TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 480.36 | Formula: C21H15FN6Na2O4
H donors: 2 H acceptors: 8 LogP: 1.06 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: [O-]C(=O)C[C@H](n1nnc(c1)c1nc(c(n1C)c1ccncc1)c1ccc(cc1)F)C(=O)[O-].[Na+].[Na+]
InChi: 1S/C21H17FN6O4.2Na/c1-27-19(13-6-8-23-9-7-13)18(12-2-4-14(22)5-3-12)24-20(27)15-11-28(26-25-15)16(21(31)32)10-17(29)30;;/h2-9,11,16H,10H2,1H3,(H,29,30)(H,31,32);;/q;2*+1/p-2/t16-;;/m0../s1
InChiKey: GHENPFANYBLHPK-SQKCAUCHSA-L

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0729	0.0697
Echinococcus granulosus	cpg binding protein	0.0032	0.0495	0.0462
Mycobacterium tuberculosis	Conserved protein	0.0072	0.1295	0.1214
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.4444	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.1295	0.2914
Echinococcus multilocularis	JmjC domain containing protein 4	0.0015	0.0167	0.0134
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0453	0.0421
Brugia malayi	jmjC domain containing protein	0.0015	0.0167	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0167	0.0253
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.1867	0.4707
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0163	0.3119	0.7984
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0498	0.0466
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.023	0.0197
Echinococcus granulosus	expressed conserved protein	0.0095	0.1756	0.1727
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.1233	0.3049
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.1015	0.7517
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0729	0.1723
Echinococcus granulosus	mitogen activated protein kinase 11	0.0152	0.2899	0.2875
Mycobacterium tuberculosis	Conserved protein	0.0072	0.1295	0.1214
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.1295	0.1265
Echinococcus granulosus	Niemann Pick C1 protein	0.0144	0.2741	0.2716
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.1295	0.1265
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0167	0.0253
Onchocerca volvulus		0.0147	0.2798	0.5875
Mycobacterium tuberculosis	Probable esterase LipL	0.0072	0.1295	0.1214
Schistosoma mansoni	jumonji domain containing protein	0.0015	0.0167	0.0134
Mycobacterium leprae	Probable lipase LipE	0.0072	0.1295	0.5
Mycobacterium tuberculosis	Probable lipase LipE	0.0072	0.1295	0.1214
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0163	0.3119	0.7984
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1295	0.3206
Mycobacterium tuberculosis	Conserved protein	0.0072	0.1295	0.1214
Echinococcus multilocularis	phd:f box containing protein	0.0015	0.0167	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0163	0.3119	0.7982
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0498	0.0466
Echinococcus granulosus	Niemann Pick C1 protein	0.0101	0.1878	0.185
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1295	0.3206
Brugia malayi	jmjC domain containing protein	0.0015	0.0167	0.0259
Mycobacterium tuberculosis	Probable lipase LipD	0.0072	0.1295	0.1214
Brugia malayi	jmjC domain containing protein	0.0015	0.0167	0.0259
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0072	0.1295	0.1214
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0167	0.0253
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.1295	0.1265
Echinococcus granulosus	mitogen activated protein kinase 14	0.0152	0.2899	0.2875
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.023	0.0518
Onchocerca volvulus		0.003	0.0461	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1233	0.3045
Onchocerca volvulus		0.0072	0.1295	0.2109
Schistosoma mansoni	ap endonuclease	0.0018	0.023	0.0197
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0163	0.3119	0.3095
Schistosoma mansoni	cpg binding protein	0.0032	0.0495	0.0462
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0851	0.0819
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.023	0.5
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.023	0.0197
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.1295	0.2914
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.2899	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0419	0.0386
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.389	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1295	0.3206
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.0999	0.0968
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.1295	0.1265
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.023	0.0424
Brugia malayi	Niemann-Pick C1 protein precursor	0.0101	0.1878	0.4735
Schistosoma mansoni	hypothetical protein	0.0032	0.0498	0.0466
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0729	0.164
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0167	0.0253
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.023	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.1033	0.1002
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.1867	0.4704
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.023	0.023
Brugia malayi	beta-lactamase family protein	0.0072	0.1295	0.321
Schistosoma mansoni	inhibitor of apoptosis protein	0.0163	0.3119	0.3095
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0163	0.3119	0.3095
Schistosoma mansoni	cpg binding protein	0.003	0.0461	0.0428
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.1295	0.2914
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.023	0.0518
Schistosoma mansoni	hypothetical protein	0.0508	1	1
Brugia malayi	CXXC zinc finger family protein	0.003	0.0461	0.1028
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0015	0.0167	0.0134
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0453	0.0421
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0152	0.2899	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0072	0.1295	1
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0017	0.0201	0.0168
Mycobacterium ulcerans	esterase/lipase LipP	0.0072	0.1295	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0072	0.1295	0.1214
Onchocerca volvulus		0.0072	0.1295	0.2109
Echinococcus granulosus	lysine specific demethylase 6a	0.0015	0.0167	0.0134
Echinococcus granulosus	jumonji domain containing 1A	0.0015	0.0167	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0167	0.0253
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0163	0.3119	0.3095
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.2899	0.2875
Schistosoma mansoni	hypothetical protein	0.0032	0.0498	0.0466
Brugia malayi	Pre-SET motif family protein	0.0029	0.0453	0.1008
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.1295	1
Schistosoma mansoni	hypothetical protein	0.0042	0.0698	0.0666
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0102	0.1909	0.1881
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0453	0.0421
Schistosoma mansoni	hypothetical protein	0.0069	0.1233	0.1203
Echinococcus granulosus	JmjC domain containing protein 4	0.0015	0.0167	0.0134
Echinococcus granulosus	GPCR family 2	0.0032	0.0498	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1295	0.3206
