Detailed information for compound 1824397

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 280.366 | Formula: C12H12N2O2S2
  • H donors: 0 H acceptors: 2 LogP: 3.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1sc(nc1C)/N=C/c1cccs1
  • InChi: 1S/C12H12N2O2S2/c1-3-16-11(15)10-8(2)14-12(18-10)13-7-9-5-4-6-17-9/h4-7H,3H2,1-2H3/b13-7+
  • InChiKey: CTIAEASIRUGWBY-NTUHNPAUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.004 0.0005
Brugia malayi Serine carboxypeptidase F41C3.5 precursor 0.0841 0.8377 1
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.0841 0.8377 0.8377
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0244 0.0292
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0419 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0029 0.0117 0.014
Leishmania major hypothetical protein, conserved 0.0028 0.0109 0.0131
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0393 0.0469
Schistosoma mansoni Smad4 0.0019 0.001 0.001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0069 0.0521 0.0582
Schistosoma mansoni ap endonuclease 0.0021 0.0036 0.0036
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0036 0.0036
Schistosoma mansoni inositol monophosphatase 0.0042 0.0244 0.0244
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Schistosoma mansoni smad1 5 8 and 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0211 0.0211
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0393 0.0393
Echinococcus granulosus muscleblind protein 0.0174 0.1594 0.1594
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.02 0.4282
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0233 0.0233
Entamoeba histolytica hypothetical protein 0.0041 0.0233 0.342
Echinococcus granulosus GTP binding nuclear protein Ran 0.0069 0.0521 0.0521
Brugia malayi MH2 domain containing protein 0.0019 0.001 0.0012
Echinococcus multilocularis importin subunit beta 1 0.0094 0.0773 0.0773
Schistosoma mansoni lysosomal protective protein precursor (cathepsin A) (carboxypeptidase 0.0083 0.0665 0.0665
Trichomonas vaginalis heat shock protein, putative 0.0023 0.0049 0.0824
Loa Loa (eye worm) endoplasmin 0.0037 0.0193 0.0193
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0233 0.0233
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0244 0.3158
Echinococcus granulosus Smad4 0.0019 0.001 0.001
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0841 0.8377 1
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0841 0.8377 1
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.0841 0.8377 1
Echinococcus multilocularis heat shock protein 90 0.0037 0.0193 0.0193
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0069 0.0521 0.0582
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0069 0.0521 0.6744
Echinococcus multilocularis Smad4 0.0019 0.001 0.001
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0419 0.0419
Schistosoma mansoni ran 0.0069 0.0521 0.0521
Brugia malayi RNA, U transporter 1 0.0267 0.2531 0.3022
Giardia lamblia Heat shock protein HSP 90-alpha 0.0037 0.0193 0.3242
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0036 0.0043
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.2288 0.2288
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0036 0.0036
Giardia lamblia Grp94/Hsp90 0.0029 0.0117 0.1675
Schistosoma mansoni smad1 5 8 and 0.0019 0.001 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0345 0.0345
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0345 0.0345
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0069 0.0521 0.6744
Leishmania major importin beta-1 subunit, putative 0.0076 0.0593 0.0708
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0001 0.0001
Echinococcus granulosus importin subunit beta 1 0.0094 0.0773 0.0773
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0069 0.0521 0.0521
Plasmodium falciparum endoplasmin, putative 0.0023 0.0049 0.0631
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0069 0.0521 0.0623
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0193 0.0189
Brugia malayi hypothetical protein 0.0028 0.0109 0.0131
Brugia malayi Endoplasmin precursor 0.0037 0.0193 0.0231
Loa Loa (eye worm) inositol-1 0.0042 0.0244 0.0244
Plasmodium vivax heat shock protein 86, putative 0.0037 0.0193 0.2499
Brugia malayi MH2 domain containing protein 0.0274 0.261 0.3116
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0117 0.1976
Loa Loa (eye worm) hypothetical protein 0.0085 0.0682 0.0682
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0109
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0117 0.0098
Brugia malayi heat shock protein 90 0.0037 0.0193 0.0231
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0916 0.9141 0.9141
Schistosoma mansoni ap endonuclease 0.0021 0.0036 0.0036
Trypanosoma brucei importin beta-1 subunit, putative 0.0094 0.0773 0.0923
Loa Loa (eye worm) hypothetical protein 0.0174 0.1594 0.1594
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0758 0.7531 0.7531
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0001 0.0001
Brugia malayi hypothetical protein 0.0018 0.0007 0.0008
Entamoeba histolytica hypothetical protein 0.0041 0.0233 0.342
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0419 0.05
Schistosoma mansoni hypothetical protein 0.0049 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0094 0.0773 0.0773
Loa Loa (eye worm) Smad1 0.0019 0.001 0.001
Echinococcus multilocularis heat shock protein 0.0037 0.0193 0.0193
