Detailed information for compound 1816277

Basic information

Technical information
  • TDR Targets ID: 1816277
  • Name: N-tert-butyl-2-methoxy-N'-(2-methoxybenzoyl)b enzohydrazide
  • MW: 356.416 | Formula: C20H24N2O4
  • H donors: 1 H acceptors: 2 LogP: 3.48 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C(=O)NN(C(C)(C)C)C(=O)c1ccccc1OC
  • InChi: 1S/C20H24N2O4/c1-20(2,3)22(19(24)15-11-7-9-13-17(15)26-5)21-18(23)14-10-6-8-12-16(14)25-4/h6-13H,1-5H3,(H,21,23)
  • InChiKey: VGRBKUJHVSAPBP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-tert-butyl-2-methoxy-N'-[(2-methoxyphenyl)-oxomethyl]benzohydrazide
  • N-tert-butyl-2-methoxy-N'-(2-methoxyphenyl)carbonyl-benzohydrazide
  • A3683/0156238
  • ZINC01428694

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0488 0.0488
Brugia malayi MH2 domain containing protein 0.0117 0.2984 0.2984
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0049 0.0919 0.0919
Schistosoma mansoni hypothetical protein 0.0031 0.0386 0.0386
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0488 0.0488
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0386 0.0386
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0198 0.5
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0251 0.0251
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0488 0.0488
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.6446 0.6446
Echinococcus granulosus lamin 0.0026 0.0251 0.0251
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0198 0.5
Brugia malayi intermediate filament protein 0.0026 0.0251 0.0251
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0488 0.0408
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.035 1 1
Loa Loa (eye worm) hypothetical protein 0.035 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0488 0.0408
Echinococcus multilocularis tumor protein p63 0.0332 0.9468 0.9468
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0488 0.0488
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.6446 0.6446
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0488 0.0488
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0488 0.0488
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0198 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.2401 0.2401
Brugia malayi hypothetical protein 0.012 0.3076 0.3076
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0488 0.0488
Echinococcus multilocularis lamin dm0 0.0026 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0034 0.0488 0.0488
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0198 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.2401 0.2401
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0034 0.0488 0.0488
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.2984 0.2984
Echinococcus multilocularis GPCR, family 2 0.0031 0.0386 0.0386
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0386 0.0386
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.2401 0.2401
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0488 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0488 0.0488
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0488 0.0488
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0198 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0098 0.2401 0.2401
Onchocerca volvulus Huntingtin homolog 0.012 0.3076 0.485
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0488 0.0488
Brugia malayi hypothetical protein 0.0025 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0034 0.0488 0.0488
Schistosoma mansoni coup transcription factor 0.0034 0.0488 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0488 0.0488
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0175 0.4731 0.4731
Schistosoma mansoni hypothetical protein 0.0031 0.0386 0.0386
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0488 0.0488
Echinococcus granulosus intermediate filament protein 0.0026 0.0251 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0031 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.012 0.3076 0.3076
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0879 0.0879
Leishmania major hypothetical protein, conserved 0.0025 0.0198 0.5
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0488 0.0488
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0488 0.0488
Brugia malayi nuclear receptor NHR-88 0.0034 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0232 0.6446 0.6446
Onchocerca volvulus Huntingtin homolog 0.012 0.3076 0.485
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0034 0.0488 0.0488
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0488 0.0488
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0488 0.0488
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0198 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.1469 0.1469
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0488 0.0488
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0488 0.0488
Brugia malayi hypothetical protein 0.0232 0.6446 0.6446
Loa Loa (eye worm) hypothetical protein 0.0034 0.0488 0.0488
Brugia malayi steroid hormone receptor 0.0034 0.0488 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0488 0.0488
Echinococcus multilocularis musashi 0.0026 0.0251 0.0251
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0251 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0488 0.0488
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0488 0.0488
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0193 0.5278 0.5278
Schistosoma mansoni survival motor neuron protein 0.0047 0.0879 0.0879
Onchocerca volvulus Bile acid receptor homolog 0.0219 0.6076 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0488 0.0488
Echinococcus granulosus lamin dm0 0.0026 0.0251 0.0251
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0488 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0488 0.0488
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0488 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0488 0.0488
Onchocerca volvulus 0.0047 0.0879 0.1079
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0488 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0488 0.0488
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0386 0.0386
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0488 0.0488
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0488 0.0488
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.035 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0251 0.0251
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.2984 0.2984
Schistosoma mansoni lamin 0.0026 0.0251 0.0251
Schistosoma mansoni lamin 0.0026 0.0251 0.0251
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0386 0.0386
Schistosoma mansoni intermediate filament proteins 0.0026 0.0251 0.0251
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0488 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0488 0.0488
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0488 0.0488
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0386 0.0386
Echinococcus granulosus GPCR family 2 0.0031 0.0386 0.0386
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.012 0.3076 0.3076
Loa Loa (eye worm) hypothetical protein 0.0034 0.0488 0.0488
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0488 0.0488
Schistosoma mansoni retinoic acid receptor RXR 0.0193 0.5278 0.5278
Loa Loa (eye worm) hypothetical protein 0.0025 0.0198 0.0198
Brugia malayi nuclear hormone receptor 0.0034 0.0488 0.0488
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0488 0.0488
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0488 0.0488
Schistosoma mansoni hypothetical protein 0.0047 0.0879 0.0879
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0919 0.0919
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.035 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0198 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0488 0.0488
Brugia malayi ecdysteroid receptor 0.0219 0.6076 0.6076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0488 0.0488
Schistosoma mansoni hypothetical protein 0.0067 0.1469 0.1469
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0488 0.0488
Echinococcus granulosus tumor protein p63 0.0332 0.9468 0.9468
Schistosoma mansoni hypothetical protein 0.0031 0.0386 0.0386
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0026 0.0236 0.0236
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0488 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0488 0.0488
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1469 0.1469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0488 0.0488
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0488 0.0488
Schistosoma mansoni hypothetical protein 0.0031 0.0386 0.0386
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0488 0.0488
Echinococcus multilocularis lamin 0.0026 0.0251 0.0251
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0488 0.0488
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0488 0.0488
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0488 0.0488
Onchocerca volvulus 0.0049 0.0919 0.1147
Loa Loa (eye worm) hypothetical protein 0.0219 0.6076 0.6076
Loa Loa (eye worm) hypothetical protein 0.0034 0.0488 0.0488
Onchocerca volvulus 0.0034 0.0488 0.0408

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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