Detailed information for compound 1955577

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 486.605 | Formula: C29H34N4O3
  • H donors: 2 H acceptors: 3 LogP: 4.2 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)C1CCN(CC1)C(=O)c1ccc(c(c1)NC(=O)NC[C@H]1CCCO1)C1CCC1
  • InChi: 1S/C29H34N4O3/c30-18-20-6-8-21(9-7-20)22-12-14-33(15-13-22)28(34)24-10-11-26(23-3-1-4-23)27(17-24)32-29(35)31-19-25-5-2-16-36-25/h6-11,17,22-23,25H,1-5,12-16,19H2,(H2,31,32,35)/t25-/m1/s1
  • InChiKey: BDGSXILOFCCMIA-RUZDIDTESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fatty acid synthase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Fatty acid synthase homolog Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum KR domain domain-containing protein, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks2 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks12 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) acyl carrier protein Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks7 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii AMP-binding enzyme domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks8 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks5 Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Soraphen polyketide synthase A, related Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks15 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii diacylglycerol kinase, putative 0.0024 0.0298 0.4737
Loa Loa (eye worm) raf kinase 0.0024 0.0298 0.0225
Loa Loa (eye worm) AGC/PKN protein kinase 0.0034 0.0513 0.0442
Mycobacterium ulcerans thioesterase 0.0025 0.0315 0.2064
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.002 0.0197 0.2259
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0032 0.0463 0.6242
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0423 0.4065
Entamoeba histolytica protein kinase, putative 0.0034 0.0513 1
Echinococcus multilocularis protein kinase c epsilon type 0.0058 0.1032 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0225
Brugia malayi Protein kinase domain containing protein 0.0034 0.0513 0.293
Brugia malayi Protein kinase domain containing protein 0.0025 0.0314 0.0216
Echinococcus granulosus protein kinase C gamma type 0.0034 0.0513 0.293
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0314 0.0216
Brugia malayi Protein kinase domain containing protein 0.0034 0.0513 0.293
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0034 0.0513 0.0442
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0025 0.0315 0.2064
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0022 0.0241 0.3255
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0463 0.6242
Echinococcus granulosus serine:threonine protein kinase N2 0.0034 0.0513 0.293
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0034 0.0513 0.0442
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0034 0.0513 0.0442
Brugia malayi Protein kinase domain containing protein 0.0034 0.0513 0.293
Brugia malayi protein kinase C II. 0.0058 0.1032 1
Onchocerca volvulus 0.0028 0.0381 0.0092
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0381 0.5131
Echinococcus multilocularis protein kinase c iota type 0.0058 0.1032 1
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0513 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0423 0.4065
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0025 0.0314 0.0216
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0032 0.0463 0.481
Entamoeba histolytica protein kinase, putative 0.0034 0.0513 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0032 0.0463 0.481
Loa Loa (eye worm) hypothetical protein 0.0017 0.014 0.0065
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0012 0.0039 0.0527
Entamoeba histolytica protein kinase, putative 0.0034 0.0513 1
Brugia malayi protein kinase C3,putative 0.0025 0.0314 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0225
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0032 0.0463 0.481
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0034 0.0513 0.293
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.003 0.0423 0.5702
Brugia malayi Hr1 repeat family protein 0.0034 0.0513 0.293
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0025 0.0305 0.4119
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0024 0.0297 0.172
Mycobacterium ulcerans thioesterase TesA 0.0025 0.0315 0.2064
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0225
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.1032 1
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.1032 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0024 0.0298 0.0225
Echinococcus granulosus NDR protein kinase 0.0034 0.0513 0.293
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0029 0.0403 0.5436
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.0423 0.5702
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0025 0.0314 0.0216
Mycobacterium ulcerans polyketide synthase 0.003 0.0423 0.4065
Schistosoma mansoni atypical protein kinase C 0.0058 0.1032 1
Loa Loa (eye worm) fatty acid synthase 0.003 0.0414 0.0342
Toxoplasma gondii type I fatty acid synthase, putative 0.0032 0.0463 0.8774
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0034 0.0513 0.293
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0513 1
Brugia malayi Protein kinase c protein 2 0.0025 0.0314 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0225
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0381 0.0308
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0513 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0058 0.1032 0.0965
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0029 0.0403 0.5436
Mycobacterium ulcerans polyketide synthase 0.0032 0.0463 0.481
Trypanosoma brucei rac serine-threonine kinase, putative 0.0034 0.0513 0.5
