Detailed information for compound 1809657

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.556 | Formula: C28H31FN2O3
  • H donors: 1 H acceptors: 2 LogP: 4.58 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](CN1CCN(CC1)c1ccc(cc1)F)COc1ccccc1C(=O)CCc1ccccc1
  • InChi: 1S/C28H31FN2O3/c29-23-11-13-24(14-12-23)31-18-16-30(17-19-31)20-25(32)21-34-28-9-5-4-8-26(28)27(33)15-10-22-6-2-1-3-7-22/h1-9,11-14,25,32H,10,15-21H2/t25-/m1/s1
  • InChiKey: UQOKEVFVYZVXCW-RUZDIDTESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni multidrug resistance protein 0.0013 0.0107 0.0107
Onchocerca volvulus Fxna peptidase homolog 0.0131 0.155 0.1459
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0.0107 1
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0107 0.069
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0131 0.155 0.155
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0131 0.155 0.155
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0107 0.069
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0107 0.0107
Leishmania major glutaminyl cyclase, putative 0.0131 0.155 1
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0131 0.155 0.155
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.0107 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0105 0.0105
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0107 0.069
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0004 0 0.5
Giardia lamblia ABC transporter, putative 0.0004 0 0.5
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0107 0.069
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0107 0.0107
Trichomonas vaginalis abcb9, putative 0.0013 0.0107 0.069
Entamoeba histolytica P-glycoprotein-5 0.0013 0.0107 1
Trypanosoma cruzi glutaminyl cyclase, putative 0.0131 0.155 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0107 0.069
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.155 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0107 0.069
Loa Loa (eye worm) leucyl aminopeptidase 0.0131 0.155 0.155
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0107 0.069
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0107 0.069
Loa Loa (eye worm) hypothetical protein 0.0131 0.155 0.155
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0131 0.155 0.155
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0107 0.069
Loa Loa (eye worm) hypothetical protein 0.0131 0.155 0.155
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0131 0.155 1
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.155 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0107 0.069
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0107 0.069
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0107 0.069
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0 0.5
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.006 0.006
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0107 0.0107
Leishmania major p-glycoprotein 0.0013 0.0107 0.069
Onchocerca volvulus Glutaminyl cyclase homolog 0.0822 1 1
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0822 1 1
Onchocerca volvulus Fxna peptidase homolog 0.0131 0.155 0.1459
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0107 0.069
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0107 0.069
Brugia malayi ABC transporter family protein 0.0013 0.0107 0.0107
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0013 0.0107 0.5
Mycobacterium ulcerans hypothetical protein 0.0131 0.155 1
Schistosoma mansoni smdr2 0.0013 0.0107 0.0107
Toxoplasma gondii hypothetical protein 0.0131 0.155 1
Loa Loa (eye worm) hypothetical protein 0.0822 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0107 0.0107
Brugia malayi FXNA 0.0131 0.155 0.155
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0107 0.0107
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0107 0.0107
Toxoplasma gondii peptidase, M28 family protein 0.0131 0.155 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0107 0.069
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0107 0.0107
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0107 0.069
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0822 1 1
Schistosoma mansoni multidrug resistance protein 0.0013 0.0107 0.0107
Leishmania major hypothetical protein, conserved 0.0131 0.155 1
Brugia malayi multidrug resistance protein 3 0.0013 0.0107 0.0107
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0013 0.0107 0.069
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0.0107 1
Trichomonas vaginalis abcb9, putative 0.0013 0.0107 0.069
Loa Loa (eye worm) hypothetical protein 0.0013 0.0107 0.0107
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0107 1
Brugia malayi nicalin 0.0131 0.155 0.155
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0009 0.006 0.0387
Echinococcus multilocularis multidrug resistance protein 1 0.0009 0.006 0.006
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.0107 0.069
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0107 0.0107
Brugia malayi leucyl aminopeptidase 0.0131 0.155 0.155
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0131 0.155 0.155
Giardia lamblia Multidrug resistance-associated protein 1 0.0004 0 0.5
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.0107 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0107 0.0107
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0.0107 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0107 0.069
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0107 0.069
Loa Loa (eye worm) hypothetical protein 0.0131 0.155 0.155
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0107 0.0107
Schistosoma mansoni Fxna peptidase (M28 family) 0.0131 0.155 0.155
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0004 0 0.5
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.0107 0.069
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 0.0107 0.069
Trypanosoma cruzi glutaminyl cyclase, putative 0.0131 0.155 1
Schistosoma mansoni multidrug resistance protein 0.0013 0.0107 0.0107
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0107 0.0107
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0131 0.155 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0107 0.069
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0107 0.0107
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0105 0.0105
Schistosoma mansoni nicalin (M28 family) 0.0131 0.155 0.155
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0107 0.069
Giardia lamblia Multidrug resistance-associated protein 1 0.0004 0 0.5
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0107 1
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.155 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0107 0.069
Loa Loa (eye worm) hypothetical protein 0.0131 0.155 0.155
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0131 0.155 0.155
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0107 0.0107
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0131 0.155 0.155
Trichomonas vaginalis abcb9, putative 0.0013 0.0107 0.069
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0107 0.069
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0107 0.0107
Entamoeba histolytica P-glycoprotein-1 0.0013 0.0107 1
Mycobacterium tuberculosis Conserved protein 0.0131 0.155 1
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0822 1 1
Trichomonas vaginalis taga, putative 0.0013 0.0107 0.069
Trypanosoma brucei glutaminyl cyclase, putative 0.0131 0.155 1
Giardia lamblia MRP-like ABC transporter 0.0004 0 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0107 0.069
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0 0.5
Onchocerca volvulus 0.0131 0.155 0.1459
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0107 0.069
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0107 0.069
Onchocerca volvulus Fxna peptidase homolog 0.0131 0.155 0.1459
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0131 0.155 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0107 0.069
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0107 0.0107
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0107 0.0107
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.006 0.006

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 7.15 SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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