TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 541.745 | Formula: C23H17BrClF3N2O3
H donors: 0 H acceptors: 2 LogP: 6.67 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: N#Cc1c(c2ccc(cc2)Cl)n(c(c1Br)C(F)(F)F)COC(=O)C(Oc1cccc(c1)C)C
InChi: 1S/C23H17BrClF3N2O3/c1-13-4-3-5-17(10-13)33-14(2)22(31)32-12-30-20(15-6-8-16(25)9-7-15)18(11-29)19(24)21(30)23(26,27)28/h3-10,14H,12H2,1-2H3
InChiKey: GXIZWKSXOGSHDH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0059	0.0938	0.0938
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0059	0.0938	0.0938
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0062	0.0062
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0059	0.0938	0.0938
Plasmodium falciparum	methionine aminopeptidase 2	0.0478	1	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.1934	0.8837
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Plasmodium falciparum	aminopeptidase P	0.0059	0.0938	0.0938
Brugia malayi	DNA-binding protein, 42 kDa containing protein	0.0059	0.0938	0.0938
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0059	0.0938	0.0938
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0059	0.0938	1
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0653	0.0653
Trypanosoma brucei	unspecified product	0.0019	0.0062	0.0062
Plasmodium falciparum	glutathione reductase	0.0046	0.0653	0.0653
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0653	0.0653
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Treponema pallidum	methionine aminopeptidase (map)	0.0059	0.0938	1
Loa Loa (eye worm)	initiation factor 2-associated protein	0.0478	1	1
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0478	1	1
Schistosoma mansoni	aminopeptidase P1 (M24 family)	0.0059	0.0938	0.0938
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0653	0.0595
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0062	0.0062
Toxoplasma gondii	methionine aminopeptidase 2, putative	0.0478	1	1
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0059	0.0938	0.0938
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Brugia malayi	Thioredoxin reductase	0.0046	0.0653	0.0653
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0059	0.0938	0.0938
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0062	0.0062
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0621	0.0621
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0059	0.0938	0.0938
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Echinococcus granulosus	methionine aminopeptidase type I	0.0059	0.0938	0.0938
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0062	0.0062
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0653	0.2985
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0478	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0059	0.0938	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0938	0.0882
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.1934	0.8837
Toxoplasma gondii	creatinase domain-containing protein	0.0059	0.0938	0.0938
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0059	0.0938	0.0938
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0062	0.0062
Plasmodium vivax	FACT complex subunit SPT16, putative	0.0059	0.0938	0.0938
Entamoeba histolytica	aminopeptidase, putative	0.0059	0.0938	0.0882
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0653	0.0653
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Mycobacterium ulcerans	methionine aminopeptidase	0.0059	0.0938	1
Mycobacterium ulcerans	dipeptidase PepE	0.0059	0.0938	1
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0062	0.0062
Mycobacterium tuberculosis	Probable cytoplasmic peptidase PepQ	0.0059	0.0938	0.4287
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0059	0.0938	1
Giardia lamblia	Methionine aminopeptidase	0.0478	1	1
Trypanosoma cruzi	aminopeptidase P, putative	0.0059	0.0938	0.0938
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0059	0.0938	0.0938
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.0059	0.0938	0.0938
Mycobacterium tuberculosis	Probable reductase	0.0105	0.1934	0.8837
Chlamydia trachomatis	methionine aminopeptidase	0.0059	0.0938	1
Echinococcus multilocularis	methionine aminopeptidase, type I	0.0059	0.0938	0.0938
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0062	0.0656
Giardia lamblia	Xaa-Pro dipeptidase	0.0059	0.0938	0.0938
Treponema pallidum	aminopeptidase P	0.0059	0.0938	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0059	0.0938	0.0938
Brugia malayi	glutathione reductase	0.0046	0.0653	0.0653
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0059	0.0938	0.0938
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0062	0.0281
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0653	0.0595
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Echinococcus granulosus	methionyl aminopeptidase 2	0.0478	1	1
Trypanosoma brucei	Xaa-Pro aminopeptidase, putative	0.0059	0.0938	0.0938
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0478	1	1
Echinococcus multilocularis	xaa Pro dipeptidase	0.0059	0.0938	0.0938
Plasmodium vivax	proliferation-associated protein 2g4, putative	0.0059	0.0938	0.0938
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0059	0.0938	0.0938
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0062	0.0062
Plasmodium falciparum	FACT complex subunit SPT16, putative	0.0059	0.0938	0.0938
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0059	0.0938	0.0938
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0059	0.0938	0.0938
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0621	0.0562
Entamoeba histolytica	peptidase, putative	0.0059	0.0938	0.0882
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Onchocerca volvulus	Methionine aminopeptidase 2 homolog	0.0478	1	1
Echinococcus multilocularis	Xaa Pro aminopeptidase 3	0.0059	0.0938	0.0938
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0059	0.0938	0.0938
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0059	0.0938	0.0882
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0621	0.0621
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.1934	0.8837
Echinococcus multilocularis	xaa Pro dipeptidase	0.0059	0.0938	0.0938
Trypanosoma cruzi	Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative	0.0059	0.0938	0.0938
Leishmania major	trypanothione reductase	0.0046	0.0653	0.0653
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0621	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0938	0.0882
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.2188	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0621	0.0621
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0062	0.0062
Echinococcus multilocularis	FACT complex subunit SPT16	0.0059	0.0938	0.0938
Chlamydia trachomatis	aminopeptidase P	0.0059	0.0938	1
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0062	0.0656
Toxoplasma gondii	peptidase D, putative	0.0059	0.0938	0.0938
