Detailed information for compound 1793834

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1025.27 | Formula: C53H88N2O17
  • H donors: 4 H acceptors: 7 LogP: 4.21 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O[C@@H]2O[C@H](C)[C@H]([C@@H]([C@H]2OC(=O)c2ccccc2)N(C)C)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C[C@H](C(=O)[C@@H]([C@H]([C@]1(C)O)O)C)C)(C)OC
  • InChi: 1S/C53H88N2O17/c1-18-36-53(11,62)44(59)29(4)39(56)27(2)25-51(9,63-16)45(71-49-41(58)35(54(12)13)24-28(3)65-49)30(5)42(31(6)47(60)68-36)69-37-26-52(10,64-17)46(33(8)66-37)72-50-43(38(55(14)15)40(57)32(7)67-50)70-48(61)34-22-20-19-21-23-34/h19-23,27-33,35-38,40-46,49-50,57-59,62H,18,24-26H2,1-17H3/t27-,28-,29+,30+,31-,32-,33+,35+,36-,37+,38+,40-,41-,42+,43-,44-,45-,46+,49+,50+,51+,52-,53-/m1/s1
  • InChiKey: VTZORXTZSSNEHA-QHKOUZCMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Brugia malayi hypothetical protein 0.005 0.0109 0.0166
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0233 0.1537 0.4168
Brugia malayi transcriptional regulator, Sir2 family protein 0.0233 0.1537 0.2341
Loa Loa (eye worm) G-protein coupled receptor 0.005 0.0109 0.0166
Plasmodium vivax NAD-dependent deacetylase, putative 0.0048 0.0096 1
Echinococcus multilocularis neuropeptide Y receptor 0.005 0.0109 0.0224
Echinococcus granulosus 7tm_1 domain containing protein 0.005 0.0109 0.0224
Onchocerca volvulus 0.005 0.0109 0.0727
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0233 0.1537 1
Brugia malayi PAN domain containing protein 0.0037 0.0014 0.0021
Schistosoma mansoni amine GPCR 0.005 0.0109 0.0109
Echinococcus granulosus neuropeptide Y receptor 0.005 0.0109 0.0224
Brugia malayi RE15519p 0.005 0.0109 0.0166
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0109 0.0224
Echinococcus multilocularis dro:myosuppressin receptor 0.005 0.0109 0.0224
Loa Loa (eye worm) G-protein coupled receptor 0.005 0.0109 0.0166
Schistosoma mansoni neuropeptide receptor 0.005 0.0109 0.0109
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.005 0.0109 0.0166
Schistosoma mansoni hypothetical protein 0.0046 0.0081 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0109 0.0109
Schistosoma mansoni hypothetical protein 0.0046 0.0081 0.0081
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0228 0.1498 0.4061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0509 0.3689 1
Giardia lamblia Sirtuin type 2 0.0048 0.0096 0.0627
Echinococcus multilocularis neuropeptide Y receptor 0.005 0.0109 0.0224
Echinococcus multilocularis CREB binding protein 0.0109 0.0573 0.1178
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.005 0.0109 0.0224
Brugia malayi G protein-coupled receptor 0.005 0.0109 0.0166
Loa Loa (eye worm) hypothetical protein 0.0154 0.092 0.1401
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Echinococcus multilocularis g protein coupled receptor 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0109 0.0109
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0096 0.0147
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.005 0.0109 0.0224
Brugia malayi PAN domain containing protein 0.0037 0.0014 0.0021
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0048 0.0096 0.0627
Brugia malayi hypothetical protein 0.0562 0.4099 0.6241
Toxoplasma gondii hypothetical protein 0.0037 0.0014 0.0033
Loa Loa (eye worm) sirtuin 4 0.0048 0.0096 0.0147
Loa Loa (eye worm) melatonin receptor type 1A 0.005 0.0109 0.0166
Toxoplasma gondii histone deacetylase SIR2-like 0.0048 0.0096 0.0227
Loa Loa (eye worm) hypothetical protein 0.0106 0.0546 0.0832
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0048 0.0096 0.0198
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Giardia lamblia Hypothetical protein 0.0233 0.1537 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0233 0.1537 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.0109 0.0224
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0154 0.092 0.2494
Toxoplasma gondii microneme protein MIC4 0.0037 0.0014 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0021
Echinococcus multilocularis G-protein coupled receptor, putative 0.005 0.0109 0.0224
Schistosoma mansoni peptide (allatostatin)-like receptor 0.005 0.0109 0.0109
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0096 0.0096
Echinococcus multilocularis g protein coupled receptor 0.005 0.0109 0.0224
Schistosoma mansoni neuropeptide f receptor 76f 0.005 0.0109 0.0109
