Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0098 | 0.0837 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.3163 | 0.3266 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.005 | 0.0564 | 0.6082 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0163 | 0.2813 | 0.2848 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0275 | 0.505 | 0.5229 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0118 | 0.1925 | 0.2262 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0068 | 0.0913 | 0.1058 |
Leishmania major | hypothetical protein, conserved | 0.005 | 0.0564 | 0.6082 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0068 | 0.0913 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0098 | 0.107 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.3163 | 0.3266 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0064 | 0.0833 | 0.0812 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0023 | 0.0023 | 0.0254 |
Brugia malayi | jmjC domain containing protein | 0.0051 | 0.0584 | 0.0667 |
Brugia malayi | beta-lactamase family protein | 0.0068 | 0.0913 | 0.1058 |
Schistosoma mansoni | hypothetical protein | 0.0091 | 0.1371 | 0.5876 |
Brugia malayi | Ubiquitin-like protein SMT3 | 0.0027 | 0.0095 | 0.0085 |
Plasmodium vivax | small ubiquitin-related modifier, putative | 0.0027 | 0.0095 | 0.1042 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.3163 | 0.3266 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.019 | 0.3357 | 0.3468 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0098 | 0.107 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.005 | 0.0564 | 0.0563 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0064 | 0.0833 | 0.9134 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0068 | 0.0913 | 0.0663 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0275 | 0.505 | 0.5978 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0064 | 0.0833 | 0.3532 |
Loa Loa (eye worm) | SMO-1 protein | 0.0027 | 0.0095 | 0.0085 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0275 | 0.505 | 0.5229 |
Trichomonas vaginalis | pps1 dual specificty phosphatase, putative | 0.0504 | 0.9637 | 1 |
Brugia malayi | hypothetical protein | 0.0444 | 0.8432 | 1 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0027 | 0.0095 | 0.0808 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0068 | 0.0913 | 0.0663 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0444 | 0.8432 | 0.8429 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.018 | 0.3163 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0163 | 0.2813 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0068 | 0.0913 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0118 | 0.1925 | 0.8292 |
Mycobacterium ulcerans | hypothetical protein | 0.0068 | 0.0913 | 0.0399 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0098 | 0.0088 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0163 | 0.2813 | 0.2902 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0023 | 0.0023 | 0.0254 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0068 | 0.0913 | 0.3877 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0068 | 0.0913 | 0.0663 |
Mycobacterium tuberculosis | Conserved protein | 0.0068 | 0.0913 | 0.0663 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0163 | 0.2813 | 0.2902 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0444 | 0.8432 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0118 | 0.1925 | 0.1907 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0068 | 0.0913 | 0.3877 |
Brugia malayi | beta-lactamase family protein | 0.0068 | 0.0913 | 0.1058 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0068 | 0.0913 | 0.0925 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0118 | 0.1925 | 0.1907 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0163 | 0.2813 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0064 | 0.0833 | 0.9134 |
Plasmodium vivax | hypothetical protein, conserved | 0.0023 | 0.0023 | 0.0254 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0068 | 0.0913 | 0.0925 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0064 | 0.0833 | 0.0964 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0163 | 0.2813 | 0.2902 |
Mycobacterium tuberculosis | Conserved protein | 0.0068 | 0.0913 | 0.0663 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0051 | 0.0584 | 0.0667 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0051 | 0.0584 | 0.2445 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0068 | 0.0913 | 0.0925 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0913 | 0.1058 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0051 | 0.0584 | 0.0667 |
Toxoplasma gondii | small ubiquitin family modifier, putative | 0.0027 | 0.0095 | 0.1042 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0068 | 0.0913 | 0.0663 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0068 | 0.0913 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1093 | 0.1273 |
Brugia malayi | jmjC domain containing protein | 0.0051 | 0.0584 | 0.0667 |
Onchocerca volvulus | 0.0068 | 0.0913 | 0.2832 | |
Leishmania major | small ubiquitin protein, putative | 0.0027 | 0.0095 | 0.0808 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0042 | 0.0395 | 0.4333 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0.0564 | 0.6082 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0051 | 0.0584 | 0.0562 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.8432 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.2317 | 1 |
Onchocerca volvulus | 0.0068 | 0.0913 | 0.2832 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0041 | 0.0372 | 0.0415 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.2317 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.3163 | 0.3266 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.3163 | 0.3266 |
Brugia malayi | hypothetical protein | 0.0077 | 0.1093 | 0.1273 |
Echinococcus multilocularis | Small ubiquitin modifier 2 | 0.0027 | 0.0095 | 0.0085 |
Entamoeba histolytica | dual specificity protein phosphatase, putative | 0.0504 | 0.9637 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.3163 | 0.3266 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0118 | 0.1925 | 0.2262 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0068 | 0.0913 | 0.0925 |
