TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 318.8 | Formula: C11H11ClN2O3S2
H donors: 0 H acceptors: 3 LogP: 2.66 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCN1C(=O)CS/C/1=N\S(=O)(=O)c1ccc(cc1)Cl
InChi: 1S/C11H11ClN2O3S2/c1-2-14-10(15)7-18-11(14)13-19(16,17)9-5-3-8(12)4-6-9/h3-6H,2,7H2,1H3/b13-11-
InChiKey: JTIYCQPAQPWHHP-QBFSEMIESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	MH2 domain containing protein	0.001	0.0006	0.0006
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0012	0.0009	0.1172
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0009	0.101
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0016	0.0016
Brugia malayi	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0009	0.1172
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0012	0.0009	0.101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Brugia malayi	Dopamine receptor protein 2	0.0012	0.0009	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0004	0.5
Schistosoma mansoni	hypothetical protein	0.0012	0.0009	0.101
Echinococcus multilocularis	lamin	0.0033	0.0036	0.8541
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Schistosoma mansoni	lamin	0.0033	0.0036	0.4023
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0012	0.0009	0.1172
Brugia malayi	putative neuropeptide receptor NPR1	0.0012	0.0009	0.0008
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0005	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0013	0.0013
Echinococcus granulosus	G protein coupled receptor 139	0.0012	0.0009	0.1172
Echinococcus granulosus	lamin dm0	0.0033	0.0036	0.8541
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0009	0.0008
Brugia malayi	G protein-coupled receptor	0.0012	0.0009	0.0008
Echinococcus granulosus	sex peptide receptor	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.0009	0.101
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0012	0.0009	0.1172
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0012	0.0009	0.0008
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.018	0.0179
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0012	0.0009	0.1172
Schistosoma mansoni	smad1 5 8 and	0.001	0.0006	0.0707
Echinococcus multilocularis	dro:myosuppressin receptor	0.0012	0.0009	0.1172
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0012	0.0009	0.1172
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.0006	0.043
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.0009	0.101
Schistosoma mansoni	amine GPCR	0.0012	0.0009	0.101
Brugia malayi	hypothetical protein	0.0012	0.0009	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0004	0.5
Echinococcus multilocularis	smad	0.001	0.0006	0.043
Schistosoma mansoni	smad	0.001	0.0006	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0009	0.101
Echinococcus multilocularis	g-protein coupled receptor	0.0012	0.0009	0.1172
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Brugia malayi	Serotonin receptor	0.0012	0.0009	0.0008
Brugia malayi	putative neuropeptide receptor	0.0012	0.0009	0.0008
Echinococcus granulosus	7TM GPCR rhodopsin	0.0012	0.0009	0.1172
Echinococcus granulosus	neuropeptide FF receptor 2	0.0012	0.0009	0.1172
Echinococcus granulosus	lamin	0.0033	0.0036	0.8541
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.0009	0.101
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0004	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0009	0.101
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Schistosoma mansoni	neuropeptide f receptor 76f	0.0012	0.0009	0.101
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus granulosus	neuropeptide s receptor	0.0012	0.0009	0.1172
Onchocerca volvulus		0.0033	0.0036	0.9071
Schistosoma mansoni	hypothetical protein	0.0012	0.0009	0.101
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0016	0.0016
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0036	0.4023
Loa Loa (eye worm)	hypothetical protein	0.7747	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0014	0.0013
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.018	0.0179
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0009	0.1172
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Schistosoma mansoni	cpg binding protein	0.0037	0.0041	0.4619
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0012	0.0009	0.1172
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.0006	0.043
Echinococcus granulosus	smad	0.001	0.0006	0.043
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0009	0.101
Onchocerca volvulus		0.0035	0.0038	1
Schistosoma mansoni	opsin-like receptor	0.0012	0.0009	0.101
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Brugia malayi	MH2 domain containing protein	0.0144	0.018	0.0179
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.7747	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0009	0.1172
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0078	0.5
Trichomonas vaginalis	helicase, putative	0.0008	0.0004	0.5
Schistosoma mansoni	amine GPCR	0.0012	0.0009	0.101
Brugia malayi	ORL1-like opioid receptor	0.0012	0.0009	0.0008
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0012	0.0009	0.1172
Echinococcus granulosus	somatostatin receptor	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0012	0.0009	0.0008
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0004	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0012	0.0009	0.1172
Brugia malayi	G-protein coupled receptor	0.0012	0.0009	0.0008
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0009	0.1172
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0004	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.0009	0.101
