Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A2 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | choline kinase | 0.0093 | 1 | 1 |
Schistosoma mansoni | choline kinase | 0.0009 | 0 | 0.5 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0093 | 1 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0093 | 1 | 1 |
Leishmania major | choline/ethanolamine kinase, putative | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | choline/ethanolamine kinase, putative | 0.0009 | 0 | 0.5 |
Giardia lamblia | Ethanolamine kinase, putative | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | choline/ethanolamine kinase | 0.0009 | 0 | 0.5 |
Trypanosoma brucei | choline/ethanolamine kinase | 0.0009 | 0 | 0.5 |
Trypanosoma cruzi | choline kinase | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Putative choline\/ethanolamine kinase | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | choline/ethanolamine kinase | 0.0009 | 0 | 0.5 |
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0009 | 0 | 0.5 |
Trypanosoma cruzi | choline ethanolamine kinase, putative | 0.0009 | 0 | 0.5 |
Leishmania major | choline kinase | 0.0009 | 0 | 0.5 |
Trypanosoma brucei | choline kinase | 0.0009 | 0 | 0.5 |
Plasmodium vivax | choline kinase, putative | 0.0093 | 1 | 1 |
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0093 | 1 | 1 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0093 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.