Detailed information for compound 1880798

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 451.046 | Formula: C16H18Cl6N2
  • H donors: 2 H acceptors: 0 LogP: 6.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)CNCCNCc1ccc(cc1Cl)Cl.Cl.Cl
  • InChi: 1S/C16H16Cl4N2.2ClH/c17-13-3-1-11(15(19)7-13)9-21-5-6-22-10-12-2-4-14(18)8-16(12)20;;/h1-4,7-8,21-22H,5-6,9-10H2;2*1H
  • InChiKey: TUNKVBKANGMVRI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.00800533 0.127802 0.234834
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0107835 0.19908 0.768352
Trichomonas vaginalis AGC family protein kinase 0.007665 0.119071 0.236638
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0149682 0.306443 0.297594
Entamoeba histolytica protein kinase, putative 0.011098 0.207148 0.396571
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0045246 0.0385009 0.0528018
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0181461 0.387973 0.765166
Loa Loa (eye worm) AGC/AKT protein kinase 0.007665 0.119071 0.134575
Giardia lamblia Kinase, CMGC GSK 0.011098 0.207148 0.764188
Trichomonas vaginalis AGC family protein kinase 0.0149682 0.306443 0.609014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073662 0.111405 0.221402
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0129749 0.255302 0.494729
Brugia malayi p70 ribosomal S6 kinase beta 0.00736276 0.111317 0.201229
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0226365 0.503178 1
Entamoeba histolytica protein kinase, putative 0.007665 0.119071 0.217036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045246 0.0385009 0.0765153
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0107835 0.19908 0.188862
Brugia malayi Protein kinase domain containing protein 0.00871317 0.145963 0.271852
Trichomonas vaginalis AGC family protein kinase 0.007665 0.119071 0.236638
Trichomonas vaginalis CMGC family protein kinase 0.011098 0.207148 0.411678
Giardia lamblia GTOR 0.0107835 0.19908 0.72468
Loa Loa (eye worm) hypothetical protein 0.0109766 0.204033 0.230599
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0129749 0.255302 1
Trichomonas vaginalis CAMK family protein kinase 0.00871317 0.145963 0.290081
Echinococcus granulosus aurora kinase A 0.0129749 0.255302 0.245801
Schistosoma mansoni serine/threonine protein kinase 0.0192758 0.416956 0.409518
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.00514712 0.0544721 0.172534
Echinococcus granulosus nervana 2 0.00460153 0.0404745 0.0282329
Trypanosoma cruzi Protein kinase B 0.00531776 0.0588502 0.0942818
Loa Loa (eye worm) AUR protein kinase 0.0129749 0.255302 0.288543
Loa Loa (eye worm) CMGC/GSK protein kinase 0.011098 0.207148 0.234119
Trichomonas vaginalis PIKK family atypical protein kinase 0.00644127 0.0876749 0.174242
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0045246 0.0385009 0.026234
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.00501551 0.0510958 0.0389897
Trichomonas vaginalis CMGC family protein kinase 0.011098 0.207148 0.411678
Trypanosoma brucei protein kinase, putative 0.011098 0.207148 0.801593
Schistosoma mansoni serine/threonine protein kinase 0.0149682 0.306443 0.297594
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.00885492 0.149599 0.564481
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0107835 0.19908 0.380125
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0107835 0.19908 0.768352
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0129749 0.255302 0.245801
Entamoeba histolytica protein kinase 2, putative 0.00501551 0.0510958 0.0784753
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0148906 0.30445 0.594912
Echinococcus granulosus protein kinase shaggy 0.011098 0.207148 0.197032
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0148906 0.30445 0.295576
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0129749 0.255302 0.494729
Trichomonas vaginalis PIKK family atypical protein kinase 0.00664777 0.092973 0.184771
Giardia lamblia Kinase, CMGC GSK 0.011098 0.207148 0.764188
Entamoeba histolytica protein kinase domain containing protein 0.0129749 0.255302 0.494729
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.00460153 0.0404745 0.0282329
Echinococcus granulosus serine:threonine protein kinase 0.0109766 0.204033 0.193878
Entamoeba histolytica protein kinase domain containing protein 0.011098 0.207148 0.396571
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0192758 0.416956 0.409518
Trichomonas vaginalis AGC family protein kinase 0.0129749 0.255302 0.507378
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0226365 0.503178 1
Schistosoma mansoni hypothetical protein 0.00829918 0.135341 0.12431
Trichomonas vaginalis PIKK family atypical protein kinase 0.00886686 0.149906 0.297917
Echinococcus granulosus nervana 2 0.00460153 0.0404745 0.0282329
Echinococcus multilocularis Glutaredoxin protein 5 0.00460153 0.0404745 0.0282329
Trichomonas vaginalis PIKK family atypical protein kinase 0.00644127 0.0876749 0.174242
