Detailed information for compound 1840826

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 540.522 | Formula: C26H28N4O9
  • H donors: 2 H acceptors: 5 LogP: 3.8 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)C1=C(C)NC(=C(C1c1ccc(cc1)OCC(=O)N/N=C/c1ccc(o1)[N+](=O)[O-])C(=O)OCC)C
  • InChi: 1S/C26H28N4O9/c1-5-36-25(32)22-15(3)28-16(4)23(26(33)37-6-2)24(22)17-7-9-18(10-8-17)38-14-20(31)29-27-13-19-11-12-21(39-19)30(34)35/h7-13,24,28H,5-6,14H2,1-4H3,(H,29,31)/b27-13+
  • InChiKey: JLCUROAUCKKTET-UVHMKAGCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major basic transcription factor 3a, putative 0.0037 0.0028 0.3061
Brugia malayi heat shock protein 90 0.0036 0.0027 0.0027
Treponema pallidum heat shock protein 90 0.0028 0.002 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0028 0.3117
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0007 0.0001 0.0001
Schistosoma mansoni ferritin light chain 0.0009 0.0002 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0069
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Toxoplasma gondii heat shock protein 75, putative 0.0015 0.0008 0.1402
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.009 1
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0007 0.0001 0.0082
Trypanosoma cruzi heat shock protein, putative 0.0015 0.0008 0.0838
Leishmania major heat shock protein, putative 0.0015 0.0008 0.0763
Echinococcus multilocularis expressed protein 0.0009 0.0002 0.0002
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0014 0.1585
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0001 0.0069
Plasmodium vivax heat shock protein 90, putative 0.0015 0.0008 0.2492
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0001 0.0001
Echinococcus multilocularis cpg binding protein 0.0033 0.0025 0.0025
Trypanosoma brucei heat shock protein, putative 0.0036 0.0027 0.2947
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0004 0.0004
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0002 0.0002
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0007 0.0001 0.0082
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0004 0.0004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0004 0.0004
Echinococcus granulosus dnaJ subfamily B 0.0449 0.0409 0.0409
Schistosoma mansoni heat shock protein 0.0036 0.0027 0.0027
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0007 0.0001 0.0001
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0004 0.0004
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0015 0.0008 0.0008
Plasmodium falciparum heat shock protein 90, putative 0.0015 0.0008 0.2492
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0004 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.009 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Brugia malayi Fli-1 protein 0.0225 0.0201 0.0201
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0002 0.0002
Echinococcus granulosus heat shock protein 90 0.0028 0.002 0.002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0004 0.0004
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0002 0.0781
Brugia malayi hypothetical protein 0.0009 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0004 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0004 0.0004
Chlamydia trachomatis DNA gyrase subunit B 0.0007 0.0001 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0004 0.0004
Toxoplasma gondii hypothetical protein 0.0009 0.0002 0.0346
Plasmodium falciparum heat shock protein 90, putative 0.0015 0.0008 0.2492
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0004 0.0004
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0015 0.0008 0.0838
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0027 0.2947
Trichomonas vaginalis helicase, putative 0.0007 0.0001 0.0069
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0004 0.0004
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0004 0.0004
Toxoplasma gondii Hsp90 domain-containing protein 0.0015 0.0008 0.1402
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0004 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0004 0.0004
Schistosoma mansoni dishevelled 0.0009 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0002 0.0002
Echinococcus granulosus cpg binding protein 0.0033 0.0025 0.0025
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Trichomonas vaginalis ferritin, putative 0.0009 0.0002 0.0251
Brugia malayi ecdysteroid receptor 0.0011 0.0004 0.0004
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0027 0.3004
Schistosoma mansoni coup transcription factor 0.0011 0.0004 0.0004
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0002 0.0002
Echinococcus multilocularis heat shock protein 0.0036 0.0027 0.0027
Toxoplasma gondii heat shock protein HSP90 0.0036 0.0027 0.5416
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.009 1
Schistosoma mansoni cpg binding protein 0.0033 0.0025 0.0025
Echinococcus multilocularis muscleblind protein 0.0157 0.0139 0.0139
Trypanosoma brucei heat shock protein, putative 0.0036 0.0027 0.2947
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0004 0.0004
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0041 0.4614
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.009 0.009
Trichomonas vaginalis sensor histidine kinase, putative 0.0007 0.0001 0.0082
Schistosoma mansoni ets-related 0.0225 0.0201 0.0201
Brugia malayi nuclear receptor NHR-88 0.0011 0.0004 0.0004
Toxoplasma gondii heat shock protein 90, putative 0.0036 0.0027 0.5416
Plasmodium vivax heat shock protein 86, putative 0.0036 0.0027 0.9627
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0007 0.0001 0.0082
