TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 604.744 | Formula: C35H40N8O2
H donors: 3 H acceptors: 5 LogP: 5.78 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CN(CCNC(=O)c1ccc(cc1)Nc1nc(nc2c1ncn2C)c1cccc(c1C)NC(=O)c1ccc(cc1)C(C)(C)C)C
InChi: 1S/C35H40N8O2/c1-22-27(9-8-10-28(22)39-34(45)24-11-15-25(16-12-24)35(2,3)4)30-40-31(29-32(41-30)43(7)21-37-29)38-26-17-13-23(14-18-26)33(44)36-19-20-42(5)6/h8-18,21H,19-20H2,1-7H3,(H,36,44)(H,39,45)(H,38,40,41)
InChiKey: QWRCMCNZGCYTPB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Bruton agammaglobulinemia tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus granulosus	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	Tyrosine-protein kinase BTK, putative	Get druggable targets OG5_129320	All targets in OG5_129320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hexose transporter	0.0038	0.0657	0.8747
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0007	0.0054	0.1193
Trypanosoma brucei	glucose transporter, putative	0.0038	0.0657	0.8747
Trypanosoma cruzi	sugar transporter, putative	0.0017	0.0254	0.3384
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0007	0.0054	0.0234
Onchocerca volvulus		0.0017	0.0254	1
Trypanosoma brucei	glucose transporter, putative	0.0038	0.0657	0.8747
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0254	0.1107
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0017	0.0254	0.0804
Trichomonas vaginalis	glycyl-tRNA synthetase, putative	0.0004	0	0.0002
Echinococcus granulosus	solute carrier family 22	0.0017	0.0254	0.0804
Trypanosoma cruzi	hypothetical protein, conserved	0.0006	0.0038	0.0508
Brugia malayi	lysyl-tRNA synthetase	0.0027	0.045	0.1962
Onchocerca volvulus		0.0017	0.0254	1
Plasmodium falciparum	threonine--tRNA ligase	0.0007	0.0054	0.0054
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0006	0.0036	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0011	0.0048
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0007	0.0054	0.0234
Schistosoma mansoni	threonyl-tRNA synthetase	0.0004	0	0.0001
Echinococcus multilocularis	calcium dependent protein kinase	0.0035	0.0602	0.1905
Giardia lamblia	Prolyl-tRNA synthetase	0.0037	0.0633	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0037	0.0633	0.2001
Loa Loa (eye worm)	hypothetical protein	0.0027	0.045	0.1962
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Onchocerca volvulus		0.0017	0.0254	1
Loa Loa (eye worm)	sugar transporter	0.0017	0.0254	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Entamoeba histolytica	protein kinase, putative	0.0037	0.0647	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0037	0.0648	0.0648
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0037	0.0647	0.2821
Trichomonas vaginalis	CAMK family protein kinase	0.0037	0.0647	0.2821
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0007	0.0054	0.1193
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Brugia malayi	major facilitator superfamily protein	0.0017	0.0254	0.1107
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0007	0.0054	0.0468
Trichomonas vaginalis	glucose transporter, putative	0.0017	0.0254	0.1107
Echinococcus multilocularis	solute carrier family 22	0.0017	0.0254	0.0804
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0037	0.0648	0.0648
Onchocerca volvulus		0.0017	0.0254	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0037	0.0647	0.2048
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0005	0.0024	0.0375
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0007	0.0053	0.0167
Plasmodium falciparum	hexose transporter	0.0122	0.2295	0.2295
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0023	0.037	1
Echinococcus granulosus	General substrate transporter	0.0105	0.1961	0.6203
Schistosoma mansoni	growth factor receptor-bound protein	0.0006	0.0036	0.0117
Entamoeba histolytica	hypothetical protein	0.0005	0.001	0.0147
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0006	0.0038	0.0508
Mycobacterium ulcerans	sugar transporter	0.0017	0.0254	0.5643
Echinococcus granulosus	solute carrier family 22	0.0017	0.0254	0.0804
Onchocerca volvulus		0.0017	0.0254	1
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Trichomonas vaginalis	sugar transport protein, putative	0.0017	0.0254	0.1107
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0007	0.0053	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0198	0.3758	0.3758
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0036	0.0158
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0037	0.0648	0.0977
Echinococcus granulosus	c src tyrosine kinase	0.0007	0.0053	0.0167
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0007	0.0054	0.0081
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0038	0.0657	0.8747
Schistosoma mansoni	glucose transporter	0.0017	0.0254	0.0818
Mycobacterium ulcerans	histidyl-tRNA synthetase	0.0004	0	0.0008
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0006	0.0038	0.0508
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0037	0.0647	0.2048
