Detailed information for compound 1802450

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 286.798 | Formula: C14H23ClN2O2
  • H donors: 1 H acceptors: 1 LogP: 4.26 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCOC[n+]1cccc(c1)/C=N/O.[Cl-]
  • InChi: 1S/C14H22N2O2.ClH/c1-2-3-4-5-6-10-18-13-16-9-7-8-14(12-16)11-15-17;/h7-9,11-12H,2-6,10,13H2,1H3;1H/b15-11+;
  • InChiKey: HQYMLJAEMHFDNP-KRWCAOSLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0041 0.0264 0.3318
Schistosoma mansoni thyroid hormone receptor 0.001 0.0017 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0023
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0194 0.0267
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0399 0.5004
Toxoplasma gondii aldo-keto reductase 0.0009 0.0014 0.0052
Echinococcus multilocularis aldo keto reductase 0.0032 0.0194 0.026
Echinococcus multilocularis voltage gated potassium channel subunit 0.0009 0.0014 0.0019
Echinococcus granulosus voltage gated potassium channel subunit 0.0009 0.0014 0.0037
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0194 0.0519
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0045
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0107 0.0797 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0017 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0209
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0017 0.0003
Trypanosoma cruzi aldo/keto reductase, putative 0.0009 0.0014 0.0052
Schistosoma mansoni hypothetical protein 0.0018 0.0083 0.0221
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0209
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0194 0.0519
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0147 0.1848
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.0264 0.0937
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0344 0.2688 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0017 0.0045
Brugia malayi jmjC domain containing protein 0.0015 0.0059 0.0081
Schistosoma mansoni cpg binding protein 0.0033 0.0207 0.0554
Echinococcus multilocularis mitogen activated protein kinase 3 0.0107 0.0797 0.1068
Schistosoma mansoni hypothetical protein 0.0018 0.0087 0.0232
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.0553 0.148
Loa Loa (eye worm) hypothetical protein 0.0041 0.0264 0.3318
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0505 0.1354
Onchocerca volvulus 0.0032 0.0194 0.018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0045
Plasmodium falciparum telomerase reverse transcriptase 0.0344 0.2688 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0264 0.0984
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0041 0.0264 0.0354
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0021 0.011 0.0411
Echinococcus multilocularis aldo keto reductase 0.0032 0.0194 0.026
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0009 0.0014 0.0052
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0194 0.2423
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0017 0.0022
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0009 0.0014 0.0052
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0194 0.2423
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0074 0.0198
Schistosoma mansoni aldo-keto reductase 0.0032 0.0194 0.0519
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0194 0.2423
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0194 0.2423
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0194 0.026
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0059 0.0157
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0022
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0257 0.0354
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.0194 0.2423
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0194 0.0519
Loa Loa (eye worm) hypothetical protein 0.0018 0.0087 0.1089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0209
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0032 0.0194 0.0721
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0087 0.0116
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0059 0.0157
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0023 0.0031
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0087 0.1089
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0059 0.0167
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.0553 0.2056
Brugia malayi nuclear receptor NHR-88 0.001 0.0017 0.0023
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0059 0.0736
Loa Loa (eye worm) hypothetical protein 0.0015 0.0059 0.0736
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0194 0.0519
Leishmania major prostaglandin f synthase, putative 0.0032 0.0194 0.0721
Brugia malayi jmjC domain containing protein 0.0056 0.0384 0.0529
Mycobacterium ulcerans monoamine oxidase 0.0041 0.0264 0.0582
Loa Loa (eye worm) hypothetical protein 0.0041 0.0264 0.3318
Brugia malayi NADH-dependent xylose reductase 0.0009 0.0014 0.0019
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0017 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0017 0.0045
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0553 0.2056
Entamoeba histolytica aldose reductase, putative 0.0032 0.0194 0.3339
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0194 0.026
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0209
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0017 0.0045
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0264 0.0937
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0576 0.4539 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0023
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0017 0.0045
Schistosoma mansoni nuclear hormone receptor 0.001 0.0017 0.0045
Mycobacterium leprae Possible oxidoreductase 0.0009 0.0014 0.0525
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0087 0.0116
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0797 1
Trypanosoma brucei ABC transporter, putative 0.0021 0.011 0.0411
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0059 0.0218
Onchocerca volvulus 0.0032 0.0194 0.018
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0504 0.1349
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0209
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0017 0.0209
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.0264 0.0937
Schistosoma mansoni hypothetical protein 0.0018 0.0087 0.0232
