TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 625.375 | Formula: C31H25Cl4N5O
H donors: 3 H acceptors: 1 LogP: 9.66 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: Clc1cccc(c1)/N=C(/Nc1ccccc1Oc1cc(Cl)ccc1Cl)\NCCCNc1ccnc2c1ccc(c2)Cl
InChi: 1S/C31H25Cl4N5O/c32-20-5-3-6-23(17-20)39-31(38-15-4-14-36-26-13-16-37-28-18-21(33)9-11-24(26)28)40-27-7-1-2-8-29(27)41-30-19-22(34)10-12-25(30)35/h1-3,5-13,16-19H,4,14-15H2,(H,36,37)(H2,38,39,40)
InChiKey: SJUBDPRJWNKMDW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.00234674	0.0385009	0.106729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00434114	0.137155	0.272578
Loa Loa (eye worm)	AUR protein kinase	0.0067296	0.255302	0.288543
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.00234674	0.0385009	0.026234
Schistosoma mansoni	serine/threonine protein kinase	0.00451919	0.145963	0.135067
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.00275812	0.0588502	0.0942818
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045989	0.149906	0.297917
Schistosoma mansoni	serine/threonine protein kinase	0.00451919	0.145963	0.135067
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.00559301	0.19908	0.380125
Leishmania major	protein kinase, putative	0.0067296	0.255302	1
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.00182307	0.0125973	0.0142375
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.00234674	0.0385009	0.0528018
Plasmodium vivax	glycogen synthase kinase 3, putative	0.00575611	0.207148	0.801593
Entamoeba histolytica	hypothetical protein	0.0094117	0.387973	0.765166
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.00238664	0.0404745	0.0282329
Echinococcus granulosus	serine:threonine protein kinase	0.00569314	0.204033	0.193878
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.00234674	0.0385009	0.106729
Toxoplasma gondii	aurora kinase	0.0067296	0.255302	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00344795	0.092973	0.184771
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.00772318	0.30445	0.295576
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.00260136	0.0510958	0.158623
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00559301	0.19908	0.395644
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.00776347	0.306443	0.346343
Brugia malayi	Protein kinase domain containing protein	0.00776347	0.306443	0.598974
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.00559301	0.19908	0.380125
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0067296	0.255302	0.245801
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.00999761	0.416956	0.409518
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.00234674	0.0385009	0.106729
Toxoplasma gondii	target of rapamycin (TOR), putative	0.00434114	0.137155	0.537228
Trichomonas vaginalis	AGC family protein kinase	0.0067296	0.255302	0.507378
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.00575611	0.207148	0.801593
Entamoeba histolytica	PH domain containing protein kinase, putative	0.00275812	0.0588502	0.0942818
Entamoeba histolytica	protein kinase domain containing protein	0.00575611	0.207148	0.396571
Trichomonas vaginalis	AGC family protein kinase	0.00397555	0.119071	0.236638
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.00234674	0.0385009	0.026234
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.00575611	0.207148	0.197032
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.00415206	0.127802	0.234834
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00334704	0.0879813	0.174851
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.00816957	0.326531	0.648936
Brugia malayi	serine/threonine kinase 12	0.0067296	0.255302	0.494729
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0217845	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00434114	0.137155	0.272578
Plasmodium falciparum	glycogen synthase kinase 3	0.00575611	0.207148	0.801593
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00334084	0.0876749	0.174242
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.00559301	0.19908	0.768352
Giardia lamblia	Aurora kinase	0.0067296	0.255302	1
Echinococcus multilocularis	serine:threonine protein kinase	0.00569314	0.204033	0.193878
Loa Loa (eye worm)	phosphatidylinositol 3	0.0194555	0.884795	1
Echinococcus granulosus	serine/threonine protein kinase	0.00275812	0.0588502	0.046843
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0117407	0.503178	1
Trichomonas vaginalis	AGC family protein kinase	0.0067296	0.255302	0.507378
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.00539419	0.189245	0.360078
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045989	0.149906	0.297917
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00234674	0.0385009	0.0765153
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.00415206	0.127802	0.25399
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.00182307	0.0125973	0.0250354
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.00559301	0.19908	0.188862
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.00234674	0.0385009	0.0528018
