TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 410.885 | Formula: C21H23ClD2O6
H donors: 4 H acceptors: 4 LogP: 2.35 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)C(c1cc(ccc1Cl)[C@@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O)([2H])[2H]
InChi: 1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1/i9D2
InChiKey: JVHXJTBJCFBINQ-UUFJFONJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 5 (sodium/glucose cotransporter), member 2	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 5 (sodium/glucose cotransporter), member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	sodium:myo inositol cotransporter	Get druggable targets OG5_127197	All targets in OG5_127197
Schistosoma japonicum	ko:K03307 solute:Na+ symporter, SSS family, putative	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus multilocularis	sodium:glucose cotransporter 2	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus multilocularis	sodium:myo inositol cotransporter	Get druggable targets OG5_127197	All targets in OG5_127197
Schistosoma mansoni	inositol transporter	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus granulosus	sodium:glucose cotransporter	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus multilocularis	solute carrier family 5	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus granulosus	solute carrier family 5	Get druggable targets OG5_127197	All targets in OG5_127197
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127197	All targets in OG5_127197
Schistosoma mansoni	inositol transporter	Get druggable targets OG5_127197	All targets in OG5_127197
Schistosoma japonicum	Sodium/myo-inositol cotransporter, putative	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus granulosus	sodium:glucose cotransporter 2	Get druggable targets OG5_127197	All targets in OG5_127197

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.009	0.0108	0.0108
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.009	0.0108	0.01
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.321	0.726	1
Schistosoma mansoni	ephrin receptor	0.031	0.0612	0.0612
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.031	0.0612	0.493
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.009	0.0108	0.0108
Onchocerca volvulus		0.009	0.0108	0.0315
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.031	0.0612	0.493
Echinococcus multilocularis	protein kinase	0.031	0.0612	0.0612
Loa Loa (eye worm)	glutamate receptor	0.0051	0.0019	0.0009
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.0612	0.0602
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.031	0.0612	0.0612
Echinococcus granulosus	tyrosine protein kinase Fyn	0.031	0.0612	0.0612
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Brugia malayi	AMP-binding enzyme family protein	0.0054	0.0026	0.0018
Echinococcus multilocularis	solute carrier family 5	0.0907	0.1981	0.1981
Loa Loa (eye worm)	PAN domain-containing protein	0.0147	0.0238	0.0228
Entamoeba histolytica	tyrosin kinase, putative	0.031	0.0612	1
Schistosoma mansoni	hypothetical protein	0.031	0.0612	0.0612
Schistosoma mansoni	hypothetical protein	0.0046	0.0006	0.0006
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.009	0.0108	0.0108
Schistosoma mansoni	protein kinase	0.031	0.0612	0.0612
Schistosoma mansoni	serine/threonine protein kinase	0.031	0.0612	0.0612
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Schistosoma mansoni	protein kinase	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.0612	0.0602
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.031	0.0612	0.0612
Brugia malayi	Raf kinase	0.031	0.0612	0.0604
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.031	0.0612	0.0612
Entamoeba histolytica	hypothetical protein	0.008	0.0084	0.1028
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.009	0.0108	0.0108
Giardia lamblia	Kinase, NEK	0.031	0.0612	0.5
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.009	0.0108	0.0108
Loa Loa (eye worm)	carboxylesterase	0.0065	0.0049	0.004
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Brugia malayi	Guanylyl cyclase protein 23	0.0315	0.0623	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.031	0.0612	0.0612
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.009	0.0108	0.01
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0342	0.0685	0.0678
Entamoeba histolytica	hypothetical protein	0.031	0.0612	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus multilocularis	high affinity choline transporter 1	0.0231	0.0432	0.0432
Loa Loa (eye worm)	TK protein kinase	0.031	0.0612	0.0602
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus multilocularis	tyrosine kinase	0.0315	0.0623	0.0623
Echinococcus granulosus	acetylcholinesterase	0.0065	0.0049	0.0049
Loa Loa (eye worm)	acetylcholinesterase 1	0.0065	0.0049	0.004
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0907	0.1981	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0275	0.0266
Trichomonas vaginalis	AGC family protein kinase	0.031	0.0612	0.493
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.031	0.0612	0.0612
Echinococcus granulosus	activated cdc42 kinase 1	0.031	0.0612	0.0612
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Loa Loa (eye worm)	TK protein kinase	0.031	0.0612	0.0602
Brugia malayi	PAN domain containing protein	0.0147	0.0238	0.023
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.031	0.0612	0.0612
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Onchocerca volvulus		0.0147	0.0238	0.0802
