Detailed information for compound 1824397

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 280.366 | Formula: C12H12N2O2S2
  • H donors: 0 H acceptors: 2 LogP: 3.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1sc(nc1C)/N=C/c1cccs1
  • InChi: 1S/C12H12N2O2S2/c1-3-16-11(15)10-8(2)14-12(18-10)13-7-9-5-4-6-17-9/h4-7H,3H2,1-2H3/b13-7+
  • InChiKey: CTIAEASIRUGWBY-NTUHNPAUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Giardia lamblia Grp94/Hsp90 0.0029 0.0117 0.1675
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0109 0.1415
Brugia malayi hypothetical protein 0.0018 0.0007 0.0008
Entamoeba histolytica Ran family GTPase 0.0069 0.0521 0.7648
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0244 0.3158
Treponema pallidum heat shock protein 90 0.0029 0.0117 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0244 0.5445
Trypanosoma brucei importin beta-1 subunit, putative 0.0094 0.0773 0.0923
Echinococcus multilocularis heat shock protein 90 0.0037 0.0193 0.0193
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0001 0.0001
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.0682 1
Echinococcus granulosus endoplasmin 0.0029 0.0117 0.0117
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0916 0.9141 0.9141
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0193 0.0189
Brugia malayi Inositol-1 0.0042 0.0244 0.0292
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0001 0.0001
Echinococcus multilocularis muscleblind protein 1 0.0174 0.1594 0.1594
Loa Loa (eye worm) heat shock protein 90 0.0037 0.0193 0.0193
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0345 0.0345
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0069 0.0521 0.0582
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0109 0.1415
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0841 0.8377 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0345 0.0345
Brugia malayi RNA, U transporter 1 0.0267 0.2531 0.3022
Schistosoma mansoni smad1 5 8 and 0.0019 0.001 0.001
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.02 1
Brugia malayi Importin beta-1 subunit 0.0094 0.0773 0.0923
Entamoeba histolytica hypothetical protein 0.0076 0.0593 0.8695
Loa Loa (eye worm) inositol-1 0.0042 0.0244 0.0244
Loa Loa (eye worm) transcription factor SMAD2 0.0274 0.261 0.261
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Echinococcus granulosus GPCR family 2 0.0018 0.0001 0.0001
Schistosoma mansoni ap endonuclease 0.0021 0.0036 0.0036
Schistosoma mansoni heat shock protein 0.0037 0.0193 0.0193
Echinococcus granulosus heat shock protein 90 0.0037 0.0193 0.0193
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.0841 0.8377 0.8377
Schistosoma mansoni hypothetical protein 0.0041 0.0233 0.0233
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0419 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0036 0.0043
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Plasmodium vivax heat shock protein 86, putative 0.0037 0.0193 0.2499
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0193 0.0231
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0233 0.0233
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0117 0.1976
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0029 0.0117 0.0117
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0117 0.0098
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0244 0.0292
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0345 0.0345
Echinococcus multilocularis GPCR, family 2 0.0018 0.0001 0.0001
Toxoplasma gondii heat shock protein 90, putative 0.0037 0.0193 0.2499
Trypanosoma brucei Heat shock protein 83, putative 0.0037 0.0193 0.0231
Echinococcus multilocularis importin subunit beta 1 0.0094 0.0773 0.0773
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0345 0.0345
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.0682 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0029 0.0117 0.3903
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0069 0.0521 0.6744
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0117 0.0098
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0345 0.0412
Brugia malayi Endoplasmin precursor 0.0037 0.0193 0.0231
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0233 0.0233
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0193 0.326
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0001 0.0001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.1001 1 1
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.0841 0.8377 1
Plasmodium falciparum importin beta, putative 0.0094 0.0773 1
Schistosoma mansoni hypothetical protein 0.0049 0.0323 0.0323
Brugia malayi hypothetical protein 0.0243 0.2288 0.2732
Plasmodium vivax importin-beta 2, putative 0.0094 0.0773 1
Entamoeba histolytica hypothetical protein 0.0041 0.0233 0.342
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0117 0.1976
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0244 1
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0758 0.7531 0.7531
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0841 0.8377 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0036 0.0525
Brugia malayi hypothetical protein 0.0041 0.0233 0.0278
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.001 0.001
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0029 0.0117 0.014
Brugia malayi heat shock protein 90 0.0037 0.0193 0.0231
Brugia malayi MH2 domain containing protein 0.0274 0.261 0.3116
