Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Sodium- and chloride-dependent glycine transporter 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.3117 | 0.185 | 0.1068 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 1.2111 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4121 | 0.276 | 0.2065 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.2079 | 0.091 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.3046 | 0.1785 | 0.0997 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.2079 | 0.091 | 0.3296 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.3046 | 0.1785 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.3117 | 0.185 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.4121 | 0.276 | 0.2065 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.2079 | 0.091 | 0.3296 |
Toxoplasma gondii | peptidase family M13 protein | 0.4121 | 0.276 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3117 | 0.185 | 0.1068 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.4121 | 0.276 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3046 | 0.1785 | 0.0997 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.2079 | 0.091 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.3046 | 0.1785 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.3117 | 0.185 | 0.1068 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.2079 | 0.091 | 0.3296 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.4121 | 0.276 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.4121 | 0.276 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3117 | 0.185 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.3117 | 0.185 | 0.1068 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.3046 | 0.1785 | 0.0997 |
Onchocerca volvulus | 0.2042 | 0.0876 | 0.5 | |
Mycobacterium ulcerans | zinc metalloprotease | 0.4121 | 0.276 | 0.5 |
Mycobacterium leprae | probable zinc metalloprotease | 0.4121 | 0.276 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3046 | 0.1785 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.4121 | 0.276 | 0.2065 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.4121 | 0.276 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 189.3 nM | BindingDB_Patents: Uptake Inhibition Assay. Glycine uptake inhibition assay. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.