Detailed information for compound 1802097

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 422.285 | Formula: C18H13Cl2N3O3S
  • H donors: 1 H acceptors: 4 LogP: 3.38 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1NC(=O)c1c(nc2n1CCS2(=O)=O)c1ccccc1)Cl
  • InChi: 1S/C18H13Cl2N3O3S/c19-12-7-4-8-13(20)15(12)21-17(24)16-14(11-5-2-1-3-6-11)22-18-23(16)9-10-27(18,25)26/h1-8H,9-10H2,(H,21,24)
  • InChiKey: ZDRYTJBYXIYVOZ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni pol-related 0.0102 0.0813 0.1084
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0086 0.0074
Brugia malayi Cytochrome P450 family protein 0.0024 0.0131 0.0136
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0013 0.0033 0.0044
Trichomonas vaginalis aldo/keto reductase, putative 0.0102 0.0813 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0102 0.0813 1
Schistosoma mansoni phosphatidylserine receptor 0.0014 0.0042 0.0056
Schistosoma mansoni microtubule-associated protein tau 0.0731 0.63 0.8397
Toxoplasma gondii aldo-keto reductase 0.003 0.0181 0.0529
Echinococcus granulosus muscleblind protein 0.0158 0.1304 0.1702
Loa Loa (eye worm) hypothetical protein 0.007 0.0537 0.397
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0042 0.0073
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0072 0.0053
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0813 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0321 0.0428
Echinococcus multilocularis aldo keto reductase 0.0102 0.0813 0.1045
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0207 0.0626
Schistosoma mansoni opsin-like receptor 0.0013 0.0033 0.0044
Entamoeba histolytica aldose reductase, putative 0.0102 0.0813 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0102 0.0813 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0013 0.0033 0.0044
Echinococcus granulosus lipoxygenase domain containing protein 0.007 0.0537 0.0676
Schistosoma mansoni potassium channel beta 0.003 0.0181 0.0242
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0813 0.1045
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0207 0.0626
Echinococcus multilocularis mitogen activated protein kinase 3 0.0098 0.0781 0.1002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0207 0.1369
Schistosoma mansoni amine GPCR 0.0013 0.0033 0.0044
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0488 0.065
Brugia malayi hypothetical protein 0.0038 0.0256 0.0309
Echinococcus multilocularis lysine specific demethylase 5A 0.0051 0.0367 0.0448
Giardia lamblia Telomerase catalytic subunit 0.0315 0.2676 1
Echinococcus granulosus hypothetical protein 0.0102 0.0813 0.1045
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0207 0.0233
Echinococcus multilocularis jumonji domain containing 1A 0.0014 0.0042 0.0012
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0488 0.1692
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0072 0.0053
Echinococcus granulosus lipoxygenase domain containing protein 0.007 0.0537 0.0676
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0207 0.0626
Schistosoma mansoni neuropeptide receptor 0.0013 0.0033 0.0044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0256 0.0299
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0537 0.1879
Schistosoma mansoni lipoxygenase 0.0421 0.3595 0.4792
Schistosoma mansoni neuropeptide receptor 0.0013 0.0033 0.0044
Trichomonas vaginalis aldo/keto reductase, putative 0.0102 0.0813 1
Echinococcus multilocularis microtubule associated protein 2 0.0731 0.63 0.839
Echinococcus granulosus mitogen activated protein kinase 0.0098 0.0781 0.1002
Trypanosoma brucei ATP-binding cassette protein, putative 0.003 0.0185 0.0544
Trypanosoma brucei ABC transporter, putative 0.003 0.0185 0.0544
Loa Loa (eye worm) hypothetical protein 0.0017 0.0071 0.0302
Echinococcus multilocularis lipoxygenase domain containing protein 0.007 0.0537 0.0676
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.003 0.0185 0.0544
Loa Loa (eye worm) hypothetical protein 0.007 0.0536 0.396
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0098 0.0781 0.2807
Schistosoma mansoni aldo-keto reductase 0.0102 0.0813 0.1084
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0256 0.0341
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0537 0.5627
Echinococcus granulosus microtubule associated protein 2 0.0731 0.63 0.839
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0056 0.0031
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.003 0.0185 0.0544
Entamoeba histolytica aldose reductase, putative 0.0102 0.0813 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0207 0.0233
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0315 0.2676 1
Loa Loa (eye worm) oxidoreductase 0.0102 0.0813 0.6139
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0033 0.0044
Echinococcus granulosus mitogen activated protein kinase 3 0.0098 0.0781 0.1002
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0207 0.0233
Schistosoma mansoni aldo-keto reductase 0.0102 0.0813 0.1084
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0014 0.0042 0.0056
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0207 0.0242
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0813 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0207 0.0233
Echinococcus multilocularis aldo keto reductase 0.0102 0.0813 0.1045
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0537 0.0675