Mycobacterium tuberculosis Probable thioesterase TesA 0.0025 0.0315 0.4254
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.003 0.0423 0.4065
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0513 1
Echinococcus multilocularis serine:threonine protein kinase 38 0.0034 0.0513 0.293
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0513 1
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0513 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0423 0.4065
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0045 0.0742 1
Loa Loa (eye worm) hypothetical protein 0.0443 0.9265 0.926
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.003 0.0423 0.4065
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0513 1
Loa Loa (eye worm) hypothetical protein 0.0443 0.9265 0.926
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0513 1
Loa Loa (eye worm) AGC/NDR protein kinase 0.0034 0.0513 0.0442
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0314 0.0216
Echinococcus granulosus protein kinase c epsilon type 0.0058 0.1032 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0025 0.0314 0.0241
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0297 0.172
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0225
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0058 0.1032 1
Loa Loa (eye worm) hypothetical protein 0.0443 0.9265 0.926
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0513 0.293
Onchocerca volvulus 0.0443 0.9265 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0058 0.1032 1
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0025 0.0314 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0225
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0225
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0045 0.0742 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0034 0.0513 0.293
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0423 0.4065
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0034 0.0513 0.293
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.1032 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0024 0.0297 0.172
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0057 0.1 0.9558
Onchocerca volvulus 0.0052 0.09 0.0672
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.003 0.0423 0.1702
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0225
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0513 0.293
Mycobacterium leprae Probable polyketide synthase Pks1 0.0032 0.0463 0.481
Loa Loa (eye worm) hypothetical protein 0.0467 0.9785 0.9783
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0034 0.0513 0.293
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0034 0.0513 0.293
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0017 0.0145 0.1953
Mycobacterium leprae Polyketide synthase Pks13 0.0045 0.0742 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0861 0.0792
Loa Loa (eye worm) AGC/AKT protein kinase 0.0034 0.0513 0.0442
Entamoeba histolytica protein kinase, putative 0.0034 0.0513 1
Schistosoma mansoni serine/threonine kinase 0.0034 0.0513 0.293
Onchocerca volvulus Fatty acid synthase homolog 0.0054 0.094 0.0716
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0513 1
Toxoplasma gondii AGC kinase 0.0034 0.0513 1
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0513 0.293
Mycobacterium ulcerans polyketide synthase Pks13 0.0045 0.0742 1
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0513 0.293
Loa Loa (eye worm) RasGEF domain-containing protein 0.0024 0.0298 0.0225
Echinococcus multilocularis serine threonine protein kinase 0.0034 0.0513 0.293
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0513 0.293
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0034 0.0513 0.293
Echinococcus granulosus protein kinase c iota type 0.0058 0.1032 1
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0024 0.0298 0.0225
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0225
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.0237 0.3254
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0225
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0025 0.0314 0.0241
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0513 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0298 0.0225
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0032 0.0463 0.6242
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0034 0.0513 0.0442
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0024 0.0298 0.0225
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0513 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0463 0.481
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0381 0.1126
Schistosoma mansoni protein kinase C mu 0.0025 0.0314 0.0216
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0423 0.5702
Brugia malayi C1-like domain containing protein 0.0025 0.0314 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0513 0.293

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 30 nM BindingDB_Patents: Biochemical Assay. The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FASN comprises about 25% of the cytosolic proteins in this cell line. SKBr3 cells were homogenized in a dounce homogenizer then centrifuged for 15 minutes at 4C. to remove particulate matter. The supernatant was then analyzed for protein content, diluted to the appropriate concentration, and used to measure FASN activity. The presence of FASN was confirmed by western blot analysis. A similar method for isolation of FASN from SKBr3 cells is described in Teresa, P. et al. (Clin. Cancer Res. 2009; 15(24), 7608-7615).FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) released during the fatty acid synthase reaction. The dye CPM (7-diethylamino-3-(4â-maleimidyl-phenyl)-4-methylcoumarin) contains a thiol reactive group that increases its fluorescence emission. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.