TDR Targets

Basic information

Technical information

TDR Targets ID: 1806402
Name: 1-(2,5-dichlorophenoxy)butan-2-yl N-(phenylme thyl)carbamate
MW: 368.254 | Formula: C18H19Cl2NO3
H donors: 1 H acceptors: 1 LogP: 5.32 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCC(OC(=O)NCc1ccccc1)COc1cc(Cl)ccc1Cl
InChi: 1S/C18H19Cl2NO3/c1-2-15(12-23-17-10-14(19)8-9-16(17)20)24-18(22)21-11-13-6-4-3-5-7-13/h3-10,15H,2,11-12H2,1H3,(H,21,22)
InChiKey: JHJVWDQYBAPXAQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[(2,5-dichlorophenoxy)methyl]propyl N-(phenylmethyl)carbamate
N-(phenylmethyl)carbamic acid 1-[(2,5-dichlorophenoxy)methyl]propyl ester
N-(benzyl)carbamic acid 1-[(2,5-dichlorophenoxy)methyl]propyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)	15-cis-phytoene desaturase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Possible oxidoreductase	Get druggable targets OG5_136205	All targets in OG5_136205

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Bile acid receptor homolog	0.005	0.0319	0.1647
Brugia malayi	jmjC domain containing protein	0.0063	0.0481	0.0705
Brugia malayi	nuclear receptor RXR	0.0026	0.0016	0.0023
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0013	0.0019
Brugia malayi	hypothetical protein	0.007	0.0571	0.0836
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.005	0.0319	0.0467
Schistosoma mansoni	hypothetical protein	0.0165	0.1792	0.1792
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0047	0.0069
Brugia malayi	nuclear hormone receptor	0.005	0.0319	0.0467
Brugia malayi	steroid hormone receptor	0.005	0.0319	0.0467
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0123	0.1248	0.1248
Onchocerca volvulus		0.005	0.0319	0.1647
Echinococcus multilocularis	ecdysone induced protein 78C	0.005	0.0319	0.0319
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0026	0.0016	0.0023
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.005	0.0319	0.0319
Echinococcus multilocularis	lysine specific demethylase 5A	0.0063	0.0481	0.0481
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.005	0.0319	0.0467
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.005	0.0319	0.0319
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0039	0.0171	0.025
Onchocerca volvulus		0.0064	0.0493	0.2546
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0065	0.0507	0.0507
Plasmodium vivax	hypothetical protein, conserved	0.0025	0	0.5
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0065	0.0507	0.1833
Schistosoma mansoni	nuclear hormone receptor	0.005	0.0319	0.0319
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0063	0.0481	0.0481
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0247	0.0362
Echinococcus multilocularis	musashi	0.0026	0.0013	0.0013
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.005	0.0319	0.0319
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.005	0.0319	0.0319
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.005	0.0319	0.0319
Leishmania major	squalene monooxygenase-like protein	0.0241	0.2768	1
Echinococcus multilocularis	jun protein	0.0081	0.0716	0.0716
Schistosoma mansoni	jumonji domain containing protein	0.0063	0.0481	0.0481
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0174	0.1906	0.1906
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0174	0.1906	0.2791
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0688	0.1007
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0025	0	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.005	0.0319	0.0319
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0065	0.0507	0.0507
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0247	0.0247
Echinococcus multilocularis	microtubule associated protein 2	0.0805	1	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0174	0.1906	0.1906
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0063	0.0481	0.0481
Entamoeba histolytica	hypothetical protein	0.007	0.0571	1
Entamoeba histolytica	hypothetical protein	0.007	0.0571	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0039	0.0171	0.025
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0247	0.0247
Echinococcus granulosus	lysosomal alpha glucosidase	0.0174	0.1906	0.1906
Brugia malayi	hypothetical protein	0.0064	0.0493	0.0722
Brugia malayi	hypothetical protein	0.0176	0.1937	0.2835
Echinococcus granulosus	neutral alpha glucosidase AB	0.0039	0.0171	0.0171
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.005	0.0319	0.0319
Echinococcus granulosus	intermediate filament protein	0.0026	0.0013	0.0013
Echinococcus multilocularis	geminin	0.0165	0.1792	0.1792
Echinococcus multilocularis	survival motor neuron protein 1	0.023	0.2629	0.2629
Entamoeba histolytica	hypothetical protein	0.007	0.0571	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.005	0.0319	0.0467
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.005	0.0319	0.0319
Loa Loa (eye worm)	hypothetical protein	0.005	0.0319	0.0467
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0039	0.0171	0.0171
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0174	0.1906	0.2791
Leishmania major	alpha glucosidase II subunit, putative	0.0039	0.0171	0.0618
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.005	0.0319	0.0319