Entamoeba histolytica	protein kinase, putative	0.0067296	0.255302	0.494729
Echinococcus multilocularis	calcium activated potassium channel	0.00451919	0.145963	0.135067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00434114	0.137155	0.272578
Trichomonas vaginalis	AGC family protein kinase	0.00397555	0.119071	0.236638
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00434114	0.137155	0.272578
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045989	0.149906	0.297917
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00559301	0.19908	0.395644
Loa Loa (eye worm)	AUR protein kinase	0.0067296	0.255302	0.288543
Trichomonas vaginalis	AGC family protein kinase	0.00776347	0.306443	0.609014
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.00999761	0.416956	0.409518
Schistosoma mansoni	serine/threonine-protein kinase	0.00275812	0.0588502	0.046843
Loa Loa (eye worm)	phosphatidylinositol 3	0.00234674	0.0385009	0.0435139
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00167551	0.00529809	0.0105292
Trypanosoma cruzi	target of rapamycin kinase 3	0.00459271	0.149599	0.279265
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.00381879	0.111317	0.125811
Onchocerca volvulus		0.00575611	0.207148	0.5
Trichomonas vaginalis	AGC family protein kinase	0.00397555	0.119071	0.236638
Trypanosoma brucei	aurora B kinase	0.0067296	0.255302	1
Schistosoma mansoni	serine/threonine kinase	0.00451919	0.145963	0.135067
Brugia malayi	Protein kinase domain containing protein	0.00397555	0.119071	0.217036
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.00575611	0.207148	0.197032
Trichomonas vaginalis	AGC family protein kinase	0.00397555	0.119071	0.236638
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00559301	0.19908	0.395644
Echinococcus multilocularis	protein kinase shaggy	0.00575611	0.207148	0.197032
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.00575611	0.207148	0.197032
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.00559301	0.19908	0.188862
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0117407	0.503178	1
Echinococcus granulosus	calcium activated potassium channel	0.00451919	0.145963	0.135067
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.00459271	0.149599	0.564481
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00359861	0.100425	0.199582
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.00559301	0.19908	0.768352
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00234674	0.0385009	0.0765153
Entamoeba histolytica	protein kinase, putative	0.00381879	0.111317	0.201229
Loa Loa (eye worm)	CAMK/CAMKL/MELK protein kinase	0.00451919	0.145963	0.164968
Schistosoma mansoni	serine/threonine protein kinase	0.0067296	0.255302	0.245801
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.00415206	0.127802	0.234834
Entamoeba histolytica	protein kinase, putative	0.0067296	0.255302	0.494729
Brugia malayi	serine/threonine protein kinase 6	0.0067296	0.255302	0.494729
Loa Loa (eye worm)	phosphatidylinositol 3	0.00347685	0.0944025	0.106694
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.00347685	0.0944025	0.166752
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0117407	0.503178	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.00260136	0.0510958	0.0784753
Loa Loa (eye worm)	phosphatidylinositol 3	0.00559301	0.19908	0.225001
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.00182307	0.0125973	0.0250354
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00370571	0.105723	0.210111
Brugia malayi	serine/threonine-protein kinase 6	0.0067296	0.255302	0.494729
Loa Loa (eye worm)	hypothetical protein	0.00401751	0.121147	0.13692
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00469982	0.154897	0.307838
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.00816957	0.326531	0.648936
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0117407	0.503178	1
Trichomonas vaginalis	CAMK family protein kinase	0.00569314	0.204033	0.405488
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00234674	0.0385009	0.0765153
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0110655	0.469779	0.931918
Echinococcus granulosus	serine threonine protein kinase nrc	0.00260136	0.0510958	0.0389897
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.00776347	0.306443	0.297594
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.00559301	0.19908	0.380125
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00334704	0.0879813	0.174851
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.00238664	0.0404745	0.0282329
Echinococcus granulosus	serine:threonine protein kinase	0.00569314	0.204033	0.193878
Entamoeba histolytica	protein kinase domain containing protein	0.00575611	0.207148	0.396571
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.00999761	0.416956	0.409518
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0067296	0.255302	0.494729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00344795	0.092973	0.184771
Giardia lamblia	Kinase, CMGC GSK	0.00575611	0.207148	0.764188
