Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | p2X purinoceptor 4 | 0.0628 | 1 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0255 | 0.28 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0145 | 0.0667 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0168 | 0.1106 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.011 | 0 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0628 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0628 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0628 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0168 | 0.1106 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0168 | 0.1106 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0255 | 0.28 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.011 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0255 | 0.28 | 0.1905 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0168 | 0.1106 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0628 | 1 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0255 | 0.28 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0255 | 0.28 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0168 | 0.1106 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0168 | 0.1106 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0628 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0628 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0628 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0168 | 0.1106 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0628 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | > 70 % | Displacement of [3H]citalopram from Sprague-Dawley rat brain stem SERT site S1 at 10 uM by scintillation counting analysis | ChEMBL. | 24237160 |
Ki (binding) | = 8.3 nM | Displacement of [3H]citalopram from Sprague-Dawley rat brain stem SERT site S1 by scintillation counting analysis | ChEMBL. | 24237160 |
T1/2 (binding) | = 22.1 min | Allosteric modulation at wild-type human SERT site S2 expressed in african green monkey COS7 cells assessed as inhibition of [3H]citalopram dissociation by measuring half life at 30 uM at 18 degC by scintillation counting analysis | ChEMBL. | 24237160 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.