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0112609 0.211326 0.784649
Trichomonas vaginalis AGC family protein kinase 0.0129749 0.255302 0.507378
Trichomonas vaginalis PIKK family atypical protein kinase 0.00645321 0.0879813 0.174851
Echinococcus multilocularis rac serine:threonine kinase 0.00531776 0.0588502 0.046843
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.00800533 0.127802 0.474672
Schistosoma mansoni hypothetical protein 0.00829918 0.135341 0.12431
Trichomonas vaginalis AGC family protein kinase 0.007665 0.119071 0.236638
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0193648 0.419239 0.828899
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0149682 0.306443 0.346343
Leishmania major phosphatidylinositol 3-kinase, putative 0.0045246 0.0385009 0.106729
Brugia malayi phosphoinositide-dependent protein kinase I 0.0149682 0.306443 0.598974
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0109766 0.204033 0.230599
Trichomonas vaginalis PIKK family atypical protein kinase 0.00836988 0.137155 0.272578
Brugia malayi intracellular kinase 0.011098 0.207148 0.396571
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.00494061 0.0491741 0.150705
Loa Loa (eye worm) hypothetical protein 0.0148906 0.30445 0.344091
Echinococcus multilocularis hypothetical protein 0.00829918 0.135341 0.12431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045246 0.0385009 0.0765153
Trichomonas vaginalis PIKK family atypical protein kinase 0.00693824 0.100425 0.199582
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0420012 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.00351495 0.0125973 0.0493428
Echinococcus granulosus Glutaredoxin protein 5 0.00460153 0.0404745 0.0282329
Schistosoma mansoni protein kinase 0.0129749 0.255302 0.245801
Brugia malayi Protein kinase domain containing protein 0.0109766 0.204033 0.390222
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00800533 0.127802 0.234834
Trichomonas vaginalis AGC family protein kinase 0.00306348 0.00101438 0.00201594
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.00501551 0.0510958 0.158623
Trichomonas vaginalis PIKK family atypical protein kinase 0.00836988 0.137155 0.272578
Echinococcus multilocularis nervana 2 0.00460153 0.0404745 0.0282329
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.00351495 0.0125973 0.0493428
Echinococcus multilocularis nervana 2 0.00460153 0.0404745 0.0282329
Trichomonas vaginalis AGC family protein kinase 0.0149682 0.306443 0.609014
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.00800533 0.127802 0.25399
Trichomonas vaginalis PIKK family atypical protein kinase 0.00644127 0.0876749 0.174242
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.00800533 0.127802 0.25399
Entamoeba histolytica PH domain containing protein kinase, putative 0.00531776 0.0588502 0.0942818
Schistosoma mansoni serine/threonine-protein kinase 0.00531776 0.0588502 0.046843
Entamoeba histolytica protein kinase, putative 0.0149682 0.306443 0.598974
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0192758 0.416956 0.409518
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.00501551 0.0510958 0.0389897
Trypanosoma cruzi aurora B kinase, putative 0.0129749 0.255302 0.494729
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.011098 0.207148 0.396571
Plasmodium falciparum serine/threonine protein kinase, putative 0.0129749 0.255302 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.011098 0.207148 0.234119
Trichomonas vaginalis PIKK family atypical protein kinase 0.00664777 0.092973 0.184771
Schistosoma mansoni serine/threonine protein kinase 0.00871317 0.145963 0.135067
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.011098 0.207148 0.811383
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.00800533 0.127802 0.116675
Trichomonas vaginalis PIKK family atypical protein kinase 0.00836988 0.137155 0.272578
Loa Loa (eye worm) hypothetical protein 0.00829918 0.135341 0.152964
Trichomonas vaginalis PIKK family atypical protein kinase 0.00886686 0.149906 0.297917
Entamoeba histolytica protein kinase , putative 0.0129749 0.255302 0.494729
Echinococcus multilocularis serine:threonine protein kinase 0.0109766 0.204033 0.193878
Toxoplasma gondii AGC kinase 0.00736276 0.111317 0.43602
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.00351495 0.0125973 0.0250354
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0129749 0.255302 0.494729
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0107835 0.19908 0.380125
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.00579221 0.0710227 0.0975822
Trypanosoma brucei rac serine-threonine kinase, putative 0.007665 0.119071 0.438697
Schistosoma mansoni serine/threonine protein kinase 0.0192758 0.416956 0.409518
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0226365 0.503178 1
Entamoeba histolytica protein kinase, putative 0.007665 0.119071 0.217036
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0420012 1 1
