Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0008 | 0.0005 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.0095 | 0.0715 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.0071 | 0.0067 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0082 | 0.0058 | 0.0095 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.2527 | 0.2194 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.014 | 0.0135 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.1464 | 0.1265 | 0.1261 |
Loa Loa (eye worm) | glutamate receptor | 0.005 | 0.003 | 0.0026 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.1464 | 0.1265 | 0.2214 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0045 | 0.0318 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1464 | 0.1265 | 0.2214 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0045 | 0.0045 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0037 | 0.0018 | 0.37 |
Brugia malayi | RNA binding protein | 0.0124 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0008 | 0.0003 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0008 | 0.0008 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0012 | 0.1622 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.0158 | 0.1217 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0039 | 0.0273 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0013 | 0.007 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0008 | 0.2 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0012 | 0.0058 |
Brugia malayi | Inositol-1 | 0.0041 | 0.0022 | 0.0022 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0013 | 0.0016 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0039 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1464 | 0.1265 | 0.2214 |
Onchocerca volvulus | 0.0231 | 0.0188 | 0.1459 | |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0107 | 0.008 | 0.0133 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0012 | 0.0013 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1464 | 0.1265 | 0.2214 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.001 | 0.0009 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.0095 | 0.0715 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0022 | 0.0026 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.0006 | 0.5 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.2527 | 0.2194 | 0.2191 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0033 | 0.0015 | 0.0011 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0039 | 0.0061 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.0022 | 0.4866 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0012 | 0.0013 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.2527 | 0.2194 | 0.3852 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0015 | 0.0011 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0008 | 0.0002 |
Schistosoma mansoni | lamin | 0.0027 | 0.001 | 0.0041 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1464 | 0.1265 | 0.2214 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0082 | 0.0058 | 0.0427 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0022 | 0.0028 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0107 | 0.008 | 0.0133 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0012 | 0.0058 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.1464 | 0.1265 | 0.2215 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0116 | 0.0087 | 0.0087 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0013 | 0.0016 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0039 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0124 | 0.0095 | 0.009 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.0164 | 0.0164 |
Echinococcus granulosus | neuropeptide s receptor | 0.046 | 0.0388 | 0.0675 |
Onchocerca volvulus | 0.1464 | 0.1265 | 1 | |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0062 | 0.0041 | 0.0041 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0062 | 0.0041 | 0.0288 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.2527 | 0.2194 | 0.3849 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0008 | 0.0324 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 0.0188 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0013 | 0.0009 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.0095 | 0.0715 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0039 | 0.0273 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0058 | 0.0054 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0012 | 0.0013 |
Brugia malayi | TAR-binding protein | 0.0124 | 0.0095 | 0.0095 |
Onchocerca volvulus | 0.1464 | 0.1265 | 1 | |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0013 | 0.0016 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.0095 | 0.0715 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0013 | 0.0016 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0033 | 0.0015 | 0.0011 |
Loa Loa (eye worm) | TAR-binding protein | 0.0124 | 0.0095 | 0.009 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0006 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0039 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0013 | 0.0016 |
Onchocerca volvulus | 0.0082 | 0.0058 | 0.0427 | |
Echinococcus multilocularis | musashi | 0.0027 | 0.001 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.001 | 0.0005 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.1464 | 0.1265 | 0.2214 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.0022 | 0.0031 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0271 | 0.0223 | 0.0219 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.1464 | 0.1265 | 0.2214 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0013 | 0.0009 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0039 | 0.0061 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.001 | 0.0009 |
Trypanosoma brucei | hypothetical protein, conserved | 0.1464 | 0.1265 | 0.5754 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.0164 | 0.016 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.001 | 0.0005 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0124 | 0.0095 | 0.0095 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0039 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0022 | 0.0072 |
