TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 435.474 | Formula: C17H15F2N7OS2
H donors: 2 H acceptors: 6 LogP: 2.95 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1csc(n1)C(c1nnc(s1)Nc1ncn(n1)Cc1c(F)cccc1F)(O)C
InChi: 1S/C17H15F2N7OS2/c1-9-7-28-13(21-9)17(2,27)14-23-24-16(29-14)22-15-20-8-26(25-15)6-10-11(18)4-3-5-12(10)19/h3-5,7-8,27H,6H2,1-2H3,(H,22,24,25)
InChiKey: CHHHEJNQMGBWRA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	Get druggable targets OG5_130466	All targets in OG5_130466
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium berghei	enoyl-acyl carrier reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Trichomonas vaginalis	hypothetical protein	Get druggable targets OG5_130466	All targets in OG5_130466
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	Get druggable targets OG5_130466	All targets in OG5_130466
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium falciparum	enoyl-acyl carrier reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Neospora caninum	enoyl-acyl carrier reductase, putative	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium vivax	enoyl-acyl carrier protein reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium knowlesi	enoyl-acyl carrier reductase, putative	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium yoelii	enoyl-acyl carrier reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	Get druggable targets OG5_130466	All targets in OG5_130466

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0015	0.0221	0.023
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0223	0.4668	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0221	0.023
Onchocerca volvulus		0.0015	0.0221	0.2812
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0015	0.0221	0.3653
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0015	0.0221	0.0379
Loa Loa (eye worm)	hypothetical protein	0.002	0.0336	0.0404
Trypanosoma brucei	pteridine reductase 1	0.0015	0.0221	1
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0336	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0221	0.023
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0221	0.023
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0015	0.0221	0.023
Mycobacterium ulcerans	oxidoreductase	0.0015	0.0221	0.023
Loa Loa (eye worm)	hypothetical protein	0.002	0.0336	0.0404
Mycobacterium tuberculosis	Possible oxidoreductase	0.0015	0.0221	0.0379
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0074	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0484	0.0629
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0015	0.0221	0.0329
Onchocerca volvulus		0.0027	0.0484	0.7697
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0221	0.023
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0484	0.0629
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0015	0.0221	0.0329
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0223	0.4668	0.6988
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0074	0.0004
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0484	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0015	0.0221	0.023
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0008	0.007	0.0052
Schistosoma mansoni	dihydropteridine reductase	0.0015	0.0221	0.0221
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.007	0.0052
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0484	0.0947
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0015	0.0221	0.023
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0221	0.023
Loa Loa (eye worm)	hypothetical protein	0.002	0.0336	0.0404
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.0015	0.0221	0.0329
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0336	0.0578
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0008	0.007	0.0052
Echinococcus granulosus	cpg binding protein	0.0035	0.0648	0.0582
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0118	0.0048
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0015	0.0221	0.3653
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0008	0.007	0.0052
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0484	0.0629
Leishmania major	oxidoreductase-like protein	0.0015	0.0221	0.3653
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0221	0.023
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0115	0.0068
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0484	0.0629
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0015	0.0221	0.023
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0015	0.0221	0.3653
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.007	0.0052
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.007	0.0017
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0015	0.0221	0.0152
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0221	0.023
Trichomonas vaginalis	glutaminase, putative	0.0316	0.665	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0608	0.0608
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0221	0.023
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0015	0.0221	0.023
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0221	0.023
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0221	0.0379
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0008	0.007	0.0052
Leishmania major	pteridine reductase 1	0.0015	0.0221	0.3653
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0221	0.023
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0484	0.0629
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0221	0.023
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0484	0.0629
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0015	0.0221	0.023
Schistosoma mansoni	hypothetical protein	0.0473	1	1
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0223	0.4668	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0484	0.0629
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.007	0.0052
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0015	0.0221	0.0379
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0015	0.0221	1
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0015	0.0221	0.0152
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0484	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0484	1
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0015	0.0221	0.0329
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0008	0.007	0.0052
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0221	0.023
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0312	0.0575
Echinococcus multilocularis	dnaJ subfamily B	0.0473	1	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.007	0.0052
Mycobacterium tuberculosis	Probable oxidoreductase	0.0015	0.0221	0.0379
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0015	0.0221	0.023
Loa Loa (eye worm)	hypothetical protein	0.002	0.0336	0.0404
Loa Loa (eye worm)	glutaminase 2	0.0316	0.665	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0484	0.09
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0008	0.007	0.0052
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.007	0.0017
Echinococcus multilocularis	cpg binding protein	0.0035	0.0648	0.0582
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0015	0.0221	0.023
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0312	0.0575
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0015	0.0221	0.0329
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0484	0.0629
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0484	0.0629
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0223	0.4668	1
Trypanosoma brucei	oxidoreductase-like protein	0.0015	0.0221	1
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0223	0.4668	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0484	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0015	0.0221	0.023
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0484	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0484	1
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0015	0.0221	0.0379
Mycobacterium tuberculosis	Possible oxidoreductase	0.0015	0.0221	0.0379
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0221	0.0379
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0608	0.0817
Schistosoma mansoni	glutaminase	0.0316	0.665	0.665
Schistosoma mansoni	cpg binding protein	0.0035	0.0648	0.0648
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0221	0.023
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.1242	0.2549
Trichomonas vaginalis	hypothetical protein	0.0223	0.4668	0.6994
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0015	0.0221	0.023
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0312	0.0575
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0484	0.0947
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0015	0.0221	0.023
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0015	0.0221	0.023
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0074	0.0004
Mycobacterium ulcerans	glutaminase	0.0316	0.665	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0015	0.0221	0.023
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0223	0.4668	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0221	0.023
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0118	0.0048
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0608	0.0817
Schistosoma mansoni	cpg binding protein	0.0035	0.0648	0.0648
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0221	0.023
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0015	0.0221	0.0329
Onchocerca volvulus		0.0015	0.0221	0.2812
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0015	0.0221	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0015	0.0221	0.023
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.1403	0.1403
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0336	0.0257
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0015	0.0221	1
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0223	0.4668	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0015	0.0221	0.023
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0015	0.0221	1
Schistosoma mansoni	acetyl-CoA synthetase	0.0008	0.007	0.007
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0484	0.0629
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.0015	0.0221	0.0329
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0008	0.007	0.0052
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0118	0.0072
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0015	0.0221	0.023
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0015	0.0221	0.023
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0312	0.0575
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.0336	0.0404
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0484	0.09
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0015	0.0221	0.023
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0015	0.0221	0.0379
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0484	0.0629
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0015	0.0221	0.0221
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0074	0.0074
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0074	0.0004
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0336	0.0626
Brugia malayi	glutaminase DH11.1	0.0316	0.665	1
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0484	0.0629
Onchocerca volvulus		0.0033	0.0608	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0221	0.023
Loa Loa (eye worm)	glutaminase	0.0316	0.665	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0484	0.0629
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0223	0.4668	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0484	0.0629
Loa Loa (eye worm)	hypothetical protein	0.002	0.0336	0.0404
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0015	0.0221	0.3653