Schistosoma mansoni	chromatin-specific transcription elongation factor 140 kDa subunit (M24 family)	0.0059	0.0938	0.0938
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0059	0.0938	0.0938
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0062	0.0062
Entamoeba histolytica	methionine aminopeptidase, putative	0.0478	1	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0062	0.0062
Trypanosoma brucei	methionine aminopeptidase, putative	0.0059	0.0938	0.0938
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0062	0.0062
Echinococcus multilocularis	Proliferation associated protein 2G4	0.0059	0.0938	0.0938
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0621	0.0621
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.1934	0.8837
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0062	0.0062
Plasmodium vivax	methionine aminopeptidase 2, putative	0.0478	1	1
Brugia malayi	metallopeptidase family M24 containing protein	0.0059	0.0938	0.0938
Echinococcus granulosus	xaa Pro dipeptidase	0.0059	0.0938	0.0938
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0062	0.0062
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0478	1	1
Leishmania major	aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Loa Loa (eye worm)	DNA-binding protein	0.0059	0.0938	0.0882
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0059	0.0938	0.0938
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0059	0.0938	0.0938
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0059	0.0938	0.0938
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0621	0.0621
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0621	0.0621
Toxoplasma gondii	methionine aminopeptidase	0.0059	0.0938	0.0938
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0062	0.0062
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Plasmodium vivax	methionine aminopeptidase 1c, putative	0.0059	0.0938	0.0938
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0653	0.0653
Echinococcus multilocularis	xaa pro aminopeptidase	0.0059	0.0938	0.0938
Schistosoma mansoni	Xaa-Pro dipeptidase (M24 family)	0.0059	0.0938	0.0938
Leishmania major	transcription factor-like protein	0.0059	0.0938	0.0938
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0478	1	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0062	0.0062
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0062	0.0062
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0062	0.0281
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0478	1	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.2188	1
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0059	0.0938	0.4287
Trypanosoma brucei	trypanothione reductase	0.0046	0.0653	0.0653
Mycobacterium tuberculosis	Dipeptidase PepE	0.0059	0.0938	0.4287
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Mycobacterium ulcerans	dipeptidase	0.0059	0.0938	1
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Entamoeba histolytica	Xaa-Pro dipeptidase, putative	0.0059	0.0938	0.0882
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.0478	1	1
Toxoplasma gondii	proliferation-associated protein 2G4, putative	0.0059	0.0938	0.0938
Plasmodium falciparum	methionine aminopeptidase 1c, putative	0.0059	0.0938	0.0938
Echinococcus granulosus	Proliferation associated protein 2G4	0.0059	0.0938	0.0938
Trypanosoma cruzi	aminopeptidase P1, putative	0.0059	0.0938	0.0938
Brugia malayi	metallopeptidase family M24 containing protein	0.0059	0.0938	0.0938
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Brugia malayi	Methionine aminopeptidase protein type I	0.0059	0.0938	0.0938
Echinococcus granulosus	FACT complex subunit SPT16	0.0059	0.0938	0.0938
Entamoeba histolytica	hypothetical protein, conserved	0.0059	0.0938	0.0882
Echinococcus granulosus	dna polymerase eta	0.0019	0.0062	0.0062
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0062	0.0062
Loa Loa (eye worm)	metallopeptidase family M24 containing protein	0.0059	0.0938	0.0882
Echinococcus granulosus	xaa pro aminopeptidase	0.0059	0.0938	0.0938
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.2188	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0059	0.0938	0.0938
Schistosoma mansoni	peptidase	0.0059	0.0938	0.0938
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0059	0.0938	0.0938
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0062	0.0062
Mycobacterium ulcerans	aminopeptidase	0.0059	0.0938	1
Echinococcus multilocularis	methionyl aminopeptidase 2	0.0478	1	1
Toxoplasma gondii	methionine aminopeptidase	0.0059	0.0938	0.0938
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.1934	0.8837
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.1934	0.7964
Plasmodium falciparum	proliferation-associated protein 2g4, putative	0.0059	0.0938	0.0938
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0059	0.0938	0.0938
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Echinococcus granulosus	xaa Pro dipeptidase	0.0059	0.0938	0.0938
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0478	1	1
Toxoplasma gondii	transcriptional elongation factor FACT140	0.0059	0.0938	0.0938
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0653	0.0653
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0059	0.0938	0.0938
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.2188	1
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0062	0.0062
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0621	0.0621
Leishmania major	DNA polymerase eta, putative	0.0019	0.0062	0.0062
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.0478	1	1
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0059	0.0938	0.0938
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0059	0.0938	0.4287
Plasmodium vivax	peptidase, putative	0.0059	0.0938	0.0938
Leishmania major	hypothetical protein, conserved	0.0059	0.0938	0.0938
Leishmania major	methionine aminopeptidase 2, putative	0.0478	1	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0938	0.0882
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Giardia lamblia	Xaa-Pro dipeptidase	0.0059	0.0938	0.0938
Echinococcus granulosus	Xaa Pro aminopeptidase 3	0.0059	0.0938	0.0938
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0059	0.0938	0.0938
Trypanosoma brucei	Facilitates chromatin transcription complex subunit spt16	0.0059	0.0938	0.0938
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0653	0.0653
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0059	0.0938	0.0938
Mycobacterium ulcerans	cytoplasmic peptidase PepQ	0.0059	0.0938	1
Trypanosoma brucei	Metallopeptidase family M24, putative	0.0059	0.0938	0.0938
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0653	0.0653
Wolbachia endosymbiont of Brugia malayi	Xaa-Pro aminopeptidase	0.0059	0.0938	1
Brugia malayi	metallopeptidase family M24 containing protein	0.0059	0.0938	0.0938

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2228667

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1816249