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Onchocerca volvulus		0.0147	0.0238	0.0802
Onchocerca volvulus		0.031	0.0612	0.2201
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.008	0.0084	0.0084
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0023	0.0014
Brugia malayi	PAN domain containing protein	0.0147	0.0238	0.023
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.031	0.0612	0.0612
Echinococcus multilocularis	protein dispatched 1	0.0054	0.0025	0.0025
Echinococcus granulosus	glycine receptor subunit alpha 1	0.009	0.0108	0.0108
Onchocerca volvulus		0.0231	0.0432	0.1529
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.031	0.0612	0.0612
Echinococcus granulosus	expressed conserved protein	0.0104	0.0139	0.0139
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.031	0.0612	0.0604
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.009	0.0108	0.01
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.031	0.0612	0.0604
Loa Loa (eye worm)	PAN domain-containing protein	0.0147	0.0238	0.0228
Onchocerca volvulus		0.031	0.0612	0.2201
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.031	0.0612	0.0612
Entamoeba histolytica	serine/threonine kinase, putative	0.031	0.0612	1
Schistosoma mansoni	serine/threonine protein kinase	0.031	0.0612	0.0612
Echinococcus multilocularis	dihydrofolate reductase	0.4405	1	1
Schistosoma mansoni	nAChR subunit	0.009	0.0108	0.0108
Echinococcus multilocularis	tyrosine kinase	0.031	0.0612	0.0612
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Onchocerca volvulus		0.031	0.0612	0.2201
Trichomonas vaginalis	protein kinase atn1, putative	0.031	0.0612	0.493
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0238	0.0228
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Brugia malayi	PAN domain containing protein	0.0147	0.0238	0.023
Echinococcus granulosus	acetylcholinesterase	0.0065	0.0049	0.0049
Echinococcus granulosus	tyrosine protein kinase Fyn	0.031	0.0612	0.0612
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Echinococcus multilocularis	glycine receptor subunit beta	0.009	0.0108	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0315	0.0623	0.2243
Entamoeba histolytica	hypothetical protein	0.031	0.0612	1
Loa Loa (eye worm)	TK protein kinase	0.031	0.0612	0.0602
Schistosoma mansoni	hypothetical protein	0.0046	0.0006	0.0006
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Echinococcus granulosus	tyrosine protein kinase csk	0.031	0.0612	0.0612
Entamoeba histolytica	hypothetical protein	0.031	0.0612	1
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Brugia malayi	Dihydrofolate reductase	0.4405	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Echinococcus granulosus	thymidylate synthase	0.1219	0.2695	0.2695
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.031	0.0612	0.0612
Echinococcus multilocularis	protein KINase family member (kin 25)	0.031	0.0612	0.0612
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0047	0.001	0.001
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.009	0.0108	0.01
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.031	0.0612	0.0612
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.031	0.0612	0.0612
Brugia malayi	PAN domain containing protein	0.0147	0.0238	0.023
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.009	0.0108	0.0108
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.031	0.0612	0.0612
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.031	0.0612	0.0602
Echinococcus multilocularis	tyrosine protein kinase pr2	0.031	0.0612	0.0612
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus granulosus	biogenic amine 5HT receptor	0.0163	0.0275	0.0275
Schistosoma mansoni	sodium/solute symporter	0.0231	0.0432	0.0432
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus granulosus	protein tyrosine kinase	0.031	0.0612	0.0612
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Brugia malayi	thymidylate synthase	0.1219	0.2695	0.2689
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0238	0.0228
Echinococcus multilocularis	integrin linked protein kinase	0.031	0.0612	0.0612
Echinococcus multilocularis	kinase suppressor of Ras 1	0.031	0.0612	0.0612
Schistosoma mansoni	protein kinase	0.031	0.0612	0.0612
Onchocerca volvulus		0.031	0.0612	0.2201
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0024	0.0024
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.009	0.0108	0.0108
Brugia malayi	AMP-binding enzyme family protein	0.0054	0.0026	0.0018
Brugia malayi	Cation transporter family protein	0.009	0.0108	0.01
Trichomonas vaginalis	conserved hypothetical protein	0.058	0.123	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Brugia malayi	PAN domain containing protein	0.0147	0.0238	0.023
Echinococcus granulosus	retinal guanylyl cyclase 2	0.031	0.0612	0.0612
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Toxoplasma gondii	PAN domain-containing protein	0.2279	0.5127	0.6963
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.009	0.0108	0.01
Entamoeba histolytica	hypothetical protein	0.031	0.0612	1
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.009	0.0108	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.0612	0.493
Brugia malayi	Carboxylesterase family protein	0.0065	0.0049	0.0041
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Echinococcus multilocularis	tyrosine protein kinase Abl	0.031	0.0612	0.0612
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Onchocerca volvulus		0.031	0.0612	0.2201