Chlamydia trachomatis	threonine--tRNA ligase	0.0007	0.0054	0.1193
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0037	0.0647	0.2048
Schistosoma mansoni	tyrosine kinase	0.0007	0.0053	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0122	0.2295	1
Trichomonas vaginalis	myo-inositol transporter, putative	0.0017	0.0254	0.1107
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0007	0.0053	0.0167
Schistosoma mansoni	sugar transporter	0.0017	0.0254	0.0818
Brugia malayi	major facilitator superfamily protein	0.0017	0.0254	0.1107
Schistosoma mansoni	hypothetical protein	0.0122	0.2295	0.7394
Brugia malayi	Sugar transporter family protein	0.0017	0.0254	0.1107
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.0053	0.0167
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0519	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0017	0.0254	0.5643
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0017	0.0254	0.1107
Echinococcus multilocularis	General substrate transporter	0.0105	0.1961	0.6203
Schistosoma mansoni	glucose transport protein	0.0122	0.2295	0.7394
Leishmania major	glucose transporter, lmgt2	0.0038	0.0657	0.8747
Treponema pallidum	glycyl-tRNA synthetase	0.0004	0	0.002
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0122	0.2295	0.726
Echinococcus granulosus	growth factor receptor bound protein 2	0.0006	0.0036	0.0115
Trichomonas vaginalis	interferon-induced, double-stranded RNA-activated protein kinase, putative	0.0004	0	0.0002
Treponema pallidum	prolyl-tRNA synthetase	0.0013	0.0172	1
Brugia malayi	hypothetical protein	0.0017	0.0254	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Giardia lamblia	Hexose transporter	0.0017	0.0254	0.4016
Brugia malayi	Sugar transporter family protein	0.0017	0.0254	0.1107
Trypanosoma cruzi	hypothetical protein, conserved	0.0006	0.0038	0.0508
Leishmania major	glycyl tRNA synthetase, putative	0.0004	0	0.0005
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0037	0.0633	0.2756
Echinococcus granulosus	lysyl tRNA synthetase	0.0027	0.045	0.1424
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0007	0.0053	0.0167
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0027	0.045	0.1962
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0027	0.045	0.6932
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0005	0.001	0.0031
Trypanosoma brucei	glucose transporter 2A	0.0038	0.0657	0.8747
Toxoplasma gondii	lysine-tRNA ligase	0.0027	0.045	0.0679
Echinococcus multilocularis	c src tyrosine kinase	0.0007	0.0053	0.0167
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0038	0.0657	0.8747
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0043	0.0751	1
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0254	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Toxoplasma gondii	histidyl-tRNA synthetase (HisRS), putative	0.0004	0	0.0001
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0007	0.0054	0.0234
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0043	0.0751	1
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0015	0.0213	0.0926
Wolbachia endosymbiont of Brugia malayi	histidyl-tRNA synthetase	0.0004	0	0.0014
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0037	0.0647	0.2048
Leishmania major	hypothetical protein, conserved	0.0006	0.0038	0.0508
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Echinococcus multilocularis	histidyl tRNA synthetase	0.0004	0	0.0001
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0037	0.0633	0.2756
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Trypanosoma cruzi	hexose transporter, putative	0.0021	0.0323	0.4299
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Trichomonas vaginalis	glucose transporter, putative	0.0038	0.0657	0.2861
Trypanosoma brucei	glucose transporter, putative	0.0038	0.0657	0.8747
Schistosoma mansoni	serine/threonine protein kinase	0.0037	0.0647	0.2085
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0198	0.3758	0.5668
Echinococcus multilocularis	NCK adaptor protein	0.0006	0.0036	0.0115
Trypanosoma brucei	sugar transporter, putative	0.0017	0.0254	0.3384
Brugia malayi	Variant SH3 domain containing protein	0.0006	0.0036	0.0158
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0122	0.2295	0.726
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0038	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0054	0.0234
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0037	0.0648	0.0648
Mycobacterium ulcerans	integral membrane transport protein	0.0017	0.0254	0.5643
Schistosoma mansoni	tyrosine kinase	0.0007	0.0053	0.017
Schistosoma mansoni	growth factor receptor-bound protein	0.0006	0.0036	0.0117
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0007	0.0053	0.0167
Echinococcus multilocularis	solute carrier family 22	0.0017	0.0254	0.0804
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Brugia malayi	Major Facilitator Superfamily protein	0.0017	0.0254	0.1107
Trichomonas vaginalis	glucose transporter, putative	0.0038	0.0657	0.2861
Echinococcus granulosus	NCK adaptor protein	0.0006	0.0036	0.0115