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0109 0.1415
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0345 0.0345
Echinococcus granulosus muscleblind protein 0.0174 0.1594 0.1594
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0069 0.0521 0.0521
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Schistosoma mansoni smad1 5 8 and 0.0019 0.001 0.001
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0069 0.0521 0.0521
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0036 0.0604
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0233 0.0233
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.0841 0.8377 1
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0117 0.1976
Trypanosoma cruzi importin beta-1 subunit, putative 0.0076 0.0593 0.0668
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.001 0.001
Trypanosoma cruzi Heat shock protein 83, putative 0.0037 0.0193 0.0189
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0029 0.0117 0.2125
Echinococcus granulosus heat shock protein 90 0.0029 0.0117 0.0117
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0109 0.0088
Loa Loa (eye worm) endoplasmin 0.0037 0.0193 0.0193
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0193 0.0189
Schistosoma mansoni inositol monophosphatase 0.0042 0.0244 0.0244
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0109 0.0088
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.2288 0.2288
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0211 0.0252
Loa Loa (eye worm) hypothetical protein 0.0174 0.1594 0.1594
Brugia malayi MH2 domain containing protein 0.0019 0.001 0.0012
Schistosoma mansoni Smad4 0.0019 0.001 0.001
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.2288 0.2288
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0036 0.0036
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0323 0.0386
Leishmania major importin beta-1 subunit, putative 0.0076 0.0593 0.0708
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0841 0.8377 1
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0244 0.0244
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0419 1
Echinococcus granulosus heat shock protein 0.0037 0.0193 0.0193
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni ran 0.0069 0.0521 0.0521
Brugia malayi Serine carboxypeptidase F41C3.5 precursor 0.0841 0.8377 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0109
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.001 0.001
Echinococcus multilocularis endoplasmin 0.0029 0.0117 0.0117
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0393 0.0469
Brugia malayi Smad1 0.0019 0.001 0.0012
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0419 0.0419
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Trichomonas vaginalis importin beta-1, putative 0.0076 0.0593 1
Echinococcus multilocularis lysosomal protective protein 0.0841 0.8377 0.8377
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0193 0.2834
Schistosoma mansoni inositol monophosphatase 0.0042 0.0244 0.0244
Plasmodium vivax endoplasmin, putative 0.0037 0.0193 0.2499
Schistosoma mansoni smad1 5 8 and 0.0019 0.001 0.001
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0069 0.0521 0.0623
Loa Loa (eye worm) hypothetical protein 0.0841 0.8377 0.8377
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0036 0.0463
Echinococcus multilocularis heat shock protein 90 0.0029 0.0117 0.0117
Plasmodium falciparum heat shock protein 90 0.0037 0.0193 0.2499
Brugia malayi MH2 domain containing protein 0.0019 0.001 0.0012
Echinococcus granulosus Smad4 0.0019 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0041 0.0233 0.342
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Brugia malayi MH1 domain containing protein 0.0019 0.001 0.0012
Echinococcus granulosus GTP binding nuclear protein Ran 0.0069 0.0521 0.0521
Loa Loa (eye worm) MH2 domain-containing protein 0.0274 0.261 0.261
Leishmania major GTP-binding protein, putative 0.0069 0.0521 0.0623
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0193 0.2834
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0193 0.0189
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0841 0.8377 1
Echinococcus multilocularis Smad4 0.0019 0.001 0.001
Echinococcus multilocularis muscleblind protein 0.0174 0.1594 0.1594
Loa Loa (eye worm) hypothetical protein 0.0094 0.0773 0.0773
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0841 0.8377 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0393 0.0469
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0069 0.0521 0.0582
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0001 0.0001
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Schistosoma mansoni survival motor neuron protein 0.0049 0.0323 0.0323
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0085 0.0682 0.0682
Brugia malayi hypothetical protein 0.0028 0.0109 0.0131
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0244 0.4119
Entamoeba histolytica hypothetical protein 0.0041 0.0233 0.342
Toxoplasma gondii heat shock protein HSP90 0.0037 0.0193 0.2499
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0001 0.0001
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.0841 0.8377 0.8377
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0069 0.0521 0.0623
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Plasmodium falciparum endoplasmin, putative 0.0023 0.0049 0.0631
Trichomonas vaginalis ran, putative 0.0069 0.0521 0.8795