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.4405	1	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.031	0.0612	0.0602
Onchocerca volvulus		0.031	0.0612	0.2201
Schistosoma mansoni	protein kinase	0.031	0.0612	0.0612
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.031	0.0612	0.0612
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.031	0.0612	0.0602
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	hypothetical protein	0.011	0.0154	0.0144
Entamoeba histolytica	hypothetical protein	0.031	0.0612	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0053	0.0023	0.0015
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0054	0.0026	0.0041
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Echinococcus granulosus	nAChR subunit	0.0053	0.0023	0.0023
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0315	0.0623	0.0613
Entamoeba histolytica	receptor protein kinase, putative	0.031	0.0612	1
Echinococcus granulosus	glycine receptor subunit beta	0.009	0.0108	0.0108
Loa Loa (eye worm)	LGC-31 protein	0.009	0.0108	0.0098
Echinococcus granulosus	sodium:glucose cotransporter	0.0907	0.1981	0.1981
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0315	0.0623	0.0623
Brugia malayi	CHE-14 protein	0.0047	0.001	0.0002
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.031	0.0612	0.0602
Echinococcus granulosus	kinase suppressor of Ras 1	0.031	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.0304	0.0598	0.0589
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.031	0.0612	0.0612
Echinococcus multilocularis	tyrosine protein kinase csk	0.031	0.0612	0.0612
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Echinococcus multilocularis	nAChR subunit	0.009	0.0108	0.0108
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0907	0.1981	0.1981
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.031	0.0612	0.0532
Echinococcus multilocularis	Niemann Pick C1 protein	0.011	0.0154	0.0154
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.031	0.0612	0.0612
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Brugia malayi	SH2 domain containing protein	0.031	0.0612	0.0604
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0053	0.0023	0.0015
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Echinococcus granulosus	tyrosine protein kinase Blk	0.031	0.0612	0.0612
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.321	0.726	1
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Echinococcus multilocularis	tyrosine protein kinase Srms	0.031	0.0612	0.0612
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0054	0.0026	0.0041
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.009	0.0108	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Brugia malayi	Tyrosine-protein kinase PR2	0.031	0.0612	0.0604
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Loa Loa (eye worm)	dihydrofolate reductase	0.4405	1	1
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0053	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.031	0.0612	0.0602
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Echinococcus granulosus	epidermal growth factor receptor	0.031	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.031	0.0612	0.0602
Schistosoma mansoni	serine/threonine protein kinase	0.031	0.0612	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.0612	0.493
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0049	0.004
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.009	0.0108	0.01
Echinococcus granulosus	glycine receptor subunit beta	0.009	0.0108	0.0108
Echinococcus granulosus	retinal guanylyl cyclase 2	0.031	0.0612	0.0612
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.031	0.0612	0.0612
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.031	0.0612	0.0612
Loa Loa (eye worm)	RGC/RGC protein kinase	0.031	0.0612	0.0602
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.031	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0238	0.0228
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0024	0.0024
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.009	0.0108	0.0108
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Echinococcus granulosus	tyrosine protein kinase shark	0.031	0.0612	0.0612
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.031	0.0612	0.0602
Echinococcus granulosus	insulin receptor	0.031	0.0612	0.0612
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0024	0.0024
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0112	0.0158	0.0158
Loa Loa (eye worm)	protein kinase domain-containing protein	0.031	0.0612	0.0602
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Echinococcus granulosus	Niemann Pick C1 protein	0.011	0.0154	0.0154
Loa Loa (eye worm)	TK protein kinase	0.031	0.0612	0.0602
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0238	0.0228
Echinococcus granulosus	tyrosine protein kinase Fyn	0.031	0.0612	0.0612
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.009	0.0108	0.0098
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Onchocerca volvulus		0.0147	0.0238	0.0802
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.321	0.726	1
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Brugia malayi	bone morphogenetic protein type 1 receptor	0.031	0.0612	0.0604
Schistosoma mansoni	protein kinase	0.031	0.0612	0.0612
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.0024	0.0016
Brugia malayi	Cation transporter family protein	0.009	0.0108	0.01
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0315	0.0623	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0023	0.0014