Echinococcus multilocularis aurora kinase A 0.0129749 0.255302 0.245801
Brugia malayi Kinase associated domain 1 family protein 0.00829918 0.135341 0.250201
Giardia lamblia Aurora kinase 0.0129749 0.255302 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0375108 0.884795 1
Echinococcus multilocularis serine:threonine protein kinase 0.0109766 0.204033 0.193878
Echinococcus granulosus serine/threonine protein kinase 0.00531776 0.0588502 0.046843
Trichomonas vaginalis AGC family protein kinase 0.0129749 0.255302 0.507378
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0226365 0.503178 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0104002 0.189245 0.360078
Plasmodium falciparum glycogen synthase kinase 3 0.011098 0.207148 0.801593
Trichomonas vaginalis PIKK family atypical protein kinase 0.00644127 0.0876749 0.174242
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0107835 0.19908 0.768352
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.00800533 0.127802 0.234834
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.011098 0.207148 0.197032
Trichomonas vaginalis PIKK family atypical protein kinase 0.00645321 0.0879813 0.174851
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0157512 0.326531 0.648936
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0420012 1 1
Brugia malayi serine/threonine kinase 12 0.0129749 0.255302 0.494729
Trichomonas vaginalis PIKK family atypical protein kinase 0.00836988 0.137155 0.272578
Trichomonas vaginalis AGC family protein kinase 0.007665 0.119071 0.236638
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0045246 0.0385009 0.026234
Trichomonas vaginalis PIKK family atypical protein kinase 0.00886686 0.149906 0.297917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107835 0.19908 0.395644
Loa Loa (eye worm) AUR protein kinase 0.0129749 0.255302 0.288543
Trichomonas vaginalis PIKK family atypical protein kinase 0.00836988 0.137155 0.272578
Trichomonas vaginalis AGC family protein kinase 0.007665 0.119071 0.236638
Trichomonas vaginalis PIKK family atypical protein kinase 0.00836988 0.137155 0.272578
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0107835 0.19908 0.188862
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0045246 0.0385009 0.0528018
Entamoeba histolytica protein kinase, putative 0.0129749 0.255302 0.494729
Echinococcus multilocularis calcium activated potassium channel 0.00871317 0.145963 0.135067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045246 0.0385009 0.0765153
Trichomonas vaginalis PIKK family atypical protein kinase 0.00886686 0.149906 0.297917
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.00800533 0.127802 0.25399
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.00351495 0.0125973 0.0250354
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.00351495 0.0125973 0.0142375
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045246 0.0385009 0.0528018
Schistosoma mansoni serine/threonine protein kinase 0.00871317 0.145963 0.135067
Trichomonas vaginalis PIKK family atypical protein kinase 0.00886686 0.149906 0.297917
Leishmania major protein kinase, putative 0.0129749 0.255302 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0107835 0.19908 0.380125
Trichomonas vaginalis PIKK family atypical protein kinase 0.00836988 0.137155 0.272578
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0045246 0.0385009 0.106729
Loa Loa (eye worm) AUR protein kinase 0.0129749 0.255302 0.288543
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0045246 0.0385009 0.026234
Schistosoma mansoni serine/threonine protein kinase 0.00871317 0.145963 0.135067
Trypanosoma cruzi rac serine-threonine kinase, putative 0.00531776 0.0588502 0.0942818
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0192758 0.416956 0.409518
Toxoplasma gondii target of rapamycin (TOR), putative 0.00836988 0.137155 0.537228
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0045246 0.0385009 0.106729
Entamoeba histolytica PH domain containing protein kinase, putative 0.00531776 0.0588502 0.0942818
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.011098 0.207148 0.801593
Trichomonas vaginalis AGC family protein kinase 0.0129749 0.255302 0.507378
Entamoeba histolytica protein kinase domain containing protein 0.011098 0.207148 0.396571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107835 0.19908 0.395644
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0149682 0.306443 0.346343
Brugia malayi Protein kinase domain containing protein 0.0149682 0.306443 0.598974
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0107835 0.19908 0.380125
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0129749 0.255302 0.245801
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.00460153 0.0404745 0.0282329
Echinococcus granulosus serine:threonine protein kinase 0.0109766 0.204033 0.193878
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0045246 0.0385009 0.106729