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0797 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0399 0.1068
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0017 0.0045
Mycobacterium ulcerans hypothetical protein 0.0009 0.0014 0.0031
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0087 0.012
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0194 0.2423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0209
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0194 0.0267
Trypanosoma brucei prostaglandin f synthase 0.0032 0.0194 0.0721
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.3219
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0147 0.0324
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0022
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0504 0.1873
Trypanosoma cruzi aldo/keto reductase, putative 0.0032 0.0194 0.0721
Schistosoma mansoni hypothetical protein 0.0116 0.0863 0.2312
Brugia malayi nuclear hormone receptor 0.001 0.0017 0.0023
Schistosoma mansoni coup transcription factor 0.001 0.0017 0.0045
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0014 0.0163
Toxoplasma gondii aldose reductase, putative 0.0032 0.0194 0.0721
Echinococcus granulosus aldo keto reductase 0.0032 0.0194 0.0519
Loa Loa (eye worm) oxidoreductase 0.0032 0.0194 0.2431
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0017 0.0023
Schistosoma mansoni amine oxidase 0.0041 0.0264 0.0708
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0797 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0209
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0021 0.011 0.0243
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0014 0.0163
Loa Loa (eye worm) hypothetical protein 0.0015 0.0059 0.0736
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0209
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0007 0.0009
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0021 0.011 0.0411
Trypanosoma brucei aldo-keto reductase, putative 0.0032 0.0194 0.0721
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0209
Brugia malayi CXXC zinc finger family protein 0.0033 0.0207 0.0285
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.0797 0.2964
Giardia lamblia Aldose reductase 0.0032 0.0194 0.0331
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0194 0.2423
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0797 0.2134
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0017 0.0045
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0059 0.0157
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 0.0194 0.046
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0017 0.0022
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0264 0.0984
Loa Loa (eye worm) hypothetical protein 0.0015 0.0059 0.0736
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.1101
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.0264 0.0937
Onchocerca volvulus 0.0041 0.0264 0.0251
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0194 0.026
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0017 0.0023
Schistosoma mansoni cpg binding protein 0.0035 0.0222 0.0595
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0209
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0059 0.0157
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0264 0.0708
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.0553 0.148
Loa Loa (eye worm) oxidoreductase 0.0032 0.0194 0.2431
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0445 0.1656
Loa Loa (eye worm) oxidoreductase 0.0032 0.0194 0.2431
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0264 0.0937
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.0553 0.0741
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0107 0.0797 0.2964
Echinococcus granulosus phd:f box containing protein 0.0015 0.0059 0.0157
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0107 0.0797 0.2964
Mycobacterium ulcerans oxidoreductase 0.0032 0.0194 0.0427
Loa Loa (eye worm) hypothetical protein 0.0041 0.0264 0.3318
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0023
Echinococcus multilocularis mitogen activated protein kinase 0.0107 0.0797 0.1068
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0009 0.0014 0.0052
Mycobacterium ulcerans oxidoreductase 0.0041 0.0264 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0017 0.0023
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0576 0.4539 1
Schistosoma mansoni hypothetical protein 0.0018 0.0087 0.0232
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0194 0.026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0023
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0536 0.4215 1
Trypanosoma cruzi ABC transporter, putative 0.0021 0.011 0.0411
Onchocerca volvulus 0.0032 0.0194 0.018
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0059 0.0736
Schistosoma mansoni pol-related 0.0032 0.0194 0.0519
Brugia malayi MAP kinase sur-1 0.0107 0.0797 0.1099
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0194 0.0519
Giardia lamblia Telomerase catalytic subunit 0.0344 0.2688 1
Echinococcus multilocularis cpg binding protein 0.0035 0.0222 0.0298
Brugia malayi steroid hormone receptor 0.001 0.0017 0.0023
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0147 0.0548
Chlamydia trachomatis protoporphyrinogen oxidase 0.0041 0.0264 0.5
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.0553 0.0762
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0504 0.1873
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0194 0.2423
Echinococcus granulosus ATP binding cassette sub family G 0.0021 0.011 0.0296
Schistosoma mansoni amine oxidase 0.0041 0.0264 0.0708
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0017 0.0045
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0087 0.0232
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0194 0.0267
Brugia malayi hypothetical protein 0.0041 0.0264 0.0365
Giardia lamblia Kinase, CMGC MAPK 0.0107 0.0797 0.2668
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0797 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0059 0.0736
Toxoplasma gondii RNA-directed DNA polymerase 0.0344 0.2688 1
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0059 0.0157
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0194 0.0519
Trypanosoma brucei telomerase reverse transcriptase 0.0344 0.2688 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0403 0.5055
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0194 0.026