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.031	0.0612	0.0612
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Loa Loa (eye worm)	SRC-1	0.031	0.0612	0.0602
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Loa Loa (eye worm)	TK/EGFR protein kinase	0.031	0.0612	0.0602
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Loa Loa (eye worm)	TK/CSK protein kinase	0.031	0.0612	0.0602
Echinococcus granulosus	tyrosine protein kinase csk	0.031	0.0612	0.0612
Onchocerca volvulus		0.031	0.0612	0.2201
Trichomonas vaginalis	STE family protein kinase	0.031	0.0612	0.493
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Onchocerca volvulus		0.0147	0.0238	0.0802
Trichomonas vaginalis	TK family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0023	0.0014
Brugia malayi	Tyrosine-protein kinase abl-1	0.031	0.0612	0.0604
Loa Loa (eye worm)	TK/DDR protein kinase	0.031	0.0612	0.0602
Echinococcus multilocularis	tyrosine protein kinase csk	0.031	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0023	0.0014
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.031	0.0612	1
Echinococcus multilocularis	thymidylate synthase	0.1219	0.2695	0.2695
Schistosoma mansoni	protein kinase	0.031	0.0612	0.0612
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.031	0.0612	0.0612
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.009	0.0108	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Schistosoma mansoni	nAChR subunit	0.009	0.0108	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Onchocerca volvulus		0.1219	0.2695	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0342	0.0685	0.0685
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Echinococcus multilocularis	acetylcholinesterase	0.0065	0.0049	0.0049
Entamoeba histolytica	receptor protein kinase, putative	0.031	0.0612	1
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.0612	0.493
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.009	0.0108	0.0108
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.009	0.0108	0.01
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.031	0.0612	0.0602
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.031	0.0612	0.0612
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Toxoplasma gondii	PAN domain-containing protein	0.2279	0.5127	0.6963
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Echinococcus granulosus	glycine receptor subunit alpha 1	0.009	0.0108	0.0108
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Echinococcus multilocularis	protein kinase	0.031	0.0612	0.0612
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0238	0.0228
Brugia malayi	AMP-binding enzyme family protein	0.0054	0.0026	0.0018
Brugia malayi	hypothetical protein	0.058	0.123	0.1223
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0023	0.0014
Brugia malayi	Immunoglobulin I-set domain containing protein	0.031	0.0612	0.0604
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Brugia malayi	C-terminal src kinase protein 1	0.031	0.0612	0.0604
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Echinococcus multilocularis	acetylcholinesterase	0.0065	0.0049	0.0049
Entamoeba histolytica	ankyrin repeat protein	0.031	0.0612	1
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Echinococcus granulosus	tyrosine protein kinase csk	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.058	0.123	0.0931
Echinococcus multilocularis	tyrosine protein kinase csk	0.031	0.0612	0.0612
Entamoeba histolytica	cysteine surface protein, putative	0.031	0.0612	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.009	0.0108	0.0098
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Schistosoma mansoni	hypothetical protein	0.0046	0.0006	0.0006
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Echinococcus multilocularis	activated cdc42 kinase 1	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus multilocularis	tyrosine protein kinase	0.031	0.0612	0.0612
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.321	0.726	1
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.0612	0.493
Schistosoma mansoni	serine/threonine RGC	0.031	0.0612	0.0612
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Onchocerca volvulus		0.031	0.0612	0.2201
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.009	0.0108	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Entamoeba histolytica	hypothetical protein	0.031	0.0612	1
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0053	0.0023	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Schistosoma mansoni	dihydrofolate reductase	0.4405	1	1
Schistosoma mansoni	patched 1	0.0047	0.001	0.001
Echinococcus multilocularis	geminin	0.0198	0.0356	0.0356
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus granulosus	geminin	0.0198	0.0356	0.0356
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0315	0.0623	0.0613
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.031	0.0612	0.0612
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0024	0.0024
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.009	0.0108	0.0108
Echinococcus granulosus	tyrosine kinase	0.031	0.0612	0.0612
Echinococcus multilocularis	tyrosine protein kinase shark	0.031	0.0612	0.0612
Onchocerca volvulus		0.031	0.0612	0.2201
Echinococcus multilocularis	activin receptor type	0.031	0.0612	0.0612
Echinococcus multilocularis	ephrin type A receptor 4 A	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Entamoeba histolytica	hypothetical protein, conserved	0.031	0.0612	1
