TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 392.572 | Formula: C24H40O4
H donors: 2 H acceptors: 4 LogP: 5.49 Rotable bonds: 14
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC1(CCC1)[C@@H](/C=C/C1CCC(=O)[C@@H]1CCCCCCCC(=O)O)O
InChi: 1S/C24H40O4/c1-2-3-16-24(17-9-18-24)22(26)15-13-19-12-14-21(25)20(19)10-7-5-4-6-8-11-23(27)28/h13,15,19-20,22,26H,2-12,14,16-18H2,1H3,(H,27,28)/b15-13+/t19?,20-,22-/m1/s1
InChiKey: UTFVSLMEOWGGIF-WYMFKJRYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0035	0.018	0.2006
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0079	0.0079
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.018	0.0205
Leishmania major	cathepsin L-like protease	0.0025	0.0079	0.0004
Echinococcus granulosus	lamin dm0	0.0021	0.0047	0.0137
Onchocerca volvulus		0.0025	0.0079	0.0514
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0091	0.0033
Loa Loa (eye worm)	ctsf protein	0.0025	0.0079	0.0886
Onchocerca volvulus		0.0025	0.0079	0.0514
Leishmania major	hypothetical protein, conserved	0.0035	0.018	0.0257
Echinococcus multilocularis	tumor protein p63	0.0369	0.3417	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0025	0.0079	0.0097
Mycobacterium tuberculosis	Conserved protein	0.0035	0.018	0.0205
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.018	0.0226
Onchocerca volvulus		0.0021	0.0047	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0035	0.018	0.2006
Loa Loa (eye worm)	hypothetical protein	0.0035	0.018	0.2006
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0174	0.1938
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.2012	0.2516
Echinococcus multilocularis	cathepsin L cysteine protease	0.0025	0.0079	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0302
Leishmania major	cathepsin L-like protease	0.0025	0.0079	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0035	0.018	0.2006
Onchocerca volvulus		0.0035	0.018	0.1165
Schistosoma mansoni	cellular tumor antigen P53	0.0054	0.0363	0.0458
Mycobacterium ulcerans	hypothetical protein	0.0174	0.1524	0.1501
Echinococcus granulosus	carbonic anhydrase	0.0024	0.0071	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0895	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0027	0.0013
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0174	0.0376
Mycobacterium leprae	Probable transmembrane transport protein	0.0203	0.1805	0.4331
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Onchocerca volvulus		0.0025	0.0079	0.0514
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0079	0.0886
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0174	0.0376
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0086	0.0674	0.2014
Onchocerca volvulus		0.0025	0.0079	0.0514
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0025	0.0079	0.0232
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0079	0.0079
Echinococcus multilocularis	carbonic anhydrase	0.0024	0.0071	0.0072
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0174	0.1524	0.1901
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0272	0.0667
Echinococcus multilocularis	cysteine protease	0.0025	0.0079	0.0097
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0091	0.0064
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0079	0.0079
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0091	0.0093
Trypanosoma cruzi	major cysteine proteinase, putative	0.0074	0.0557	0.1622
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0025	0.0079	0.0079
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0025	0.0079	0.0232
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0105	0.0855	0.9554
Leishmania major	cathepsin L-like protease	0.0094	0.0753	0.17
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0091	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0079	0.0886
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0091	0.0064
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.033	0.3037	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0094	0.0753	0.2282
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0024	0.0071	0.0794
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.0434	0.405	1
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0079	0.0196
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0289	0.0715
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.018	0.2006
Schistosoma mansoni	carbonic anhydrase-related	0.0024	0.0071	0.009
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0174	0.0508
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.0415	0.3859	0.4846
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0561	0.6269
Loa Loa (eye worm)	carbonic anhydrase 3	0.0105	0.0855	0.9554
Onchocerca volvulus	Putative sulfate transporter	0.0176	0.1541	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0024	0.0071	0.0794
Brugia malayi	beta-lactamase family protein	0.0035	0.018	0.2006
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0091	0.1011
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.018	0.0205
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.018	0.0205
Entamoeba histolytica	carbonic anhydrase, putative	0.0434	0.405	1
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0152	0.1311	0.1653
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0078	0.6045
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0091	0.0064
Leishmania major	cathepsin L-like protease	0.0025	0.0079	0.0004
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.018	0.018
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0203	0.1805	0.2256
Trypanosoma cruzi	cruzipain precursor, putative	0.0094	0.0753	0.2282
Leishmania major	cathepsin L-like protease	0.0094	0.0753	0.17
Schistosoma mansoni	carbonic anhydrase-related	0.0024	0.0071	0.009
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.018	0.0226
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0156	0.1353	0.3211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0272	0.0795
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.0079	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0043	0.0479
Plasmodium falciparum	inorganic anion exchanger, inorganic anion antiporter	0.0028	0.0111	1
Plasmodium vivax	vivapain-2	0.0025	0.0079	0.3423
Trichomonas vaginalis	esterase, putative	0.0035	0.018	0.018
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0079	0.0886
Onchocerca volvulus		0.0021	0.0047	0.0303
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0094	0.0753	0.2282
