Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Histamine H3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Histamine H3 receptor | 445 aa | 384 aa | 22.4 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Histamine H3 receptor | 445 aa | 405 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0044 | 0.5 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.5 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.5 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0044 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0044 | 0.5 | 0.5 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.5 | 0.5 |
Plasmodium vivax | polyprenol reductase, putative | 0.0044 | 0.5 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0044 | 0.5 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.5 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0044 | 0.5 | 0.5 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0044 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.5 | 0.5 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0044 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.5 | 0.5 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0044 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.5 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.5 | 0.5 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.0044 | 0.5 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0044 | 0.5 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0044 | 0.5 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.5 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0044 | 0.5 | 0.5 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0044 | 0.5 | 0.5 | |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0044 | 0.5 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.5 | 0.5 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0044 | 0.5 | 0.5 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.0044 | 0.5 | 0.5 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0044 | 0.5 | 0.5 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.5 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0044 | 0.5 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.5 | 0.5 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0044 | 0.5 | 0.5 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0044 | 0.5 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0044 | 0.5 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0044 | 0.5 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 10 mg kg-1 | In vivo inhibition of brain N-methylhistamine formation in mice when administered perorally in presence of oxalate salt | ChEMBL. | 15163206 |
ED50 (functional) | > 10 mg kg-1 | In vivo inhibition of brain N-methylhistamine formation in mice when administered perorally in presence of oxalate salt | ChEMBL. | 15163206 |
Intrinsic activity (functional) | < 0.1 | In vitro intrinsic activity of the compound against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes with respect to histamine; No detectable agonism | ChEMBL. | 15163206 |
Intrinsic activity (functional) | < 0.1 | In vitro intrinsic activity of the compound against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes with respect to histamine; No detectable agonism | ChEMBL. | 15163206 |
Ki (binding) | = 108 nM | In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes | ChEMBL. | 15163206 |
Ki (binding) | = 108 nM | In vitro inhibitory activity against against histamine H3 receptor using [3H]-Histamine as radioligand from rat cerebral cortex synaptosomes | ChEMBL. | 15163206 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.