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0037	0.0647	0.2048
Toxoplasma gondii	protein kinase, putative	0.0346	0.663	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0006	0.0036	0.0158
Brugia malayi	Variant SH3 domain containing protein	0.0006	0.0036	0.0158
Schistosoma mansoni	glycyl-tRNA synthetase	0.0007	0.0054	0.0173
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0006	0.0036	0.0115
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0037	0.0648	0.0648
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0254	0.1107
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0007	0.0053	0.017
Leishmania major	histidyl-tRNA synthetase, putative	0.0004	0	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0027	0.045	1
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0007	0.0054	0.2114
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Giardia lamblia	Lysyl-tRNA synthetase	0.0027	0.045	0.7117
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0017	0.0254	0.5643
Entamoeba histolytica	histidyl-tRNA synthetase, putative	0.0004	0	0.0005
Treponema pallidum	threonyl-tRNA synthetase	0.0007	0.0054	0.3127
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0017	0.0254	0.3384
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0122	0.2295	0.726
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0005	0.0011	0.0048
Toxoplasma gondii	anticodon binding domain-containing protein	0.0004	0	0.0001
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0005	0.001	0.003
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0009	0.0098	0.0311
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0017	0.0254	0.0254
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0037	0.0633	0.9773
Plasmodium falciparum	proline--tRNA ligase	0.0043	0.0751	0.0751
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0037	0.0633	0.2038
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0198	0.3758	0.3758
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0007	0.0054	0.0262
Onchocerca volvulus		0.0017	0.0254	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0122	0.2295	0.726
Schistosoma mansoni	glucose transport protein	0.0122	0.2295	0.7394
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Schistosoma mansoni	tyrosine kinase	0.0007	0.0053	0.017
Echinococcus granulosus	synaptic vesicle 2 protein	0.0017	0.0254	0.0804
Brugia malayi	Cam kinase protein 1	0.0037	0.0647	0.2821
Onchocerca volvulus		0.0017	0.0254	1
Chlamydia trachomatis	histidine--tRNA ligase	0.0004	0	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Trypanosoma brucei	glucose transporter 1E	0.0038	0.0657	0.8747
Plasmodium vivax	sugar transporter, putative	0.0017	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.0053	0.0167
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0007	0.0054	0.0234
Trichomonas vaginalis	sugar transporter, putative	0.0038	0.0657	0.2861
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0254	0.1107
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0007	0.0054	0.0715
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0037	0.0648	0.0648
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0037	0.0647	0.2048
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0122	0.2295	0.726
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Brugia malayi	hypothetical protein	0.0017	0.0254	0.1107
Onchocerca volvulus		0.0017	0.0254	1
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0017	0.0254	0.6499
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0037	0.0633	0.2038
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0007	0.0053	0.0167
Echinococcus granulosus	histidyl tRNA synthetase	0.0004	0	0.0001
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0037	0.0647	0.2821
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0007	0.0054	0.0715
Entamoeba histolytica	protein kinase, putative	0.0037	0.0647	1
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0254	0.1107
Echinococcus granulosus	calcium dependent protein kinase	0.0035	0.0602	0.1905
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Leishmania major	protein kinase, putative	0.0037	0.0647	0.8623
Schistosoma mansoni	sugar transporter	0.0017	0.0254	0.0818
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0007	0.0053	0.0167
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0007	0.0054	0.083
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0023	0.037	0.5587
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0385	0.1677
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0027	0.045	1
Schistosoma mansoni	vav2	0.0005	0.0011	0.0035
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0007	0.0053	0.0167
Trypanosoma cruzi	glucose transporter, putative	0.0017	0.0254	0.3384
Schistosoma mansoni	sugar transporter	0.0017	0.0254	0.0818
Leishmania major	glucose transporter, lmgt1	0.0038	0.0657	0.8747
Brugia malayi	SRC-1	0.0007	0.0053	0.023
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0254	0.3384
Plasmodium vivax	lysine--tRNA ligase, putative	0.0027	0.045	0.045