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0109	0.0895	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.018	0.018
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0156	0.1353	0.4309
Plasmodium falciparum	carbonic anhydrase	0.0024	0.0071	0.5266
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0094	0.0753	0.2282
Leishmania major	cathepsin L-like protease	0.0025	0.0079	0.0004
Toxoplasma gondii	inorganic anion transporter, sulfate permease (SulP) family protein	0.0028	0.0111	0.1392
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0094	0.0753	0.2282
Toxoplasma gondii	hypothetical protein	0.0053	0.0355	1
Mycobacterium leprae	Probable lipase LipE	0.0035	0.018	0.0225
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0094	0.0753	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0078	0.0867
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0174	0.1938
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0079	0.0886
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0079	0.0886
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0079	0.0196
Leishmania major	cathepsin L-like protease	0.0025	0.0079	0.0004
Mycobacterium ulcerans	carbonic anhydrase	0.0434	0.405	0.4034
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0079	0.0886
Loa Loa (eye worm)	hypothetical protein	0.0035	0.018	0.2006
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0091	0.1011
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.018	0.0153
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0025	0.0079	0.0886
Leishmania major	mitochondrial DNA polymerase beta	0.033	0.3037	0.7451
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.018	0.0345
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.018	0.0394
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0174	0.1938
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.0561	0.6269
Schistosoma mansoni	carbonic anhydrase	0.0434	0.405	0.5107
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.0289	0.0715
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0289	0.0715
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.018	0.0525
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.018	0.0205
Trichomonas vaginalis	conserved hypothetical protein	0.1048	1	1
Schistosoma mansoni	lamin	0.0021	0.0047	0.0059
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0091	0.0064
Mycobacterium ulcerans	transmembrane carbonic anhydrase, SulP	0.0028	0.0111	0.0084
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.018	0.018
Echinococcus multilocularis	carbonic anhydrase	0.0024	0.0071	0.0072
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0109	0.0895	1
Trypanosoma brucei	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0028	0.0111	0.0112
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0025	0.0079	0.0097
Leishmania major	carbonic anhydrase family protein, putative	0.0434	0.405	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0078	0.3312
Loa Loa (eye worm)	cysteine protease	0.0025	0.0079	0.0886
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0024	0.0071	0.0794
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.033	0.3037	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0094	0.0753	0.2282
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0272	0.0342
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0109	0.0895	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Onchocerca volvulus		0.0176	0.1541	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0272	0.0667
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0091	0.0064
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0079	0.0886
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0047	0.0521
Echinococcus granulosus	carbonic anhydrase II	0.0105	0.0855	0.2503
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.018	0.0205
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0094	0.0753	0.2282
Leishmania major	cysteine peptidase A (CPA)	0.0025	0.0079	0.0004
Mycobacterium ulcerans	beta-lactamase	0.0035	0.018	0.0153
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0174	0.0376
Onchocerca volvulus		0.0025	0.0079	0.0514
Schistosoma mansoni	intermediate filament proteins	0.0021	0.0047	0.0059
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0079	0.0196
Leishmania major	cathepsin L-like protease	0.0094	0.0753	0.17
Chlamydia trachomatis	sulfate transporter	0.0028	0.0111	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0272	0.0342
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0105	0.0855	0.2628
Schistosoma mansoni	hypothetical protein	0.0034	0.0174	0.0219
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0174	0.0508
Onchocerca volvulus		0.0035	0.018	0.1165
Toxoplasma gondii	cathepsin CPL	0.0025	0.0079	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0302
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0079	0.0886
Loa Loa (eye worm)	intermediate filament protein	0.0021	0.0047	0.0521
Schistosoma mansoni	carbonic anhydrase-related	0.0024	0.0071	0.009
Schistosoma mansoni	cathepsin F (C01 family)	0.0025	0.0079	0.01
Echinococcus multilocularis	cysteine protease	0.0025	0.0079	0.0097
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0091	0.0224
Brugia malayi	Intermediate filament tail domain containing protein	0.0021	0.0047	0.0521
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0272	0.3033
Mycobacterium tuberculosis	Conserved protein	0.0035	0.018	0.0205
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.018	0.0205
Brugia malayi	beta-lactamase	0.0035	0.018	0.2006
Schistosoma mansoni	hypothetical protein	0.0034	0.0174	0.0219
Onchocerca volvulus		0.0035	0.018	0.1165
Trypanosoma cruzi	cysteine peptidase, putative	0.0094	0.0753	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0302
Trypanosoma cruzi	cysteine peptidase, putative	0.0094	0.0753	0.2282
Echinococcus multilocularis	carbonic anhydrase	0.0024	0.0071	0.0072
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0024	0.0071	0.0794
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.018	0.0225
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.033	0.3037	1
Brugia malayi	hypothetical protein	0.0025	0.0078	0.0867
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0105	0.0855	0.2628
Schistosoma mansoni	carbonic anhydrase	0.0024	0.0071	0.009
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0272	0.3033
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0105	0.0855	0.1078
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.018	1
Echinococcus granulosus	intermediate filament protein	0.0021	0.0047	0.0137