Schistosoma mansoni	nAChR subunit	0.009	0.0108	0.0108
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.031	0.0612	0.0604
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.009	0.0108	0.0108
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.031	0.0612	0.0612
Schistosoma mansoni	nAChR subunit	0.009	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0063	0.0046	0.0046
Echinococcus granulosus	tyrosine protein kinase Srms	0.031	0.0612	0.0612
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Echinococcus multilocularis	natriuretic peptide receptor 1	0.031	0.0612	0.0612
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.009	0.0108	0.0098
Echinococcus granulosus	Niemann Pick C1 protein	0.0158	0.0263	0.0263
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.031	0.0612	0.0602
Echinococcus granulosus	c src tyrosine kinase	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.031	0.0612	0.0612
Onchocerca volvulus		0.031	0.0612	0.2201
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.031	0.0612	0.0612
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.031	0.0612	1
Echinococcus granulosus	epidermal growth factor receptor	0.031	0.0612	0.0612
Echinococcus granulosus	natriuretic peptide receptor 1	0.031	0.0612	0.0612
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Brugia malayi	PAN domain containing protein	0.0147	0.0238	0.023
Schistosoma mansoni	protein kinase	0.031	0.0612	0.0612
Loa Loa (eye worm)	thymidylate synthase	0.1219	0.2695	0.2688
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Entamoeba histolytica	hypothetical protein	0.008	0.0084	0.1028
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0907	0.1981	0.1981
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.031	0.0612	0.0612
Echinococcus multilocularis	transfer RNA-Thr	0.031	0.0612	0.0612
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.009	0.0108	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus granulosus	retinal guanylyl cyclase 2	0.031	0.0612	0.0612
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0907	0.1981	0.1981
Echinococcus granulosus	solute carrier family 5	0.0907	0.1981	0.1981
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.031	0.0612	0.0612
Echinococcus multilocularis	epidermal growth factor receptor	0.031	0.0612	0.0612
Brugia malayi	integrin-linked kinase	0.031	0.0612	0.0604
Schistosoma mansoni	protein kinase	0.031	0.0612	0.0612
Schistosoma mansoni	hypothetical protein	0.0198	0.0356	0.0356
Onchocerca volvulus		0.009	0.0108	0.0315
Echinococcus granulosus	nAChR subunit	0.009	0.0108	0.0108
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.321	0.726	1
Loa Loa (eye worm)	TK protein kinase	0.031	0.0612	0.0602
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.031	0.0612	0.493
Echinococcus granulosus	tyrosine kinase	0.031	0.0612	0.0612
Entamoeba histolytica	acyl-coA synthetase, putative	0.0054	0.0026	0.0041
Echinococcus multilocularis	nAChR subunit	0.0053	0.0023	0.0023
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.031	0.0612	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.031	0.0612	0.493
Entamoeba histolytica	serine/threonine kinase, putative	0.031	0.0612	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Brugia malayi	SRC-1	0.031	0.0612	0.0604
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Brugia malayi	hypothetical protein	0.008	0.0084	0.0076
Echinococcus granulosus	tyrosine protein kinase Lyn	0.031	0.0612	0.0612
Echinococcus multilocularis	Niemann Pick C1 protein	0.0158	0.0263	0.0263
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0051	0.0019	0.0011
Mycobacterium ulcerans	thymidylate synthase	0.1219	0.2695	0.2676
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0023	0.0014
Loa Loa (eye worm)	TK/INSR protein kinase	0.031	0.0612	0.0602
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Brugia malayi	excitatory GABA receptor EXP-1A	0.009	0.0108	0.01
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.009	0.0108	0.0098
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Onchocerca volvulus		0.031	0.0612	0.2201
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0163	0.0275	0.0275
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.009	0.0108	0.0108
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.031	0.0612	0.0612
Echinococcus granulosus	tyrosine protein kinase Src42A	0.031	0.0612	0.0612
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Echinococcus granulosus	activated cdc42 kinase 1	0.031	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Brugia malayi	hypothetical protein	0.031	0.0612	0.0604
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.009	0.0108	0.0108
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0231	0.0432	0.0432
Brugia malayi	Niemann-Pick C1 protein precursor	0.011	0.0154	0.0146
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.031	0.0612	0.0612
Onchocerca volvulus		0.031	0.0612	0.2201
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.011	0.0154	0.2223
Schistosoma mansoni	ephrin receptor	0.031	0.0612	0.0612
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.009	0.0108	0.0098
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Entamoeba histolytica	tyrosin kinase, putative	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.0612	0.0602
Loa Loa (eye worm)	PAN domain-containing protein	0.0147	0.0238	0.0228
Echinococcus multilocularis	serotonin receptor	0.0163	0.0275	0.0275
Chlamydia trachomatis	dihydrofolate reductase	0.4405	1	0.5