Schistosoma mansoni kinase 0.0053 0.0043 0.0043
Schistosoma mansoni ferritin 0.0009 0.0002 0.0002
Echinococcus granulosus protein C ets 2 0.0011 0.0004 0.0004
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0002 0.0146
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0027 0.3004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0004 0.0004
Trypanosoma brucei heat shock protein, putative 0.0036 0.0027 0.2947
Echinococcus multilocularis heat shock protein 90 0.0028 0.002 0.002
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0004 0.0004
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0004 0.0004
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0002 0.0002
Schistosoma mansoni ferritin 0.0009 0.0002 0.0002
Brugia malayi Ets-domain containing protein 0.0074 0.0062 0.0062
Schistosoma mansoni endoplasmin 0.0036 0.0027 0.0027
Echinococcus multilocularis ferritin 0.0009 0.0002 0.0002
Trypanosoma brucei heat shock protein, putative 0.0036 0.0027 0.2947
Schistosoma mansoni ferritin 0.0009 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0001 0.0069
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0004 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0069
Plasmodium falciparum heat shock protein 90 0.0036 0.0027 0.9627
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0049 1
Giardia lamblia Grp94/Hsp90 0.0028 0.002 0.2193
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0004 0.0004
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.002 0.2257
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.009 0.5461
Brugia malayi Ets-domain containing protein 0.0074 0.0062 0.0062
Echinococcus granulosus ferritin 0.0009 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0004 0.0004
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0007 0.0001 0.0001
Trichomonas vaginalis heat shock protein, putative 0.0015 0.0008 0.0838
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0004 0.0004
Trypanosoma brucei heat shock protein, putative 0.0036 0.0027 0.2947
Echinococcus granulosus endoplasmin 0.0028 0.002 0.002
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0004 0.0004
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.002 0.2193
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0004 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0069
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0028 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0001
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0184 0.0164 1
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0015 0.0008 0.0008
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0004 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0004 0.0004
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0027 0.3004
Trichomonas vaginalis heat shock protein, putative 0.0028 0.002 0.2257
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.002 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0028 0.3117
Brugia malayi DIX domain containing protein 0.0009 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.009 1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0002 0.0781
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.009 0.009
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0004 0.0004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0028 0.3117
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.009 0.009
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0004 0.0234
Mycobacterium ulcerans heat shock protein 90 0.0028 0.002 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0002 0.0002
Echinococcus multilocularis muscleblind protein 1 0.0157 0.0139 0.0139
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0028 0.3117
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Brugia malayi Muscleblind-like protein 0.0157 0.0139 0.0139
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0002 0.0781
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0028 0.3117
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0001 0.0069
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0004 0.0004
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0007 0.0001 0.0001
Schistosoma mansoni dishevelled 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.009 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0007 0.0001 0.0082
Schistosoma mansoni apoferritin-2 0.0009 0.0002 0.0002
Trichomonas vaginalis DNA topoisomerase II, putative 0.0007 0.0001 0.0082
Trichomonas vaginalis receptor histidine kinase, putative 0.0007 0.0001 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0069
Trypanosoma cruzi DNA topoisomerase II, putative 0.0007 0.0001 0.0082
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0013 0.15
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0004 0.0004
Echinococcus granulosus alpha 16 mannosyl glycoprotein 1.0829 1 1
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0002 0.0002
Brugia malayi steroid hormone receptor 0.0011 0.0004 0.0004
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0007 0.0001 0.0082
Echinococcus multilocularis dnaJ subfamily B 0.0449 0.0409 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0001 0.0069
Echinococcus multilocularis endoplasmin 0.0028 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0001 0.0069
Trypanosoma cruzi DNA topoisomerase II, putative 0.0007 0.0001 0.0082
Echinococcus multilocularis geminin 0.0364 0.033 0.033
Schistosoma mansoni cpg binding protein 0.0033 0.0025 0.0025
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0003 0.0003
Plasmodium falciparum endoplasmin, putative 0.0022 0.0014 0.4954
