TDR Targets

Basic information

Technical information

TDR Targets ID: 188581
Name: butyl 2-[2-(4-chlorophenyl)-5-thiophen-3-yl-1 ,3-oxazol-4-yl]acetate
MW: 375.869 | Formula: C19H18ClNO3S
H donors: 0 H acceptors: 2 LogP: 5.05 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCOC(=O)Cc1nc(oc1c1cscc1)c1ccc(cc1)Cl
InChi: 1S/C19H18ClNO3S/c1-2-3-9-23-17(22)11-16-18(14-8-10-25-12-14)24-19(21-16)13-4-6-15(20)7-5-13/h4-8,10,12H,2-3,9,11H2,1H3
InChiKey: KSHWPCBEOFKQGL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

butyl 2-[2-(4-chlorophenyl)-5-(3-thienyl)oxazol-4-yl]acetate
2-[2-(4-chlorophenyl)-5-(3-thienyl)-4-oxazolyl]acetic acid butyl ester
butyl 2-[2-(4-chlorophenyl)-5-thiophen-3-yl-1,3-oxazol-4-yl]ethanoate
2-[2-(4-chlorophenyl)-5-(3-thienyl)oxazol-4-yl]acetic acid butyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0203	0.0117	0.0119
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Trypanosoma cruzi	glycerol uptake protein, putative	0.0365	0.0244	1
Echinococcus granulosus	tyrosine kinase	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0365	0.0244	0.0131
Schistosoma mansoni	protein tyrosine kinase	0.0203	0.0117	0.0117
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Brugia malayi	MBOAT family protein	0.0365	0.0244	0.0131
Trichomonas vaginalis	conserved hypothetical protein	0.0365	0.0244	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0203	0.0117	0.4801
Giardia lamblia	Kinase, NEK	0.0203	0.0117	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0365	0.0244	0.0248
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0203	0.0117	0.0119
Echinococcus multilocularis	protein tyrosine kinase	0.0203	0.0117	0.0119
Echinococcus multilocularis	c src tyrosine kinase	0.0203	0.0117	0.0119
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0203	0.0117	0.0119
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0203	0.0117	0.0119
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0203	0.0117	0.0119
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0203	0.0117	0.0117
Toxoplasma gondii	hypothetical protein	0.0365	0.0244	1
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Loa Loa (eye worm)	MBOAT family protein	0.0365	0.0244	0.0131
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Schistosoma mansoni	serine/threonine protein kinase	0.0203	0.0117	0.0117
Brugia malayi	diacylglycerol acyltransferase	0.0365	0.0244	0.0131
Echinococcus granulosus	insulin receptor	0.0203	0.0117	0.0119
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0203	0.0117	0.0119
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0203	0.0117	0.0119
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0203	0.0117	0.4801
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0203	0.0117	0.0119
Loa Loa (eye worm)	hypothetical protein	0.337	0.261	0.2564
Echinococcus granulosus	tyrosine protein kinase shark	0.0203	0.0117	0.0119
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0203	0.0117	0.0119
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0203	0.0117	0.0119
Echinococcus multilocularis	tyrosine protein kinase csk	0.0203	0.0117	0.0119
Giardia lamblia	Protein 21.1	0.0203	0.0117	0.5
Loa Loa (eye worm)	hypothetical protein	0.0365	0.0244	0.0131
Leishmania major	protein kinase, putative	0.0203	0.0117	0.4801
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0203	0.0117	0.0119
Toxoplasma gondii	protein kinase domain-containing protein	0.0203	0.0117	0.4801
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0054	0	0.5
Echinococcus granulosus	activin receptor type	0.0203	0.0117	0.0119
Schistosoma mansoni	microtubule-associated protein tau	0.0619	0.0445	0.0445
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0203	0.0117	0.0119
Schistosoma mansoni	hypothetical protein	0.0203	0.0117	0.0117
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0203	0.0117	0.0119
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0365	0.0244	0.0248
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0365	0.0244	0.0244
Echinococcus multilocularis	tyrosine kinase	0.0203	0.0117	0.0119
Echinococcus multilocularis	protein kinase	0.0203	0.0117	0.0119
Echinococcus multilocularis	microtubule associated protein 2	0.0619	0.0445	0.0452
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0365	0.0244	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0203	0.0117	0.0119
Schistosoma mansoni	protein kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0203	0.0117	0.0119
Echinococcus granulosus	microtubule associated protein 2	0.0619	0.0445	0.0452
