Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0813 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0813 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.1467 | 0.1467 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.1467 | 0.1467 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.1467 | 0.1467 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0813 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.1467 | 0.1467 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0813 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.1467 | 0.1467 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.1467 | 0.1467 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.008 | 0.037 | 0.037 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0813 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.1467 | 0.1467 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.1467 | 0.1467 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.1467 | 0.1467 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.1467 | 0.1467 |
Loa Loa (eye worm) | hypothetical protein | 0.0813 | 1 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.0813 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1467 | 0.1467 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0813 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1467 | 0.1467 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0813 | 1 | 1 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0732 | 0.8944 | 0.8944 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0813 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.1467 | 0.1467 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0732 | 0.8944 | 0.8944 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0813 | 1 | 1 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0813 | 1 | 0.5 |
Echinococcus multilocularis | lysosomal protective protein | 0.0813 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0813 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.88 uM | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition by Ellman's method | ChEMBL. | 24148835 |
IC50 (binding) | = 8.72 uM | Inhibition of equine serum BChE using butylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition by Ellman's method | ChEMBL. | 24148835 |
Inhibition (binding) | = 34.81 % | Inhibition of amyloid beta (1 to 42) aggregation (unknown origin) at 20 uM after 48 hrs by thioflavin-T fluorescence assay relative to control | ChEMBL. | 24148835 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.