Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0203 | 0.078 | 0.5 |
Onchocerca volvulus | 0.0203 | 0.078 | 0.0904 | |
Onchocerca volvulus | Fxna peptidase homolog | 0.0203 | 0.078 | 0.0904 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0203 | 0.078 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0203 | 0.078 | 1 |
Brugia malayi | RNase H family protein | 0.0139 | 0.0417 | 0.0362 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0139 | 0.0417 | 0.4 |
Toxoplasma gondii | hypothetical protein | 0.0203 | 0.078 | 1 |
Brugia malayi | Peptidase family M28 containing protein | 0.1273 | 0.6879 | 1 |
Brugia malayi | RNase H family protein | 0.0139 | 0.0417 | 0.0362 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0151 | 0.0484 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.078 | 0.1134 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.0174 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0151 | 0.0484 | 0.0315 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0203 | 0.078 | 0.0904 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0203 | 0.078 | 1 |
Brugia malayi | RNase H family protein | 0.0139 | 0.0417 | 0.0362 |
Leishmania major | ribonuclease H1, putative | 0.0139 | 0.0417 | 0.4 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0203 | 0.078 | 0.0904 |
Echinococcus granulosus | ribonuclease H1 | 0.0139 | 0.0417 | 0.0362 |
Toxoplasma gondii | ribonuclease HI protein | 0.0139 | 0.0417 | 0.4 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0203 | 0.078 | 1 |
Giardia lamblia | Ribonuclease H | 0.0139 | 0.0417 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.1273 | 0.6879 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0139 | 0.0417 | 0.0362 |
Brugia malayi | nicalin | 0.0203 | 0.078 | 0.0904 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0203 | 0.078 | 1 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0203 | 0.078 | 1 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0203 | 0.078 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0203 | 0.078 | 0.0904 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0174 | 0.0253 |
Echinococcus multilocularis | ribonuclease H1 | 0.0139 | 0.0417 | 0.0362 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0203 | 0.078 | 0.0617 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.0174 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.078 | 0.1134 |
Mycobacterium tuberculosis | Conserved protein | 0.0203 | 0.078 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.1273 | 0.6879 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0203 | 0.078 | 0.0904 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0203 | 0.078 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0203 | 0.078 | 0.0904 |
Schistosoma mansoni | phosphoglucomutase | 0.0139 | 0.0417 | 0.0362 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.0174 | 0.5 |
Schistosoma mansoni | phosphoglucomutase | 0.0139 | 0.0417 | 0.0362 |
Brugia malayi | FXNA | 0.0203 | 0.078 | 0.0904 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0203 | 0.078 | 1 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.1273 | 0.6879 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0203 | 0.078 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.078 | 0.1134 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0203 | 0.078 | 0.0904 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0151 | 0.0484 | 0.0315 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0203 | 0.078 | 0.0904 |
Schistosoma mansoni | hypothetical protein | 0.052 | 0.259 | 0.3603 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.0174 | 0.0253 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0139 | 0.0417 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.1273 | 0.6879 | 1 |
Trypanosoma brucei | ribonuclease H1 | 0.0139 | 0.0417 | 0.0247 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.0578 | 0.292 | 0.4095 |
Loa Loa (eye worm) | hypothetical protein | 0.1273 | 0.6879 | 1 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.0174 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0139 | 0.0417 | 0.4 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0151 | 0.0484 | 0.0315 |
Brugia malayi | leucyl aminopeptidase | 0.0203 | 0.078 | 0.0904 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0139 | 0.0417 | 0.0362 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0203 | 0.078 | 0.0904 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0578 | 0.292 | 0.4095 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0203 | 0.078 | 0.0904 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0139 | 0.0417 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.078 | 0.1134 |
Schistosoma mansoni | nicalin (M28 family) | 0.0203 | 0.078 | 0.0904 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0203 | 0.078 | 0.1134 |
Trypanosoma brucei | unspecified product | 0.0151 | 0.0484 | 0.0315 |
Leishmania major | glutaminyl cyclase, putative | 0.0203 | 0.078 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0174 | 0.0253 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0203 | 0.078 | 0.0904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.3 uM | Activation of recombinant human His6-tagged glucokinase by G6PDH-coupled spectrophotometry | ChEMBL. | No reference |
max activation (binding) | = 1.29 | Activation of recombinant human His6-tagged glucokinase by G6PDH-coupled spectrophotometry relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.