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.03 uM	Inhibition of Mycobacterium tuberculosis full length inhA expressed in Escherichia coli BL21 preincubated for 15 mins by fluorescence based assay in presence of NADH	ChEMBL.	24107081
IC50 (ADMET)	= 48 uM	Inhibition of CYP3A4 (unknown origin)	ChEMBL.	24107081
Inhibition (binding)	= 63 %	Inhibition of adenosine A1 receptor (unknown origin) at 30 uM	ChEMBL.	24107081
Inhibition (binding)	= 70 %	Inhibition of adenosine A3 receptor (unknown origin) at 30 uM	ChEMBL.	24107081
MIC (functional)	= 0.391 uM	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as parasite growth inhibition after 7 days by Alamar Blue assay	ChEMBL.	24107081
MIC (functional)	> 25 uM	Antitubercular activity against Mycobacterium tuberculosis H37Rv expressing inhA G96V mutant assessed as parasite growth inhibition after 7 days by Alamar Blue assay	ChEMBL.	24107081
MIC (functional)	> 25 uM	Antitubercular activity against Mycobacterium tuberculosis H37Rv expressing inhA M103I mutant assessed as parasite growth inhibition after 7 days by Alamar Blue assay	ChEMBL.	24107081
MIC (functional)	> 25 uM	Antitubercular activity against Mycobacterium tuberculosis H37Rv expressing inhA M103L mutant assessed as parasite growth inhibition after 7 days by Alamar Blue assay	ChEMBL.	24107081
MIC (ADMET)	> 100 uM	Cytotoxicity against human A549 cells assessed as growth inhibition after 7 days by Alamar Blue assay	ChEMBL.	24107081

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3088175

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1840851