Entamoeba histolytica	hypothetical protein	0.008	0.0084	0.1028
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Onchocerca volvulus		0.0147	0.0238	0.0802
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0049	0.004
Toxoplasma gondii	STE kinase	0.031	0.0612	0.0532
Echinococcus granulosus	sterol regulatory element binding protein	0.0047	0.001	0.001
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0034	0.0024
Brugia malayi	Receptor family ligand binding region containing protein	0.0315	0.0623	0.0615
Echinococcus granulosus	activin receptor type	0.031	0.0612	0.0612
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.009	0.0108	0.01
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.031	0.0612	0.2201
Echinococcus multilocularis	tyrosine protein kinase Blk	0.031	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0275	0.0266
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Schistosoma mansoni	inositol transporter	0.0907	0.1981	0.1981
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.031	0.0612	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.031	0.0612	0.0612
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0024	0.0024
Schistosoma mansoni	serine/threonine protein kinase	0.031	0.0612	0.0612
Leishmania major	hypothetical protein, conserved	0.031	0.0612	0.081
Echinococcus multilocularis	insulin receptor	0.031	0.0612	0.0612
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Onchocerca volvulus		0.0054	0.0026	0.0009
Giardia lamblia	Kinase	0.031	0.0612	0.5
Loa Loa (eye worm)	hypothetical protein	0.0342	0.0685	0.0676
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0024	0.0024
Echinococcus granulosus	tyrosine protein kinase pr2	0.031	0.0612	0.0612
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.0612	0.493
Loa Loa (eye worm)	TK protein kinase	0.031	0.0612	0.0602
Entamoeba histolytica	tyrosin kinase, putative	0.031	0.0612	1
Entamoeba histolytica	serine/threonine kinase, putative	0.031	0.0612	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus multilocularis	protein patched	0.0047	0.001	0.001
Echinococcus granulosus	receptor type guanylyl cyclase	0.0315	0.0623	0.0623
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.009	0.0108	0.01
Onchocerca volvulus	Tyrosine kinase homolog	0.031	0.0612	0.2201
Echinococcus multilocularis	tyrosine protein kinase HCK	0.031	0.0612	0.0612
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Onchocerca volvulus		0.0147	0.0238	0.0802
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.0612	0.0602
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.009	0.0108	0.01
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.1219	0.2695	0.2676
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Entamoeba histolytica	hypothetical protein	0.031	0.0612	1
Giardia lamblia	Protein 21.1	0.031	0.0612	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.031	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Entamoeba histolytica	serine/threonine kinase, putative	0.031	0.0612	1
Echinococcus multilocularis	c src tyrosine kinase	0.031	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Schistosoma mansoni	tyrosine kinase	0.0315	0.0623	0.0623
Brugia malayi	PAN domain containing protein	0.0147	0.0238	0.023
Schistosoma mansoni	tyrosine kinase	0.0315	0.0623	0.0623
Schistosoma mansoni	hypothetical protein	0.008	0.0084	0.0084
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.0432	0.0423
Echinococcus granulosus	integrin linked protein kinase	0.031	0.0612	0.0612
Onchocerca volvulus		0.009	0.0108	0.0315
Brugia malayi	Sodium:solute symporter family protein	0.0231	0.0432	0.0424
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.1219	0.2695	0.2695
Echinococcus multilocularis	raf serine:threonine protein kinase	0.031	0.0612	0.0612
Leishmania major	protein kinase, putative	0.031	0.0612	0.081
Echinococcus granulosus	tyrosine kinase	0.0315	0.0623	0.0623
Loa Loa (eye worm)	TK/ALK protein kinase	0.031	0.0612	0.0602
Onchocerca volvulus		0.0147	0.0238	0.0802
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus granulosus	ephrin type A receptor 4 A	0.031	0.0612	0.0612
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.009	0.0108	0.0108
Onchocerca volvulus		0.0147	0.0238	0.0802
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Echinococcus multilocularis	FL cytokine receptor	0.031	0.0612	0.0612
Toxoplasma gondii	protein kinase	0.031	0.0612	0.0532
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Brugia malayi	PAN domain containing protein	0.0147	0.0238	0.023
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.031	0.0612	0.0612
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.1219	0.2695	0.2676
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.031	0.0612	0.0604
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.031	0.0612	0.0602
Brugia malayi	ephrin receptor 1 precursor	0.031	0.0612	0.0604
Loa Loa (eye worm)	ACC-1 protein	0.009	0.0108	0.0098
Echinococcus granulosus	glycine receptor subunit alpha 1	0.009	0.0108	0.0108
Loa Loa (eye worm)	TK/ACK protein kinase	0.031	0.0612	0.0602
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.321	0.726	1
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Entamoeba histolytica	ankyrin repeat protein	0.031	0.0612	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.031	0.0612	0.0602
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus granulosus	protein kinase	0.031	0.0612	0.0612
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.031	0.0612	1
