Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ezrin | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Ezrin radixin moesin ERM | 0.0012 | 0.0737 | 0.0737 |
Onchocerca volvulus | 0.0012 | 0.0737 | 0.5 | |
Echinococcus granulosus | SPRY domain containing protein | 0.0012 | 0.0737 | 0.0737 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.1264 | 0.5 |
Schistosoma mansoni | merlin/moesin/ezrin/radixin | 0.0037 | 0.5608 | 0.5608 |
Echinococcus multilocularis | Pleckstrin y | 0.0012 | 0.0737 | 0.0737 |
Brugia malayi | neurofibromatosis homolog protein 1 | 0.0035 | 0.5128 | 0.5128 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0012 | 0.0737 | 0.0737 |
Echinococcus multilocularis | FERM domain containing protein 5 | 0.0012 | 0.0737 | 0.0737 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | GRP1 binding protein | 0.0009 | 0.0191 | 0.0191 |
Echinococcus granulosus | protein 4.1 | 0.0012 | 0.0737 | 0.0737 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.1264 | 0.1264 |
Onchocerca volvulus | Putative 4.1 G protein | 0.0012 | 0.0737 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0737 | 0.0737 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0012 | 0.0737 | 0.0737 |
Echinococcus multilocularis | radixin | 0.0033 | 0.4872 | 0.4872 |
Echinococcus granulosus | SPRY domain containing protein | 0.0012 | 0.0737 | 0.0737 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0012 | 0.0737 | 0.0737 |
Echinococcus multilocularis | FERM and pleckstrin domain containing protein | 0.0012 | 0.0737 | 0.0737 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.1264 | 0.5 |
Echinococcus granulosus | merlin:moesin:ezrin:radixin | 0.0012 | 0.0737 | 0.0737 |
Brugia malayi | Ferm domain | 0.0012 | 0.0737 | 0.0737 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0737 | 0.0737 |
Echinococcus granulosus | FERM and pleckstrin domain containing protein | 0.0012 | 0.0737 | 0.0737 |
Echinococcus multilocularis | ezrin | 0.0033 | 0.4872 | 0.4872 |
Echinococcus granulosus | H17g protein tegumental antigen | 0.0061 | 1 | 1 |
Echinococcus multilocularis | merlin:moesin:ezrin:radixin | 0.0012 | 0.0737 | 0.0737 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0191 | 0.0191 |
Echinococcus multilocularis | SPRY domain containing protein | 0.0012 | 0.0737 | 0.0737 |
Brugia malayi | Ferm domain | 0.0012 | 0.0737 | 0.0737 |
Echinococcus granulosus | FERM domain containing protein 5 | 0.0012 | 0.0737 | 0.0737 |
Schistosoma mansoni | Band 4.1-like protein | 0.0012 | 0.0737 | 0.0737 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0737 | 0.0737 |
Echinococcus granulosus | Pleckstrin y | 0.0012 | 0.0737 | 0.0737 |
Echinococcus multilocularis | FERM domain containing protein 3 | 0.0012 | 0.0737 | 0.0737 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0737 | 0.0737 |
Schistosoma mansoni | merlin/moesin/ezrin/radixin | 0.0061 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0023 | 0.2953 | 0.2953 |
Onchocerca volvulus | 0.0012 | 0.0737 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.1264 | 0.1264 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.1264 | 0.1264 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0012 | 0.0737 | 0.0737 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2953 | 0.2953 |
Loa Loa (eye worm) | moesin | 0.0061 | 1 | 1 |
Echinococcus granulosus | FERM domain containing protein 3 | 0.0012 | 0.0737 | 0.0737 |
Echinococcus multilocularis | SPRY domain containing protein | 0.0012 | 0.0737 | 0.0737 |
Onchocerca volvulus | 0.0012 | 0.0737 | 0.5 | |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0.1264 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0737 | 0.0737 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.1264 | 0.1264 |
Echinococcus granulosus | SPRY domain containing protein | 0.0012 | 0.0737 | 0.0737 |
Echinococcus multilocularis | 0.0012 | 0.0737 | 0.0737 | |
Echinococcus multilocularis | H17g protein, tegumental antigen | 0.0061 | 1 | 1 |
Echinococcus multilocularis | Ezrin radixin moesin ERM | 0.0012 | 0.0737 | 0.0737 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0737 | 0.0737 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.1264 | 0.1264 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0737 | 0.0737 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0737 | 0.0737 |
Echinococcus granulosus | radixin | 0.0033 | 0.4872 | 0.4872 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0737 | 0.0737 |
Schistosoma mansoni | merlin/moesin/ezrin/radixin | 0.0054 | 0.8718 | 0.8718 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0057 | 0.0057 |
Echinococcus granulosus | ezrin | 0.0033 | 0.4872 | 0.4872 |
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 0.1264 | 0.5 |
Brugia malayi | FERM domain | 0.0012 | 0.0737 | 0.0737 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2953 | 0.2953 |
Brugia malayi | GRP1 binding protein | 0.0012 | 0.0737 | 0.0737 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.1264 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of ezrin in mouse K7M2 cells assessed as reduction in phosphorylation at Thr 567 at 10 uM after 6 hrs by immunoblotting analysis | ChEMBL. | 24326277 | |
Kd (binding) | = 5 uM | Binding affinity to recombinant ezrin (unknown origin) by surface plasmon resonance spectrometry | ChEMBL. | 24326277 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.