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0152	0.2899	1
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0152	0.2899	0.7407
Brugia malayi	beta-lactamase family protein	0.0072	0.1295	0.321
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0498	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0147	0.2798	0.7141
Schistosoma mansoni	hypothetical protein	0.0508	1	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.023	0.023
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0461	0.1022
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.1295	0.3206
Loa Loa (eye worm)	hypothetical protein	0.01	0.1867	0.4704
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.1295	0.321
Schistosoma mansoni	phd/f-box containing protein	0.0015	0.0167	0.0134
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0498	0.1126
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0163	0.3119	0.3095
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1878	0.4732
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0923	0.2232
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.2899	1
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.2899	0.2875
Brugia malayi	jmjC domain containing protein	0.0059	0.1033	0.2524
Brugia malayi	jmjC domain containing protein	0.0015	0.0167	0.0259
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0017	0.0201	0.0168
Echinococcus multilocularis	Niemann Pick C1 protein	0.0144	0.2741	0.2716
Onchocerca volvulus		0.0072	0.1295	0.2109
Brugia malayi	beta-lactamase	0.0072	0.1295	0.321
Mycobacterium ulcerans	lipase LipD	0.0072	0.1295	1
Onchocerca volvulus	Deterin homolog	0.0163	0.3119	0.668
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.0999	0.0968
Trichomonas vaginalis	esterase, putative	0.0072	0.1295	0.2914
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0498	0.0466
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0729	0.1723
Schistosoma mansoni	protein phosphatase 2C	0.0015	0.0167	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0498	0.112
Leishmania major	hypothetical protein, conserved	0.0072	0.1295	0.4128
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0498	0.0466
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.1295	0.4128
Brugia malayi	CHE-14 protein	0.0043	0.0729	0.1729
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0729	0.0697
Echinococcus multilocularis	cpg binding protein	0.0032	0.0495	0.0462
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0453	0.0421
Schistosoma mansoni	hypothetical protein	0.0032	0.0498	0.0466
Schistosoma mansoni	cpg binding protein	0.0032	0.0495	0.0462
Loa Loa (eye worm)	beta-lactamase	0.0072	0.1295	0.3206
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.0999	0.0968
Plasmodium vivax	SET domain protein, putative	0.0029	0.0453	0.2537
Schistosoma mansoni	patched 1	0.0043	0.0729	0.0697
Onchocerca volvulus		0.0229	0.4444	1
Echinococcus multilocularis	protein patched	0.0043	0.0729	0.0697
Echinococcus multilocularis	expressed conserved protein	0.0095	0.1756	0.1727
Echinococcus multilocularis	jumonji domain containing 1A	0.0015	0.0167	0.0134
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0458	0.9001	1
Mycobacterium tuberculosis	Probable hydrolase	0.0072	0.1295	0.1214
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0101	0.1878	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.115	0.112
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0167	0.0253
Mycobacterium ulcerans	beta-lactamase	0.0072	0.1295	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0498	0.0466
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.1295	0.4128
Echinococcus multilocularis	geminin	0.0508	1	1
Echinococcus granulosus	phd:f box containing protein	0.0015	0.0167	0.0134
Brugia malayi	P38 map kinase family protein 2	0.0152	0.2899	0.7408
Mycobacterium leprae	conserved hypothetical protein	0.0072	0.1295	0.5
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0453	0.1003
Toxoplasma gondii	exonuclease III APE	0.0018	0.023	0.0558
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0498	0.112
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.023	0.023
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.1033	0.2519
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.023	0.0418
Schistosoma mansoni	hypothetical protein	0.0042	0.0698	0.0666
Schistosoma mansoni	hypothetical protein	0.0042	0.0698	0.0666
Onchocerca volvulus		0.0163	0.3119	0.668
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.1295	0.2914
Echinococcus granulosus	lysine specific demethylase 5A	0.0059	0.1033	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1295	0.3206
Brugia malayi	jmjC domain containing protein	0.0057	0.0999	0.2435
Mycobacterium ulcerans	hypothetical protein	0.0072	0.1295	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0453	0.0421
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.023	0.5
Schistosoma mansoni	hypothetical protein	0.0032	0.0498	0.0466
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.1867	0.4707
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.1295	0.2914
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0453	0.0421
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.023	0.023
Schistosoma mansoni	hypothetical protein	0.0042	0.0698	0.0666
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.2899	0.2875
Echinococcus granulosus	inhibitor of apoptosis protein	0.0163	0.3119	0.3095
Echinococcus multilocularis	lysine specific demethylase 6a	0.0015	0.0167	0.0134
Schistosoma mansoni	phosphatidylserine receptor	0.0015	0.0167	0.0134
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.1033	0.1002
Brugia malayi	hypothetical protein	0.0147	0.2798	0.7143
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0071	0.0036
Schistosoma mansoni	hypothetical protein	0.0163	0.3119	0.3095
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1295	0.3206
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.2899	0.2875
Brugia malayi	Pre-SET motif family protein	0.0202	0.389	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0729	0.0697
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0453	0.0421
Toxoplasma gondii	ABC1 family protein	0.0072	0.1295	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.023	0.0558
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.0999	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0163	0.3119	0.7982
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0071	0.0036
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.023	0.5
Schistosoma mansoni	ap endonuclease	0.0018	0.023	0.0197
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0072	0.1295	0.1214
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0453	0.2537
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.1295	0.4128
Echinococcus multilocularis	Niemann Pick C1 protein	0.0101	0.1878	0.185

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.3 uM	Inhibition of p38a MAPK (unknown origin) by radiometric assay	ChEMBL.	24508134

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3120982

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1830842