Brugia malayi	Carboxylesterase family protein	0.0065	0.0049	0.0041
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.031	0.0612	0.0612
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.031	0.0612	0.0604
Echinococcus multilocularis	protein tyrosine kinase	0.031	0.0612	0.0612
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1857	0.416	0.416
Brugia malayi	Cation transporter family protein	0.009	0.0108	0.01
Loa Loa (eye worm)	TK/Met protein kinase	0.031	0.0612	0.0602
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.031	0.0612	0.0532
Echinococcus granulosus	high affinity choline transporter 1	0.0231	0.0432	0.0432
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Brugia malayi	SH2 domain containing protein	0.031	0.0612	0.0604
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.031	0.0612	0.0612
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.031	0.0612	0.0604
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0058	0.0035	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.009	0.0108	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.031	0.0612	0.0602
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	hypothetical protein	0.031	0.0612	0.0602
Loa Loa (eye worm)	PAN domain-containing protein	0.0147	0.0238	0.0228
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.4405	1	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.0432	0.0423
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.031	0.0612	0.0602
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.031	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0023	0.0014
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Schistosoma mansoni	high-affinity choline transporter	0.0231	0.0432	0.0432
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	hypothetical protein	0.031	0.0612	0.0602
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0065	0.0049	0.0049
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.031	0.0612	0.493
Schistosoma mansoni	protein tyrosine kinase	0.031	0.0612	0.0612
Schistosoma mansoni	nAChR subunit	0.009	0.0108	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Giardia lamblia	Kinase, NEK	0.031	0.0612	0.5
Echinococcus multilocularis	serotonin receptor	0.0163	0.0275	0.0275
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Echinococcus multilocularis	glycine receptor subunit beta	0.009	0.0108	0.0108
Loa Loa (eye worm)	TK protein kinase	0.031	0.0612	0.0602
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Loa Loa (eye worm)	TK/ABL protein kinase	0.031	0.0612	0.0602
Onchocerca volvulus		0.0147	0.0238	0.0802
Echinococcus granulosus	tyrosine protein kinase HCK	0.031	0.0612	0.0612
Echinococcus granulosus	carboxylesterase 5A	0.0065	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0046	0.0006	0.0006
Schistosoma mansoni	protein kinase	0.031	0.0612	0.0612
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0053	0.0023	0.0023
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.031	0.0612	0.0612
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.009	0.0108	0.0108
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0023	0.0014
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Echinococcus multilocularis	tyrosine protein kinase csk	0.031	0.0612	0.0612
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.0612	0.0602
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.031	0.0612	0.0604
Loa Loa (eye worm)	TK protein kinase	0.031	0.0612	0.0602
Loa Loa (eye worm)	ACC-1 protein	0.009	0.0108	0.0098
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.031	0.0612	0.0612
Onchocerca volvulus		0.031	0.0612	0.2201
Loa Loa (eye worm)	hypothetical protein	0.031	0.0612	0.0602
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0231	0.0432	0.0277
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.031	0.0612	0.0612
Echinococcus granulosus	dihydrofolate reductase	0.4405	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.031	0.0612	0.0602
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.031	0.0612	0.0612
Brugia malayi	PAN domain containing protein	0.0147	0.0238	0.023
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0238	0.0228
Entamoeba histolytica	hypothetical protein	0.031	0.0612	1
Entamoeba histolytica	hypothetical protein	0.031	0.0612	1
Entamoeba histolytica	serine/threonine kinase, putative	0.031	0.0612	1
Echinococcus granulosus	Protein patched homolog 1	0.0047	0.001	0.001
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0053	0.0023	0.0015
Entamoeba histolytica	hypothetical protein	0.008	0.0084	0.1028
Brugia malayi	hypothetical protein	0.031	0.0612	0.0604
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Onchocerca volvulus		0.0147	0.0238	0.0802
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.009	0.0108	0.01
Toxoplasma gondii	protein kinase domain-containing protein	0.031	0.0612	0.0532
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Echinococcus granulosus	tyrosine protein kinase	0.031	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0238	0.0228
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.0612	0.493
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.031	0.0612	0.0612
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Loa Loa (eye worm)	hypothetical protein	0.031	0.0612	0.0602
Entamoeba histolytica	hypothetical protein	0.031	0.0612	1
Brugia malayi	hypothetical protein	0.031	0.0612	0.0604
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Mycobacterium tuberculosis	Hypothetical protein	0.058	0.123	0.1208