Giardia lamblia	Sugar-proton symporter	0.0017	0.0254	0.4016
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0007	0.0053	0.0167
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0007	0.0054	0.017
Leishmania major	myo-inositol/proton symporter (MIT)	0.0017	0.0254	0.3384
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0007	0.0053	0.0167
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Brugia malayi	Major Facilitator Superfamily protein	0.0017	0.0254	0.1107
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0038	0.0657	0.8747
Leishmania major	glucose transporter, lmgt3	0.0038	0.0657	0.8747
Loa Loa (eye worm)	hypothetical protein	0.003	0.0499	0.2174
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0007	0.0054	0.083
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0657	0.2861
Echinococcus multilocularis	solute carrier family 22	0.0017	0.0254	0.0804
Loa Loa (eye worm)	sugar transporter	0.0122	0.2295	1
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0011	0.0048
Trypanosoma cruzi	hexose transporter, putative	0.0038	0.0657	0.8747
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0037	0.0647	0.2048
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0023	0.037	1
Toxoplasma gondii	sugar transporter ST2	0.0017	0.0254	0.0383
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Schistosoma mansoni	nck2/grb4	0.0006	0.0036	0.0117
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Onchocerca volvulus		0.0017	0.0254	1
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0037	0.0633	1
Trypanosoma cruzi	hexose transporter, putative	0.0038	0.0657	0.8747
Schistosoma mansoni	lysyl-tRNA synthetase	0.0027	0.045	0.145
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.0053	0.0167
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0017	0.0254	0.0818
Onchocerca volvulus		0.0017	0.0254	1
Echinococcus multilocularis	solute carrier family 22	0.0017	0.0254	0.0804
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0038	0.0657	0.8747
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0027	0.045	0.5997
Brugia malayi	Major Facilitator Superfamily protein	0.0017	0.0254	0.1107
Giardia lamblia	Glycyl-tRNA synthetase	0.0007	0.0054	0.0849
Onchocerca volvulus		0.0017	0.0254	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0043	0.0751	1
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0007	0.0053	0.0167
Schistosoma mansoni	lysyl-tRNA synthetase	0.0027	0.045	0.145
Echinococcus multilocularis	glycyl tRNA synthetase	0.0007	0.0054	0.017
Chlamydia trachomatis	proline--tRNA ligase	0.0013	0.0172	0.3815
Leishmania major	lysyl-tRNA synthetase, putative	0.0027	0.045	0.5997
Trypanosoma cruzi	glycyl-tRNA synthetase, putative	0.0004	0	0.0005
Giardia lamblia	Threonyl-tRNA synthetase	0.0007	0.0054	0.0849
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0007	0.0054	0.0715
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0043	0.0751	0.1132
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0657	0.2861
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0037	0.0648	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0633	0.2756
Entamoeba histolytica	hypothetical protein	0.0027	0.045	0.6955
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0037	0.0647	0.2048
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0037	0.0648	0.0648
Schistosoma mansoni	histidyl-tRNA synthetase	0.0004	0	0.0001
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0037	0.0647	0.8623
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0038	0.0166
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0037	0.0633	0.2001
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0037	0.0648	0.0977
Loa Loa (eye worm)	histidyl-tRNA synthetase	0.0004	0	0.0002
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0005	0.001	0.003
Schistosoma mansoni	glucose transport protein	0.0122	0.2295	0.7394
Echinococcus granulosus	glycyl tRNA synthetase	0.0007	0.0054	0.017
Schistosoma mansoni	protein kinase	0.0037	0.0647	0.2085
Onchocerca volvulus		0.0017	0.0254	1
Toxoplasma gondii	sugar transporter ST3	0.0017	0.0254	0.0383
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0038	0.0166
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Plasmodium vivax	proline--tRNA ligase, putative	0.0043	0.0751	0.0751
Brugia malayi	Sex muscle abnormal protein 5	0.0006	0.0036	0.0158
Brugia malayi	glycyl-tRNA synthetase	0.0007	0.0054	0.0234
Echinococcus granulosus	solute carrier family 22	0.0017	0.0254	0.0804
Onchocerca volvulus		0.0017	0.0254	1
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0006	0.0038	0.0508
Trypanosoma cruzi	glycyl-tRNA synthetase, putative	0.0004	0	0.0005
Trypanosoma brucei	histidyl-tRNA synthetase	0.0004	0	0.0005
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0013	0.0172	0.3815
Echinococcus multilocularis	lysyl tRNA synthetase	0.0027	0.045	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0647	0.2821
Plasmodium falciparum	lysine--tRNA ligase	0.0027	0.045	0.045
Trypanosoma brucei	glucose transporter, putative	0.0038	0.0657	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0007	0.0054	0.2114