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0813 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0813 0.1045
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0051 0.0367 0.0448
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.082 0.619
Plasmodium falciparum aldo-keto reductase, putative 0.003 0.0181 0.0529
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0932 0.3378
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0185 0.0799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0033 0.0044
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0421 0.3595 0.4769
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0813 0.1045
Giardia lamblia Kinase, CMGC MAPK 0.0098 0.0781 0.2403
Schistosoma mansoni biogenic amine receptor 0.0013 0.0033 0.0044
Brugia malayi hypothetical protein 0.007 0.0537 0.0699
Toxoplasma gondii RNA-directed DNA polymerase 0.0315 0.2676 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0321 0.0386
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0813 0.1045
Echinococcus multilocularis Polycystic kidney disease protein 0.007 0.0537 0.0676
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0207 0.0626
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.003 0.0181 0.0529
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0098 0.0781 0.2807
Echinococcus granulosus aldo keto reductase family 1, member B4 0.003 0.0181 0.0199
Schistosoma mansoni neuropeptide receptor 0.0013 0.0033 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0813 1
Plasmodium vivax aldehyde reductase, putative 0.003 0.0181 0.0529
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0321 0.0399
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0813 0.1045
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0033 0.0044
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0102 0.0813 0.1082
Brugia malayi Cytochrome P450 family protein 0.0024 0.0131 0.0136
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0013 0.0033 0.0044
Schistosoma mansoni rab6-interacting 0.007 0.0537 0.0716
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0256 0.0299
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0813 0.1045
Loa Loa (eye worm) hypothetical protein 0.0032 0.0207 0.1372
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0207 0.0233
Entamoeba histolytica ABC transporter, putative 0.003 0.0185 0.0063
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0102 0.0813 0.2928
Echinococcus granulosus geminin 0.0348 0.2961 0.392
Schistosoma mansoni loxhd1 0.007 0.0537 0.0716
Plasmodium vivax ABC transporter G family member 2, putative 0.003 0.0185 0.0544
Entamoeba histolytica aldose reductase, putative 0.0102 0.0813 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0321 0.0386
Plasmodium falciparum telomerase reverse transcriptase 0.0315 0.2676 1
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0276
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0813 0.1045
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0537 0.1879
Loa Loa (eye worm) ABC transporter 0.0025 0.0146 0.0887
Echinococcus multilocularis muscleblind protein 0.0158 0.1304 0.1702
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0042 0.0073
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0398 0.2871
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0813 0.1045
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0813 1
Entamoeba histolytica hypothetical protein 0.0038 0.0256 0.1183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0033 0.0044
Echinococcus multilocularis cpg binding protein 0.0064 0.0486 0.0607
Echinococcus multilocularis aldehyde reductase 0.0072 0.0556 0.07
Echinococcus granulosus Polycystic kidney disease protein 0.007 0.0537 0.0676
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0315 0.2676 1
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0781 0.1042
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.003 0.0181 0.0529
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0033 0.0044
Mycobacterium leprae Conserved hypothetical protein 0.0072 0.0556 0.5922
Echinococcus multilocularis mitogen activated protein kinase 0.0098 0.0781 0.1002
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0537 0.0675
Loa Loa (eye worm) hypothetical protein 0.007 0.0537 0.397
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0033 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0181 0.1783
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0207 0.0233
Schistosoma mansoni phd/f-box containing protein 0.0014 0.0042 0.0056
Echinococcus multilocularis GPCR, family 2 0.0032 0.0207 0.0233
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0098 0.0781 0.2807
Onchocerca volvulus 0.0102 0.0813 0.0783
Giardia lamblia Aldose reductase 0.0102 0.0813 0.253
Echinococcus granulosus dnaJ subfamily B 0.0869 0.7502 1
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0279 0.0329
Brugia malayi glutamate-cysteine ligase modifier subunit 0.003 0.0181 0.0206
Echinococcus multilocularis dnaJ subfamily B 0.0869 0.7502 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0056 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0033 0.0044
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0207 0.0626
Plasmodium falciparum LCCL domain-containing protein 0.007 0.0537 0.1881
Onchocerca volvulus 0.007 0.0537 0.0506
Loa Loa (eye worm) oxidoreductase 0.0102 0.0813 0.6139