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0009	0.101
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0009	0.1172
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0009	0.1172
Brugia malayi	intermediate filament protein	0.0033	0.0036	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Brugia malayi	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Brugia malayi	follicle stimulating hormone receptor	0.0012	0.0009	0.0008
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0009	0.1172
Echinococcus multilocularis	serotonin receptor	0.0012	0.0009	0.1172
Echinococcus granulosus	Smad4	0.001	0.0006	0.043
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0009	0.1172
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Schistosoma mansoni	histamine h1 receptor	0.0012	0.0009	0.101
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0035	0.0034
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0009	0.1172
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0004	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0009	0.0008
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0089	1
Brugia malayi	sulfakinin receptor protein	0.0012	0.0009	0.0008
Brugia malayi	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0036	0.0035
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0012	0.0009	0.0008
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0012	0.0009	0.101
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Brugia malayi	neuropeptide F receptor	0.0012	0.0009	0.0008
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0009	0.1172
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0009	0.1172
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0004	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0013	0.0013
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0012	0.0009	0.101
Brugia malayi	MH1 domain containing protein	0.001	0.0006	0.0006
Echinococcus multilocularis	allatostatin A receptor	0.0012	0.0009	0.1172
Echinococcus granulosus	hypothetical protein	0.0012	0.0009	0.1172
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0009	0.1172
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0009	0.101
Echinococcus granulosus	orexin receptor type 2	0.0012	0.0009	0.1172
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0009	0.1172
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0016	0.0014	0.2532
Loa Loa (eye worm)	TYRA-2 protein	0.0012	0.0009	0.0008
Schistosoma mansoni	cpg binding protein	0.0035	0.0038	0.4331
Echinococcus multilocularis	Smad4	0.001	0.0006	0.043
Schistosoma mansoni	amine GPCR	0.0012	0.0009	0.101
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0009	0.1172
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0004	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0009	0.1172
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0006	0.0006
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0012	0.0009	0.101
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0009	0.1172
Echinococcus granulosus	fmrfamide receptor	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0012	0.0009	0.1172
Echinococcus granulosus	serotonin receptor	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Brugia malayi	larval opioid receptor	0.0012	0.0009	0.0008
Brugia malayi	neuropeptide F receptor	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Schistosoma mansoni	smad1 5 8 and	0.001	0.0006	0.0707
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0004	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	Smad1	0.001	0.0006	0.0006
Brugia malayi	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus multilocularis	sex peptide receptor	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.7747	1	1
Schistosoma mansoni	myosin xvIII	0.0012	0.0009	0.101
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0012	0.0009	0.1172
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0004	0.5
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0036	0.0035
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0009	0.1172
Brugia malayi	Dopamine receptor	0.0012	0.0009	0.0008
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0009	0.0008
Onchocerca volvulus		0.0033	0.0036	0.9071
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0009	0.1172
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0012	0.0009	0.1172
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0004	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Schistosoma mansoni	Smad4	0.001	0.0006	0.0707
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.0006	0.043
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0009	0.101
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0009	0.101
Brugia malayi	RE15519p	0.0012	0.0009	0.0008
Brugia malayi	Serotonin receptor	0.0012	0.0009	0.0008
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0009	0.101
Schistosoma mansoni	lamin	0.0033	0.0036	0.4023
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.0009	0.101
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0012	0.0009	0.101
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0012	0.0009	0.101
Brugia malayi	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0012	0.0009	0.1172
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0009	0.1172
Echinococcus granulosus	cpg binding protein	0.0037	0.0041	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0009	0.1172
Brugia malayi	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0036	0.0035
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0036	0.0035
Echinococcus granulosus	7tm_1 domain containing protein	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	melatonin receptor type 1A	0.0012	0.0009	0.0008