Brugia malayi	GH02984p	0.0231	0.0432	0.0424
Schistosoma mansoni	nAChR subunit	0.009	0.0108	0.0108
Schistosoma mansoni	tyrosine protein kinase	0.031	0.0612	0.0612
Schistosoma mansoni	neurotransmitter gated ion channel	0.0053	0.0023	0.0023
Loa Loa (eye worm)	serine/threonine protein kinase	0.031	0.0612	0.0602
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.009	0.0108	0.0108
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.009	0.0108	0.0098
Loa Loa (eye worm)	TK/RYK protein kinase	0.031	0.0612	0.0602
Loa Loa (eye worm)	TK protein kinase	0.031	0.0612	0.0602
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0147	0.0238	0.0228
Schistosoma mansoni	transcription factor LCR-F1	0.008	0.0084	0.0084
Brugia malayi	protein-tyrosine kinase	0.031	0.0612	0.0604
Trichomonas vaginalis	CAMK family protein kinase	0.031	0.0612	0.493
Brugia malayi	PAN domain containing protein	0.0147	0.0238	0.023
Brugia malayi	Protein kinase domain containing protein	0.031	0.0612	0.0604
Onchocerca volvulus	Putative nachr subunit	0.009	0.0108	0.0315
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.031	0.0612	0.0532
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0063	0.0046	0.0046
Schistosoma mansoni	nAChR subunit	0.009	0.0108	0.0108
Echinococcus granulosus	tyrosine protein kinase Src64B	0.031	0.0612	0.0612
Onchocerca volvulus		0.009	0.0108	0.0315
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.4405	1	1
Onchocerca volvulus		0.0315	0.0623	0.2243
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Onchocerca volvulus		0.009	0.0108	0.0315
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.009	0.0108	0.01
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Entamoeba histolytica	protein kinase, putative	0.031	0.0612	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.008	0.0084	0.0084
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Entamoeba histolytica	tyrosin kinase, putative	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Schistosoma mansoni	protein kinase	0.031	0.0612	0.0612
Loa Loa (eye worm)	TK/FER protein kinase	0.031	0.0612	0.0602
Entamoeba histolytica	hypothetical protein	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0046	0.0036
Onchocerca volvulus		0.009	0.0108	0.0315
Entamoeba histolytica	serine/threonine kinase, putative	0.031	0.0612	1
Schistosoma mansoni	protein kinase	0.0315	0.0623	0.0623
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.031	0.0612	0.0612
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Loa Loa (eye worm)	GABA receptor subunit	0.0053	0.0023	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0342	0.0685	0.0676
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.009	0.0108	0.01
Schistosoma mansoni	inositol transporter	0.0907	0.1981	0.1981
Echinococcus granulosus	tyrosine protein kinase ABL1	0.031	0.0612	0.0612
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.009	0.0108	0.01
Entamoeba histolytica	protein kinase domain containing protein	0.031	0.0612	1
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Echinococcus multilocularis	epidermal growth factor receptor	0.031	0.0612	0.0612
Brugia malayi	Furin-like cysteine rich region family protein	0.031	0.0612	0.0604
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.031	0.0612	0.0612
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.031	0.0612	0.0612
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Echinococcus multilocularis	expressed conserved protein	0.0104	0.0139	0.0139
Trichomonas vaginalis	TKL family protein kinase	0.031	0.0612	0.493
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.009	0.0108	0.01
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Leishmania major	protein kinase, putative	0.031	0.0612	0.081
Echinococcus multilocularis	heat shock protein 70	0.031	0.0612	0.0612
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.009	0.0108	0.01
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0023	0.0014
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.031	0.0612	0.0612
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.009	0.0108	0.0108
Entamoeba histolytica	tyrosine kinase, putative	0.031	0.0612	1
Loa Loa (eye worm)	TK protein kinase	0.031	0.0612	0.0602
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.009	0.0108	0.0108
Schistosoma mansoni	hypothetical protein	0.0198	0.0356	0.0356
Loa Loa (eye worm)	hypothetical protein	0.009	0.0108	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0315	0.0623	0.0613
Echinococcus granulosus	fibroblast growth factor receptor 4	0.031	0.0612	0.0612
Echinococcus multilocularis	carboxylesterase 5A	0.0065	0.0049	0.0049
Onchocerca volvulus		0.031	0.0612	0.2201
Trichomonas vaginalis	conserved hypothetical protein	0.031	0.0612	0.493
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0231	0.0432	0.0432
Schistosoma mansoni	tyrosine kinase	0.031	0.0612	0.0612
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.031	0.0612	0.0612
Onchocerca volvulus		0.0147	0.0238	0.0802
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.0024	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0026	0.0016

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.2 nM	Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation counting analysis	ChEMBL.	24456245
IC50 (binding)	= 3988 nM	Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation counting analysis	ChEMBL.	24456245

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3125455

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1824301