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0069
Trypanosoma cruzi Heat shock protein 83, putative 0.0036 0.0027 0.3004
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0002 0.0002
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0028 0.3117
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.009 1
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0028 1
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0004 0.0004
Schistosoma mansoni ferritin light chain 0.0009 0.0002 0.0002
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0062 0.0062
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0364 0.033 0.033
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.009 1
Schistosoma mansoni endoplasmin 0.0036 0.0027 0.0027
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Trichomonas vaginalis heat shock protein, putative 0.0028 0.002 0.2257
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0027 0.3004
Brugia malayi Endoplasmin precursor 0.0036 0.0027 0.0027
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0001 0.0001
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0028 0.3061
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0007 0.0001 0.0001
Brugia malayi Probable DNA topoisomerase II 0.0007 0.0001 0.0001
Schistosoma mansoni pyruvate dehydrogenase 0.0007 0.0001 0.0001
Giardia lamblia Heat shock protein HSP 90-alpha 0.0036 0.0027 0.2947
Onchocerca volvulus 0.0011 0.0004 0.0234
Schistosoma mansoni dep domain containing protein 0.0009 0.0002 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0004 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0004 0.0004
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0007 0.0001 0.0045
Loa Loa (eye worm) heat shock protein 90 0.0036 0.0027 0.0027
Schistosoma mansoni ferritin 0.0009 0.0002 0.0002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0004 0.0004
Echinococcus granulosus heat shock protein 90 0.0036 0.0027 0.0027
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0004 0.0234
Loa Loa (eye worm) hypothetical protein 1.0829 1 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0007 0.0001 0.0001
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.009 0.009
Entamoeba histolytica DNA topoisomerase II, putative 0.0007 0.0001 0.0082
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0003 0.0003
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0007 0.0001 0.0082
Schistosoma mansoni transcription factor btf3 0.0037 0.0028 0.0028
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0004 0.0004
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0002 0.0002
Trypanosoma brucei polo-like protein kinase 0.0104 0.009 1
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0002 0.0781
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0001 0.0069
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0056 0.0056
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0004 0.0004
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0002 0.0002
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0007 0.0001 0.0082
Brugia malayi transcription factor E74 isoform 0.0011 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.002 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Brugia malayi N-terminal motif family protein 0.0184 0.0164 0.0164
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0004 0.0004
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0062 0.0062
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Echinococcus granulosus muscleblind protein 0.0157 0.0139 0.0139
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.0027 0.3004
Entamoeba histolytica hypothetical protein 0.0037 0.0028 0.3117
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0041 0.4614
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0004 0.0004
Chlamydia trachomatis DNA gyrase subunit B 0.0007 0.0001 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0004 0.0004
Brugia malayi beta-NAC-like protein 0.0037 0.0028 0.0028
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0002 0.0002
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0002 0.0781
Trypanosoma brucei heat shock protein 84, putative 0.0015 0.0008 0.0763
Schistosoma mansoni DNA topoisomerase II 0.0007 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0001 0.0069
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Brugia malayi CXXC zinc finger family protein 0.0032 0.0023 0.0023
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0004 0.0004
Trypanosoma brucei heat shock protein, putative 0.0036 0.0027 0.2947
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 1.0829 1 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0007 0.0001 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.0052 0.0052
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0002 0.0002
Brugia malayi Ets-domain containing protein 0.0011 0.0004 0.0004
Loa Loa (eye worm) histone methyltransferase 0.001 0.0003 0.0003
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0028 0.5626
Brugia malayi hypothetical protein 0.0009 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0004 0.0004
Loa Loa (eye worm) fli-1 protein 0.0225 0.0201 0.0201
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0007 0.0001 0.0082
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0004 0.0004
Loa Loa (eye worm) heat shock protein 75 0.0015 0.0008 0.0008
Schistosoma mansoni apoferritin-2 0.0009 0.0002 0.0002
Echinococcus granulosus expressed protein 0.0009 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0449 0.0409 0.0409
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0007 0.0001 0.0045