Schistosoma mansoni | ubiquitin-like protein sumo/smt3-related | 0.0027 | 0.0095 | 0.0313 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0118 | 0.1925 | 0.2262 |
Plasmodium falciparum | small ubiquitin-related modifier | 0.0027 | 0.0095 | 0.1141 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.3163 | 0.3266 |
Onchocerca volvulus | 0.0068 | 0.0913 | 0.2832 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0068 | 0.0913 | 0.0925 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0068 | 0.0913 | 0.0663 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.0027 | 0.0095 | 0.0808 |
Brugia malayi | beta-lactamase | 0.0068 | 0.0913 | 0.1058 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0098 | 0.1171 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0041 | 0.0372 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0913 | 0.1058 |
Echinococcus granulosus | geminin | 0.0138 | 0.2317 | 0.2299 |
Onchocerca volvulus | 0.0091 | 0.1371 | 0.4293 | |
Trichomonas vaginalis | esterase, putative | 0.0068 | 0.0913 | 0.0925 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0118 | 0.1925 | 0.2262 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0163 | 0.2813 | 0.2902 |
Trypanosoma brucei | small ubiquitin-related modifier | 0.0027 | 0.0095 | 0.0808 |
Mycobacterium ulcerans | lipase LipD | 0.0068 | 0.0913 | 0.0399 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0042 | 0.0395 | 0.0373 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0064 | 0.0833 | 0.9134 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0091 | 0.1371 | 0.1603 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0116 | 0.0405 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.019 | 0.3357 | 0.3468 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0068 | 0.0913 | 0.0663 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0068 | 0.0913 | 0.0891 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0432 | 0.8191 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0064 | 0.0833 | 0.0964 |
Plasmodium falciparum | metacaspase-like protein | 0.0023 | 0.0023 | 0.0279 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0163 | 0.2813 | 0.3317 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0113 | 0.1811 | 0.1816 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0064 | 0.0833 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0.0564 | 0.6082 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0275 | 0.505 | 0.5229 |
Plasmodium vivax | metacaspase 1, putative | 0.0023 | 0.0023 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0913 | 0.1058 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0028 | 0.0116 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1093 | 0.1273 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0913 | 0.1058 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0068 | 0.0913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0372 | 0.0415 |
Mycobacterium ulcerans | beta-lactamase | 0.0068 | 0.0913 | 0.0399 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0042 | 0.0395 | 0.0443 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0051 | 0.0584 | 0.0562 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0095 | 0.0075 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0023 | 0.0023 | 0.0254 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0163 | 0.2813 | 0.2848 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0068 | 0.0913 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0098 | 0.0837 |
Schistosoma mansoni | eyes absent homolog | 0.0077 | 0.1093 | 0.4665 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0913 | 0.1058 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0064 | 0.0833 | 0.9134 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0116 | 0.011 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0068 | 0.0913 | 0.1058 |
Plasmodium falciparum | metacaspase 1 | 0.0023 | 0.0023 | 0.0279 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0068 | 0.0913 | 0.0399 |
Leishmania major | hypothetical protein, conserved | 0.0068 | 0.0913 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0275 | 0.505 | 0.5229 |
Toxoplasma gondii | ABC1 family protein | 0.0068 | 0.0913 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0068 | 0.0913 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0275 | 0.505 | 0.5229 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0163 | 0.2813 | 0.2902 |
Mycobacterium tuberculosis | Conserved protein | 0.0068 | 0.0913 | 0.0663 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0051 | 0.0584 | 0.2445 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0163 | 0.2813 | 0.3317 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0064 | 0.0833 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0098 | 0.0837 |
Mycobacterium leprae | Probable lipase LipE | 0.0068 | 0.0913 | 1 |
Echinococcus multilocularis | geminin | 0.0138 | 0.2317 | 0.2728 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0275 | 0.505 | 0.5978 |
Schistosoma mansoni | jumonji domain containing protein | 0.0051 | 0.0584 | 0.2445 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0064 | 0.0833 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0068 | 0.0913 | 0.0399 |
Loa Loa (eye worm) | beta-lactamase | 0.0068 | 0.0913 | 0.1058 |
Schistosoma mansoni | survival motor neuron protein | 0.0091 | 0.1371 | 0.5876 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0098 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0913 | 0.1058 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0098 | 0.0837 |
Onchocerca volvulus | 0.0163 | 0.2813 | 0.8885 | |
Echinococcus granulosus | Small ubiquitin modifier 2 | 0.0027 | 0.0095 | 0.0072 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0051 | 0.0584 | 0.0667 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0041 | 0.0372 | 0.0415 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0163 | 0.2813 | 0.2902 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0064 | 0.0833 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.005 | 0.0564 | 0.0563 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0275 | 0.505 | 0.5229 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0068 | 0.0913 | 0.1058 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0098 | 0.1171 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0064 | 0.0833 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0833 | 0.0964 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.