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0365	0.0244	0.0248
Echinococcus granulosus	tyrosine protein kinase csk	0.0203	0.0117	0.0119
Giardia lamblia	Kinase	0.0203	0.0117	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0203	0.0117	0.0119
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Schistosoma mansoni	protein kinase	0.0203	0.0117	0.0117
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0203	0.0117	0.0117
Loa Loa (eye worm)	hhat protein	0.0365	0.0244	0.0131
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0203	0.0117	0.0119
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0203	0.0117	0.0119
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0365	0.0244	1
Loa Loa (eye worm)	MBOAT family protein	0.0365	0.0244	0.0131
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0203	0.0117	0.0119
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0365	0.0244	0.0244
Echinococcus multilocularis	survival motor neuron protein 1	0.0212	0.0124	0.0126
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0203	0.0117	0.0119
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0203	0.0117	0.0119
Schistosoma mansoni	protein kinase	0.0203	0.0117	0.0117
Toxoplasma gondii	STE kinase	0.0203	0.0117	0.4801
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0203	0.0117	0.0119
Echinococcus granulosus	tyrosine protein kinase csk	0.0203	0.0117	0.0119
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Schistosoma mansoni	protein kinase	0.0203	0.0117	0.0117
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0365	0.0244	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0203	0.0117	0.0119
Leishmania major	protein kinase, putative	0.0203	0.0117	0.4801
Echinococcus granulosus	ephrin type A receptor 4 A	0.0203	0.0117	0.0119
Schistosoma mansoni	hypothetical protein	0.0365	0.0244	0.0244
Echinococcus granulosus	tyrosine kinase	0.0203	0.0117	0.0119
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Schistosoma mansoni	protein kinase	0.0203	0.0117	0.0117
Schistosoma mansoni	protein kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0203	0.0117	0.0119
Treponema pallidum	alginate O-acetylation protein (algI)	0.0365	0.0244	0.5
Loa Loa (eye worm)	MBOAT family protein	0.0365	0.0244	0.0131
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0203	0.0117	0.0119
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0203	0.0117	0.0119
Echinococcus granulosus	sterol O acyltransferase 1	0.3735	0.2897	0.2945
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0365	0.0244	0.0248
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0203	0.0117	0.0119
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0054	0	0.5
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0365	0.0244	0.0131
Leishmania major	glycerol uptake protein, putative	0.0365	0.0244	1
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0365	0.0244	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0203	0.0117	0.0119
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0203	0.0117	0.0119
Loa Loa (eye worm)	hypothetical protein	1.2552	0.984	1
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0203	0.0117	0.0119
Entamoeba histolytica	vacuolar protein sorting 26	0.0365	0.0244	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0203	0.0117	0.0119
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0203	0.0117	0.0119
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Brugia malayi	MBOAT family protein	0.0365	0.0244	0.0131
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Leishmania major	hypothetical protein, conserved	0.0365	0.0244	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0203	0.0117	0.0119
Trypanosoma cruzi	glycerol uptake protein, putative	0.0365	0.0244	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0203	0.0117	0.0119
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0203	0.0117	0.0119
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	activated cdc42 kinase 1	0.0203	0.0117	0.0119
Leishmania major	hypothetical protein, conserved	0.0203	0.0117	0.4801
Echinococcus multilocularis	epidermal growth factor receptor	0.0203	0.0117	0.0119
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0203	0.0117	0.4801
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0203	0.0117	0.0119
Toxoplasma gondii	protein kinase	0.0203	0.0117	0.4801
Leishmania major	glycerol uptake protein, putative	0.0365	0.0244	1
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0365	0.0244	0.0248
Leishmania major	glycerol uptake protein, putative	0.0365	0.0244	1
