Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0371 | 0.1255 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0371 | 0.1255 | 1 |
Brugia malayi | FXNA | 0.0371 | 0.1255 | 0.1255 |
Brugia malayi | leucyl aminopeptidase | 0.0371 | 0.1255 | 0.1255 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0371 | 0.1255 | 0.1255 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0371 | 0.1255 | 0.1255 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.1255 | 0.1255 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0371 | 0.1255 | 0.1255 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0371 | 0.1255 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0371 | 0.1255 | 0.1255 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0371 | 0.1255 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0371 | 0.1255 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0371 | 0.1255 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0371 | 0.1255 | 0.5 |
Brugia malayi | nicalin | 0.0371 | 0.1255 | 0.1255 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0371 | 0.1255 | 0.1255 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0371 | 0.1255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.1255 | 0.1255 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0371 | 0.1255 | 0.1255 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0371 | 0.1255 | 0.1255 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.2329 | 1 | 1 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.2329 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0371 | 0.1255 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0371 | 0.1255 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0371 | 0.1255 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0371 | 0.1255 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0371 | 0.1255 | 0.1255 |
Leishmania major | glutaminyl cyclase, putative | 0.0371 | 0.1255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2329 | 1 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.009 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.2329 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0371 | 0.1255 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.1255 | 0.1255 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0371 | 0.1255 | 0.1255 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0371 | 0.1255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.1255 | 0.1255 |
Schistosoma mansoni | nicalin (M28 family) | 0.0371 | 0.1255 | 0.1255 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.2329 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 99 uM.hr | AUC (0 to 24 hrs) in BALB-nu/nu mouse at 100 mg/kg, po by LC-MS/MS analysis | ChEMBL. | 24900605 |
CL (ADMET) | = 13 ml/min/mg | Clearance in human liver microsomes at 5 uM by LC-MS/MS analysis | ChEMBL. | 24900605 |
IC50 (binding) | Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assay | ChEMBL. | 24900605 | |
IC50 (functional) | = 22 nM | Antiproliferative activity against human HCT116 cells assessed as cell viability after 96 hrs by cell counting kit-8 assay | ChEMBL. | 24900605 |
IC50 (binding) | = 64 nM | Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 mins by IMAP fluorescence polarization assay | ChEMBL. | 24900605 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24900605 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.