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0109 0.1415
Entamoeba histolytica hypothetical protein 0.0076 0.0593 0.8695
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0233 0.0233
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0345 0.0412
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0419 0.0419
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0109 0.0088
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0109 0.0131
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0244 0.3582
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0345 0.0345
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Echinococcus multilocularis heat shock protein 90 0.0029 0.0117 0.0117
Echinococcus granulosus lysosomal protective protein 0.0841 0.8377 0.8377
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0069 0.0521 0.0521
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0036 0.0043
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0029 0.0117 0.0117
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0419 0.0419
Brugia malayi MH1 domain containing protein 0.0019 0.001 0.0012
Trichomonas vaginalis endoplasmin, putative 0.0023 0.0049 0.0824
Loa Loa (eye worm) MH2 domain-containing protein 0.0274 0.261 0.261
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0193 0.0231
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Brugia malayi hypothetical protein 0.0243 0.2288 0.2732
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0393 0.0469
Entamoeba histolytica hypothetical protein 0.0041 0.0233 0.342
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0244 0.4119
Toxoplasma gondii exonuclease III APE 0.0021 0.0036 0.0463
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0001 0.0001
Echinococcus multilocularis muscleblind protein 0.0174 0.1594 0.1594
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.001 0.001
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0117 0.1976
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0036 0.0604
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0036 0.0036
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0193 0.2834
Loa Loa (eye worm) heat shock protein 90 0.0037 0.0193 0.0193
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0193 0.326
Giardia lamblia Heat shock protein HSP 90-alpha 0.0029 0.0117 0.1675
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0001 0.0001
Echinococcus granulosus endoplasmin 0.0029 0.0117 0.0117
Plasmodium falciparum importin beta, putative 0.0094 0.0773 1
Echinococcus granulosus smad 0.0019 0.001 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0193 0.0189
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0323 0.0386
Brugia malayi MH1 domain containing protein 0.0019 0.001 0.0012
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.0682 1
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.0841 0.8377 1
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0193 0.0189
Schistosoma mansoni inositol monophosphatase 0.0042 0.0244 0.0244
Echinococcus multilocularis smad 0.0019 0.001 0.001
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Trypanosoma cruzi importin beta-1 subunit, putative 0.0076 0.0593 0.0668
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0036 0.0604
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0345 0.0345
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0036 0.0525
Schistosoma mansoni endoplasmin 0.0037 0.0193 0.0193
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0076 0.0593 1
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Toxoplasma gondii heat shock protein HSP90 0.0037 0.0193 0.2499
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0244 0.0244
Trichomonas vaginalis importin beta-1, putative 0.0076 0.0593 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0244 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0345 0.0345
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.001 0.001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0036 0.0463
Echinococcus multilocularis endoplasmin 0.0029 0.0117 0.0117
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0076 0.0593 1
Trypanosoma brucei Heat shock protein 83, putative 0.0037 0.0193 0.0231
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0193 0.0231
Loa Loa (eye worm) hypothetical protein 0.0243 0.2288 0.2288
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Schistosoma mansoni endoplasmin 0.0037 0.0193 0.0193
Schistosoma mansoni smad 0.0019 0.001 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0001 0.0001
Entamoeba histolytica Ran family GTPase 0.0069 0.0521 0.7648
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.001 0.001
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0211 0.0252
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0244 0.4119
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.02 1
Schistosoma mansoni importin beta-1 0.0094 0.0773 0.0773
Brugia malayi Importin beta-1 subunit 0.0094 0.0773 0.0923
Schistosoma mansoni hypothetical protein 0.0041 0.0233 0.0233
Schistosoma mansoni hypothetical protein 0.1001 1 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0069 0.0521 0.6744
Brugia malayi Inositol-1 0.0042 0.0244 0.0292
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.001 0.001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0069 0.0521 0.0623
Echinococcus multilocularis lysosomal protective protein 0.0841 0.8377 0.8377
