Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine-specific demethylase | 0.0086 | 0.0376 | 1 |
Plasmodium vivax | amine transporter, putative | 0.0031 | 0.0069 | 0.1835 |
Echinococcus multilocularis | 0.0086 | 0.0376 | 0.1215 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0098 | 0.0391 |
Toxoplasma gondii | hypothetical protein | 0.0031 | 0.0069 | 0.1835 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0086 | 0.0376 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0468 | 0.2511 | 0.3727 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0069 | 0.0069 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0031 | 0.0069 | 0.0223 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0086 | 0.0376 | 0.0552 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0069 | 0.0069 |
Mycobacterium tuberculosis | Conserved protein | 0.0468 | 0.2511 | 0.4014 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0152 | 0.0224 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0037 | 0.0098 | 0.2611 |
Schistosoma mansoni | hypothetical protein | 0.0572 | 0.3091 | 0.4545 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0185 | 0.0926 | 0.0926 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0152 | 0.0224 |
Brugia malayi | hypothetical protein | 0.0086 | 0.0376 | 0.0376 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.0069 | 0.1835 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0185 | 0.0926 | 0.0926 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0031 | 0.0069 | 0.0223 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0926 | 0.0926 |
Echinococcus multilocularis | serotonin transporter | 0.0185 | 0.0926 | 0.2996 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0086 | 0.0376 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0152 | 0.0152 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0031 | 0.0069 | 0.0223 |
Mycobacterium ulcerans | oxidoreductase | 0.0086 | 0.0376 | 0.0558 |
Schistosoma mansoni | hypothetical protein | 0.0468 | 0.2511 | 0.3692 |
Plasmodium falciparum | transporter, putative | 0.0031 | 0.0069 | 0.1835 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0031 | 0.0069 | 0.0101 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0185 | 0.0926 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0069 | 0.1835 |
Loa Loa (eye worm) | hypothetical protein | 0.1235 | 0.6802 | 0.6802 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0086 | 0.0376 | 0.0558 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0086 | 0.0376 | 0.1215 |
Echinococcus granulosus | GPCR family 2 | 0.0572 | 0.3091 | 1 |
Plasmodium falciparum | amino acid transporter, putative | 0.0031 | 0.0069 | 0.1835 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0086 | 0.0376 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0376 | 0.0376 |
Onchocerca volvulus | 0.0086 | 0.0376 | 0.0453 | |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0031 | 0.0069 | 0.0101 |
Brugia malayi | Thioredoxin family protein | 0.0468 | 0.2511 | 0.2511 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0086 | 0.0376 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0031 | 0.0069 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0069 | 0.0069 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0468 | 0.2511 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0086 | 0.0376 | 0.1215 |
Mycobacterium ulcerans | monoamine oxidase | 0.0086 | 0.0376 | 0.0558 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0185 | 0.0926 | 0.1361 |
Echinococcus multilocularis | Transglutaminase | 0.0468 | 0.2511 | 0.8124 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0152 | 0.0224 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0031 | 0.0069 | 0.0101 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0037 | 0.0098 | 0.0317 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0031 | 0.0069 | 0.0101 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0031 | 0.0069 | 0.0223 |
Trypanosoma brucei | glucosidase, putative | 0.0037 | 0.0098 | 1 |
Schistosoma mansoni | amine oxidase | 0.0086 | 0.0376 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 0.3091 | 0.3091 |
Schistosoma mansoni | alpha glucosidase | 0.0037 | 0.0098 | 0.0144 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0152 | 0.0493 |
Mycobacterium ulcerans | hypothetical protein | 0.0468 | 0.2511 | 0.3727 |
Schistosoma mansoni | amine oxidase | 0.0086 | 0.0376 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0069 | 0.0069 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0069 | 0.1835 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0098 | 0.0391 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0572 | 0.3091 | 0.3091 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0086 | 0.0376 | 0.0376 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0152 | 0.0493 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0165 | 0.0815 | 0.2636 |
Plasmodium vivax | hypothetical protein, conserved | 0.0086 | 0.0376 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0572 | 0.3091 | 0.3091 |
Brugia malayi | SWIRM domain containing protein | 0.0086 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0376 | 0.0376 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0069 | 0.1835 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0037 | 0.0098 | 0.0391 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0086 | 0.0376 | 0.06 |
Giardia lamblia | Hypothetical protein | 0.0468 | 0.2511 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0086 | 0.0376 | 0.06 |
Schistosoma mansoni | hypothetical protein | 0.0572 | 0.3091 | 0.4545 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0468 | 0.2511 | 0.4014 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0152 | 0.0493 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0165 | 0.0815 | 0.0815 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0031 | 0.0069 | 0.0101 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0031 | 0.0069 | 0.1835 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0069 | 0.0069 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0031 | 0.0069 | 0.0223 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0185 | 0.0926 | 0.0926 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0572 | 0.3091 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0468 | 0.2511 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0086 | 0.0376 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1807 | 1 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0086 | 0.0376 | 1 |