Entamoeba histolytica	protein kinase domain containing protein	0.0067296	0.255302	0.494729
Entamoeba histolytica	protein kinase 2, putative	0.00260136	0.0510958	0.0784753
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.00772318	0.30445	0.594912
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.00772318	0.30445	0.295576
Echinococcus granulosus	protein kinase shaggy	0.00575611	0.207148	0.197032
Trypanosoma brucei	protein kinase, putative	0.00575611	0.207148	0.801593
Trichomonas vaginalis	CMGC family protein kinase	0.00575611	0.207148	0.411678
Schistosoma mansoni	serine/threonine protein kinase	0.00776347	0.306443	0.297594
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.00459271	0.149599	0.564481
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.00559301	0.19908	0.768352
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.00559301	0.19908	0.380125
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0067296	0.255302	0.245801
Schistosoma mansoni	hypothetical protein	0.00430447	0.135341	0.12431
Trichomonas vaginalis	AGC family protein kinase	0.00397555	0.119071	0.236638
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0100438	0.419239	0.828899
Trichomonas vaginalis	AGC family protein kinase	0.0067296	0.255302	0.507378
Echinococcus multilocularis	rac serine:threonine kinase	0.00275812	0.0588502	0.046843
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00334704	0.0879813	0.174851
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.00415206	0.127802	0.474672
Echinococcus multilocularis	Glutaredoxin protein 5	0.00238664	0.0404745	0.0282329
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00334084	0.0876749	0.174242
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.00584058	0.211326	0.784649
Trichomonas vaginalis	AGC family protein kinase	0.0067296	0.255302	0.507378
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0117407	0.503178	1
Schistosoma mansoni	hypothetical protein	0.00430447	0.135341	0.12431
Echinococcus granulosus	nervana 2	0.00238664	0.0404745	0.0282329
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045989	0.149906	0.297917
Trichomonas vaginalis	AGC family protein kinase	0.00397555	0.119071	0.236638
Giardia lamblia	GTOR	0.00559301	0.19908	0.72468
Trichomonas vaginalis	CMGC family protein kinase	0.00575611	0.207148	0.411678
Loa Loa (eye worm)	hypothetical protein	0.00569314	0.204033	0.230599
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0117407	0.503178	1
Entamoeba histolytica	protein kinase, putative	0.00397555	0.119071	0.217036
Brugia malayi	p70 ribosomal S6 kinase beta	0.00381879	0.111317	0.201229
Trichomonas vaginalis	AGC family protein kinase	0.00776347	0.306443	0.609014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00382057	0.111405	0.221402
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0067296	0.255302	0.494729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00234674	0.0385009	0.0765153
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.00559301	0.19908	0.188862
Brugia malayi	Protein kinase domain containing protein	0.00451919	0.145963	0.271852
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0094117	0.387973	0.765166
Loa Loa (eye worm)	AGC/AKT protein kinase	0.00397555	0.119071	0.134575
Giardia lamblia	Kinase, CMGC GSK	0.00575611	0.207148	0.764188
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.00415206	0.127802	0.234834
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.00559301	0.19908	0.768352
Trichomonas vaginalis	AGC family protein kinase	0.00397555	0.119071	0.236638
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.00776347	0.306443	0.297594
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.00234674	0.0385009	0.0528018
Entamoeba histolytica	protein kinase, putative	0.00575611	0.207148	0.396571
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.00234674	0.0385009	0.026234
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.00260136	0.0510958	0.0389897
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00334084	0.0876749	0.174242
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.00575611	0.207148	0.234119
Loa Loa (eye worm)	AUR protein kinase	0.0067296	0.255302	0.288543
Trypanosoma cruzi	Protein kinase B	0.00275812	0.0588502	0.0942818
Echinococcus granulosus	aurora kinase A	0.0067296	0.255302	0.245801
Trichomonas vaginalis	CAMK family protein kinase	0.00451919	0.145963	0.290081
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0067296	0.255302	1
Schistosoma mansoni	serine/threonine protein kinase	0.00999761	0.416956	0.409518
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.00266962	0.0544721	0.172534
Echinococcus granulosus	nervana 2	0.00238664	0.0404745	0.0282329
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.00575611	0.207148	0.811383
Schistosoma mansoni	serine/threonine protein kinase	0.00451919	0.145963	0.135067
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.00415206	0.127802	0.116675
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00434114	0.137155	0.272578
