TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 453.326 | Formula: C20H25Cl2F3N2O2
H donors: 2 H acceptors: 0 LogP: 5.56 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1CN[C@H]1CCNC[C@H]1c1ccccc1)OC(F)(F)F.Cl.Cl
InChi: 1S/C20H23F3N2O2.2ClH/c1-26-19-8-7-16(27-20(21,22)23)11-15(19)12-25-18-9-10-24-13-17(18)14-5-3-2-4-6-14;;/h2-8,11,17-18,24-25H,9-10,12-13H2,1H3;2*1H/t17-,18-;;/m0../s1
InChiKey: ONXQEJJADHLNRM-MPGISEFESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tachykinin receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04224 tachykinin receptor 3, putative	Get druggable targets OG5_137770	All targets in OG5_137770

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0024	0.0192	0.0913
Echinococcus multilocularis	caspase 8	0.0027	0.024	0.1144
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Trypanosoma cruzi	small ubiquitin protein, putative	0.0032	0.0311	0.4037
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0024	0.0192	0.0913
Schistosoma mansoni	protein tyrosine phosphatase	0.0024	0.0192	0.0913
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0024	0.0192	0.0913
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0024	0.0192	0.0199
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.024	0.0249
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.024	0.0249
Trypanosoma cruzi	hypothetical protein, conserved	0.006	0.0769	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.024	0.0249
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0134	0.1989	0.5
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0024	0.0192	0.0913
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0024	0.0192	0.0913
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0192
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0789	0.2657
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.024	0.0249
Onchocerca volvulus	Cell death protein 3 homolog	0.0027	0.024	0.0174
Echinococcus granulosus	caspase 8	0.0027	0.024	0.024
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.024	0.0249
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0193	0.2969	0.3079
Entamoeba histolytica	ubiquitin like protein	0.0032	0.0311	0.0322
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0061	0.0789	0.3755
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0913
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0016	0.0056	0.0265
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0016	0.0056	0.1793
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Plasmodium falciparum	metacaspase 1	0.0027	0.024	0.7736
Trichomonas vaginalis	pten, drome, putative	0.0024	0.0192	0.0199
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0913
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0056	0.0724
Schistosoma mansoni	protein tyrosine phosphatase	0.0024	0.0192	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0027	0.024	0.0809
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0024	0.0192	0.0646
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0024	0.0192	0.0913
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0024	0.0192	0.0913
Schistosoma mansoni	phosphatidylserine receptor	0.0016	0.0056	0.0265
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0192
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0192
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0024	0.0192	0.0913
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0193	0.2969	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Leishmania major	tyrosine specific protein phosphatase, putative	0.0024	0.0192	0.2494
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0024	0.0192	0.0192
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0024	0.0192	0.0913
Leishmania major	hypothetical protein, conserved	0.0016	0.0056	0.0724
Echinococcus multilocularis	jumonji domain containing 1A	0.0016	0.0056	0.0265
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0024	0.0192	0.0913
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0027	0.024	0.024
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0193	0.2969	0.3079
Echinococcus multilocularis	lysine specific demethylase 5A	0.0061	0.0789	0.3755
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0192
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0024	0.0192	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0024	0.0192	0.0646
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0061	0.0789	0.0789
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0027	0.024	0.0809
Brugia malayi	hypothetical protein	0.0024	0.0192	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Echinococcus multilocularis		0.0024	0.0192	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Giardia lamblia	Sentrin	0.0032	0.0311	0.1046
Loa Loa (eye worm)	hypothetical protein	0.0027	0.024	0.0809
Trypanosoma brucei	Metacaspase-4	0.0027	0.024	0.3123
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Leishmania major	small ubiquitin protein, putative	0.0032	0.0311	0.4037
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0056	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0061	0.0789	0.3755
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0024	0.0192	0.0192
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0193	0.2969	0.3079
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0193	0.2969	0.3079
Giardia lamblia	Protein tyrosine phosphatase	0.0024	0.0192	0.0646
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0193	0.2969	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0913
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0024	0.0192	0.0913
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.006	0.0769	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0056	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0024	0.0192	0.0646