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.001 0.001
Toxoplasma gondii exonuclease III APE 0.0021 0.0036 0.0463
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0244 0.0292
Loa Loa (eye worm) Smad1 0.0019 0.001 0.001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0244 0.025
Giardia lamblia Heat shock protein HSP 90-alpha 0.0037 0.0193 0.3242
Trichomonas vaginalis heat shock protein, putative 0.0023 0.0049 0.0824
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0419 1
Schistosoma mansoni heat shock protein 0.0037 0.0193 0.0193
Schistosoma mansoni lysosomal protective protein precursor (cathepsin A) (carboxypeptidase 0.0083 0.0665 0.0665
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0001 0.0001
Schistosoma mansoni endoplasmin 0.0037 0.0193 0.0193
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0841 0.8377 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0345 0.0345
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0758 0.7531 0.7531
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0393 0.0393
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0056 0.0393 0.0393
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0069 0.0521 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0243 0.2288 0.2288
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0109 0.0131
Echinococcus multilocularis heat shock protein 0.0037 0.0193 0.0193
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Giardia lamblia Heat shock protein HSP 90-alpha 0.0029 0.0117 0.1675
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0841 0.8377 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.02 0.4282
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Schistosoma mansoni smad 0.0019 0.001 0.001
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.001 0.001
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Schistosoma mansoni endoplasmin 0.0037 0.0193 0.0193
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0036 0.0036
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0378 0.0378
Schistosoma mansoni hypothetical protein 0.1001 1 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0419 0.05
Echinococcus multilocularis snurportin 1 0.1001 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0076 0.0593 1
Echinococcus granulosus lysosomal protective protein 0.0841 0.8377 0.8377
Loa Loa (eye worm) hypothetical protein 0.0174 0.1594 0.1594
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0244 0.025
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0069 0.0521 0.6744
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0001 0.0001
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0109 0.1415
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0244 0.3582
Trypanosoma brucei importin beta-1 subunit, putative 0.0094 0.0773 0.0923
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Schistosoma mansoni ap endonuclease 0.0021 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0039 0.0211 0.0211
Trypanosoma brucei heat shock protein, putative 0.0037 0.0193 0.0231
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0036 0.0043
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0036 0.0463
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0345 0.0345
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0193 0.0189
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0193 0.0231
Trichomonas vaginalis endoplasmin, putative 0.0023 0.0049 0.0824
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0069 0.0521 0.6744
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0244 0.4119
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0419 0.05
Echinococcus granulosus importin subunit beta 1 0.0094 0.0773 0.0773
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0244 0.0244
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0419 0.0419
Schistosoma mansoni importin beta-1 0.0094 0.0773 0.0773
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Mycobacterium ulcerans heat shock protein 90 0.0029 0.0117 0.2125
Toxoplasma gondii HEAT repeat-containing protein 0.0094 0.0773 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0076 0.0593 1
Leishmania major hypothetical protein, conserved 0.0028 0.0109 0.0131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0345 0.0345
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0036 0.0043
Brugia malayi Muscleblind-like protein 0.0174 0.1594 0.1903
Leishmania major heat shock protein 83-1 0.0037 0.0193 0.0231
Echinococcus granulosus smad 0.0019 0.001 0.001
Schistosoma mansoni ran 0.0069 0.0521 0.0521
Echinococcus multilocularis smad 0.0019 0.001 0.001
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0244 0.4119
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0419 0.0419
Brugia malayi MH1 domain containing protein 0.0019 0.001 0.0012
Schistosoma mansoni hypothetical protein 0.0039 0.0211 0.0211
Entamoeba histolytica hypothetical protein 0.0041 0.0233 0.342
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0036 0.0604

Activities

Activity type Activity value Assay description Source Reference
IZ (functional) > 13 mm Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition at 1 mg/mL after 48 hrs by agar-cup diffusion method ChEMBL. 24583356
IZ (functional) > 13 mm Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition at 1 mg/mL after 24 hrs by agar-cup diffusion method ChEMBL. 24583356

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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