Schistosoma mansoni	serine/threonine protein kinase	0.0203	0.0117	0.0117
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0203	0.0117	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0365	0.0244	0.0131
Leishmania major	glycerol uptake protein, putative	0.0365	0.0244	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus multilocularis	activated cdc42 kinase 1	0.0203	0.0117	0.0119
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0054	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0203	0.0117	0.0119
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0365	0.0244	0.0248
Schistosoma mansoni	serine/threonine RGC	0.0203	0.0117	0.0117
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0365	0.0244	0.0244
Schistosoma mansoni	ephrin receptor	0.0203	0.0117	0.0117
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Schistosoma mansoni	sterol O-acyltransferase 1	0.3735	0.2897	0.2897
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Trichomonas vaginalis	porcupine, putative	0.0365	0.0244	1
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0365	0.0244	0.0248
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0203	0.0117	0.0119
Schistosoma mansoni	serine/threonine protein kinase	0.0203	0.0117	0.0117
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0203	0.0117	0.0119
Giardia lamblia	Kinase, NEK	0.0203	0.0117	0.5
Brugia malayi	MBOAT family protein	0.0365	0.0244	0.0131
Trypanosoma brucei	glycerol uptake protein, putative	0.0365	0.0244	1
Schistosoma mansoni	protein kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0203	0.0117	0.0119
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0365	0.0244	0.0248
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Brugia malayi	MBOAT family protein	0.0365	0.0244	0.0131
Echinococcus multilocularis	tyrosine protein kinase csk	0.0203	0.0117	0.0119
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0203	0.0117	0.0119
Schistosoma mansoni	protein kinase	0.0203	0.0117	0.0117
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0203	0.0117	0.0117
Echinococcus multilocularis	tyrosine protein kinase	0.0203	0.0117	0.0119
Echinococcus multilocularis	transfer RNA-Thr	0.0203	0.0117	0.0119
Echinococcus multilocularis	insulin receptor	0.0203	0.0117	0.0119
Trichomonas vaginalis	conserved hypothetical protein	0.0365	0.0244	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0203	0.0117	0.0117
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0365	0.0244	1
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0365	0.0244	0.0248
Trypanosoma brucei	glycerol uptake protein, putative	0.0365	0.0244	1
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0365	0.0244	0.0244
Echinococcus granulosus	tyrosine protein kinase Blk	0.0203	0.0117	0.0119
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0203	0.0117	0.0117
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0203	0.0117	0.0119
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0365	0.0244	1
Brugia malayi	hypothetical protein	0.0212	0.0124	0.0007
Echinococcus granulosus	c src tyrosine kinase	0.0203	0.0117	0.0119
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0203	0.0117	0.0119
Echinococcus multilocularis	integrin linked protein kinase	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	protein kinase	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine protein kinase	0.0203	0.0117	0.0117
Brugia malayi	MBOAT family protein	0.0365	0.0244	0.0131
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0203	0.0117	0.0119
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	1.2552	0.984	1
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0365	0.0244	0.0248
Trichomonas vaginalis	conserved hypothetical protein	0.0365	0.0244	1
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0124	0.0007
Echinococcus granulosus	receptor type guanylyl cyclase	0.0203	0.0117	0.0119
Echinococcus multilocularis	protein kinase	0.0203	0.0117	0.0119
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0365	0.0244	0.0248
Loa Loa (eye worm)	hypothetical protein	1.2552	0.984	1
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0365	0.0244	0.0244
Entamoeba histolytica	hypothetical protein, conserved	0.0365	0.0244	1
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0365	0.0244	0.0248
Echinococcus multilocularis	sterol O acyltransferase 1	0.3735	0.2897	0.2945
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0203	0.0117	0.0117
Brugia malayi	Protein kinase domain containing protein	1.2552	0.984	1
Leishmania major	glycerol uptake protein, putative	0.0365	0.0244	1