Schistosoma mansoni CREB-binding protein 2 0.0144 0.0843 0.0843
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0233 0.1537 1
Onchocerca volvulus 0.005 0.0109 0.0727
Echinococcus granulosus g protein coupled receptor 0.005 0.0109 0.0224
Echinococcus granulosus neuropeptide s receptor 0.005 0.0109 0.0224
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.005 0.0109 0.0224
Echinococcus granulosus somatostatin receptor 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.0146 0.0856 0.1304
Echinococcus granulosus orexin receptor type 2 0.005 0.0109 0.0224
Onchocerca volvulus 0.0228 0.1498 1
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Toxoplasma gondii hypothetical protein 0.0037 0.0014 0.0033
Echinococcus multilocularis Bromodomain containing protein 0.0228 0.1498 0.3077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0109 0.0109
Loa Loa (eye worm) bromodomain containing protein 0.0228 0.1498 0.2281
Leishmania major silent information regulator 2, putative 0.0233 0.1537 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0021
Echinococcus multilocularis neuropeptide receptor 0.005 0.0109 0.0224
Schistosoma mansoni hypothetical protein 0.0046 0.0081 0.0081
Leishmania major sir2-family protein-like protein 0.0048 0.0096 0.0627
Schistosoma mansoni neuropeptide F-like receptor 0.005 0.0109 0.0109
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0109 0.0224
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0081 0.0167
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Onchocerca volvulus 0.0037 0.0014 0.0094
Loa Loa (eye worm) hypothetical protein 0.01 0.0497 0.0757
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0048 0.0096 0.0627
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0109 0.0224
Echinococcus multilocularis serotonin receptor 0.005 0.0109 0.0224
Brugia malayi Serotonin receptor 0.005 0.0109 0.0166
Echinococcus multilocularis fmrfamide receptor 0.005 0.0109 0.0224
Schistosoma mansoni neuropeptide receptor 0.005 0.0109 0.0109
Schistosoma mansoni growth hormone secretagogue receptor 0.005 0.0109 0.0109
Brugia malayi hypothetical protein 0.005 0.0109 0.0166
Brugia malayi Melatonin receptor type 1A 0.005 0.0109 0.0166
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Schistosoma mansoni hypothetical protein 0.0046 0.0081 0.0081
Onchocerca volvulus 0.005 0.0109 0.0727
Toxoplasma gondii microneme protein MIC17A 0.0037 0.0014 0.0033
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Echinococcus granulosus g protein coupled receptor 0.005 0.0109 0.0224
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0233 0.1537 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.005 0.0109 0.0109
Brugia malayi gonadotropin-releasing hormone receptor 2 0.005 0.0109 0.0166
Entamoeba histolytica bromodomain-containing protein 0.0228 0.1498 0.9744
Schistosoma mansoni biogenic amine receptor 0.005 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0021
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Onchocerca volvulus 0.005 0.0109 0.0727
Echinococcus granulosus neuropeptide receptor 0.0661 0.4868 1
Brugia malayi sulfakinin receptor protein 0.005 0.0109 0.0166
Onchocerca volvulus 0.0037 0.0014 0.0094
Brugia malayi Serotonin receptor 0.005 0.0109 0.0166
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0014 0.0021
Brugia malayi Bromodomain containing protein 0.0879 0.6568 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0096 0.0261
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0096 0.0261
Onchocerca volvulus 0.0037 0.0014 0.0094
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0048 0.0096 0.0627
Brugia malayi hypothetical protein 0.005 0.0109 0.0166
Toxoplasma gondii PAN/Apple domain-containing protein 0.0037 0.0014 0.0033
Echinococcus granulosus chromatin regulatory protein sir2 0.0233 0.1537 0.3158
Toxoplasma gondii microneme protein MIC17C 0.0037 0.0014 0.0033
Echinococcus multilocularis orexin receptor type 2 0.005 0.0109 0.0224
Toxoplasma gondii bromodomain-containing protein 0.0228 0.1498 0.352
Brugia malayi Serotonin/octopamine receptor family protein 7 0.005 0.0109 0.0166
Echinococcus multilocularis neuropeptide s receptor 0.005 0.0109 0.0224
Schistosoma mansoni neuropeptide receptor 0.005 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0154 0.092 0.5985
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.0109 0.0224
