Detailed information for compound 1807061

Basic information

Technical information
  • TDR Targets ID: 1807061
  • Name: (3-tert-butylphenyl) N,N-dimethylcarbamate
  • MW: 221.295 | Formula: C13H19NO2
  • H donors: 0 H acceptors: 1 LogP: 3.36 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(C)C)Oc1cccc(c1)C(C)(C)C
  • InChi: 1S/C13H19NO2/c1-13(2,3)10-7-6-8-11(9-10)16-12(15)14(4)5/h6-9H,1-5H3
  • InChiKey: CJXRFEACYKDEKK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N-dimethylcarbamic acid (3-tert-butylphenyl) ester
  • 24487-50-1
  • BRN 3053671
  • Phenol, m-tert-butyl-, dimethylcarbamate
  • m-tert-Butylphenol dimethylcarbamate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0281 0.0175
Brugia malayi beta-lactamase 0.0039 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0039 0.0281 0.0281
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0108 0.5
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0049 0.0049
Echinococcus granulosus wd40 repeat 0.0073 0.0586 0.0586
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0281 0.0814
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0281 0.0175
Echinococcus multilocularis geminin 0.0186 0.1626 0.1626
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0196 0.1721 0.1721
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.003 0.019 0.019
Loa Loa (eye worm) SPRY domain-containing protein 0.0042 0.0305 0.0305
Mycobacterium ulcerans lipase LipD 0.0039 0.0281 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0305 0.02
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0379 0.0379
Plasmodium falciparum SPRY domain, putative 0.0042 0.0305 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0281 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0281 0.0281
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1122 0.1122
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0281 0.0175
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0049
Echinococcus multilocularis set1:ash2 histone methyltransferase complex 0.0042 0.0305 0.0305
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0281 0.0175
Brugia malayi ShTK domain containing protein 0.0196 0.1721 0.1721
Brugia malayi follicle stimulating hormone receptor 0.0254 0.2253 0.2253
Trichomonas vaginalis esterase, putative 0.0039 0.0281 0.0175
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0281 0.0814
Loa Loa (eye worm) hypothetical protein 0.0039 0.0281 0.0281
Onchocerca volvulus 0.0039 0.0281 0.0093
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0049 0.0049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0281 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0586 0.0484
Mycobacterium leprae Probable lipase LipE 0.0039 0.0281 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0305 0.02
Echinococcus granulosus geminin 0.0186 0.1626 0.1626
Mycobacterium ulcerans hypothetical protein 0.0039 0.0281 1
Toxoplasma gondii ABC1 family protein 0.0039 0.0281 1
Brugia malayi Hypothetical WD-repeat protein F21H12.1 in chromosome II 0.0073 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.0029 0.0185 0.0185
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0281 0.0175
Schistosoma mansoni tyrosinase precursor 0.0196 0.1721 0.1721
Schistosoma mansoni ap endonuclease 0.0021 0.0108 0.0108
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.019 0.019
Echinococcus granulosus lamin 0.003 0.019 0.019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0379 0.0379
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0281 0.0281
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0108 0.0108
Loa Loa (eye worm) tyrosinase 1 0.0196 0.1721 0.1721
Echinococcus multilocularis lamin dm0 0.003 0.019 0.019
Loa Loa (eye worm) beta-lactamase 0.0039 0.0281 0.0281
Leishmania major hypothetical protein, conserved 0.0039 0.0281 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0196 0.1721 0.1721
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0281 0.0281
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0281 0.0814
Loa Loa (eye worm) ShTK domain-containing protein 0.0196 0.1721 0.1721
Loa Loa (eye worm) hypothetical protein 0.0196 0.1721 0.1721
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0281 0.0281
Schistosoma mansoni ap endonuclease 0.0021 0.0108 0.0108
Mycobacterium tuberculosis Conserved protein 0.0039 0.0281 0.0814
Echinococcus multilocularis musashi 0.003 0.019 0.019
Brugia malayi MH2 domain containing protein 0.0131 0.1122 0.1122
Schistosoma mansoni trithorax protein ash2 0.0042 0.0305 0.0305
Mycobacterium ulcerans beta-lactamase 0.0039 0.0281 1
Echinococcus multilocularis lamin 0.003 0.019 0.019
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0281 0.0814
Schistosoma mansoni tyrosinase precursor 0.0196 0.1721 0.1721
Echinococcus multilocularis wd40 repeat 0.0073 0.0586 0.0586
Schistosoma mansoni hypothetical protein 0.1095 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0379 0.0379
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0281 1
Onchocerca volvulus 0.0039 0.0281 0.0093
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1122 0.1122
Loa Loa (eye worm) SPRY domain-containing protein 0.0039 0.0274 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0274 0.0168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0379 0.0379
Trichomonas vaginalis WD repeat domain, putative 0.1095 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0586 0.0586
Mycobacterium tuberculosis Conserved protein 0.0039 0.0281 0.0814
Brugia malayi Common central domain of tyrosinase family protein 0.0196 0.1721 0.1721
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0108 0.0108
Schistosoma mansoni lamin 0.003 0.019 0.019
Toxoplasma gondii SPRY domain-containing protein 0.0039 0.0274 0.9611
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0252 0.2237 1
Schistosoma mansoni lamin 0.003 0.019 0.019
Echinococcus multilocularis protein will die slowly 0.1095 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.2253 0.2253
Brugia malayi beta-lactamase family protein 0.0039 0.0281 0.0281
Loa Loa (eye worm) WD40 repeat protein 0.1095 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0108 0.5
Schistosoma mansoni intermediate filament proteins 0.003 0.019 0.019
Onchocerca volvulus 0.0039 0.0281 0.0093
Echinococcus granulosus set1:ash2 histone methyltransferase complex 0.0042 0.0305 0.0305
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0196 0.1721 0.1721
Onchocerca volvulus 0.0196 0.1721 0.156
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0186 0.1626 0.1626
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0196 0.1721 0.1721
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0108 0.0108
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0379 0.0379
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0281 1
Onchocerca volvulus 0.0196 0.1721 0.156
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0281 0.0814
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0281 0.0281
Trichomonas vaginalis retinoblastoma binding protein, putative 0.0073 0.0586 0.0484
Onchocerca volvulus 0.0196 0.1721 0.156
Onchocerca volvulus 0.0196 0.1721 0.156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0379 0.0379
Brugia malayi SPRY domain containing protein 0.0042 0.0305 0.0305
Echinococcus granulosus protein will die slowly 0.1095 1 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0196 0.1721 0.1721
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0281 0.0814
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0379 0.0379
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0196 0.1721 0.1721
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0039 0.0281 0.0281
Mycobacterium tuberculosis Conserved protein 0.0039 0.0281 0.0814
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0281 1
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0305 1
Loa Loa (eye worm) intermediate filament protein 0.003 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0044
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0108 0.5
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0108 0.0108
Onchocerca volvulus 0.1095 1 1
Schistosoma mansoni retinoblastoma binding protein 0.0073 0.0586 0.0586
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0281 0.8783
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.019 0.019
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0108 0.5
Brugia malayi beta-lactamase family protein 0.0039 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0039 0.0281 0.0281
Brugia malayi intermediate filament protein 0.003 0.019 0.019
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0281 0.0814
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0281 0.0281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0379 0.0379
Echinococcus granulosus lamin dm0 0.003 0.019 0.019
Schistosoma mansoni hypothetical protein 0.0186 0.1626 0.1626
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0281 0.5
Echinococcus granulosus intermediate filament protein 0.003 0.019 0.019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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