Schistosoma mansoni	protein kinase	0.0203	0.0117	0.0117
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	1.2552	0.984	1
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	tyrosine protein kinase csk	0.0203	0.0117	0.0119
Echinococcus multilocularis	FL cytokine receptor	0.0203	0.0117	0.0119
Echinococcus granulosus	tyrosine kinase	0.0203	0.0117	0.0119
Echinococcus granulosus	tyrosine protein kinase	0.0203	0.0117	0.0119
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0203	0.0117	0.0119
Loa Loa (eye worm)	hypothetical protein	0.3735	0.2897	0.2859
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0203	0.0117	0.0119
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0365	0.0244	0.0244
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0203	0.0117	0.0119
Echinococcus granulosus	tyrosine protein kinase Srms	0.0203	0.0117	0.0119
Schistosoma mansoni	protein kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	epidermal growth factor receptor	0.0203	0.0117	0.0119
Echinococcus granulosus	integrin linked protein kinase	0.0203	0.0117	0.0119
Echinococcus granulosus	kinase suppressor of Ras 1	0.0203	0.0117	0.0119
Echinococcus granulosus	tyrosine protein kinase pr2	0.0203	0.0117	0.0119
Echinococcus granulosus	raf serine:threonine protein kinase	0.0203	0.0117	0.0119
Schistosoma mansoni	ephrin receptor	0.0203	0.0117	0.0117
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0203	0.0117	0.0119
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0203	0.0117	0.0117
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0203	0.0117	0.0119
Echinococcus granulosus	survival motor neuron protein 1	0.0212	0.0124	0.0126
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0203	0.0117	0.0119
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0365	0.0244	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0203	0.0117	0.0119
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0365	0.0244	0.0248
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus multilocularis	tyrosine kinase	0.0203	0.0117	0.0119
Trypanosoma cruzi	GUP1, putative	0.0365	0.0244	1
Echinococcus multilocularis	heat shock protein 70	0.0203	0.0117	0.0119
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0365	0.0244	0.0248
Echinococcus granulosus	natriuretic peptide receptor 1	0.0203	0.0117	0.0119
Schistosoma mansoni	zinc finger protein	0.0365	0.0244	0.0244
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0365	0.0244	0.0131
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0054	0	0.5
Onchocerca volvulus		0.0365	0.0244	1
Brugia malayi	Hhat protein	0.0365	0.0244	0.0131
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0365	0.0244	0.0248
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0365	0.0244	1
Echinococcus multilocularis	activin receptor type	0.0203	0.0117	0.0119
Echinococcus granulosus	epidermal growth factor receptor	0.0203	0.0117	0.0119
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	1.2552	0.984	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0203	0.0117	0.0119
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0203	0.0117	0.0119
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0203	0.0117	0.0119
Trypanosoma cruzi	GUP1, putative	0.0365	0.0244	1
Trypanosoma cruzi	glycerol uptake protein, putative	0.0365	0.0244	1
Loa Loa (eye worm)	hhat protein	0.0365	0.0244	0.0131
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	activated cdc42 kinase 1	0.0203	0.0117	0.0119
Schistosoma mansoni	tyrosine kinase	0.0203	0.0117	0.0117
Entamoeba histolytica	hypothetical protein	0.0365	0.0244	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0203	0.0117	0.0119
Echinococcus granulosus	protein tyrosine kinase	0.0203	0.0117	0.0119
Schistosoma mansoni	protein kinase	0.0203	0.0117	0.0117
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0365	0.0244	0.0248
Echinococcus multilocularis	tyrosine protein kinase csk	0.0203	0.0117	0.0119
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0203	0.0117	0.0119

Activities

Activity type	Activity value	Assay description	Source	Reference
Reduction (functional)	= 17 %	Percent decrease in triglyceride (TG) after 7 days at 0.05 percent in the diet of SD male rats in comparison to control animals	ChEMBL.	3950914
Reduction (functional)	= 22 %	Percent decrease in serum cholesterol (Cho) after 7 days at 0.05 percent in the diet of SD male rats in comparison to control animals	ChEMBL.	3950914

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL115503
PubChem: 13105451

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 188581