Onchocerca volvulus		0.0026	0.0091	0.0587
Mycobacterium tuberculosis	Conserved protein	0.0035	0.018	0.0205
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0091	0.0064
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0094	0.0753	0.2282
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0078	0.6045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0094	0.0753	0.2282
Plasmodium vivax	sulfate transporter, putative	0.0028	0.0111	0.5479
Plasmodium vivax	vivapain-2	0.0025	0.0079	0.3423
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.018	0.0153
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0094	0.0753	0.2282
Mycobacterium tuberculosis	Beta-carbonic anhydrase CanB	0.0222	0.1996	0.2496
Schistosoma mansoni	hypothetical protein	0.0074	0.0561	0.0708
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.018	0.0205
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.018	0.0345
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0079	0.0886
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0021	0.0047	0.0521
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0156	0.1353	0.4309
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0174	0.1938
Brugia malayi	beta-lactamase family protein	0.0035	0.018	0.2006
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0071	0.0794
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0078	0.0229
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.0079	0.0514
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.018	0.018
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0025	0.0079	0.0097
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.0079	0.0514
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.0289	0.0715
Echinococcus granulosus	carbonic anhydrase	0.0024	0.0071	0.0208
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0079	0.0079
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0025	0.0079	0.6248
Trypanosoma brucei	carbonic anhydrase-like protein	0.0105	0.0855	0.2628
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0071	0.0794
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0091	0.0224
Mycobacterium ulcerans	integral membrane transporter	0.0028	0.0111	0.0084
Echinococcus granulosus	lamin	0.0021	0.0047	0.0137
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0079	0.0079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0091	0.1011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Mycobacterium ulcerans	lipase LipD	0.0035	0.018	0.0153
Echinococcus granulosus	tumor protein p63	0.0369	0.3417	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0071	0.0794
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0024	0.0071	0.0794
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0025	0.0079	0.6248
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.018	0.2006
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0028	0.0111	0.0112
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.018	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0091	0.1011
Toxoplasma gondii	ABC1 family protein	0.0035	0.018	0.3818
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0272	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0302
Schistosoma mansoni	hypothetical protein	0.0024	0.0071	0.009
Brugia malayi	intermediate filament protein	0.0021	0.0047	0.0521
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0025	0.0079	0.6248
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0079	0.0079
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0105	0.0855	0.9554
Trichomonas vaginalis	conserved hypothetical protein	0.1048	1	1
Onchocerca volvulus		0.0054	0.0363	0.2356
Echinococcus granulosus	carbonic anhydrase	0.0024	0.0071	0.0208
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0272	0.0795
Mycobacterium ulcerans	hypothetical protein	0.0035	0.018	0.0153
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0028	0.0111	0.0112
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0079	0.0079
Trypanosoma cruzi	cysteine peptidase, putative	0.0094	0.0753	0.2282
Loa Loa (eye worm)	fibroinase	0.0025	0.0079	0.0886
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0024	0.0071	0.0794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Schistosoma mansoni	hypothetical protein	0.0034	0.0174	0.0219
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0057	0.0387	0.1047
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0079	0.0079
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0094	0.0753	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0035	0.018	0.2006
Mycobacterium tuberculosis	Beta-carbonic anhydrase	0.0836	0.7946	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0091	0.0033
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.0835	0.793	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0079	0.0079
Echinococcus granulosus	GPCR family 2	0.0034	0.0174	0.0508
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0091	0.0093
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0105	0.0855	0.1078
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0105	0.0855	0.9554
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0025	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0363	0.4057
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.018	0.018
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0091	0.0033
Onchocerca volvulus	Cathepsin F homolog	0.0025	0.0079	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0027	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0091	0.1011
Mycobacterium ulcerans	transmembrane carbonic anhydrase, SulP	0.0028	0.0111	0.0084
Schistosoma mansoni	hypothetical protein	0.0034	0.0174	0.0219
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0091	0.0064
Schistosoma mansoni	lamin	0.0021	0.0047	0.0059
Onchocerca volvulus		0.0025	0.0079	0.0514
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0091	0.1011
Onchocerca volvulus		0.0025	0.0079	0.0514
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0091	0.0064
Leishmania major	carbonic anhydrase-like protein	0.0105	0.0855	0.1958
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0079	0.0079
Echinococcus granulosus	cathepsin l1	0.0025	0.0079	0.0232
Loa Loa (eye worm)	beta-lactamase	0.0035	0.018	0.2006
Echinococcus multilocularis	carbonic anhydrase II	0.0105	0.0855	0.2399
Schistosoma mansoni	cathepsin F (C01 family)	0.0025	0.0079	0.01

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3248797

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1891767