Schistosoma mansoni neuropeptide f receptor 76f 0.0013 0.0033 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0813 1
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0033 0.0044
Brugia malayi isocitrate dehydrogenase 0.0032 0.0207 0.0241
Onchocerca volvulus 0.0061 0.0456 0.0424
Trypanosoma cruzi ABC transporter, putative 0.003 0.0185 0.0544
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0098 0.0781 0.2807
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0098 0.0781 0.2807
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0321 0.0428
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0537 0.1879
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.096 0.7296
Schistosoma mansoni hypothetical protein 0.0348 0.2961 0.3946
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0813 0.1045
Onchocerca volvulus 0.0102 0.0813 0.0783
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0813 0.1045
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0073
Plasmodium vivax multidomain scavenger receptor, putative 0.007 0.0537 0.1881
Schistosoma mansoni polycystin 1-related 0.007 0.0537 0.0716
Onchocerca volvulus 0.0102 0.0813 0.0783
Echinococcus multilocularis lysine specific demethylase 6a 0.0014 0.0042 0.0012
Entamoeba histolytica hypothetical protein 0.0038 0.0256 0.1183
Entamoeba histolytica hypothetical protein 0.0038 0.0256 0.1183
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0185 0.0204
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0813 0.1045
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0207 0.0242
Loa Loa (eye worm) hypothetical protein 0.0103 0.082 0.619
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0488 0.0609
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0813 0.1045
Leishmania major aldo-keto reductase-like protein 0.0102 0.0813 0.2928
Echinococcus granulosus lysine specific demethylase 5A 0.0054 0.0398 0.0489
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0813 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0813 0.1045
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0813 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.003 0.0181 0.1783
Schistosoma mansoni jumonji domain containing protein 0.0051 0.0367 0.049
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0813 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0813 0.6139
Loa Loa (eye worm) oxidoreductase 0.0102 0.0813 0.6139
Trypanosoma cruzi aldo-keto reductase 0.0102 0.0813 0.2928
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0207 0.096
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0207 0.0626
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0813 0.1045
Echinococcus multilocularis JmjC domain containing protein 4 0.0014 0.0042 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0321 0.0386
Schistosoma mansoni biogenic amine receptor 0.0013 0.0033 0.0044
Echinococcus granulosus aldo keto reductase 0.0102 0.0813 0.1045
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.003 0.0185 0.0544
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0013 0.0033 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0781 0.9587
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0185 0.0799
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.003 0.0185 0.0247
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0536 0.0698
Brugia malayi Muscleblind-like protein 0.0158 0.1304 0.1762
Schistosoma mansoni jumonji domain containing protein 0.0014 0.0042 0.0056
Plasmodium falciparum aldehyde reductase, putative 0.003 0.0181 0.0529
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0321 0.0386
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0813 0.1045
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0276
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0181 0.1783
Echinococcus granulosus jumonji domain containing 1A 0.0014 0.0042 0.0012
Brugia malayi jmjC domain containing protein 0.0054 0.0398 0.0506
Schistosoma mansoni amine GPCR 0.0013 0.0033 0.0044
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0207 0.1372
Schistosoma mansoni myosin xvIII 0.0013 0.0033 0.0044
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0207 0.0233
Schistosoma mansoni cpg binding protein 0.0064 0.0486 0.0648
Echinococcus granulosus voltage gated potassium channel subunit 0.003 0.0181 0.0199
Onchocerca volvulus 0.003 0.0181 0.0149
Schistosoma mansoni amine GPCR 0.0013 0.0033 0.0044
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.003 0.0181 0.0529
Mycobacterium ulcerans oxidoreductase 0.0102 0.0813 1
Echinococcus multilocularis voltage gated potassium channel subunit 0.003 0.0181 0.0199
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0185 0.0204
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0207 0.0233
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0456 0.3328
Mycobacterium ulcerans hypothetical protein 0.003 0.0181 0.0741
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0813 0.1045
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0013 0.0033 0.0044
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0185 0.0204
Schistosoma mansoni cpg binding protein 0.0061 0.0456 0.0608
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0813 0.1045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0813 0.1045
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0098 0.0781 0.2807