Mycobacterium tuberculosis Conserved protein 0.0009 0.0014 0.0033
Brugia malayi Cytochrome P450 family protein 0.0026 0.0147 0.0203
Brugia malayi SWIRM domain containing protein 0.0041 0.0264 0.0365
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0059 0.0218
Echinococcus multilocularis aldo keto reductase 0.0032 0.0194 0.026
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0018 0.0083 0.0196
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0014 0.0163
Mycobacterium ulcerans dehydrogenase 0.0041 0.0264 0.0582
Onchocerca volvulus 0.0032 0.0194 0.018
Brugia malayi jmjC domain containing protein 0.0015 0.0059 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0023
Brugia malayi jmjC domain containing protein 0.0015 0.0059 0.0081
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0147 0.1848
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0056 0.0384 0.0514
Echinococcus granulosus ATP binding cassette sub family G 0.0021 0.011 0.0296
Plasmodium falciparum ABC transporter G family member 2 0.0021 0.011 0.0361
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0399 0.1068
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0023 0.0061
Trypanosoma brucei aldo/keto reductase, putative 0.0009 0.0014 0.0052
Echinococcus multilocularis 0.0041 0.0264 0.0354
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0194 0.2423
Onchocerca volvulus 0.001 0.0017 0.0003
Entamoeba histolytica ABC transporter, putative 0.0021 0.011 0.1792
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0194 0.2423
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0264 0.0708
Leishmania major telomerase reverse transcriptase, putative 0.0344 0.2688 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0264 0.3318
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0147 0.0548
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0107 0.0797 0.2964
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0059 0.0157
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0194 0.026
Echinococcus granulosus GPCR family 2 0.0018 0.0087 0.0232
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.0553 1
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0504 0.1349
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0045
Schistosoma mansoni hypothetical protein 0.0475 0.3733 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0059 0.0218
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0022 0.003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0017 0.0022
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0295 0.0395
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0009 0.0014 0.0163
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0041 0.0264 0.0582
Echinococcus granulosus mitogen activated protein kinase 3 0.0107 0.0797 0.2134
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0194 0.0519
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0147 0.1848
Schistosoma mansoni thyroid hormone receptor 0.001 0.0017 0.0045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0264 0.0627
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0007 0.0018
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.0264 0.0937
Schistosoma mansoni jumonji domain containing protein 0.0056 0.0384 0.1027
Loa Loa (eye worm) ABC transporter 0.0018 0.0085 0.1062
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0504 0.1109
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0009 0.0014 0.0037
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.0194 0.2423
Loa Loa (eye worm) histone methyltransferase 0.001 0.0023 0.0288
Giardia lamblia Aldose reductase 0.0032 0.0194 0.0331
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0087 0.012
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0021 0.011 0.0411
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0403 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0023
Echinococcus granulosus hypothetical protein 0.0032 0.0194 0.0519
Trypanosoma brucei RNA helicase, putative 0.0116 0.0863 0.3211
Onchocerca volvulus 0.0032 0.0194 0.018
Plasmodium vivax ABC transporter G family member 2, putative 0.0021 0.011 0.0361
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0017 0.0045
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0504 0.0675
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0021 0.011 0.0411
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0021 0.011 0.0243
Echinococcus multilocularis aldo keto reductase 0.0032 0.0194 0.026
Plasmodium vivax telomerase reverse transcriptase, putative 0.0344 0.2688 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0194 0.2423
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.0194 0.2423
Echinococcus multilocularis ATP binding cassette sub family G 0.0021 0.011 0.0148
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0209
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0022
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.0264 0.0984
Echinococcus granulosus dnaJ subfamily B 0.0475 0.3733 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0194 0.026
Loa Loa (eye worm) oxidoreductase 0.0032 0.0194 0.2431
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0059 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0023
Entamoeba histolytica aldose reductase, putative 0.0032 0.0194 0.3339
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0504 0.1195
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0194 0.0519
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.0194 0.2423
Echinococcus multilocularis dnaJ subfamily B 0.0475 0.3733 0.5005
Echinococcus multilocularis ATP binding cassette sub family G 0.0021 0.011 0.0148
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0021 0.011 0.0296
Echinococcus granulosus FTZ F1 alpha 0.001 0.0017 0.0045
Schistosoma mansoni hypothetical protein 0.004 0.0257 0.0687
Brugia malayi jmjC domain containing protein 0.0015 0.0059 0.0081
Loa Loa (eye worm) hypothetical protein 0.0058 0.0403 0.5055
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0009 0.0014 0.0019
Echinococcus granulosus aldo keto reductase 0.0032 0.0194 0.0519
Brugia malayi ABC transporter family protein 0.0018 0.0085 0.0117
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.0797 0.2964
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0007 0.0009
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0074 0.0099
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0032 0.0194 0.0721
