Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sirtuin 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | transcriptional regulatory protein sir2a | sirtuin 2 | 234 aa | 207 aa | 26.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0153 | 0.1282 | 0.1092 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0207 | 0.1982 | 0.1993 |
Onchocerca volvulus | 0.0102 | 0.0629 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0629 | 0.0424 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1329 | 0.1139 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0135 | 0.1046 | 0.0939 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0072 | 0.0231 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1282 | 0.1092 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1329 | 0.1139 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0135 | 0.1046 | 1 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0135 | 0.1046 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0207 | 0.1982 | 0.1807 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0072 | 0.0231 | 0.002 |
Giardia lamblia | Hypothetical protein | 0.0135 | 0.1046 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0072 | 0.0231 | 0.0216 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0135 | 0.1046 | 0.528 |
Trichomonas vaginalis | STE family protein kinase | 0.0072 | 0.0231 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.1982 | 0.1807 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0072 | 0.0231 | 0.002 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0104 | 0.0653 | 0.3296 |
Schistosoma mansoni | protein kinase | 0.0072 | 0.0231 | 0.1168 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0135 | 0.1046 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0072 | 0.0231 | 0.0216 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0104 | 0.0653 | 0.3296 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0135 | 0.1046 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0072 | 0.0231 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1282 | 0.1092 |
Schistosoma mansoni | protein kinase | 0.007 | 0.0213 | 0.1077 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0207 | 0.1982 | 0.1993 |
Loa Loa (eye worm) | transcriptional regulator | 0.0135 | 0.1046 | 0.0851 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1329 | 0.1139 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.007 | 0.0213 | 0.1077 |
Entamoeba histolytica | protein kinase, putative | 0.0072 | 0.0231 | 0.0216 |
Trichomonas vaginalis | STE family protein kinase | 0.0072 | 0.0231 | 0.0216 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0072 | 0.0231 | 0.002 |
Leishmania major | silent information regulator 2, putative | 0.0135 | 0.1046 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0072 | 0.0231 | 0.1168 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0135 | 0.1046 | 0.0851 |
Brugia malayi | Peptidase family M13 containing protein | 0.0207 | 0.1982 | 0.1807 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0135 | 0.1046 | 0.528 |
Schistosoma mansoni | serine/threonine protein kinase | 0.007 | 0.0213 | 0.1077 |
Schistosoma mansoni | tyrosine kinase | 0.007 | 0.0213 | 0.1077 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0104 | 0.0653 | 0.3296 |
Entamoeba histolytica | protein kinase, putative | 0.0072 | 0.0231 | 0.0216 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0072 | 0.0231 | 0.002 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0135 | 0.1046 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0072 | 0.0231 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1329 | 0.1139 |
Schistosoma mansoni | protein kinase | 0.0072 | 0.0231 | 0.1168 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0104 | 0.0653 | 0.3296 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0213 | 0.1077 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0104 | 0.0653 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1329 | 0.1139 |
Entamoeba histolytica | protein kinase, putative | 0.0072 | 0.0231 | 0.0216 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0135 | 0.1046 | 0.0939 |
Brugia malayi | Protein kinase domain | 0.0072 | 0.0231 | 0.0018 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0135 | 0.1046 | 0.0939 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0213 | 0.1077 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0135 | 0.1046 | 0.528 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0207 | 0.1982 | 0.5 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0207 | 0.1982 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0153 | 0.1282 | 0.1092 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0135 | 0.1046 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0072 | 0.0231 | 0.0216 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0213 | 0.1077 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0824 | 1 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0072 | 0.0231 | 0.002 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0754 | 0.9087 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1282 | 0.1092 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0207 | 0.1982 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0754 | 0.9087 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.1982 | 0.1807 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0207 | 0.1982 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.1982 | 0.1807 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0072 | 0.0231 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1282 | 0.1092 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0135 | 0.1046 | 0.0939 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0135 | 0.1046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1329 | 0.1139 |
Toxoplasma gondii | peptidase family M13 protein | 0.0207 | 0.1982 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.5 uM | Inhibition of SIRT-2 (unknown origin) by fluorescence assay | ChEMBL. | 24602787 |
Inhibition (binding) | = 0 % | Inhibition of SIRT-1 (unknown origin) at 10 uM by fluorescence assay | ChEMBL. | 24602787 |
Inhibition (binding) | = 6 % | Inhibition of SIRT-3 (unknown origin) at 10 uM by fluorescence assay | ChEMBL. | 24602787 |
Inhibition (binding) | = 37 % | Inhibition of SIRT-2 (unknown origin) at 10 uM by fluorescence assay | ChEMBL. | 24602787 |
Papp (ADMET) | = 25.7 ucm/s | Apparent permeability from apical to basolateral side in human Caco2 cells after 2 hrs | ChEMBL. | 24602787 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.