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0813 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0088 0.0074
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0056 0.0074
Brugia malayi Doublecortin family protein 0.007 0.0537 0.0699
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0013 0.0033 0.0044
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0102 0.0813 0.1082
Brugia malayi jmjC domain containing protein 0.0014 0.0042 0.0013
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0033 0.0044
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0863 0.7456 0.9938
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0056 0.0031
Schistosoma mansoni protein phosphatase 2C 0.0014 0.0042 0.0056
Schistosoma mansoni alpha-1 adrenergic receptor 0.0013 0.0033 0.0044
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0131 0.0337
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.096 0.7296
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0207 0.0626
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0033 0.0044
Brugia malayi jmjC domain containing protein 0.0014 0.0042 0.0013
Schistosoma mansoni biogenic amine receptor 0.0013 0.0033 0.0044
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0813 0.1045
Toxoplasma gondii aldose reductase, putative 0.0102 0.0813 0.2928
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0051 0.0367 0.0448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0033 0.0044
Schistosoma mansoni growth hormone secretagogue receptor 0.0013 0.0033 0.0044
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0537 0.0699
Schistosoma mansoni hypothetical protein 0.0013 0.0033 0.0044
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0098 0.0781 0.2807
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0033 0.0044
Plasmodium falciparum ABC transporter G family member 2 0.003 0.0185 0.0544
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0033 0.0044
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0033 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0131 0.0771
Trypanosoma brucei telomerase reverse transcriptase 0.0315 0.2676 1
Schistosoma mansoni opsin-like receptor 0.0013 0.0033 0.0044
Brugia malayi jmjC domain containing protein 0.0014 0.0042 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0321 0.0428
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0276
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0073
Schistosoma mansoni hypothetical protein 0.007 0.0536 0.0715
Trypanosoma brucei protein kinase, putative 0.0098 0.0781 0.2807
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0185 0.0799
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0207 0.0233
Echinococcus multilocularis muscleblind protein 1 0.0158 0.1304 0.1702
Schistosoma mansoni histamine h1 receptor 0.0013 0.0033 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0813 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0421 0.3595 0.4769
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0033 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0813 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0813 1
Echinococcus multilocularis aldo keto reductase 0.0102 0.0813 0.1045
Echinococcus multilocularis geminin 0.0348 0.2961 0.392
Echinococcus granulosus phd:f box containing protein 0.0014 0.0042 0.0012
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0098 0.0781 0.589
Brugia malayi MAP kinase sur-1 0.0098 0.0781 0.1038
Entamoeba histolytica hypothetical protein 0.0038 0.0256 0.1183
Trypanosoma cruzi aldo/keto reductase, putative 0.0102 0.0813 0.2928
Onchocerca volvulus 0.0102 0.0813 0.0783
Schistosoma mansoni amine GPCR 0.0013 0.0033 0.0044
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0131 0.0771
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0537 0.1879
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0488 0.5147
Schistosoma mansoni amine GPCR 0.0013 0.0033 0.0044
Schistosoma mansoni neuropeptide receptor 0.0013 0.0033 0.0044
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0185 0.0204
Brugia malayi CXXC zinc finger family protein 0.0061 0.0456 0.0586
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0488 0.5231
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0131 0.0337
Brugia malayi hypothetical protein 0.007 0.0537 0.0699
Echinococcus multilocularis RUN 0.007 0.0537 0.0676
Trypanosoma cruzi aldo/keto reductase, putative 0.003 0.0181 0.0529
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0102 0.0813 1
Loa Loa (eye worm) doublecortin family protein 0.007 0.0537 0.397
Echinococcus granulosus RUN 0.007 0.0537 0.0676
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0537 0.3965
Schistosoma mansoni rab6-interacting 0.007 0.0537 0.0716
Schistosoma mansoni hypothetical protein 0.0025 0.0142 0.019
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0042 0.0073
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.082 0.109
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0185 0.0204
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0102 0.0813 0.1082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0207 0.0233
Trypanosoma brucei prostaglandin f synthase 0.0102 0.0813 0.2928
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0185 0.0204
Echinococcus multilocularis lipoxygenase domain containing protein 0.007 0.0537 0.0676
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0102 0.0813 0.2928
Schistosoma mansoni ABC transporter 0.0025 0.0146 0.0194