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.005	0.0319	0.0467
Brugia malayi	Nuclear hormone receptor-like 1	0.0026	0.0016	0.0023
Plasmodium vivax	hypothetical protein, conserved	0.0025	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0016	0.0023
Loa Loa (eye worm)	steroid hormone receptor	0.005	0.0319	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0013	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0016	0.0023
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.007	0.0571	0.0571
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0025	0	0.5
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0171	0.5
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0039	0.0171	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0173	0.1891	0.1891
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0013	0.0013
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0039	0.0171	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1937	0.2835
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.005	0.0319	0.0319
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.005	0.0319	0.0319
Loa Loa (eye worm)	hypothetical protein	0.005	0.0319	0.0467
Trypanosoma brucei	squalene monooxygenase, putative	0.0241	0.2768	1
Schistosoma mansoni	lamin	0.0026	0.0013	0.0013
Schistosoma mansoni	RAR-like nuclear receptor	0.005	0.0319	0.0319
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0247	0.0247
Trypanosoma cruzi	squalene monooxygenase, putative	0.0241	0.2768	1
Schistosoma mansoni	microtubule-associated protein tau	0.0805	1	1
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0039	0.0171	0.3372
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0025	0	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0558	0.6837	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0507	0.0507
Brugia malayi	small heat shock protein	0.0558	0.6831	1
Schistosoma mansoni	thyroid hormone receptor	0.0173	0.1891	0.1891
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.005	0.0319	0.0467
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0123	0.1248	0.1248
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.007	0.0571	0.0571
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0171	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0507	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0171	0.5
Schistosoma mansoni	alpha-glucosidase	0.015	0.1596	0.1596
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.005	0.0319	0.0467
Brugia malayi	hypothetical protein	0.0026	0.0016	0.0023
Loa Loa (eye worm)	hypothetical protein	0.005	0.0319	0.0467
Toxoplasma gondii	aldehyde dehydrogenase	0.0065	0.0507	1
Entamoeba histolytica	hypothetical protein	0.007	0.0571	1
Loa Loa (eye worm)	hypothetical protein	0.0558	0.6831	1
Onchocerca volvulus		0.0101	0.0966	0.4988
Brugia malayi	nuclear receptor NHR-88	0.005	0.0319	0.0467
Echinococcus multilocularis	lamin dm0	0.0026	0.0013	0.0013
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0013	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0016	0.0023
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0247	0.0247
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0507	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0063	0.0481	0.0481
Echinococcus multilocularis	lamin	0.0026	0.0013	0.0013
Brugia malayi	Steroid receptor seven-up type 2	0.005	0.0319	0.0467
Schistosoma mansoni	hypothetical protein	0.0047	0.0278	0.0278
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0026	0.0016	0.0016
Brugia malayi	hypothetical protein	0.0026	0.0016	0.0023
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0065	0.0507	0.0742
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0047	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0016	0.0023
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.005	0.0319	0.0319
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.005	0.0319	0.0467
Echinococcus granulosus	survival motor neuron protein 1	0.023	0.2629	0.2629
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.005	0.0319	0.0467
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0226	0.2568	0.376
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.005	0.0319	0.0467
Schistosoma mansoni	thyroid hormone receptor	0.0173	0.1891	0.1891
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.005	0.0319	0.0467
Onchocerca volvulus	Protein ultraspiracle homolog	0.005	0.0319	0.1647
Echinococcus multilocularis	FTZ F1 alpha	0.005	0.0319	0.0319
Schistosoma mansoni	alpha-glucosidase	0.015	0.1596	0.1596
Echinococcus granulosus	lamin	0.0026	0.0013	0.0013
Schistosoma mansoni	alpha glucosidase	0.0039	0.0171	0.0171
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0081	0.0716	0.0716
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.005	0.0319	0.0467
Brugia malayi	Nuclear hormone receptor-like 1	0.0026	0.0016	0.0023
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.005	0.0319	0.0319
Brugia malayi	hypothetical protein	0.023	0.2629	0.3849
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0026	0.0016	0.0016
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.005	0.0319	0.0467
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.005	0.0319	0.0467
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0025	0	0.5
