Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Torpedo californica | Acetylcholinesterase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Acetylcholinesterase | 586 aa | 564 aa | 29.4 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 586 aa | 602 aa | 24.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 586 aa | 546 aa | 29.3 % |
Onchocerca volvulus | Acetylcholinesterase | 586 aa | 562 aa | 25.1 % | |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 586 aa | 487 aa | 23.0 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 586 aa | 480 aa | 24.6 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 586 aa | 552 aa | 37.7 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 586 aa | 535 aa | 31.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 586 aa | 588 aa | 28.1 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 586 aa | 643 aa | 32.2 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 586 aa | 551 aa | 40.7 % |
Onchocerca volvulus | Acetylcholinesterase | 586 aa | 612 aa | 25.5 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 586 aa | 648 aa | 32.6 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Acetylcholinesterase | 586 aa | 577 aa | 33.6 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 586 aa | 509 aa | 24.8 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 586 aa | 592 aa | 28.0 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 586 aa | 571 aa | 25.0 % |
Schistosoma mansoni | gliotactin | Acetylcholinesterase | 586 aa | 474 aa | 31.6 % |
Echinococcus granulosus | neuroligin | Acetylcholinesterase | 586 aa | 493 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0432 | 0.2082 | 0.2082 |
Schistosoma mansoni | hypothetical protein | 0.0429 | 0.2053 | 0.2053 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0432 | 0.2082 | 0.2082 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0432 | 0.2082 | 0.343 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0432 | 0.2082 | 0.343 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0432 | 0.2082 | 0.2082 |
Echinococcus granulosus | calcium activated potassium channel | 0.0432 | 0.2082 | 0.343 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.0867 | 0.6071 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.1295 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0429 | 0.2053 | 0.2053 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0432 | 0.2082 | 0.343 |
Brugia malayi | Kinase associated domain 1 family protein | 0.0429 | 0.2053 | 0.2053 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1295 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.1295 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0432 | 0.2082 | 0.2082 |
Echinococcus multilocularis | hypothetical protein | 0.0429 | 0.2053 | 0.3381 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0432 | 0.2082 | 0.343 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0432 | 0.2082 | 0.2082 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0432 | 0.2082 | 0.343 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.0867 | 0.6071 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0429 | 0.2053 | 0.2053 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.67 nM | Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate assessed as ROS-induced enzyme inactivation preincubated for 10 mins followed by substrate addition measured every 30 secs for 20 mins in presence of horseradish peroxidase and H2O2 | ChEMBL. | No reference |
IC50 (binding) | = 80.1 nM | Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate preincubated for 10 mins followed by substrate addition measured every 30 secs for 30 mins by Ellmans method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.