Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.078 | 0.1134 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0203 | 0.078 | 0.0617 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.0174 | 0.5 |
Echinococcus multilocularis | ribonuclease H1 | 0.0139 | 0.0417 | 0.0362 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0174 | 0.0253 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0203 | 0.078 | 0.0904 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0203 | 0.078 | 1 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0203 | 0.078 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0203 | 0.078 | 1 |
Brugia malayi | nicalin | 0.0203 | 0.078 | 0.0904 |
Schistosoma mansoni | phosphoglucomutase | 0.0139 | 0.0417 | 0.0362 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.1273 | 0.6879 | 1 |
Giardia lamblia | Ribonuclease H | 0.0139 | 0.0417 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0203 | 0.078 | 1 |
Echinococcus granulosus | ribonuclease H1 | 0.0139 | 0.0417 | 0.0362 |
Toxoplasma gondii | ribonuclease HI protein | 0.0139 | 0.0417 | 0.4 |
Leishmania major | ribonuclease H1, putative | 0.0139 | 0.0417 | 0.4 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0203 | 0.078 | 0.0904 |
Brugia malayi | RNase H family protein | 0.0139 | 0.0417 | 0.0362 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0203 | 0.078 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.0174 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0203 | 0.078 | 0.0904 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0151 | 0.0484 | 0.0315 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0151 | 0.0484 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.078 | 0.1134 |
Brugia malayi | RNase H family protein | 0.0139 | 0.0417 | 0.0362 |
Toxoplasma gondii | hypothetical protein | 0.0203 | 0.078 | 1 |
Brugia malayi | Peptidase family M28 containing protein | 0.1273 | 0.6879 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0203 | 0.078 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0139 | 0.0417 | 0.4 |
Brugia malayi | RNase H family protein | 0.0139 | 0.0417 | 0.0362 |
Mycobacterium ulcerans | hypothetical protein | 0.0203 | 0.078 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0203 | 0.078 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0203 | 0.078 | 0.0904 |
Onchocerca volvulus | 0.0203 | 0.078 | 0.0904 | |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0174 | 0.0253 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0203 | 0.078 | 0.0904 |
Leishmania major | glutaminyl cyclase, putative | 0.0203 | 0.078 | 1 |
Trypanosoma brucei | unspecified product | 0.0151 | 0.0484 | 0.0315 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0203 | 0.078 | 0.1134 |
Schistosoma mansoni | nicalin (M28 family) | 0.0203 | 0.078 | 0.0904 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.078 | 0.1134 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0139 | 0.0417 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0203 | 0.078 | 0.0904 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0203 | 0.078 | 0.0904 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0578 | 0.292 | 0.4095 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0139 | 0.0417 | 0.0362 |
Brugia malayi | leucyl aminopeptidase | 0.0203 | 0.078 | 0.0904 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.0174 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0139 | 0.0417 | 0.4 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0151 | 0.0484 | 0.0315 |
Trypanosoma brucei | ribonuclease H1 | 0.0139 | 0.0417 | 0.0247 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.0578 | 0.292 | 0.4095 |
Loa Loa (eye worm) | hypothetical protein | 0.1273 | 0.6879 | 1 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0139 | 0.0417 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.1273 | 0.6879 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.0174 | 0.0253 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0151 | 0.0484 | 0.0315 |
Schistosoma mansoni | hypothetical protein | 0.052 | 0.259 | 0.3603 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0203 | 0.078 | 0.0904 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0203 | 0.078 | 0.0904 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.078 | 0.1134 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0203 | 0.078 | 1 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.1273 | 0.6879 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0203 | 0.078 | 0.5 |
Schistosoma mansoni | phosphoglucomutase | 0.0139 | 0.0417 | 0.0362 |
Brugia malayi | FXNA | 0.0203 | 0.078 | 0.0904 |
Schistosoma mansoni | phosphoglucomutase | 0.0139 | 0.0417 | 0.0362 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.0174 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0203 | 0.078 | 0.0904 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.1273 | 0.6879 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0203 | 0.078 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0203 | 0.078 | 0.0904 |
Mycobacterium tuberculosis | Conserved protein | 0.0203 | 0.078 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.17 uM | Activation of recombinant human His6-tagged glucokinase by G6PDH-coupled spectrophotometry | ChEMBL. | No reference |
max activation (binding) | = 1.3 | Activation of recombinant human His6-tagged glucokinase by G6PDH-coupled spectrophotometry relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.