Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.0049 | 0.0049 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.0281 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0073 | 0.0586 | 0.0484 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0039 | 0.0281 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0281 | 0.0281 |
Onchocerca volvulus | 0.0039 | 0.0281 | 0.0093 | |
Echinococcus multilocularis | set1:ash2 histone methyltransferase complex | 0.0042 | 0.0305 | 0.0305 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0281 | 0.0175 |
Brugia malayi | ShTK domain containing protein | 0.0196 | 0.1721 | 0.1721 |
Brugia malayi | follicle stimulating hormone receptor | 0.0254 | 0.2253 | 0.2253 |
Trichomonas vaginalis | esterase, putative | 0.0039 | 0.0281 | 0.0175 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0379 | 0.0379 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0281 | 1 |
Plasmodium falciparum | SPRY domain, putative | 0.0042 | 0.0305 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.1122 | 0.1122 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0281 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0049 | 0.0049 |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.0281 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0305 | 0.02 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0281 | 0.0175 |
Echinococcus multilocularis | geminin | 0.0186 | 0.1626 | 0.1626 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0064 | 0.0064 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0196 | 0.1721 | 0.1721 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.019 | 0.019 |
Loa Loa (eye worm) | SPRY domain-containing protein | 0.0042 | 0.0305 | 0.0305 |
Echinococcus granulosus | wd40 repeat | 0.0073 | 0.0586 | 0.0586 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0039 | 0.0281 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0044 | 0.0044 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0281 | 0.0175 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0281 | 0.0281 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0108 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.0049 | 0.0049 |
Echinococcus multilocularis | lamin | 0.003 | 0.019 | 0.019 |
Schistosoma mansoni | trithorax protein ash2 | 0.0042 | 0.0305 | 0.0305 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.0281 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0196 | 0.1721 | 0.1721 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.1721 | 0.1721 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0281 | 0.0281 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0281 | 0.0814 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0108 | 0.0108 |
Echinococcus multilocularis | musashi | 0.003 | 0.019 | 0.019 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.1122 | 0.1122 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.0281 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0281 | 0.0281 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.1721 | 0.1721 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0039 | 0.0281 | 0.0814 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.019 | 0.019 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0281 | 0.0281 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0379 | 0.0379 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0281 | 0.0281 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0196 | 0.1721 | 0.1721 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0281 | 0.0175 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0108 | 0.0108 |
Schistosoma mansoni | tyrosinase precursor | 0.0196 | 0.1721 | 0.1721 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.019 | 0.019 |
Echinococcus granulosus | lamin | 0.003 | 0.019 | 0.019 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.0281 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0305 | 0.02 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.0281 | 1 |
Echinococcus granulosus | geminin | 0.0186 | 0.1626 | 0.1626 |
Brugia malayi | Hypothetical WD-repeat protein F21H12.1 in chromosome II | 0.0073 | 0.0586 | 0.0586 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.0281 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0185 | 0.0185 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0108 | 0.0108 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0281 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0379 | 0.0379 |
Onchocerca volvulus | 0.0196 | 0.1721 | 0.156 | |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0039 | 0.0281 | 0.0814 |
Onchocerca volvulus | 0.0196 | 0.1721 | 0.156 | |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0064 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.1626 | 0.1626 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0196 | 0.1721 | 0.1721 |
Onchocerca volvulus | 0.0039 | 0.0281 | 0.0093 | |
Echinococcus granulosus | set1:ash2 histone methyltransferase complex | 0.0042 | 0.0305 | 0.0305 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0196 | 0.1721 | 0.1721 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0108 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.019 | 0.019 |
Schistosoma mansoni | lamin | 0.003 | 0.019 | 0.019 |
Echinococcus multilocularis | protein will die slowly | 0.1095 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0254 | 0.2253 | 0.2253 |
Loa Loa (eye worm) | WD40 repeat protein | 0.1095 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0281 | 0.0281 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0196 | 0.1721 | 0.1721 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0108 | 0.0108 |
Schistosoma mansoni | lamin | 0.003 | 0.019 | 0.019 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0252 | 0.2237 | 1 |
Toxoplasma gondii | SPRY domain-containing protein | 0.0039 | 0.0274 | 0.9611 |
Loa Loa (eye worm) | SPRY domain-containing protein | 0.0039 | 0.0274 | 0.0274 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0274 | 0.0168 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0379 | 0.0379 |
Trichomonas vaginalis | WD repeat domain, putative | 0.1095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0586 | 0.0586 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0281 | 0.0814 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0039 | 0.0281 | 0.0814 |
Echinococcus multilocularis | wd40 repeat | 0.0073 | 0.0586 | 0.0586 |
Schistosoma mansoni | tyrosinase precursor | 0.0196 | 0.1721 | 0.1721 |
Schistosoma mansoni | hypothetical protein | 0.1095 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0379 | 0.0379 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.0281 | 1 |
Onchocerca volvulus | 0.0039 | 0.0281 | 0.0093 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.1122 | 0.1122 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.1626 | 0.1626 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.019 | 0.019 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.0281 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.019 | 0.019 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0039 | 0.0281 | 0.0814 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0281 | 0.0281 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0379 | 0.0379 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0108 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0281 | 0.0281 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0281 | 0.0281 |
Brugia malayi | intermediate filament protein | 0.003 | 0.019 | 0.019 |
Schistosoma mansoni | retinoblastoma binding protein | 0.0073 | 0.0586 | 0.0586 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.0281 | 0.8783 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.019 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0044 | 0.0044 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0108 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0108 | 0.0108 |
Onchocerca volvulus | 0.1095 | 1 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0281 | 0.0814 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.0281 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0305 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.019 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0196 | 0.1721 | 0.1721 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0379 | 0.0379 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0039 | 0.0281 | 0.0814 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0196 | 0.1721 | 0.1721 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0379 | 0.0379 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0281 | 0.0281 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0281 | 0.0281 |
Trichomonas vaginalis | retinoblastoma binding protein, putative | 0.0073 | 0.0586 | 0.0484 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0379 | 0.0379 |
Onchocerca volvulus | 0.0196 | 0.1721 | 0.156 | |
Onchocerca volvulus | 0.0196 | 0.1721 | 0.156 | |
Brugia malayi | SPRY domain containing protein | 0.0042 | 0.0305 | 0.0305 |
Echinococcus granulosus | protein will die slowly | 0.1095 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.