Trypanosoma brucei	metacaspase MCA3	0.0027	0.024	0.3123
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0016	0.0056	0.1793
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0024	0.0192	0.0913
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.014	0.2101	0.2101
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0024	0.0192	0.2494
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.024	0.0249
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Brugia malayi	hypothetical protein	0.0091	0.1287	0.4335
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0024	0.0192	0.2494
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0027	0.024	0.1144
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0024	0.0192	0.0913
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.014	0.2101	1
Trypanosoma brucei	metacaspase 5, putative	0.0027	0.024	0.3123
Plasmodium vivax	metacaspase 1, putative	0.0027	0.024	0.7736
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0024	0.0192	0.0192
Echinococcus multilocularis	JmjC domain containing protein 4	0.0016	0.0056	0.0265
Schistosoma mansoni	eyes absent homolog	0.0091	0.1287	0.6126
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.024	0.0249
Echinococcus granulosus	lysine specific demethylase 6a	0.0016	0.0056	0.0056
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0016	0.0056	0.1793
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1287	0.4335
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0024	0.0192	0.0913
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0024	0.0192	0.2494
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.014	0.2101	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.024	0.0249
Trypanosoma cruzi	metacaspase, putative	0.0027	0.024	0.3123
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0024	0.0192	0.2494
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0024	0.0192	0.0913
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0016	0.0056	0.0265
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.024	0.0249
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0192
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0056	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0061	0.0789	0.3755
Brugia malayi	jmjC domain containing protein	0.0016	0.0056	0.0188
Schistosoma mansoni	ubiquitin-like protein sumo/smt3-related	0.0032	0.0311	0.1478
Brugia malayi	Ubiquitin-like protein SMT3	0.0032	0.0311	0.1046
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0016	0.0056	0.0724
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Trypanosoma brucei	small ubiquitin-related modifier	0.0032	0.0311	0.4037
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0193	0.2969	0.3079
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0024	0.0192	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Echinococcus granulosus	phd:f box containing protein	0.0016	0.0056	0.0056
Brugia malayi	hypothetical protein	0.0024	0.0192	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Brugia malayi	Cell death protein 3 precursor	0.0027	0.024	0.0809
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0024	0.0192	0.0192
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0193	0.2969	0.3079
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.0599	0.9645	1
Echinococcus multilocularis	Small ubiquitin modifier 2	0.0032	0.0311	0.1478
Brugia malayi	hypothetical protein	0.0024	0.0192	0.0646
Brugia malayi	Protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.024	0.0249
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.024	0.0249
Schistosoma mansoni	phd/f-box containing protein	0.0016	0.0056	0.0265
Schistosoma mansoni	pcd6 interacting protein-related	0.0024	0.0192	0.0913
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.024	0.0249
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0024	0.0192	0.0913
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0027	0.024	0.7736
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0024	0.0192	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0027	0.024	0.7736
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0311	0.0322
Echinococcus multilocularis	lysine specific demethylase 6a	0.0016	0.0056	0.0265
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Onchocerca volvulus		0.0193	0.2969	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0024	0.0192	0.0913
Trypanosoma cruzi	small ubiquitin protein, putative	0.0032	0.0311	0.4037
Echinococcus granulosus	Small ubiquitin modifier 2	0.0032	0.0311	0.0311
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0056	0.0188
Trypanosoma brucei	metacaspase MCA2	0.0027	0.024	0.3123
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.014	0.2101	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Schistosoma mansoni	jumonji domain containing protein	0.0016	0.0056	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0056	0.0188
Schistosoma mansoni	caspase-3 (C14 family)	0.0027	0.024	0.1144
Echinococcus granulosus	lysine specific demethylase 5A	0.0061	0.0789	0.0789
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0024	0.0192	0.2494
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0193	0.2969	0.3079
Plasmodium vivax	JmjC domain containing protein	0.0016	0.0056	0.1793
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0192
Toxoplasma gondii	small ubiquitin family modifier, putative	0.0032	0.0311	1
Brugia malayi	jmjC domain containing protein	0.0061	0.0789	0.2657
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0056	0.0188
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0016	0.0056	0.0056
Echinococcus granulosus	jumonji domain containing 1A	0.0016	0.0056	0.0056