Echinococcus multilocularis tachykinin peptides receptor 99D 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Echinococcus multilocularis G protein coupled receptor 139 0.0661 0.4868 1
Onchocerca volvulus 0.005 0.0109 0.0727
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.005 0.0109 0.0224
Toxoplasma gondii subtilisin SUB12 0.0037 0.0014 0.0033
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0154 0.092 0.2494
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Brugia malayi Tachykinin-like peptides receptor 99D 0.005 0.0109 0.0166
Brugia malayi ORL1-like opioid receptor 0.005 0.0109 0.0166
Entamoeba histolytica bromodomain-containing protein 0.0228 0.1498 0.9744
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Onchocerca volvulus 0.005 0.0109 0.0727
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.0856 0.1304
Trichomonas vaginalis conserved hypothetical protein 0.0281 0.1913 0.5187
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Echinococcus granulosus CREB binding protein 0.0144 0.0843 0.1732
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Brugia malayi hypothetical protein 0.005 0.0109 0.0166
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.005 0.0109 0.0224
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.005 0.0109 0.0109
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.005 0.0109 0.0224
Echinococcus multilocularis alpha 1A adrenergic receptor 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Brugia malayi hypothetical protein 0.005 0.0109 0.0166
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0109 0.0224
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0014 0.0021
Brugia malayi neuropeptide F receptor 0.005 0.0109 0.0166
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0109 0.0224
Schistosoma mansoni hypothetical protein 0.005 0.0109 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.2191 0.5939
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0048 0.0096 0.5
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0096 0.0096
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0109 0.0224
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0109 0.0224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Echinococcus granulosus hypothetical protein 0.005 0.0109 0.0224
Schistosoma mansoni serine-type protease inhibitor 0.132 1 1
Brugia malayi G-protein coupled receptor 0.005 0.0109 0.0166
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0014 0.0033
Onchocerca volvulus 0.0037 0.0014 0.0094
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0233 0.1537 0.3158
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0096 0.0147
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Echinococcus multilocularis GPCR, family 2 0.0046 0.0081 0.0167
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0048 0.0096 0.0198
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0014 0.0033
Onchocerca volvulus 0.005 0.0109 0.0727
Echinococcus granulosus bromodomain containing 2 0.0509 0.3689 0.7577
Onchocerca volvulus 0.005 0.0109 0.0727
Loa Loa (eye worm) TYRA-2 protein 0.005 0.0109 0.0166
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0233 0.1537 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Brugia malayi follicle stimulating hormone receptor 0.005 0.0109 0.0166
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.005 0.0109 0.0224
Schistosoma mansoni hypothetical protein 0.005 0.0109 0.0109
Trichomonas vaginalis bromodomain containing protein, putative 0.0228 0.1498 0.4061
Brugia malayi putative neuropeptide receptor NPR1 0.005 0.0109 0.0166
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0014 0.0021
Giardia lamblia Kinase, putative 0.0228 0.1498 0.9744
Mycobacterium ulcerans NAD-dependent deacetylase 0.0048 0.0096 0.5
Schistosoma mansoni chromatin regulatory protein sir2 0.0233 0.1537 0.1537
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0109 0.0109
Echinococcus granulosus biogenic amine 5HT receptor 0.005 0.0109 0.0224
Brugia malayi TAZ zinc finger family protein 0.0144 0.0843 0.1284
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Onchocerca volvulus 0.005 0.0109 0.0727
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0509 0.3689 0.3689
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.0109 0.0224
Giardia lamblia Transcriptional regulator, Sir2 family 0.0048 0.0096 0.0627
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0109 0.0224
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.005 0.0109 0.0166