Schistosoma mansoni	opsin-like receptor	0.0012	0.0009	0.101
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0009	0.1172
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0009	0.1172
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0012	0.0009	0.101
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0012	0.0009	0.1172
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.0006	0.043
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0007	0.0754
Brugia malayi	Dopamine receptor protein 1	0.0012	0.0009	0.0008
Echinococcus granulosus	g-protein coupled receptor	0.0012	0.0009	0.1172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0009	0.101
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0004	0.5
Brugia malayi	G-protein coupled receptor	0.0012	0.0009	0.0008
Brugia malayi	MH1 domain containing protein	0.001	0.0006	0.0006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Schistosoma mansoni	cpg binding protein	0.0037	0.0041	0.4619
Brugia malayi	G protein-coupled receptor F59B2.13	0.0012	0.0009	0.0008
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0009	0.101
Schistosoma mansoni	hypothetical protein	0.0012	0.0009	0.101
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0009	0.1172
Echinococcus multilocularis	musashi	0.0033	0.0036	0.8541
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0004	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0012	0.0009	0.1172
Echinococcus granulosus	intermediate filament protein	0.0033	0.0036	0.8541
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0038	0.0038
Schistosoma mansoni	smad1 5 8 and	0.001	0.0006	0.0707
Echinococcus multilocularis	neuropeptide s receptor	0.0012	0.0009	0.1172
Echinococcus granulosus	allatostatin A receptor	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0006	0.0707
Brugia malayi	MH2 domain containing protein	0.001	0.0006	0.0006
Brugia malayi	hypothetical protein	0.0012	0.0009	0.0008
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0012	0.0009	0.101
Schistosoma mansoni	amine GPCR	0.0012	0.0009	0.101
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0009	0.101
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Brugia malayi	Smad1	0.001	0.0006	0.0006
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0012	0.0009	0.1172
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0016	0.0014	0.2532
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0009	0.101
Echinococcus multilocularis	serotonin receptor	0.0012	0.0009	0.1172
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0006	0.0006
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0009	0.101
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0012	0.0009	0.1172
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0009	0.1172
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0009	0.1172
Schistosoma mansoni	adenoreceptor	0.0012	0.0009	0.101
Echinococcus multilocularis	cpg binding protein	0.0037	0.0041	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0004	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0009	0.101
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0009	0.0008
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0038	0.0038
Schistosoma mansoni	hypothetical protein	0.0012	0.0009	0.101
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0012	0.0009	0.0008
Schistosoma mansoni	growth hormone secretagogue receptor	0.0012	0.0009	0.101
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0007	0.0754
Echinococcus multilocularis	orexin receptor type 2	0.0012	0.0009	0.1172
Brugia malayi	Melatonin receptor type 1A	0.0012	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Brugia malayi	GnHR receptor homolog	0.0012	0.0009	0.0008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0012	0.0009	0.0008
Echinococcus granulosus	neuropeptide receptor A26	0.0012	0.0009	0.1172
Brugia malayi	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0009	0.1172
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0009	0.1172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Schistosoma mansoni	opsin-like receptor	0.0012	0.0009	0.101
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0009	0.1172
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0012	0.0009	0.101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0009	0.101
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus multilocularis	somatostatin receptor	0.0012	0.0009	0.1172
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0012	0.0009	0.0008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0009	0.1172
Brugia malayi	AKH receptor	0.0012	0.0009	0.0008
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.0009	0.101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0009	0.101
Schistosoma mansoni	amine GPCR	0.0012	0.0009	0.101
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0012	0.0009	0.0008
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0004	0.5
Echinococcus multilocularis	lamin dm0	0.0033	0.0036	0.8541
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0009	0.101
Echinococcus multilocularis	neuropeptide receptor A26	0.0012	0.0009	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0008
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0012	0.0009	0.0008
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0009	0.101
Echinococcus granulosus	dro:myosuppressin receptor	0.0012	0.0009	0.1172

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 1 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	= 1.4125 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3211675

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1889076