Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sirtuin 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | transcriptional regulatory protein sir2a | sirtuin 2 | 234 aa | 207 aa | 26.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0072 | 0.0231 | 0.002 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0135 | 0.1046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1282 | 0.1092 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0135 | 0.1046 | 0.0939 |
Toxoplasma gondii | peptidase family M13 protein | 0.0207 | 0.1982 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1329 | 0.1139 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.1982 | 0.1807 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0754 | 0.9087 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0207 | 0.1982 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.1982 | 0.1807 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0824 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0213 | 0.1077 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0072 | 0.0231 | 0.002 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0754 | 0.9087 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1282 | 0.1092 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0207 | 0.1982 | 1 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0207 | 0.1982 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0135 | 0.1046 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0153 | 0.1282 | 0.1092 |
Entamoeba histolytica | p21-activated kinase | 0.0072 | 0.0231 | 0.0216 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0135 | 0.1046 | 0.0939 |
Brugia malayi | Protein kinase domain | 0.0072 | 0.0231 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0213 | 0.1077 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0207 | 0.1982 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0135 | 0.1046 | 0.528 |
Entamoeba histolytica | protein kinase, putative | 0.0072 | 0.0231 | 0.0216 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0135 | 0.1046 | 0.0939 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0104 | 0.0653 | 0.3296 |
Schistosoma mansoni | protein kinase | 0.0072 | 0.0231 | 0.1168 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0213 | 0.1077 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0104 | 0.0653 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1329 | 0.1139 |
Entamoeba histolytica | protein kinase, putative | 0.0072 | 0.0231 | 0.0216 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0104 | 0.0653 | 0.3296 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0072 | 0.0231 | 0.002 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0135 | 0.1046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1329 | 0.1139 |
Entamoeba histolytica | protein kinase, putative | 0.0072 | 0.0231 | 0.0216 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0135 | 0.1046 | 0.0851 |
Brugia malayi | Peptidase family M13 containing protein | 0.0207 | 0.1982 | 0.1807 |
Schistosoma mansoni | protein kinase | 0.0072 | 0.0231 | 0.1168 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0135 | 0.1046 | 0.528 |
Schistosoma mansoni | serine/threonine protein kinase | 0.007 | 0.0213 | 0.1077 |
Schistosoma mansoni | tyrosine kinase | 0.007 | 0.0213 | 0.1077 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.007 | 0.0213 | 0.1077 |
Trichomonas vaginalis | STE family protein kinase | 0.0072 | 0.0231 | 0.0216 |
Entamoeba histolytica | protein kinase, putative | 0.0072 | 0.0231 | 0.0216 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0072 | 0.0231 | 0.002 |
Leishmania major | silent information regulator 2, putative | 0.0135 | 0.1046 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0207 | 0.1982 | 0.1993 |
Schistosoma mansoni | protein kinase | 0.007 | 0.0213 | 0.1077 |
Loa Loa (eye worm) | transcriptional regulator | 0.0135 | 0.1046 | 0.0851 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1329 | 0.1139 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0104 | 0.0653 | 0.3296 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0135 | 0.1046 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1282 | 0.1092 |
Trichomonas vaginalis | STE family protein kinase | 0.0072 | 0.0231 | 0.0216 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0135 | 0.1046 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0072 | 0.0231 | 0.1168 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0072 | 0.0231 | 0.002 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0104 | 0.0653 | 0.3296 |
Trichomonas vaginalis | STE family protein kinase | 0.0072 | 0.0231 | 0.0216 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0207 | 0.1982 | 0.1807 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0135 | 0.1046 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0135 | 0.1046 | 1 |
Giardia lamblia | Hypothetical protein | 0.0135 | 0.1046 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0072 | 0.0231 | 0.002 |
Trichomonas vaginalis | STE family protein kinase | 0.0072 | 0.0231 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.1982 | 0.1807 |
Trichomonas vaginalis | STE family protein kinase | 0.0072 | 0.0231 | 0.0216 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0135 | 0.1046 | 0.528 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0072 | 0.0231 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1329 | 0.1139 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1282 | 0.1092 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0153 | 0.1282 | 0.1092 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0207 | 0.1982 | 0.1993 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1329 | 0.1139 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0629 | 0.0424 |
Onchocerca volvulus | 0.0102 | 0.0629 | 0.5 | |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0135 | 0.1046 | 0.0939 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.8 uM | Inhibition of SIRT-2 (unknown origin) by fluorescence assay | ChEMBL. | 24602787 |
Inhibition (binding) | = 0 % | Inhibition of SIRT-1 (unknown origin) at 0.5 uM by fluorescence assay | ChEMBL. | 24602787 |
Inhibition (binding) | = 0 % | Inhibition of SIRT-3 (unknown origin) at 0.5 uM by fluorescence assay | ChEMBL. | 24602787 |
Inhibition (binding) | = 3 % | Inhibition of SIRT-1 (unknown origin) at 10 uM by fluorescence assay | ChEMBL. | 24602787 |
Inhibition (binding) | = 5 % | Inhibition of SIRT-1 (unknown origin) at 25 uM by fluorescence assay | ChEMBL. | 24602787 |
Inhibition (binding) | = 10 % | Inhibition of SIRT-3 (unknown origin) at 10 uM by fluorescence assay | ChEMBL. | 24602787 |
Inhibition (binding) | = 13 % | Inhibition of SIRT-1 (unknown origin) at 50 uM by fluorescence assay | ChEMBL. | 24602787 |
Inhibition (binding) | = 14 % | Inhibition of SIRT-3 (unknown origin) at 25 uM by fluorescence assay | ChEMBL. | 24602787 |
Inhibition (binding) | = 33 % | Inhibition of SIRT-3 (unknown origin) at 50 uM by fluorescence assay | ChEMBL. | 24602787 |
Inhibition (binding) | = 37 % | Inhibition of SIRT-2 (unknown origin) at 10 uM by fluorescence assay | ChEMBL. | 24602787 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.