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.0109 0.0224
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0154 0.092 0.189
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0014 0.0033
Echinococcus granulosus biogenic amine 5HT receptor 0.005 0.0109 0.0224
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.005 0.0109 0.0109
Schistosoma mansoni biogenic amine (5HT) receptor 0.005 0.0109 0.0109
Trichomonas vaginalis bromodomain-containing protein, putative 0.0317 0.2191 0.5939
Onchocerca volvulus 0.0037 0.0014 0.0094
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0109 0.0224
Schistosoma mansoni myosin xvIII 0.005 0.0109 0.0109
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0048 0.0096 0.0627
Echinococcus granulosus g-protein coupled receptor 0.005 0.0109 0.0224
Toxoplasma gondii PAN domain-containing protein 0.0582 0.4255 1
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0048 0.0096 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.005 0.0109 0.0224
Echinococcus multilocularis allatostatin A receptor 0.005 0.0109 0.0224
Echinococcus multilocularis sex peptide receptor 0.005 0.0109 0.0224
Echinococcus multilocularis biogenic amine (5HT) receptor 0.005 0.0109 0.0224
Echinococcus granulosus alpha 1A adrenergic receptor 0.005 0.0109 0.0224
Brugia malayi G protein-coupled receptor F59B2.13 0.005 0.0109 0.0166
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Brugia malayi Dopamine receptor protein 2 0.005 0.0109 0.0166
Brugia malayi Bromodomain containing protein 0.0509 0.3689 0.5617
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0233 0.1537 0.4168
Onchocerca volvulus 0.0037 0.0014 0.0094
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0081 0.0167
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0096 0.0261
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.005 0.0109 0.0109
Trichomonas vaginalis bromodomain containing protein, putative 0.0317 0.2191 0.5939
Schistosoma mansoni opsin-like receptor 0.005 0.0109 0.0109
Brugia malayi hypothetical protein 0.005 0.0109 0.0166
Brugia malayi putative neuropeptide receptor 0.005 0.0109 0.0166
Brugia malayi PAN domain containing protein 0.0037 0.0014 0.0021
Brugia malayi PAN domain containing protein 0.0037 0.0014 0.0021
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0144 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.0046 0.0081 0.0124
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.005 0.0109 0.0109
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0081 0.0124
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0048 0.0096 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0109 0.0224
Brugia malayi PAN domain containing protein 0.0037 0.0014 0.0021
Schistosoma mansoni alpha-1 adrenergic receptor 0.005 0.0109 0.0109
Onchocerca volvulus 0.005 0.0109 0.0727
Brugia malayi Dopamine receptor protein 1 0.005 0.0109 0.0166
Schistosoma mansoni opsin-like receptor 0.005 0.0109 0.0109
Echinococcus granulosus dro:myosuppressin receptor 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0021
Echinococcus granulosus neuropeptides capa receptor 0.005 0.0109 0.0224
Brugia malayi PAN domain containing protein 0.0037 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Echinococcus granulosus 7TM GPCR rhodopsin 0.005 0.0109 0.0224
Echinococcus granulosus GPCR family 2 0.0046 0.0081 0.0167
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0154 0.092 0.189
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Schistosoma mansoni hypothetical protein 0.005 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Toxoplasma gondii PAN domain-containing protein 0.0582 0.4255 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.005 0.0109 0.0109
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0096 0.0627
Echinococcus multilocularis serotonin receptor 0.005 0.0109 0.0224
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0014 0.0021
Brugia malayi hypothetical protein 0.005 0.0109 0.0166
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Echinococcus multilocularis fmrfamide receptor 0.005 0.0109 0.0224
Brugia malayi hypothetical protein 0.005 0.0109 0.0166
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Echinococcus multilocularis neuropeptide receptor A26 0.005 0.0109 0.0224
Brugia malayi PAN domain containing protein 0.0037 0.0014 0.0021
Onchocerca volvulus 0.005 0.0109 0.0727
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0081 0.0167