Schistosoma mansoni	hypothetical protein	0.0066	0.0522	0.0522
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.005	0.0319	0.0319
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0278	0.0408
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.005	0.0319	0.0319
Echinococcus granulosus	geminin	0.0165	0.1792	0.1792
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0171	0.0618
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0247	0.0247
Brugia malayi	Nuclear hormone receptor-like 1	0.005	0.0319	0.0467
Brugia malayi	bZIP transcription factor family protein	0.0081	0.0716	0.1049
Loa Loa (eye worm)	hypothetical protein	0.005	0.0319	0.0467
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.005	0.0319	0.0319
Loa Loa (eye worm)	hypothetical protein	0.023	0.2629	0.3849
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.005	0.0319	0.0467
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.005	0.0319	0.0467
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0247	0.0247
Schistosoma mansoni	steroid hormone receptor ad4bp	0.005	0.0319	0.0319
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.005	0.0319	0.0319
Onchocerca volvulus		0.0026	0.0013	0.0067
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0026	0.0016	0.0016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.005	0.0319	0.0467
Echinococcus granulosus	ecdysone induced protein 78C	0.005	0.0319	0.0319
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.005	0.0319	0.1647
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0171	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0247	0.0362
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.005	0.0319	0.0467
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.0481	0.0705
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0026	0.0016	0.0016
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0081	0.0716	0.0716
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0063	0.0481	0.0481
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0507	0.0507
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0013	0.0019
Schistosoma mansoni	transcription factor LCR-F1	0.007	0.0571	0.0571
Schistosoma mansoni	lamin	0.0026	0.0013	0.0013
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0247	0.0247
Schistosoma mansoni	hypothetical protein	0.0123	0.1248	0.1248
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0025	0	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.005	0.0319	0.0319
Schistosoma mansoni	coup transcription factor	0.005	0.0319	0.0319
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.005	0.0319	0.0467
Onchocerca volvulus		0.0026	0.0013	0.0067
Schistosoma mansoni	jun-related protein	0.0066	0.0522	0.0522
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0278	0.0278
Onchocerca volvulus		0.0176	0.1937	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0016	0.0023
Loa Loa (eye worm)	hypothetical protein	0.005	0.0319	0.0467
Plasmodium falciparum	protoporphyrinogen oxidase	0.0025	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.0319	0.0467
Trypanosoma cruzi	squalene monooxygenase, putative	0.0241	0.2768	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0007	0.001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.005	0.0319	0.0467
Schistosoma mansoni	hypothetical protein	0.0165	0.1792	0.1792
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0171	0.0618
Echinococcus granulosus	lamin dm0	0.0026	0.0013	0.0013
Schistosoma mansoni	hypothetical protein	0.007	0.0571	0.0571
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.005	0.0319	0.0467
Echinococcus granulosus	FTZ F1 alpha	0.005	0.0319	0.0319
Brugia malayi	follicle stimulating hormone receptor	0.0226	0.2568	0.376
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0171	0.5
Brugia malayi	jmjC domain containing protein	0.0063	0.0481	0.0705
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0507	1
Onchocerca volvulus		0.0047	0.0278	0.1438
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0025	0	0.5
Brugia malayi	ecdysteroid receptor	0.005	0.0319	0.0467
Brugia malayi	intermediate filament protein	0.0026	0.0013	0.0019
Loa Loa (eye worm)	hypothetical protein	0.005	0.0319	0.0467
Schistosoma mansoni	retinoic acid receptor RXR	0.005	0.0319	0.0319
Echinococcus granulosus	lysine specific demethylase 5A	0.0063	0.0481	0.0481
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.005	0.0319	0.0467
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.005	0.0319	0.0319
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0171	0.5
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0171	0.5
Echinococcus granulosus	jun protein	0.0081	0.0716	0.0716
Loa Loa (eye worm)	hypothetical protein	0.005	0.0319	0.0467

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 4	Inhibition of Capsicum annuum (pepper) zeta-carotene desaturase expressed in Escherichia coli using zeta-carotene as substrate after 8 hr by Dixon plot analysis	ChEMBL.	12720390
IC50 (binding)	= 5.4	Inhibition of Synechococcus PCC 7942 phytoene desaturase expressed in Escherichia coli JM101 using phytoene as substrate after 8 hr by Dixon plot analysis	ChEMBL.	12720390

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2272970

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1806402