Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain containing 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0476 | 0.1455 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0476 | 0.1455 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0476 | 0.1455 | 0.1342 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0476 | 0.1455 | 0.1342 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0476 | 0.1455 | 0.1342 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0476 | 0.1455 | 0.5 |
Brugia malayi | FXNA | 0.0476 | 0.1455 | 0.1342 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0476 | 0.1455 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.1455 | 0.1342 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0053 | 0.0019 | 0.0133 |
Leishmania major | glutaminyl cyclase, putative | 0.0476 | 0.1455 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.1455 | 0.1342 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0476 | 0.1455 | 0.1342 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0476 | 0.1455 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0019 | 0.0133 |
Mycobacterium tuberculosis | Conserved protein | 0.0476 | 0.1455 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2993 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0086 | 0.013 | 0.0895 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0476 | 0.1455 | 0.5 |
Brugia malayi | nicalin | 0.0476 | 0.1455 | 0.1342 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0476 | 0.1455 | 0.1342 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.2993 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0086 | 0.013 | 0.0895 |
Leishmania major | hypothetical protein, conserved | 0.0476 | 0.1455 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0476 | 0.1455 | 0.5 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0053 | 0.0019 | 0.0133 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0053 | 0.0019 | 0.0133 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0476 | 0.1455 | 0.1342 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.2993 | 1 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0476 | 0.1455 | 0.1342 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.1455 | 0.1342 |
Brugia malayi | leucyl aminopeptidase | 0.0476 | 0.1455 | 0.1342 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0476 | 0.1455 | 0.1342 |
Schistosoma mansoni | nicalin (M28 family) | 0.0476 | 0.1455 | 0.1342 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0476 | 0.1455 | 1 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0476 | 0.1455 | 0.1342 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.1455 | 0.1342 |
Mycobacterium ulcerans | hypothetical protein | 0.0476 | 0.1455 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0053 | 0.0019 | 0.0133 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0476 | 0.1455 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.2993 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0476 | 0.1455 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.2993 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0476 | 0.1455 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.7 | Inhibition of BRD4 bromodomain-1 (unknown origin) by AlphaScreen assay | ChEMBL. | 26682033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.