Onchocerca volvulus 0.005 0.0109 0.0727
Brugia malayi G-protein coupled receptor 0.005 0.0109 0.0166
Loa Loa (eye worm) hypothetical protein 0.0879 0.6568 1
Brugia malayi GnHR receptor homolog 0.005 0.0109 0.0166
Schistosoma mansoni amine GPCR 0.005 0.0109 0.0109
Brugia malayi PAN domain containing protein 0.0037 0.0014 0.0021
Echinococcus multilocularis neuropeptides capa receptor 0.005 0.0109 0.0224
Onchocerca volvulus 0.005 0.0109 0.0727
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.0109 0.0224
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.005 0.0109 0.0109
Trichomonas vaginalis bromodomain-containing protein, putative 0.0509 0.3689 1
Echinococcus granulosus fmrfamide receptor 0.005 0.0109 0.0224
Schistosoma mansoni adenoreceptor 0.005 0.0109 0.0109
Echinococcus granulosus g protein coupled receptor 0.005 0.0109 0.0224
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0048 0.0096 0.0627
Echinococcus granulosus serotonin receptor 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Brugia malayi PAN domain containing protein 0.0037 0.0014 0.0021
Brugia malayi PAN domain containing protein 0.0037 0.0014 0.0021
Schistosoma mansoni biogenic amine receptor 0.005 0.0109 0.0109
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0233 0.1537 0.3158
Onchocerca volvulus 0.0037 0.0014 0.0094
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0096 0.0147
Brugia malayi hypothetical protein 0.005 0.0109 0.0166
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0228 0.1498 0.4061
Schistosoma mansoni amine GPCR 0.005 0.0109 0.0109
Brugia malayi AKH receptor 0.005 0.0109 0.0166
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0052 0.0125 0.0191
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.005 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Brugia malayi larval opioid receptor 0.005 0.0109 0.0166
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0096 0.0096
Echinococcus granulosus neuropeptide Y receptor 0.005 0.0109 0.0224
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0014 0.0021
Brugia malayi neuropeptide F receptor 0.005 0.0109 0.0166
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0014 0.0033
Brugia malayi Dopamine receptor 0.005 0.0109 0.0166
Brugia malayi NAD-dependent deacetylase SIRT1 0.0154 0.092 0.1401
Toxoplasma gondii microneme protein, putative 0.0037 0.0014 0.0033
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.005 0.0109 0.0224
Onchocerca volvulus 0.005 0.0109 0.0727
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0048 0.0096 0.0627
Trypanosoma brucei SIR2-like protein 4, putative 0.0048 0.0096 0.0627
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0081 0.0167
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Onchocerca volvulus Neuropeptide F receptor homolog 0.005 0.0109 0.0727
Schistosoma mansoni neuropeptide receptor 0.0661 0.4868 0.4868
Onchocerca volvulus 0.0037 0.0014 0.0094
Onchocerca volvulus 0.005 0.0109 0.0727
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0109 0.0109
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0096 0.0261
Echinococcus multilocularis neuropeptide FF receptor 2 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0021
Trichomonas vaginalis bromodomain-containing protein, putative 0.0317 0.2191 0.5939
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0021
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.005 0.0109 0.0224
Echinococcus granulosus neuropeptide FF receptor 2 0.005 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0154 0.092 0.2494
Echinococcus granulosus neuropeptides capa receptor 0.005 0.0109 0.0224
Onchocerca volvulus 0.0037 0.0014 0.0094
Onchocerca volvulus 0.0037 0.0014 0.0094
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0109 0.0224
Schistosoma mansoni chromatin regulatory protein sir2 0.0233 0.1537 0.1537
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Schistosoma mansoni amine GPCR 0.005 0.0109 0.0109
Trichomonas vaginalis bromodomain-containing protein, putative 0.0317 0.2191 0.5939
Loa Loa (eye worm) CBP-B 0.011 0.0581 0.0884
Mycobacterium ulcerans Sir2-like regulatory protein 0.0048 0.0096 0.5
Onchocerca volvulus 0.005 0.0109 0.0727
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Schistosoma mansoni histamine h1 receptor 0.005 0.0109 0.0109
Loa Loa (eye worm) follicle stimulating hormone receptor 0.005 0.0109 0.0166
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.005 0.0109 0.0166
