuberculosis | Conserved protein | 0.002 | 0.0049 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1141 | 0.7147 | 0.9828 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0253 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 0.4137 | 0.5689 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0139 | 1 |
Brugia malayi | UBASH3A protein homolog | 0.002 | 0.0049 | 0.0345 |
Echinococcus multilocularis | geminin | 0.0192 | 0.1142 | 0.1142 |
Onchocerca volvulus | 0.002 | 0.0049 | 0.0067 | |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.002 | 0.0049 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0049 | 0.0049 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0139 | 0.0139 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1161 | 0.7272 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0139 | 0.0192 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0049 | 0.0067 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1592 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0049 | 0.0067 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0139 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1141 | 0.7147 | 0.9828 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.002 | 0.0049 | 0.5 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.002 | 0.0049 | 0.0049 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.002 | 0.0049 | 0.5 |
Onchocerca volvulus | 0.1161 | 0.7272 | 1 | |
Onchocerca volvulus | Huntingtin homolog | 0.0144 | 0.0834 | 0.1147 |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.002 | 0.0049 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0236 | 0.1419 | 0.1952 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.002 | 0.0049 | 0.0067 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.002 | 0.0049 | 0.0049 |
Echinococcus granulosus | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Echinococcus granulosus | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.002 | 0.0049 | 0.0049 |
Giardia lamblia | Hypothetical protein | 0.0685 | 0.4261 | 0.5 |
Plasmodium falciparum | phosphoglucomutase-2 | 0.002 | 0.0049 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0685 | 0.4261 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0542 | 0.3356 | 0.3356 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0139 | 0.0139 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.002 | 0.0049 | 0.5 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.002 | 0.0049 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.002 | 0.0049 | 0.5 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.002 | 0.0049 | 0.0049 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0253 | 0.0253 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0049 | 0.0049 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0253 | 0.0253 |
Brugia malayi | hypothetical protein | 0.0144 | 0.0834 | 0.5876 |
Echinococcus granulosus | 6 phosphofructo 2 kinase:fructose 2 | 0.1161 | 0.7272 | 0.7272 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.002 | 0.0049 | 0.0067 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0253 | 0.0253 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1141 | 0.7147 | 0.9828 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.002 | 0.0049 | 0.0049 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0253 | 0.0253 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0139 | 0.0139 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1161 | 0.7272 | 1 |
Giardia lamblia | Hypothetical protein | 0.0685 | 0.4261 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0049 | 0.0049 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1161 | 0.7272 | 0.7272 |
Echinococcus granulosus | neuropeptide s receptor | 0.0542 | 0.3356 | 0.3356 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0542 | 0.3356 | 0.3356 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 12 % | Inhibition of snake venom phosphodiesterase using bis-(para-nitrophenyl)phosphate as substrate at 0.2 mM after 30 min by spectrophotometric analysis | ChEMBL. | No reference |
IZ (functional) | = 18 mm | Antibacterial activity against Escherichia coli assessed as growth inhibition after 24 hr by agar well diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.