Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase | 0.0039 | 0.1142 | 0.1308 |
Brugia malayi | Doublecortin family protein | 0.0022 | 0.0424 | 0.0485 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.1142 | 1 |
Brugia malayi | hypothetical protein | 0.0072 | 0.2462 | 0.282 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0424 | 0.0485 |
Onchocerca volvulus | 0.0022 | 0.0424 | 0.0424 | |
Schistosoma mansoni | loxhd1 | 0.0022 | 0.0424 | 0.0891 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.2564 | 0.5391 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.025 | 0.0286 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0022 | 0.0424 | 0.0891 |
Schistosoma mansoni | lipoxygenase | 0.0129 | 0.4755 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.1142 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.1142 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0022 | 0.0424 | 0.0891 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.4819 | 0.5519 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.025 | 0.0526 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.1753 | 0.2007 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.025 | 0.0526 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3156 | 0.3614 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.1142 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.1142 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.1142 | 0.2402 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0871 | 0.1831 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.025 | 0.0526 |
Echinococcus multilocularis | RUN | 0.0022 | 0.0424 | 0.0891 |
Onchocerca volvulus | 0.0039 | 0.1142 | 0.1142 | |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.0822 | 0.1729 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0228 | 0.8732 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0871 | 0.1831 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0252 | 0.9698 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.1142 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0129 | 0.4755 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.1142 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.025 | 0.0526 |
Schistosoma mansoni | lipoxygenase | 0.009 | 0.319 | 0.6709 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0092 | 0.3257 | 0.685 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0129 | 0.4755 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.025 | 0.0286 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.0097 | 0.0111 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.1142 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0871 | 0.6222 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1142 | 0.1308 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.025 | 0.0286 |
Schistosoma mansoni | polycystin 1-related | 0.0022 | 0.0424 | 0.0891 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.1142 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.1142 | 0.1308 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0424 | 0.0891 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.4819 | 0.5519 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.025 | 0.0526 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.1142 | 0.2402 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0424 | 0.0485 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.1142 | 0.1308 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0022 | 0.0424 | 0.0891 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.1753 | 0.2007 |
Brugia malayi | Pre-SET motif family protein | 0.0228 | 0.8732 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0022 | 0.0424 | 0.0891 |
Onchocerca volvulus | 0.0039 | 0.1142 | 0.1142 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1057 | 0.1211 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0871 | 0.1831 |
Schistosoma mansoni | rab6-interacting | 0.0022 | 0.0424 | 0.0891 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.1142 | 0.2402 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.0097 | 0.0111 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0424 | 0.0485 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.1142 | 0.1308 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.025 | 0.0526 |
Onchocerca volvulus | 0.0022 | 0.0424 | 0.0424 | |
Onchocerca volvulus | 0.0039 | 0.1142 | 0.1142 | |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.025 | 0.0526 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1142 | 0.1308 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.025 | 0.0526 |
Echinococcus granulosus | jun protein | 0.0092 | 0.3257 | 0.685 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0097 | 0.0111 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.1142 | 0.2402 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0022 | 0.0424 | 0.0891 |
Onchocerca volvulus | 0.0033 | 0.0871 | 0.0871 | |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.1142 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1057 | 0.2223 |
Brugia malayi | bZIP transcription factor family protein | 0.0092 | 0.3257 | 0.3731 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0424 | 0.0485 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0022 | 0.0424 | 0.0891 |
Loa Loa (eye worm) | doublecortin family protein | 0.0022 | 0.0424 | 0.0485 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.025 | 0.0286 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0022 | 0.0424 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.4819 | 0.5519 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.0097 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1142 | 0.1308 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.025 | 0.0526 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.1142 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0871 | 0.0997 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0871 | 0.0997 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0092 | 0.3257 | 0.685 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0871 | 0.1831 |
Schistosoma mansoni | jun-related protein | 0.0075 | 0.2564 | 0.5391 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.1142 | 0.1308 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.025 | 0.0526 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0871 | 0.1831 |
Echinococcus multilocularis | jun protein | 0.0092 | 0.3257 | 0.685 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.1753 | 0.2007 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.1142 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0871 | 0.1831 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1753 | 0.2007 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0022 | 0.0424 | 0.0891 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.1142 | 1 |
Onchocerca volvulus | 0.0072 | 0.2462 | 0.2462 | |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1142 | 0.1308 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0871 | 0.1831 |
Echinococcus granulosus | RUN | 0.0022 | 0.0424 | 0.0891 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.1142 | 0.1308 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1142 | 0.1308 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1142 | 0.1308 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0097 | 0.0111 |
Trichomonas vaginalis | set domain proteins, putative | 0.0259 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1057 | 0.1211 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.