Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.004 | 0.0041 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.004 | 0.0041 | 0.5 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.005 | 0.0431 | 0.0522 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0049 | 0.039 | 0.0519 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0154 | 0.4482 | 0.5959 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0163 | 0.4848 | 0.6445 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0153 | 0.4464 | 0.5935 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0153 | 0.4464 | 0.5912 |
Brugia malayi | AMP-binding enzyme family protein | 0.0148 | 0.4266 | 0.4242 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0163 | 0.4848 | 0.6229 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0122 | 0.3256 | 0.3984 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0232 | 0.7522 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0122 | 0.3256 | 0.4298 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.008 | 0.1614 | 0.3272 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0153 | 0.4464 | 0.5912 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0153 | 0.4464 | 0.4441 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0153 | 0.4464 | 0.5688 |
Onchocerca volvulus | 0.0276 | 0.925 | 0.9285 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.012 | 0.2522 |
Giardia lamblia | Methyltransferase like 2 | 0.0048 | 0.0352 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0048 | 0.0352 | 0.0468 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0153 | 0.4464 | 0.5912 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0153 | 0.4464 | 0.5688 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0286 | 0.9634 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0232 | 0.7522 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.005 | 0.0431 | 0.0574 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.8668 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0352 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0163 | 0.4848 | 0.6426 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0163 | 0.4848 | 0.6229 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0114 | 0.2931 | 0.3896 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0132 | 0.3641 | 0.4841 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0154 | 0.4482 | 0.5959 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.039 | 0.035 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0113 | 0.289 | 0.5927 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0124 | 0.3337 | 0.4437 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0048 | 0.0352 | 0.0312 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.004 | 0.0041 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0153 | 0.4464 | 0.5935 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0122 | 0.3256 | 0.4298 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.01 | 0.237 | 0.2734 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0232 | 0.7522 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0064 | 0.099 | 0.1316 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.01 | 0.237 | 0.3113 |
Schistosoma mansoni | methyltransferase-related | 0.0048 | 0.0352 | 1 |
Loa Loa (eye worm) | acyl carrier protein | 0.0073 | 0.1332 | 0.1497 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0163 | 0.4848 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0153 | 0.4464 | 0.5912 |
Mycobacterium tuberculosis | Conserved protein | 0.0048 | 0.0352 | 0.0468 |
Mycobacterium ulcerans | thioesterase | 0.0132 | 0.3641 | 0.4813 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.004 | 0.0041 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1745 | 0.1976 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0163 | 0.4848 | 0.6426 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0153 | 0.4464 | 0.5935 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0163 | 0.4848 | 0.6445 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0232 | 0.7522 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0157 | 0.459 | 0.5273 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0049 | 0.039 | 0.0467 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.004 | 0.0041 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.012 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.012 | 0.2522 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0148 | 0.4266 | 0.4897 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.012 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0153 | 0.4464 | 0.5912 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.004 | 0.0041 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0132 | 0.3641 | 0.4527 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.004 | 0.0041 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0042 | 0.012 | 0.0091 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.01 | 0.237 | 0.3113 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.012 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0049 | 0.0407 | 0.0541 |
Leishmania major | hypothetical protein, conserved | 0.0048 | 0.0352 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0148 | 0.4266 | 0.5671 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0042 | 0.012 | 0.0079 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0163 | 0.4848 | 0.6229 |
Mycobacterium ulcerans | thioesterase TesA | 0.0132 | 0.3641 | 0.4813 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.012 | 0.2522 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.012 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0163 | 0.4848 | 0.6445 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0103 | 0.25 | 0.5115 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0163 | 0.4848 | 0.6426 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.009 | 0.2004 | 0.2665 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | > 1000 mg kg-1 | Acute toxicity in po dosed Mus musculus ICR (mouse) assessed as mortality measured after 14 days | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.