Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase family, member 3 | Starlite/ChEMBL | References |
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | poly(adp-ribose) polymerase | poly (ADP-ribose) polymerase family, member 3 | 540 aa | 497 aa | 37.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0524 | 0.1325 | 0.5 |
Brugia malayi | nicalin | 0.0524 | 0.1325 | 0.1003 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0293 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.1325 | 0.1215 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0524 | 0.1325 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0524 | 0.1325 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.3291 | 1 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0524 | 0.1325 | 0.1325 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.3291 | 1 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0524 | 0.1325 | 0.1003 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0524 | 0.1325 | 0.1003 |
Leishmania major | glutaminyl cyclase, putative | 0.0524 | 0.1325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3291 | 1 | 1 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0293 | 0.0602 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0524 | 0.1325 | 0.5 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0215 | 0.0357 | 0.0357 |
Mycobacterium tuberculosis | Conserved protein | 0.0524 | 0.1325 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0524 | 0.1325 | 1 |
Brugia malayi | WGR domain containing protein | 0.0293 | 0.0602 | 0.0254 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.3291 | 1 | 1 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0293 | 0.0602 | 0.0254 |
Toxoplasma gondii | hypothetical protein | 0.0524 | 0.1325 | 1 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0524 | 0.1325 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0524 | 0.1325 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0524 | 0.1325 | 0.1215 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0524 | 0.1325 | 0.1325 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0245 | 0.0122 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.3291 | 1 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0215 | 0.0357 | 0.0114 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0524 | 0.1325 | 0.1106 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.1325 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.0357 | 0.0235 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0524 | 0.1325 | 0.5 |
Brugia malayi | FXNA | 0.0524 | 0.1325 | 0.1003 |
Brugia malayi | leucyl aminopeptidase | 0.0524 | 0.1325 | 0.1003 |
Schistosoma mansoni | nicalin (M28 family) | 0.0524 | 0.1325 | 0.1106 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0293 | 0.0602 | 0.0365 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0524 | 0.1325 | 0.1106 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0524 | 0.1325 | 0.1106 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0524 | 0.1325 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0524 | 0.1325 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.1325 | 0.1215 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0524 | 0.1325 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.1325 | 0.1215 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0524 | 0.1325 | 0.1003 |
Leishmania major | hypothetical protein, conserved | 0.0524 | 0.1325 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta Tm (binding) | = 0.01 degrees C | Binding affinity to ATRD8 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | ChEMBL. | 24188023 |
Delta Tm (binding) | = 0.88 degrees C | Binding affinity to ATRD2 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | ChEMBL. | 24188023 |
Delta Tm (binding) | = 2.88 degrees C | Binding affinity to ATRD1 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | ChEMBL. | 24188023 |
Delta Tm (binding) | = 7.07 degrees C | Binding affinity to ATRD3 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | ChEMBL. | 24188023 |
IC50 (binding) | = 3.1 uM | Inhibition of catalytic domain of ATRD1 (unknown origin) | ChEMBL. | 24188023 |
IC50 (binding) | = 9.6 uM | Inhibition of full length ATRD3 (unknown origin) | ChEMBL. | 24188023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.