Schistosoma mansoni	serine/threonine-protein kinase	0.00275812	0.0588502	0.046843
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.00999761	0.416956	0.409518
Entamoeba histolytica	PH domain containing protein kinase, putative	0.00275812	0.0588502	0.0942818
Entamoeba histolytica	protein kinase, putative	0.00776347	0.306443	0.598974
Trypanosoma cruzi	aurora B kinase, putative	0.0067296	0.255302	0.494729
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.00260136	0.0510958	0.0389897
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0067296	0.255302	1
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.00575611	0.207148	0.396571
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00344795	0.092973	0.184771
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.00575611	0.207148	0.234119
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.00182307	0.0125973	0.0493428
Echinococcus multilocularis	nervana 2	0.00238664	0.0404745	0.0282329
Trichomonas vaginalis	AGC family protein kinase	0.00776347	0.306443	0.609014
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.00415206	0.127802	0.25399
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00334084	0.0876749	0.174242
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.00415206	0.127802	0.25399
Echinococcus multilocularis	nervana 2	0.00238664	0.0404745	0.0282329
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0217845	1	1
Entamoeba histolytica	protein kinase, putative	0.00397555	0.119071	0.217036
Echinococcus multilocularis	aurora kinase A	0.0067296	0.255302	0.245801
Brugia malayi	Kinase associated domain 1 family protein	0.00430447	0.135341	0.250201
Schistosoma mansoni	serine/threonine protein kinase	0.00999761	0.416956	0.409518
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0117407	0.503178	1
Echinococcus multilocularis	serine:threonine protein kinase	0.00569314	0.204033	0.193878
Toxoplasma gondii	AGC kinase	0.00381879	0.111317	0.43602
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0067296	0.255302	0.494729
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.00182307	0.0125973	0.0250354
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.00559301	0.19908	0.380125
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0030042	0.0710227	0.0975822
Trypanosoma brucei	rac serine-threonine kinase, putative	0.00397555	0.119071	0.438697
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045989	0.149906	0.297917
Loa Loa (eye worm)	hypothetical protein	0.00430447	0.135341	0.152964
Entamoeba histolytica	protein kinase , putative	0.0067296	0.255302	0.494729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00234674	0.0385009	0.0765153
Echinococcus multilocularis	hypothetical protein	0.00430447	0.135341	0.12431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00359861	0.100425	0.199582
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0217845	1	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.00182307	0.0125973	0.0493428
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.00256251	0.0491741	0.150705
Loa Loa (eye worm)	hypothetical protein	0.00772318	0.30445	0.344091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00434114	0.137155	0.272578
Brugia malayi	intracellular kinase	0.00575611	0.207148	0.396571
Leishmania major	phosphatidylinositol 3-kinase, putative	0.00234674	0.0385009	0.106729
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.00776347	0.306443	0.346343
Brugia malayi	phosphoinositide-dependent protein kinase I	0.00776347	0.306443	0.598974
Loa Loa (eye worm)	CAMK/CAMKL/MARK protein kinase	0.00569314	0.204033	0.230599
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00434114	0.137155	0.272578
Trichomonas vaginalis	AGC family protein kinase	0.00158891	0.00101438	0.00201594
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.00260136	0.0510958	0.158623
Brugia malayi	Protein kinase domain containing protein	0.00569314	0.204033	0.390222
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.00415206	0.127802	0.234834
Echinococcus granulosus	Glutaredoxin protein 5	0.00238664	0.0404745	0.0282329
Schistosoma mansoni	protein kinase	0.0067296	0.255302	0.245801

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 77.71 nM	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay	ChEMBL.	24630564
IC50 (functional)	= 87.68 nM	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay	ChEMBL.	24630564
MIC (functional)	= 6.25 ug ml-1	Antimicrobial activity against Escherichia coli ATCC 9637 after 24 hrs by standard broth microdilution method	ChEMBL.	24630564
MIC (functional)	= 25 ug ml-1	Antifungal activity against Candida albicans clinical isolate after 24 to 48 hrs by standard broth microdilution method	ChEMBL.	24630564
MIC (functional)	= 50 ug ml-1	Antifungal activity against Cryptococcus neoformans clinical isolate after 24 to 48 hrs by standard broth microdilution method	ChEMBL.	24630564

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum		24630564

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3235274

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1880804