Loa Loa (eye worm) endoplasmin 0.0036 0.0027 0.0027
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0004 0.0004
Brugia malayi Hsp90 protein 0.0015 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0001 0.0069
Plasmodium vivax endoplasmin, putative 0.0036 0.0027 0.9627
Trypanosoma brucei heat shock protein, putative 0.0036 0.0027 0.2947
Schistosoma mansoni hypothetical protein 0.0364 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0184 0.0164 0.0164
Schistosoma mansoni heat shock protein 0.0036 0.0027 0.0027
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0027 0.2947
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0004 0.0234
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0001 0.0069
Loa Loa (eye worm) TOPoisomerase family member 0.0007 0.0001 0.0001
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0007 0.0001 0.0082
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.002 0.2193
Giardia lamblia Kinase, PLK 0.0104 0.009 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.0139 0.0139
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0002 0.0002
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0004 0.0004
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0002 0.0781
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0002 0.0781
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.009 0.009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0004 0.0004
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0004 0.0004
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0027 0.3004
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Echinococcus multilocularis heat shock protein 90 0.0036 0.0027 0.0027
Echinococcus multilocularis ets variant gene 4 0.0011 0.0004 0.0004
Brugia malayi kinase, mitochondrial precursor 0.0007 0.0001 0.0001
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0004 0.0004
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0015 0.0008 0.0458
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0004 0.0004
Plasmodium vivax heat shock protein, putative 0.0015 0.0008 0.2492
Loa Loa (eye worm) hypothetical protein 0.0157 0.0139 0.0139
Echinococcus granulosus transcription factor btf3 0.0037 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0001 0.0069
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0014 0.1585
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0004 0.0004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0001
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0027 0.3004
Schistosoma mansoni ets 0.0011 0.0004 0.0004
Echinococcus multilocularis transcription factor btf3 0.0037 0.0028 0.0028
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.002 0.002
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.009 1
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Onchocerca volvulus 0.0009 0.0002 0.0146
Echinococcus multilocularis protein C ets 2 0.0011 0.0004 0.0004
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0002 0.0002
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0004 0.0004
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0004 0.0004
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0004 0.0004
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0007 0.0001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.0032 0.0023 0.0023
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0002 0.0002
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0002 0.0002
Trichomonas vaginalis heat shock protein, putative 0.0028 0.002 0.2257
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.009 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0004 0.0004
Trypanosoma brucei heat shock protein, putative 0.0036 0.0027 0.2947
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0001 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.009 1
Echinococcus granulosus geminin 0.0364 0.033 0.033
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0004 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0069
Schistosoma mansoni gabp alpha 0.0074 0.0062 0.0062
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0023 0.0023
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0004 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0004 0.0004
Echinococcus granulosus heat shock protein 0.0036 0.0027 0.0027
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 1.0829 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0004 0.0004
Schistosoma mansoni heat shock protein 0.0015 0.0008 0.0008
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0062 0.0062
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Brugia malayi nuclear hormone receptor 0.0011 0.0004 0.0004
Schistosoma mansoni ets-related 0.0011 0.0004 0.0004
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.002 0.2257
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0007 0.0001 0.0001
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0028 0.002 1
Schistosoma mansoni elf1 0.0011 0.0004 0.0004
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0007 0.0001 0.0082
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.009 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0004 0.0004
Onchocerca volvulus 0.0032 0.0023 0.1407
Trypanosoma brucei Heat shock protein 83, putative 0.0036 0.0027 0.2947
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0004 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0003 0.0003
Leishmania major heat shock protein 83-1 0.0036 0.0027 0.2947

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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