Brugia malayi | hypothetical protein | 0.0031 | 0.0069 | 0.0069 |
Echinococcus granulosus | Transglutaminase | 0.0468 | 0.2511 | 0.8124 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0031 | 0.0069 | 0.0223 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0165 | 0.0815 | 0.2636 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0156 | 0.0768 | 0.1129 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0086 | 0.0376 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0376 | 0.0376 |
Schistosoma mansoni | hypothetical protein | 0.1235 | 0.6802 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0468 | 0.2511 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0185 | 0.0926 | 0.1361 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0069 | 0.0069 |
Schistosoma mansoni | hypothetical protein | 0.0572 | 0.3091 | 0.4545 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1223 | 0.6738 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0086 | 0.0376 | 0.1215 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0098 | 0.2611 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0098 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0098 | 0.2611 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0031 | 0.0069 | 0.0101 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0159 | 0.0786 | 0.2541 |
Onchocerca volvulus | 0.1242 | 0.684 | 1 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0069 | 0.0069 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1807 | 1 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1223 | 0.6738 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0098 | 0.0391 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0031 | 0.0069 | 0.0223 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0037 | 0.0098 | 0.0098 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0086 | 0.0376 | 1 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.0468 | 0.2511 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0926 | 0.0926 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0572 | 0.3091 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0069 | 0.0069 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1137 | 0.6256 | 1 |
Mycobacterium tuberculosis | Long conserved protein | 0.0468 | 0.2511 | 0.4014 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0098 | 0.0391 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0098 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0926 | 0.0926 |
Mycobacterium ulcerans | dehydrogenase | 0.0086 | 0.0376 | 0.0558 |
Schistosoma mansoni | hypothetical protein | 0.0572 | 0.3091 | 0.4545 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0086 | 0.0376 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0031 | 0.0069 | 0.0223 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0572 | 0.3091 | 0.3091 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0572 | 0.3091 | 1 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0031 | 0.0069 | 0.0223 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0468 | 0.2511 | 0.4014 |
Schistosoma mansoni | alpha-glucosidase | 0.0142 | 0.0687 | 0.1009 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0468 | 0.2511 | 0.3727 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1807 | 1 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0031 | 0.0069 | 0.0101 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0165 | 0.0815 | 0.2636 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0031 | 0.0069 | 0.0101 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0572 | 0.3091 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0031 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | serotonin transporter b | 0.0185 | 0.0926 | 0.0926 |
Echinococcus multilocularis | GPCR, family 2 | 0.0572 | 0.3091 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0185 | 0.0926 | 0.2996 |
Onchocerca volvulus | 0.0095 | 0.0426 | 0.0528 | |
Echinococcus multilocularis | ankyrin repeat protein | 0.0156 | 0.0768 | 0.2484 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0165 | 0.0815 | 0.0815 |
Echinococcus granulosus | ankyrin repeat protein | 0.0156 | 0.0768 | 0.2484 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.016 | 0.0787 | 0.2546 |
Schistosoma mansoni | alpha-glucosidase | 0.0142 | 0.0687 | 0.1009 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0098 | 0.0391 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0031 | 0.0069 | 0.0069 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0031 | 0.0069 | 0.0223 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0031 | 0.0069 | 0.0101 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.1235 | 0.6802 | 0.6802 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0098 | 0.0391 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0098 | 0.2611 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0468 | 0.2511 | 0.4014 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0037 | 0.0098 | 0.0098 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0086 | 0.0376 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0037 | 0.0098 | 0.0391 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0031 | 0.0069 | 0.0101 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0098 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0376 | 0.0376 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0086 | 0.0376 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0376 | 0.0376 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0086 | 0.0376 | 0.0552 |
Onchocerca volvulus | 0.0185 | 0.0926 | 0.1266 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0086 | 0.0376 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0152 | 0.0493 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0031 | 0.0069 | 0.0223 |
Mycobacterium ulcerans | transglutaminase family protein | 0.0468 | 0.2511 | 0.3727 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0037 | 0.0098 | 0.0317 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.