Loa Loa (eye worm)	SRC-1	0.0007	0.0053	0.023
Plasmodium vivax	glycine--tRNA ligase, putative	0.0007	0.0054	0.0054
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0122	0.2295	0.726
Plasmodium vivax	threonine--tRNA ligase, putative	0.0007	0.0054	0.0054
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0122	0.2295	0.726
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0007	0.0053	0.0167
Toxoplasma gondii	sugar transporter ST1	0.0017	0.0254	0.0383
Schistosoma mansoni	protein kinase	0.0037	0.0647	0.2085
Mycobacterium ulcerans	hypothetical protein	0.0006	0.0038	0.0848
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0006	0.0036	0.0117
Trypanosoma brucei	glucose transporter, putative	0.0038	0.0657	0.8747
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0167	0.3161	1
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0007	0.0054	0.0234
Brugia malayi	hypothetical protein	0.0017	0.0254	0.1107
Leishmania major	hypothetical protein, conserved	0.0017	0.0254	0.3384
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0027	0.045	0.5997
Echinococcus granulosus	solute carrier family 22	0.0017	0.0254	0.0804
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0017	0.0254	0.0804
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0254	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Brugia malayi	Tyrosine-protein kinase abl-1	0.0007	0.0053	0.023
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0037	0.0648	0.0648
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0007	0.0054	0.017
Toxoplasma gondii	facilitative glucose transporter GT1	0.0122	0.2295	0.3462
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0633	0.2756
Schistosoma mansoni	protein kinase	0.0037	0.0647	0.2085
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Trypanosoma cruzi	histidyl-tRNA synthetase	0.0004	0	0.0005
Toxoplasma gondii	transporter, major facilitator family protein	0.0017	0.0254	0.0383
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0037	0.0633	0.2756
Trypanosoma brucei	glucose transporter, putative	0.0038	0.0657	0.8747
Schistosoma mansoni	histidyl-tRNA synthetase	0.0004	0	0.0001
Onchocerca volvulus		0.0017	0.0254	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0037	0.0648	0.0977
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0017	0.0254	1
Chlamydia trachomatis	lysine--tRNA ligase	0.0027	0.045	1
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0122	0.2295	0.726
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0007	0.0054	0.0715
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0017	0.0254	0.1107
Entamoeba histolytica	protein kinase, putative	0.0005	0.0024	0.0375
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0043	0.0751	1
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Onchocerca volvulus		0.0017	0.0254	1
Leishmania major	threonyl-tRNA synthetase, putative	0.0007	0.0054	0.0715
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Brugia malayi	Sugar transporter family protein	0.0122	0.2295	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0037	0.0647	0.2821
Trypanosoma cruzi	hexose transporter, putative	0.0038	0.0657	0.8747
Toxoplasma gondii	YbaK/proline-tRNA ligase associated domain-containing protein	0.0006	0.0038	0.0058
Schistosoma mansoni	sugar transporter	0.0017	0.0254	0.0818
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0007	0.0053	0.0167
Trypanosoma brucei	glucose transporter, putative	0.0038	0.0657	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0038	0.0657	0.2861
Trypanosoma brucei	glucose transporter, putative	0.0038	0.0657	0.8747
Plasmodium falciparum	protein kinase 7	0.0346	0.663	0.663
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0167	0.3161	1
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0017	0.0254	0.0804
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0007	0.0053	0.0167
Onchocerca volvulus		0.0017	0.0254	1
Onchocerca volvulus	Putative transporter	0.0017	0.0254	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0043	0.0751	1
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0017	0.0254	0.6499
Schistosoma mansoni	tyrosine kinase	0.0007	0.0053	0.017
Plasmodium vivax	hexose transporter	0.0122	0.2295	0.2295
Schistosoma mansoni	tyrosine kinase	0.0164	0.3104	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0037	0.0648	0.0648
Toxoplasma gondii	glycyl-tRNA synthetase	0.0007	0.0054	0.0081
Trichomonas vaginalis	sugar transporter, putative	0.0038	0.0657	0.2861
Leishmania major	hypothetical protein, conserved	0.0006	0.0038	0.0508
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0254	0.1107
Schistosoma mansoni	adapter molecule crk	0.0006	0.0036	0.0117

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.087 uM	Inhibition of full length human wild type his-tagged BTK expressed in Sf9 cells using biotinylated peptide as substrate after 1 hr by Fluorescence assay	ChEMBL.	24685542

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3263637

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1910040