Schistosoma mansoni | choline o-acyltransferase | 0.1464 | 0.1265 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0124 | 0.0095 | 0.009 |
Echinococcus multilocularis | tar DNA binding protein | 0.0124 | 0.0095 | 0.0159 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.0022 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0011 | 0.0011 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0033 | 0.0015 | 0.0015 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0683 | 0.0583 | 0.1018 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0045 | 0.004 |
Echinococcus granulosus | tar DNA binding protein | 0.0124 | 0.0095 | 0.0159 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0021 | 0.0004 | 0.0004 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0022 | 0.0141 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.1464 | 0.1265 | 0.5754 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0009 | 0.0005 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.0022 | 0.0018 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0107 | 0.008 | 0.0599 |
Echinococcus granulosus | geminin | 0.0196 | 0.0158 | 0.027 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0012 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 1.146 | 1 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1464 | 0.1265 | 0.2214 |
Loa Loa (eye worm) | glutamate receptor | 0.0128 | 0.0098 | 0.0094 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.1464 | 0.1265 | 0.2214 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0013 | 0.0013 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1464 | 0.1265 | 0.1265 |
Brugia malayi | Choline O-acetyltransferase | 0.1464 | 0.1265 | 0.1265 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0157 | 0.0124 | 0.021 |
Echinococcus multilocularis | neuropeptide s receptor | 0.046 | 0.0388 | 0.0675 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0128 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.1464 | 0.1265 | 0.1261 |
Echinococcus granulosus | lamin | 0.0027 | 0.001 | 0.0009 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.046 | 0.0388 | 0.0675 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0012 | 1 |
Onchocerca volvulus | 0.1464 | 0.1265 | 1 | |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.0022 | 0.4866 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0145 | 0.0113 | 0.0864 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0157 | 0.0124 | 0.021 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0176 | 0.014 | 0.014 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.0158 | 0.1217 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0013 | 0.007 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0037 | 0.0018 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.6526 | 0.5689 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0012 | 0.0007 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0008 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0013 | 0.0013 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0022 | 0.0141 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.001 | 0.0005 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.0022 | 0.0031 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0008 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0271 | 0.0223 | 0.0223 |
Echinococcus multilocularis | lamin | 0.0027 | 0.001 | 0.0009 |
Onchocerca volvulus | 0.0027 | 0.001 | 0.0041 | |
Echinococcus granulosus | choline O acetyltransferase | 0.1464 | 0.1265 | 0.2218 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0082 | 0.0058 | 0.0058 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0013 | 0.007 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.2527 | 0.2194 | 0.3852 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.1464 | 0.1265 | 0.5754 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.001 | 0.0041 |
Schistosoma mansoni | choline o-acyltransferase | 0.1464 | 0.1265 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0012 | 0.0058 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0082 | 0.0058 | 0.0095 |
Echinococcus multilocularis | choline O acetyltransferase | 0.1464 | 0.1265 | 0.2218 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.046 | 0.0388 | 0.0675 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.0095 | 0.0715 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0013 | 0.007 |
Echinococcus multilocularis | geminin | 0.0196 | 0.0158 | 0.027 |
Onchocerca volvulus | 0.0027 | 0.001 | 0.0041 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.1464 | 0.1265 | 0.5754 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.001 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0071 | 0.0067 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.6526 | 0.5689 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.1464 | 0.1265 | 0.1265 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.1464 | 0.1265 | 0.1261 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.0071 | 0.0071 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0683 | 0.0583 | 0.1018 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.6526 | 0.5689 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0683 | 0.0583 | 0.4591 |
Onchocerca volvulus | 0.1464 | 0.1265 | 1 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.0071 | 0.0071 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0124 | 0.0119 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0013 | 0.0016 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0022 | 0.0026 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.2527 | 0.2194 | 0.2194 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0039 | 0.0057 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1464 | 0.1265 | 0.2214 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.001 | 0.001 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.2527 | 0.2194 | 0.385 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.6526 | 0.5689 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0171 | 0.0136 | 0.6819 |
Schistosoma mansoni | lamin | 0.0027 | 0.001 | 0.0041 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.6526 | 0.5689 | 1 |
Onchocerca volvulus | 0.0029 | 0.0012 | 0.0058 | |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.0022 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.