Toxoplasma gondii aurora kinase 0.0129749 0.255302 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.00664777 0.092973 0.184771
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0148906 0.30445 0.295576
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.00501551 0.0510958 0.158623
Entamoeba histolytica hypothetical protein 0.0181461 0.387973 0.765166
Plasmodium vivax glycogen synthase kinase 3, putative 0.011098 0.207148 0.801593
Loa Loa (eye worm) phosphatidylinositol 3 0.0107835 0.19908 0.225001
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.00670349 0.0944025 0.166752
Loa Loa (eye worm) phosphatidylinositol 3 0.00670349 0.0944025 0.106694
Trypanosoma cruzi rac serine-threonine kinase, putative 0.00501551 0.0510958 0.0784753
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0226365 0.503178 1
Entamoeba histolytica protein kinase, putative 0.0129749 0.255302 0.494729
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.00800533 0.127802 0.234834
Brugia malayi serine/threonine protein kinase 6 0.0129749 0.255302 0.494729
Schistosoma mansoni serine/threonine protein kinase 0.0129749 0.255302 0.245801
Echinococcus granulosus serine threonine protein kinase nrc 0.00501551 0.0510958 0.0389897
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0149682 0.306443 0.297594
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0107835 0.19908 0.380125
Trichomonas vaginalis PIKK family atypical protein kinase 0.00645321 0.0879813 0.174851
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0213346 0.469779 0.931918
Loa Loa (eye worm) hypothetical protein 0.0077459 0.121147 0.13692
Trichomonas vaginalis PIKK family atypical protein kinase 0.00906142 0.154897 0.307838
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0226365 0.503178 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0157512 0.326531 0.648936
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045246 0.0385009 0.0765153
Trichomonas vaginalis CAMK family protein kinase 0.0109766 0.204033 0.405488
Trichomonas vaginalis PIKK family atypical protein kinase 0.00714475 0.105723 0.210111
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.00351495 0.0125973 0.0250354
Brugia malayi serine/threonine-protein kinase 6 0.0129749 0.255302 0.494729
Schistosoma mansoni serine/threonine kinase 0.00871317 0.145963 0.135067
Trypanosoma brucei aurora B kinase 0.0129749 0.255302 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.00323044 0.00529809 0.0105292
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.00736276 0.111317 0.125811
Trypanosoma cruzi target of rapamycin kinase 3 0.00885492 0.149599 0.279265
Trichomonas vaginalis AGC family protein kinase 0.007665 0.119071 0.236638
Onchocerca volvulus 0.011098 0.207148 0.5
Trichomonas vaginalis AGC family protein kinase 0.0149682 0.306443 0.609014
Schistosoma mansoni serine/threonine-protein kinase 0.00531776 0.0588502 0.046843
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0192758 0.416956 0.409518
Loa Loa (eye worm) phosphatidylinositol 3 0.0045246 0.0385009 0.0435139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045246 0.0385009 0.0765153
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0107835 0.19908 0.768352
Entamoeba histolytica protein kinase, putative 0.00736276 0.111317 0.201229
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.00871317 0.145963 0.164968
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0226365 0.503178 1
Echinococcus granulosus calcium activated potassium channel 0.00871317 0.145963 0.135067
Trypanosoma brucei target of rapamycin kinase 3, putative 0.00885492 0.149599 0.564481
Trichomonas vaginalis PIKK family atypical protein kinase 0.00693824 0.100425 0.199582
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.011098 0.207148 0.197032
Brugia malayi Protein kinase domain containing protein 0.007665 0.119071 0.217036
Trichomonas vaginalis AGC family protein kinase 0.007665 0.119071 0.236638
Echinococcus multilocularis protein kinase shaggy 0.011098 0.207148 0.197032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107835 0.19908 0.395644
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0107835 0.19908 0.188862
Echinococcus granulosus glycogen synthase kinase 3 beta 0.011098 0.207148 0.197032

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 12.35 uM Antimicrobial activity against procyclic stage of Trypanosoma brucei 427 after 24 hrs by MTT assay ChEMBL. 24630563
IC50 (functional) = 16.78 uM Antimicrobial activity against epimastigote stage of Trypanosoma brucei 29-13 after 24 hrs by MTT assay ChEMBL. 24630563
IC50 (functional) = 51.44 uM Antimicrobial activity against epimastigote stage of Trypanosoma cruzi Y after 72 hrs by MTT assay ChEMBL. 24630563
IC50 (ADMET) = 280.57 uM Cytotoxicity against human HepG2 cells by MTT assay ChEMBL. 24630563

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei ChEMBL23 24630563
Trypanosoma brucei gambiense 24630563

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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