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0037 0.0014 0.0033
Schistosoma mansoni neuropeptide F-like receptor 0.005 0.0109 0.0109
Echinococcus multilocularis somatostatin receptor 0.005 0.0109 0.0224
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.005 0.0109 0.0727
Toxoplasma gondii microneme protein MIC17B 0.0037 0.0014 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0109 0.0224
Schistosoma mansoni hypothetical protein 0.005 0.0109 0.0109
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Echinococcus multilocularis g-protein coupled receptor 0.005 0.0109 0.0224
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.0856 0.1304
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Schistosoma mansoni amine GPCR 0.005 0.0109 0.0109
Echinococcus granulosus neuropeptide receptor A26 0.005 0.0109 0.0224
Echinococcus multilocularis chromatin regulatory protein sir2 0.0233 0.1537 0.3158
Echinococcus multilocularis bromodomain containing 2 0.0509 0.3689 0.7577
Echinococcus granulosus G protein coupled receptor 139 0.005 0.0109 0.0224
Loa Loa (eye worm) neuropeptide F receptor 0.005 0.0109 0.0166
Schistosoma mansoni chromatin regulatory protein sir2 0.0233 0.1537 0.1537
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.0109 0.0109
Onchocerca volvulus 0.005 0.0109 0.0727
Echinococcus multilocularis g protein coupled receptor 0.005 0.0109 0.0224
Echinococcus multilocularis neuropeptides capa receptor 0.005 0.0109 0.0224
Schistosoma mansoni opsin-like receptor 0.005 0.0109 0.0109
Entamoeba histolytica bromodomain-containing protein 0.0228 0.1498 0.9744
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.005 0.0109 0.0166
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0497 0.0757
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0109 0.0224
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0081 0.0124
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0096 1
Loa Loa (eye worm) transcriptional regulator 0.0233 0.1537 0.2341
Echinococcus granulosus CREB binding protein 0.0102 0.0514 0.1056
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0048 0.0096 0.0198
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.005 0.0109 0.0224
Echinococcus granulosus sex peptide receptor 0.005 0.0109 0.0224
Echinococcus granulosus tachykinin peptides receptor 99D 0.005 0.0109 0.0224
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.005 0.0109 0.0166
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.005 0.0109 0.0224
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.005 0.0109 0.0109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0109 0.0109
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.005 0.0109 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0228 0.1498 0.4061
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.005 0.0109 0.0166
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0048 0.0096 0.0198
Toxoplasma gondii histone deacetylase SIR2 0.0048 0.0096 0.0227
Echinococcus granulosus allatostatin A receptor 0.005 0.0109 0.0224
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Onchocerca volvulus 0.0037 0.0014 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0109 0.0109
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Schistosoma mansoni biogenic amine receptor 0.005 0.0109 0.0109
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0154 0.092 0.2494
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.005 0.0109 0.0109
Schistosoma mansoni chromatin regulatory protein sir2 0.0154 0.092 0.092
Echinococcus multilocularis neuropeptide receptor 0.0661 0.4868 1
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0096 0.0147
Echinococcus granulosus neuropeptide receptor 0.005 0.0109 0.0224
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.0856 0.1304
Trichomonas vaginalis bromodomain-containing protein, putative 0.0228 0.1498 0.4061
Loa Loa (eye worm) neuropeptide F receptor 0.005 0.0109 0.0166
Brugia malayi hypothetical protein 0.005 0.0109 0.0166
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.0166
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0081 0.0124
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.005 0.0109 0.0224
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0096 0.0261
Schistosoma mansoni hypothetical protein 0.01 0.0497 0.0497

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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