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.0264 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0023
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0553 0.2056
Onchocerca volvulus 0.0032 0.0194 0.018
Brugia malayi Cytochrome P450 family protein 0.0026 0.0147 0.0203
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0059 0.0218
Loa Loa (eye worm) oxidoreductase 0.0032 0.0194 0.2431
Onchocerca volvulus 0.0033 0.0207 0.0193
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0504 0.1109
Trypanosoma brucei protein kinase, putative 0.0107 0.0797 0.2964
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0344 0.2688 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0399 0.1068
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0264 0.0354
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0023
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0041 0.0264 0.0708
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0045
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0194 0.2423
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0194 0.026
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0021 0.011 0.0243
Echinococcus granulosus aldehyde reductase 0.0023 0.012 0.0322
Plasmodium vivax JmjC domain containing protein 0.0015 0.0059 0.0167
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0553 0.2056
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0504 0.1349
Echinococcus granulosus mitogen activated protein kinase 0.0107 0.0797 0.2134
Schistosoma mansoni hypothetical protein 0.0018 0.0087 0.0232
Leishmania major aldo-keto reductase-like protein 0.0032 0.0194 0.0721
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.0264 0.0627
Schistosoma mansoni aldo-keto reductase 0.0032 0.0194 0.0519
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0403 0.0555
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0059 0.0157
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0194 0.0267
Loa Loa (eye worm) hypothetical protein 0.0041 0.0264 0.3318
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0056 0.0384 0.1027
Echinococcus multilocularis lysine specific demethylase 5A 0.0056 0.0384 0.0514
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.0264 0.0708
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.0553 0.6936
Echinococcus granulosus ATP binding cassette sub family G 0.0021 0.011 0.0296
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0264 0.0937
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0209
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0043 0.0281 0.1044
Echinococcus multilocularis ATP binding cassette sub family G 0.0021 0.011 0.0148
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0059 0.0218
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0007 0.0018
Schistosoma mansoni cpg binding protein 0.0035 0.0222 0.0595
Echinococcus granulosus cpg binding protein 0.0035 0.0222 0.0595
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0017 0.0023
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0147 0.0548
Leishmania major cytochrome p450-like protein 0.0026 0.0147 0.0548
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0023
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0059 0.0157
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0017 0.0003
Leishmania major hypothetical protein, conserved 0.0015 0.0059 0.0218
Loa Loa (eye worm) hypothetical protein 0.0032 0.0194 0.2431
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0107 0.0797 0.2964
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0017 0.0209
Schistosoma mansoni ABC transporter 0.0018 0.0085 0.0227
Brugia malayi jmjC domain containing protein 0.0057 0.0399 0.055
Brugia malayi ecdysteroid receptor 0.001 0.0017 0.0023
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0107 0.0797 0.2964
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0017 0.0022
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0032 0.0194 0.7328
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0017 0.0045
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0041 0.0264 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0504 0.1109
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0014 0.0163
Echinococcus multilocularis aldehyde reductase 0.0023 0.012 0.0161
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0194 0.0519
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0194 0.026
Trypanosoma cruzi aldo-keto reductase 0.0032 0.0194 0.0721
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0107 0.0797 0.2964
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0207 0.2596
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0194 0.026
Echinococcus granulosus aldo keto reductase 0.0032 0.0194 0.0519
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0007 0.0018
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0059 0.0079
Echinococcus multilocularis GPCR, family 2 0.0018 0.0087 0.0116
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0059 0.0079
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0194 0.2423
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.0194 0.2423
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0009 0.0014 0.0174
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0017 0.0045
Entamoeba histolytica aldose reductase, putative 0.0032 0.0194 0.3339
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0087 0.0232
Mycobacterium leprae Conserved hypothetical protein 0.0023 0.012 0.4554
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0295 0.079
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0942 0.746 1
Leishmania major UDP-galactopyranose mutase 0.0041 0.0264 0.0984
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0059 0.0079
Brugia malayi Telomerase reverse transcriptase 0.0916 0.7252 1
Schistosoma mansoni potassium channel beta 0.0009 0.0014 0.0037
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0017 0.0045
Trypanosoma brucei ATP-binding cassette protein, putative 0.0021 0.011 0.0411
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0194 0.026
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.0194 0.2423

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Reactivation of VX-inhibited Electrophorus electricus (electric eel) acetylcholinesterase using acetylthiocholine iodide as substrate at 1 mM incubated at 15 min post VX-inhibition measured after 40 min by Ellman method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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