Leishmania major cytochrome p450-like protein 0.0024 0.0131 0.0337
Onchocerca volvulus 0.0102 0.0813 0.0783
Echinococcus multilocularis aldo keto reductase 0.0102 0.0813 0.1045
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0088 0.0074
Giardia lamblia Aldose reductase 0.0102 0.0813 0.253
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.003 0.0181 0.1169
Loa Loa (eye worm) oxidoreductase 0.0102 0.0813 0.6139
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0488 0.5231
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0488 0.065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0488 0.5231
Echinococcus granulosus aldo keto reductase 0.0102 0.0813 0.1045
Mycobacterium tuberculosis Conserved protein 0.003 0.0181 0.0579
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0102 0.0813 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0181 0.1783
Loa Loa (eye worm) hypothetical protein 0.0158 0.1304 1
Onchocerca volvulus 0.0102 0.0813 0.0783
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.082 0.109
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0131 0.0771
Plasmodium vivax telomerase reverse transcriptase, putative 0.0315 0.2676 1
Echinococcus granulosus aldo keto reductase 0.0102 0.0813 0.1045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0033 0.0044
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0207 0.0626
Schistosoma mansoni hypothetical protein 0.0869 0.7502 1
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0781 0.9587
Brugia malayi Telomerase reverse transcriptase 0.084 0.7248 1
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0131 0.0337
Echinococcus granulosus aldehyde reductase 0.0072 0.0556 0.07
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0488 0.1692
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.003 0.0181 0.0529
Schistosoma mansoni hypothetical protein 0.0038 0.0256 0.0341
Brugia malayi jmjC domain containing protein 0.0051 0.0367 0.0464
Schistosoma mansoni lipoxygenase 0.0294 0.249 0.3319
Schistosoma mansoni hypothetical protein 0.0348 0.2961 0.3946
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0073
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0781 0.9587
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0321 0.2266
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0813 0.1045
Echinococcus granulosus GPCR family 2 0.0032 0.0207 0.0233
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.0181 0.1783
Onchocerca volvulus 0.007 0.0537 0.0506
Echinococcus granulosus JmjC domain containing protein 4 0.0014 0.0042 0.0012
Schistosoma mansoni opsin-like receptor 0.0013 0.0033 0.0044
Trypanosoma brucei aldo-keto reductase, putative 0.0102 0.0813 0.2928
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0207 0.0276
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0088 0.0437
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0102 0.0813 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1052 0.1403
Schistosoma mansoni hypothetical protein 0.007 0.0537 0.0716
Schistosoma mansoni hypothetical protein 0.0013 0.0033 0.0044
Brugia malayi jmjC domain containing protein 0.0014 0.0042 0.0013
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0207 0.0241
Schistosoma mansoni cpg binding protein 0.0064 0.0486 0.0648
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0488 0.0609
Schistosoma mansoni adenoreceptor 0.0013 0.0033 0.0044
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0102 0.0813 0.1082
Echinococcus granulosus cpg binding protein 0.0064 0.0486 0.0607
Leishmania major telomerase reverse transcriptase, putative 0.0315 0.2676 1
Loa Loa (eye worm) oxidoreductase 0.0102 0.0813 0.6139
Brugia malayi ABC transporter family protein 0.0025 0.0146 0.0156
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0279 0.0329
Trypanosoma brucei aldo/keto reductase, putative 0.003 0.0181 0.0529
Echinococcus multilocularis phd:f box containing protein 0.0014 0.0042 0.0012
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0013 0.0033 0.0044
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0098 0.0781 0.2807
Schistosoma mansoni jumonji/arid domain-containing protein 0.0054 0.0398 0.053
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0013 0.0033 0.0044
Leishmania major prostaglandin f synthase, putative 0.0102 0.0813 0.2928
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0537 0.0716
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0207 0.0626
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0033 0.0044
Brugia malayi MH2 domain containing protein 0.0119 0.096 0.1285
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0056 0.0031
Schistosoma mansoni hypothetical protein 0.0032 0.0207 0.0276
Schistosoma mansoni hypothetical protein 0.0013 0.0033 0.0044
Schistosoma mansoni hypothetical protein 0.0013 0.0033 0.0044
Trypanosoma cruzi ATP-binding cassette protein, putative 0.003 0.0185 0.0544
Echinococcus granulosus lysine specific demethylase 6a 0.0014 0.0042 0.0012
Schistosoma mansoni jumonji/arid domain-containing protein 0.0054 0.0398 0.053
Brugia malayi NADH-dependent xylose reductase 0.003 0.0181 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0033 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0781 0.9587
Loa Loa (eye worm) hypothetical protein 0.0158 0.1304 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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