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Echinococcus multilocularis muscleblind protein 1 0.0174 0.1594 0.1594
Trypanosoma brucei importin beta-1 subunit, putative 0.0094 0.0773 0.0923
Loa Loa (eye worm) hypothetical protein 0.0174 0.1594 0.1594
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0001 0.0001
Schistosoma mansoni heat shock protein 0.0037 0.0193 0.0193
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.0841 0.8377 0.8377
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0345 0.0345
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.0682 1
Toxoplasma gondii HEAT repeat-containing protein 0.0094 0.0773 1
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0419 1
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Brugia malayi Muscleblind-like protein 0.0174 0.1594 0.1903
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.001 0.001
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Toxoplasma gondii heat shock protein 90, putative 0.0037 0.0193 0.2499
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0758 0.7531 0.7531
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0841 0.8377 1
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0244 0.5445
Plasmodium vivax importin-beta 2, putative 0.0094 0.0773 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.0323 0.0323
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0109 0.1415
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0841 0.8377 1
Plasmodium vivax endoplasmin, putative 0.0037 0.0193 0.2499
Loa Loa (eye worm) hypothetical protein 0.0841 0.8377 0.8377
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0109 0.0088
Echinococcus multilocularis GPCR, family 2 0.0018 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0041 0.0233 0.342
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0244 0.025
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0069 0.0521 1
Schistosoma mansoni ran 0.0069 0.0521 0.0521
Brugia malayi hypothetical protein 0.0041 0.0233 0.0278
Schistosoma mansoni heat shock protein 0.0037 0.0193 0.0193
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0109 0.1415
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0419 0.05
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0117 0.0098
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.1001 1 1
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0036 0.0463
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Trichomonas vaginalis ran, putative 0.0069 0.0521 0.8795
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0117 0.1976
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0029 0.0117 0.3903
Brugia malayi Smad1 0.0019 0.001 0.0012
Loa Loa (eye worm) transcription factor SMAD2 0.0274 0.261 0.261
Trypanosoma cruzi Heat shock protein 83, putative 0.0037 0.0193 0.0189
Leishmania major GTP-binding protein, putative 0.0069 0.0521 0.0623
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0109 0.1415
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0036 0.0043
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0193 0.0189
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.001 0.001
Echinococcus granulosus heat shock protein 0.0037 0.0193 0.0193
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0244 0.0292
Schistosoma mansoni hypothetical protein 0.0039 0.0211 0.0211
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0193 0.2834
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Treponema pallidum heat shock protein 90 0.0029 0.0117 1
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.2288 0.2288
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0244 0.0244
Mycobacterium ulcerans heat shock protein 90 0.0029 0.0117 0.2125
Echinococcus granulosus heat shock protein 90 0.0029 0.0117 0.0117
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0244 0.4119
Schistosoma mansoni smad1 5 8 and 0.0019 0.001 0.001
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Echinococcus granulosus heat shock protein 90 0.0037 0.0193 0.0193
Brugia malayi MH2 domain containing protein 0.0019 0.001 0.0012
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0841 0.8377 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0393 0.0393
Echinococcus multilocularis snurportin 1 0.1001 1 1
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0841 0.8377 1
Plasmodium falciparum heat shock protein 90 0.0037 0.0193 0.2499
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0345 0.0345
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0841 0.8377 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0378 0.0378
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0345 0.0345
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0029 0.0117 0.2125
Echinococcus granulosus GPCR family 2 0.0018 0.0001 0.0001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0244 0.025
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0419 1

Activities

Activity type Activity value Assay description Source Reference
IZ (functional) > 13 mm Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition at 1 mg/mL after 48 hrs by agar-cup diffusion method ChEMBL. 24583356
IZ (functional) > 13 mm Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition at 1 mg/mL after 24 hrs by agar-cup diffusion method ChEMBL. 24583356

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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