Trypanosoma cruzi	metacaspase, putative	0.0027	0.024	0.3123
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Echinococcus multilocularis	caspase	0.0027	0.024	0.1144
Schistosoma mansoni	caspase-7 (C14 family)	0.0027	0.024	0.1144
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0027	0.024	0.1144
Plasmodium falciparum	small ubiquitin-related modifier	0.0032	0.0311	1
Schistosoma mansoni	jumonji domain containing protein	0.0061	0.0789	0.3755
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0193	0.2969	1
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0024	0.0192	0.0646
Plasmodium vivax	hypothetical protein, conserved	0.0027	0.024	0.7736
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0024	0.0192	0.0646
Trypanosoma cruzi	metacaspase 5, putative	0.0027	0.024	0.3123
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0024	0.0192	0.0913
Trypanosoma cruzi	metacaspase 5, putative	0.0027	0.024	0.3123
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0024	0.0192	0.0913
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0024	0.0192	0.0192
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0192
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Echinococcus granulosus	JmjC domain containing protein 4	0.0016	0.0056	0.0056
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0024	0.0192	0.0913
Brugia malayi	jmjC domain containing protein	0.0016	0.0056	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1287	0.4335
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0913
Leishmania major	metacaspase, putative	0.0027	0.024	0.3123
Loa Loa (eye worm)	SMO-1 protein	0.0032	0.0311	0.1046
Brugia malayi	hypothetical protein	0.0024	0.0192	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0024	0.0192	0.0913
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0599	0.9645	1
Plasmodium vivax	small ubiquitin-related modifier, putative	0.0032	0.0311	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0913
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0024	0.0192	0.0913
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0024	0.0192	0.0913
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.024	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Brugia malayi	jmjC domain containing protein	0.0061	0.0789	0.2657
Brugia malayi	hypothetical protein	0.0024	0.0192	0.0646
Trypanosoma cruzi	metacaspase, putative	0.0027	0.024	0.3123
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.006	0.0769	0.0798
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0193	0.2969	0.3079
Brugia malayi	jmjC domain containing protein	0.0016	0.0056	0.0188
Schistosoma mansoni	protein phosphatase 2C	0.0016	0.0056	0.0265
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0024	0.0192	0.0192
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0024	0.0192	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0056	0.0188
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0024	0.0192	0.0913
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0027	0.024	0.7736
Echinococcus multilocularis	phd:f box containing protein	0.0016	0.0056	0.0265
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Echinococcus granulosus	caspase	0.0027	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0024	0.0192	0.0199
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0024	0.0192	0.0913
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Schistosoma mansoni	protein tyrosine phosphatase	0.0024	0.0192	0.0913
Brugia malayi	Protein-tyrosine phosphatase 1	0.0024	0.0192	0.0646
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.014	0.2101	0.7076
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Schistosoma mansoni	caspase-7 (C14 family)	0.0027	0.024	0.1144
Echinococcus granulosus	caspase 2	0.0027	0.024	0.024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Trypanosoma cruzi	hypothetical protein, conserved	0.006	0.0769	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.024	0.0249
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0024	0.0192	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0024	0.0192	0.0192
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0024	0.0192	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Trypanosoma brucei	metacaspase	0.0027	0.024	0.3123
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.014	0.2101	0.7076
Leishmania major	hypothetical protein, conserved	0.006	0.0769	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Brugia malayi	Protein-tyrosine phosphatase	0.0024	0.0192	0.0646
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0024	0.0192	0.0913
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Brugia malayi	jmjC domain containing protein	0.0016	0.0056	0.0188
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.006	0.0769	1
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0024	0.0192	0.0199
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.024	0.0249
Echinococcus multilocularis	hypothetical protein	0.0024	0.0192	0.0913
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0024	0.0192	0.0646
Plasmodium falciparum	metacaspase-like protein	0.0027	0.024	0.7736
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0646
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0193	0.2969	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.014	0.2101	0.2101
Trypanosoma cruzi	metacaspase, putative	0.0027	0.024	0.3123
Echinococcus multilocularis	caspase 2	0.0027	0.024	0.1144

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8.4 nM	Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting	ChEMBL.	21944973

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3217199

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1864222